DK255888A - Diastereomere 5r,6s-6-(1r-hydroxyethyl)-2-(cis-1-oxo-3-thiolanylthio)-2-penem-3-carboxylsyre-forbindelser samt mellemprodukter ved deres fremstilling og fremgangsmaade til fremstilling af mellemprodukterne - Google Patents

Diastereomere 5r,6s-6-(1r-hydroxyethyl)-2-(cis-1-oxo-3-thiolanylthio)-2-penem-3-carboxylsyre-forbindelser samt mellemprodukter ved deres fremstilling og fremgangsmaade til fremstilling af mellemprodukterne

Info

Publication number: DK255888A
Authority: DK; Denmark
Prior art keywords: thiolanylthio; penem; oxo; hydroxyethyl; carboxylic acid
Prior art date: 1987-05-11

Application number

DK255888A

Other languages

English (en)

Other versions

DK170443B1 (da

DK255888D0 (da

Inventor

Robert Alfred Volkmann

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-05-11

Filing date

1988-05-10

Publication date

1989-02-07

1988-05-10 Application filed by Pfizer filed Critical Pfizer

1988-05-10 Publication of DK255888D0 publication Critical patent/DK255888D0/da

1989-02-07 Publication of DK255888A publication Critical patent/DK255888A/da

1995-09-04 Application granted granted Critical

1995-09-04 Publication of DK170443B1 publication Critical patent/DK170443B1/da

Links

239000000543 intermediate Substances 0.000 title abstract 2
230000001737 promoting effect Effects 0.000 title 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
230000009885 systemic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/86—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/32—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/46—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings substituted on the ring sulfur atom
- C07D333/48—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings substituted on the ring sulfur atom by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Epoxy Compounds (AREA)
Cephalosporin Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Steroid Compounds (AREA)

DK255888A 1987-05-11 1988-05-10 Optisk aktive 5R,6S-6-(1R-hydroxyethyl)-2-(cis-1-oxo-3-thiolanylthio)-2-penem-3-carboxylsyreforbindelser samt mellemprodukter ved deres fremstilling DK170443B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
PCT/US1987/001114 WO1988008845A1 (en)	1987-05-11	1987-05-11	Diastereomeric 5r,6s-6-(1r-hydroxyethyl)-2-(cis-1-oxo-3-thiolanylthio)-2-penem-3-carboxylic acids
US8701114		1987-05-11

Publications (3)

Publication Number	Publication Date
DK255888D0 DK255888D0 (da)	1988-05-10
DK255888A true DK255888A (da)	1989-02-07
DK170443B1 DK170443B1 (da)	1995-09-04

Family

ID=22202388

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK255888A DK170443B1 (da)	1987-05-11	1988-05-10	Optisk aktive 5R,6S-6-(1R-hydroxyethyl)-2-(cis-1-oxo-3-thiolanylthio)-2-penem-3-carboxylsyreforbindelser samt mellemprodukter ved deres fremstilling

Country Status (27)

Country	Link
US (2)	US5013729A (da)
EP (1)	EP0294934B1 (da)
JP (2)	JPH0737463B2 (da)
KR (1)	KR900006840B1 (da)
CN (2)	CN1023016C (da)
AT (1)	ATE132869T1 (da)
AU (1)	AU603665B2 (da)
CA (1)	CA1338830C (da)
CS (1)	CS269999B2 (da)
DD (1)	DD270074A5 (da)
DE (1)	DE3854874T2 (da)
DK (1)	DK170443B1 (da)
EG (1)	EG18481A (da)
ES (1)	ES2081805T3 (da)
FI (1)	FI96423C (da)
GR (1)	GR3019094T3 (da)
IE (1)	IE70587B1 (da)
IL (1)	IL86288A0 (da)
MA (1)	MA21265A1 (da)
MY (1)	MY104306A (da)
NZ (1)	NZ224552A (da)
PH (1)	PH23931A (da)
PL (1)	PL159558B1 (da)
PT (1)	PT87443B (da)
WO (1)	WO1988008845A1 (da)
YU (1)	YU45059B (da)
ZA (1)	ZA883291B (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0352977A3 (en) *	1988-07-28	1991-08-07	Pfizer Inc.	Stereoselective oxidation process
EP0382418A3 (en) *	1989-02-09	1991-10-23	Pfizer Inc.	Process for optically active 3-thiolanyl sulfonate esters
MX20084A (es) *	1989-03-28	1993-03-01	Pfizer	Derivados de 2 -carbapenem antibacterianos
US5321020A (en) *	1989-03-28	1994-06-14	Pfizer Inc.	Antibacterial 2-carbapenem derivatives
US5075439A (en) *	1990-08-17	1991-12-24	Pfizer Inc.	Processes for (3S,4R)-3-[1(R)-t-butyl-dimethylsilyloxy)-ethyl]-4-[1-oxo-3-thiolanylthio(thiocarbonyl)thio]azetidin-2-ones and intermediates therefor
EP1712633A1 (en) *	2003-12-02	2006-10-18	Mercian Corporation	Process for producing optically active tetrahydrothiophene derivative and method of crystallizing optically active tetrahydrothiophen-3-ol
JP2005314374A (ja) *	2004-03-31	2005-11-10	Daiso Co Ltd	３−ヒドロキシチオランの新規製法
KR100939347B1 (ko)	2005-07-20	2010-01-29	(주)카이로드	광학적으로 순수한 (ｓ)-3-히드록시 피롤리딘의 제조방법
PE20080940A1 (es) *	2006-06-28	2008-07-09	Pfizer Prod Inc	Profarmacos de penem
CN101479279B (zh) *	2006-06-28	2011-08-17	辉瑞产品公司	培南前药
WO2008059367A1 (en) *	2006-11-14	2008-05-22	Pfizer Products Inc.	Penem prodrugs
US20080125408A1 (en) *	2006-11-14	2008-05-29	Pfizer Inc	Penem prodrug
EP2195443B1 (en)	2007-08-24	2015-01-07	Codexis, Inc.	Improved ketoreductase polypeptides for the stereoselective production of (r)-3-hydroxythiolane
CN105061394A (zh) *	2015-09-11	2015-11-18	北京工商大学	一种2-丙基-4-乙酰氧基四氢噻吩的制备方法
EP4382529A1 (en)	2022-12-07	2024-06-12	Bayer Consumer Care AG	A process for preparing pure (3s)-pyrrolidin-3-ol and pure (3s)-pyrrolidin-3-ol hydrochloride

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0130025B1 (en) *	1983-06-21	1987-07-08	Pfizer Inc.	2-alkylthiopenem derivatives
US4619924A (en) *	1984-05-18	1986-10-28	Pfizer Inc.	2-alkylthiopenem derivatives
US4739047A (en) *	1985-10-17	1988-04-19	Pfizer Inc.	Intermediates for 2-(1-oxo-3-thiolanyl)-2-penem antibiotics
ZA867809B (en) *	1985-10-17	1988-05-25	Pfizer	Process for 2-(1-oxo-3-thiolanyl)-2-penem antibiotics
EP0223397B1 (en) *	1985-10-17	1991-09-04	Pfizer Inc.	Process for 2-(1-oxo-3-thiolanyl)-2-penem antibiotics
US4806637A (en) *	1986-03-17	1989-02-21	Schering Corporation	6-(Hydroxyethyl)-2-(heterocyclylthio)-penem-3-carboxylates
US4695626A (en) *	1986-07-29	1987-09-22	Pfizer Inc.	1-aza-4,5-dithiabicyclo [4.2.0] oct-2-en-8-one-2 carboxylate esters
PH24872A (en) *	1986-08-25	1990-12-26	Schering Corp	(5r,6s,8r)-6-(-1-hydroxyethyl)-2-(3r-pyrrolidin-2-one-3-yl)thiopenem-3-carboxylic acid

1987
- 1987-05-11 US US07/460,118 patent/US5013729A/en not_active Expired - Lifetime
- 1987-05-11 WO PCT/US1987/001114 patent/WO1988008845A1/en not_active Ceased
1988
- 1988-05-04 ES ES88304016T patent/ES2081805T3/es not_active Expired - Lifetime
- 1988-05-04 DE DE3854874T patent/DE3854874T2/de not_active Expired - Fee Related
- 1988-05-04 AT AT88304016T patent/ATE132869T1/de not_active IP Right Cessation
- 1988-05-04 EP EP88304016A patent/EP0294934B1/en not_active Expired - Lifetime
- 1988-05-05 CA CA000565961A patent/CA1338830C/en not_active Expired - Fee Related
- 1988-05-05 IL IL86288A patent/IL86288A0/xx unknown
- 1988-05-06 MY MYPI88000475A patent/MY104306A/en unknown
- 1988-05-06 CS CS883119A patent/CS269999B2/cs not_active IP Right Cessation
- 1988-05-08 EG EG256/88A patent/EG18481A/xx active
- 1988-05-09 NZ NZ224552A patent/NZ224552A/xx unknown
- 1988-05-09 PL PL1988272358A patent/PL159558B1/pl unknown
- 1988-05-09 PT PT87443A patent/PT87443B/pt not_active IP Right Cessation
- 1988-05-10 JP JP63111717A patent/JPH0737463B2/ja not_active Expired - Lifetime
- 1988-05-10 DK DK255888A patent/DK170443B1/da not_active IP Right Cessation
- 1988-05-10 ZA ZA883291A patent/ZA883291B/xx unknown
- 1988-05-10 IE IE141188A patent/IE70587B1/en not_active IP Right Cessation
- 1988-05-10 DD DD88315631A patent/DD270074A5/de not_active IP Right Cessation
- 1988-05-10 AU AU15896/88A patent/AU603665B2/en not_active Ceased
- 1988-05-10 MA MA21506A patent/MA21265A1/fr unknown
- 1988-05-10 KR KR1019880005398A patent/KR900006840B1/ko not_active Expired
- 1988-05-10 CN CN88102863A patent/CN1023016C/zh not_active Expired - Fee Related
- 1988-05-10 PH PH36907A patent/PH23931A/en unknown
- 1988-05-10 YU YU906/88A patent/YU45059B/xx unknown
1989
- 1989-11-10 FI FI895369A patent/FI96423C/fi not_active IP Right Cessation
1992
- 1992-11-17 CN CN92113234A patent/CN1036996C/zh not_active Expired - Fee Related
1993
- 1993-02-11 US US08/016,413 patent/US5319103A/en not_active Expired - Lifetime
1994
- 1994-10-19 JP JP6278577A patent/JP2544902B2/ja not_active Expired - Lifetime
1996
- 1996-02-23 GR GR960400514T patent/GR3019094T3/el unknown

Also Published As

Publication number	Publication date
AU1589688A (en)	1988-11-17
IE70587B1 (en)	1996-12-11
ES2081805T3 (es)	1996-03-16
JPH0737463B2 (ja)	1995-04-26
ATE132869T1 (de)	1996-01-15
DK170443B1 (da)	1995-09-04
CS269999B2 (en)	1990-05-14
NZ224552A (en)	1989-10-27
EP0294934A3 (en)	1989-01-25
EP0294934B1 (en)	1996-01-10
FI96423B (fi)	1996-03-15
JPS63287781A (ja)	1988-11-24
MA21265A1 (fr)	1988-12-31
MY104306A (en)	1994-03-31
YU45059B (en)	1991-06-30
PL159558B1 (pl)	1992-12-31
IE881411L (en)	1988-11-11
PT87443A (pt)	1989-05-31
DK255888D0 (da)	1988-05-10
JPH07278137A (ja)	1995-10-24
ZA883291B (en)	1989-12-27
KR880013943A (ko)	1988-12-22
PL272358A1 (en)	1989-10-30
CA1338830C (en)	1997-01-07
AU603665B2 (en)	1990-11-22
GR3019094T3 (en)	1996-05-31
US5319103A (en)	1994-06-07
PH23931A (en)	1990-01-23
DD270074A5 (de)	1989-07-19
KR900006840B1 (ko)	1990-09-22
CN1036996C (zh)	1998-01-14
DE3854874D1 (de)	1996-02-22
EG18481A (en)	1993-06-30
EP0294934A2 (en)	1988-12-14
YU90688A (en)	1989-12-31
CS311988A2 (en)	1989-08-14
PT87443B (pt)	1992-08-31
IL86288A0 (en)	1988-11-15
US5013729A (en)	1991-05-07
WO1988008845A1 (en)	1988-11-17
JP2544902B2 (ja)	1996-10-16
FI96423C (fi)	1996-06-25
CN1073442A (zh)	1993-06-23
CN88102863A (zh)	1988-12-21
CN1023016C (zh)	1993-12-08
DE3854874T2 (de)	1996-05-23
FI895369A0 (fi)	1989-11-10

Legal Events

Date	Code	Title	Description
1995-09-04	B1	Patent granted (law 1993)
1998-01-19	PBP	Patent lapsed

Publication	Publication Date	Title
DK255888D0 (da)	1988-05-10	Diastereomere 5r,6s-6-(1r-hydroxyethyl)-2-(cis-1-oxo-3-thiolanylthio)-2-penem-3-carboxylsyre-forbindelser samt mellemprodukter ved deres fremstilling og fremgangsmaade til fremstilling af mellemprodukterne
DK140996A (da)	1996-12-09	Fremgangsmåde til fremstilling af 2,3,4,5-tetraflour-6-alkyl-benzoesyreforbindelser
DK518683A (da)	1984-05-16	Fremgangsmaade til fremstilling af 4aeepi-9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin a eller farmaceutisk acceptable syreadditionssalte deraf og mellemprodukter ved fremgangsmaaden
FI904204A0 (fi)	1990-08-24	Foerfarande foer framstaellning av cykliska aminosyraderivat och mellanprodukter.
DE3853962D1 (de)	1995-07-20	Verfahren zur Kristallisation von Kalium-Clavulanat.
DE3485419D1 (de)	1992-02-13	Glyzerinderivate.
IT1207172B (it)	1989-05-17	Processo per la preparazione dicorpi microporosi inglobanti uno o piu' agenti attivi.
AU527894B2 (en)	1983-03-31	Bis-penicillin esters of alkane diols
DE69002859D1 (de)	1993-09-30	Verfahren zur Haltbarmachung von Natriumperboratmonohydrat.
IT8120307A0 (it)	1981-03-12	Disposizione per il trattamento termico di pezzi d'opera.
IT8026793A0 (it)	1980-12-19	Procedimento per la produzione di ascorbato ossidasi.
IT8723124A0 (it)	1987-12-21	Processo per la preparazione di intermedi per antibiotici.
ES2086395T3 (es)	1996-07-01	Fosfolipidos para el tratamiento de esclerosis multiple.
NO175368C (no)	1994-10-05	Mellomprodukter for fremstilling av terapeutisk aktive diastereomere 5R,6S-6-(1R-hydroksyetyl)-2-(cis-1-okso-3-tiolanyltio)-2-penem-3-karboksylsyrer
ES555466A0 (es)	1987-05-01	Mejoras introducidas en el objeto de la patente de invencion 516.212 por perfeccionamientos introducidos en atomizadores agricolas
IT8741685A0 (it)	1987-09-22	Comando di potenza per l'organo operativo di una macchina industriale.
IT8834035V0 (it)	1988-07-08	Gioco educativo per la composizione di pannelli decorativi.
IT8720114A0 (it)	1987-04-14	Procedimento migliorato per la purificazione di l-carnitinato di l-carnitina.
IT7928384A0 (it)	1979-12-24	Processo per la depurazione delle acque di vegetazione.
IT8785586A0 (it)	1987-07-31	Gioco di abilita'.
IT8021939V0 (it)	1980-05-30	Pinza universale per l'afferramento di teglie o simili.