DK2561065T3 - Cellekulturmedium, der omfatter små peptider - Google Patents

Cellekulturmedium, der omfatter små peptider Download PDF

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Publication number
DK2561065T3
DK2561065T3 DK11772796.6T DK11772796T DK2561065T3 DK 2561065 T3 DK2561065 T3 DK 2561065T3 DK 11772796 T DK11772796 T DK 11772796T DK 2561065 T3 DK2561065 T3 DK 2561065T3
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cells
cell
free
cysteine
serum
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DK11772796.6T
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Shawn Barrett
Scott Jacobia
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Life Technologies Corp
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/005—Protein-free medium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998—Proteins not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Claims (14)

1. Serumfrit, koncentreret, eukaryot enkeltdels-næringsmiddel, der omfatter små peptider, der omfatter cystein og tyrosin, idet hver af peptiderne omfatter seks eller færre aminosyrer, hvor det for hvert peptid gælder, at mindst én af aminosyreme er en cystein og/eller en tyrosin, og hvor det eukaryote koncentrerede næringsmiddel er hydrolysatfrit.
2. Serumfrit, koncentreret næringsmiddel ifølge krav 1, hvor det for hvert peptid gælder, at mindst én af de resterende aminosyrer er udvalgt fra gruppen, der består af alanin, serin, glycin, valin, prolin, asparaginsyre og glutaminsyre, fortrinsvis alanin eller glycin.
3. Serumfrit, koncentreret næringsmiddel ifølge et hvilket som helst af kravene 1 eller 2, hvor det koncentrerede enkeltdels-næringsmiddel er ved et neutralt pH.
4. Serumfrit, koncentreret næringsmiddel ifølge et hvilket som helst af kravene 1 til 3, som øger titeren af et rekombinant protein, der dannes i cellekultursystemet.
5. Serumfrit, koncentreret næringsmiddel ifølge et hvilket som helst af kravene 1 til 4, der øger den levedygtige celledensitet i cellekultursystemet.
6. Serumfrit, koncentreret næringsmiddel ifølge et hvilket som helst af kravene 1 til 5, hvor mindst ét af de små peptider er et dipeptid udvalgt fra gruppen, der består af X-tyrosin, X-cystein, tyrosin-X og cystein-X eller et salt deraf, og hvor X er udvalgt fra gruppen, der består af alanin, glycin, valin, prolin, asparaginsyre og glutaminsyre, fortrinsvis hvor X er alanin eller glycin.
7. Serumfrit, koncentreret næringsmiddel ifølge et hvilket som helst af kravene 1 til 6, hvor den N-terminale aminosyre af de små peptider har en fri aminogruppe.
8. Serumfrit, koncentreret næringsmiddel ifølge et hvilket som helst af kravene 1-7, hvor det koncentrerede næringsmiddel er en væskeformig opløsning eller et tørt pulver eller et granuleret tørt pulver.
9. Serumfrit, koncentreret næringsmiddel ifølge et hvilket som helst af ovennævnte krav, hvor de små peptider eller dipeptider er til stede ved en koncentration på 1 g/L til 16 g/L, fortrinsvis 2,5 g/L til 8,5 g/L.
10. Serumfrit, koncentreret næringsmiddel ifølge et hvilket som helst af ovennævnte krav, som er en væskeformig opløsning, der forbliver fri for præcipitat i over 12 måneder ved opbevaring ved 2-8 °C.
11. Serumfrit, koncentreret næringsmiddel ifølge et hvilket som helst af ovennævnte krav, hvor næringsmidlet også er proteinfrit.
12. Fremgangsmåde til fremstilling af et serumfrit, koncentreret næringsmiddel, der omfatter kombinering af små peptider, der omfatter cystein og tyrosin, ifølge et hvilket som helst af ovennævnte krav med et carbohydrat, fortrinsvis glucose, og mindst én aminosyre eller et salt deraf.
13. Kit til dyrkning af en celle in vitro, hvilket kit omfatter en eller flere beholdere, hvor en første beholder indeholder et serumfrit, koncentreret næringsmiddel ifølge et hvilket som helst af kravene 1 til 11, og hvor det serumfrie, koncentrerede næringsmiddel understøtter væksten af cellen i kultur og/eller ekspressionen af rekombinant protein eller et virus og/eller en viruspartikel.
14. Anvendelse af et serumfrit, koncentreret næringsmiddel ifølge et hvilket som helst af kravene 1 til 11 eller kit ifølge krav 13 til dyrkning af celler og/eller til produktion af et virus eller et rekombinant protein, hvor cellerne er udvalgt blandt insektceller, nematodeceller, CHO-celler, COS-celler, VERO-celler, BHK-celler, AE-1-celler, SP2/0-celler, L5.1-celler, PerC6- og hybridomaceller.
DK11772796.6T 2010-04-23 2011-04-22 Cellekulturmedium, der omfatter små peptider DK2561065T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32764410P 2010-04-23 2010-04-23
US13/092,016 US20110262965A1 (en) 2010-04-23 2011-04-21 Cell culture medium comprising small peptides
PCT/US2011/033630 WO2011133902A2 (en) 2010-04-23 2011-04-22 Cell culture medium comprising small peptides

Publications (1)

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DK2561065T3 true DK2561065T3 (da) 2017-02-13

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DK16198499.2T DK3168295T3 (da) 2010-04-23 2011-04-22 Celledyrkningsmedium, der omfatter små peptider
DK11772796.6T DK2561065T3 (da) 2010-04-23 2011-04-22 Cellekulturmedium, der omfatter små peptider
DK16192190.3T DK3165600T3 (da) 2010-04-23 2011-04-22 Celledyrkningsmedium, der omfatter små peptider

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US (6) US20110262965A1 (da)
EP (4) EP3168295B1 (da)
JP (7) JP6016783B2 (da)
KR (6) KR101733834B1 (da)
CN (3) CN102892878A (da)
AU (6) AU2011242496C1 (da)
DE (1) DE202011110859U1 (da)
DK (3) DK3168295T3 (da)
SG (3) SG10201503196VA (da)
WO (1) WO2011133902A2 (da)

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