DK257183D0 - Isonitril-radionuclidkomplekser og deres anvendelse til maerknings-og afbildningsmidler - Google Patents

Isonitril-radionuclidkomplekser og deres anvendelse til maerknings-og afbildningsmidler

Info

Publication number
DK257183D0
DK257183D0 DK2571/83A DK257183A DK257183D0 DK 257183 D0 DK257183 D0 DK 257183D0 DK 2571/83 A DK2571/83 A DK 2571/83A DK 257183 A DK257183 A DK 257183A DK 257183 D0 DK257183 D0 DK 257183D0
Authority
DK
Denmark
Prior art keywords
isonitril
labeling
imaging agents
radionuclide complexes
radionuclide
Prior art date
Application number
DK2571/83A
Other languages
English (en)
Other versions
DK257183A (da
DK172154B1 (da
Inventor
Alun G Jones
Michael J Abrams
Alan Davidson
Original Assignee
Harvard College
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US06/373,511 priority Critical patent/US4452774A/en
Priority to DE8383902147T priority patent/DE3372709D1/de
Priority to PCT/US1983/000638 priority patent/WO1983003761A1/en
Priority to EP83902147A priority patent/EP0107734B1/en
Priority to CA000427085A priority patent/CA1218666A/en
Application filed by Harvard College, Massachusetts Inst Technology filed Critical Harvard College
Priority to DK257183A priority patent/DK172154B1/da
Publication of DK257183D0 publication Critical patent/DK257183D0/da
Publication of DK257183A publication Critical patent/DK257183A/da
Priority to NL950023C priority patent/NL950023I2/nl
Application granted granted Critical
Publication of DK172154B1 publication Critical patent/DK172154B1/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1217—Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols
    • A61K51/1234—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/025—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus inorganic Tc complexes or compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
DK257183A 1982-04-30 1983-06-06 Isonitrilkompleks omfattende et radionuclid, middel til anvendelse ved mærkning, afbildning eller detektering og indeholdende et sådant kompleks, kit til fremstilling af et sådant kompleks, og fremgangsmåde til mærkning af en celle eller et liposom in vitro DK172154B1 (da)

Priority Applications (7)

Application Number Priority Date Filing Date Title
US06/373,511 US4452774A (en) 1982-04-30 1982-04-30 Isonitrile radionuclide complexes for labelling and imaging agents
DE8383902147T DE3372709D1 (en) 1982-04-30 1983-04-26 Isonitrile radionuclide complexes for labelling and imaging agents
PCT/US1983/000638 WO1983003761A1 (en) 1982-04-30 1983-04-26 Isonitrile radionuclide complexes for labelling and imaging agents
EP83902147A EP0107734B1 (en) 1982-04-30 1983-04-26 Isonitrile radionuclide complexes for labelling and imaging agents
CA000427085A CA1218666A (en) 1982-04-30 1983-04-29 Isonitrile radionuclide complexes for labelling and imaging agents
DK257183A DK172154B1 (da) 1982-04-30 1983-06-06 Isonitrilkompleks omfattende et radionuclid, middel til anvendelse ved mærkning, afbildning eller detektering og indeholdende et sådant kompleks, kit til fremstilling af et sådant kompleks, og fremgangsmåde til mærkning af en celle eller et liposom in vitro
NL950023C NL950023I2 (nl) 1982-04-30 1995-10-24 Radionuclide isonitrilcomplexen voor merkende en beeldvormende middelen.

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US37351182 1982-04-30
US06/373,511 US4452774A (en) 1982-04-30 1982-04-30 Isonitrile radionuclide complexes for labelling and imaging agents
DK257183A DK172154B1 (da) 1982-04-30 1983-06-06 Isonitrilkompleks omfattende et radionuclid, middel til anvendelse ved mærkning, afbildning eller detektering og indeholdende et sådant kompleks, kit til fremstilling af et sådant kompleks, og fremgangsmåde til mærkning af en celle eller et liposom in vitro
DK257183 1983-06-06

Publications (3)

Publication Number Publication Date
DK257183D0 true DK257183D0 (da) 1983-06-06
DK257183A DK257183A (da) 1984-12-07
DK172154B1 DK172154B1 (da) 1997-12-01

Family

ID=39577807

Family Applications (1)

Application Number Title Priority Date Filing Date
DK257183A DK172154B1 (da) 1982-04-30 1983-06-06 Isonitrilkompleks omfattende et radionuclid, middel til anvendelse ved mærkning, afbildning eller detektering og indeholdende et sådant kompleks, kit til fremstilling af et sådant kompleks, og fremgangsmåde til mærkning af en celle eller et liposom in vitro

Country Status (7)

Country Link
US (1) US4452774A (da)
EP (1) EP0107734B1 (da)
CA (1) CA1218666A (da)
DE (1) DE3372709D1 (da)
DK (1) DK172154B1 (da)
NL (1) NL950023I2 (da)
WO (1) WO1983003761A1 (da)

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US4764359A (en) * 1984-05-25 1988-08-16 Lemelson Jerome H Drug compositions and their use in treating human or other mammalian patients
US4681091A (en) * 1984-08-03 1987-07-21 Picker Donald H Combination modality cancer therapy
US4707544A (en) * 1984-11-28 1987-11-17 President And Fellows Of Harvard College Metal-isonitrile adducts for preparing radionuclide complexes for labelling and imaging agents
US4826961A (en) * 1984-11-28 1989-05-02 President And Fellows Of Harvard College Method for preparing radiopharmaceutical complexes
US4789543A (en) * 1984-11-30 1988-12-06 E. I. Du Pont De Nemours And Company Neutral technetium 99-m complexes useful as radiodiagnostic agents
US4795626A (en) * 1985-05-10 1989-01-03 University Of Cincinnati 99m Tc.sup.(III) myocardial imaging agents which are non-reducable in vivo
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US4894445A (en) * 1985-08-05 1990-01-16 E. I. Du Pont De Nemours And Company Metal-isonitrile adducts for preparing radionuclide complexes
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US4735793A (en) * 1985-08-30 1988-04-05 Massachusetts Institute Of Technology Carboxy, carboalkoxy and carbamile substituted isonitrile radionuclide complexes
GB8531296D0 (en) * 1985-12-19 1986-01-29 Amersham Int Plc Cationic complexes of technetium
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US4925925A (en) * 1988-06-15 1990-05-15 University Of Cincinnati Radioactive rhenium ligated to 2-hydroxy isobutyric acid and method of use
US5279968A (en) * 1989-07-20 1994-01-18 Syncor International Corporation Method of labelling leucocytes with Tc-99m, d,1-HMPAO
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US5143713A (en) * 1990-05-30 1992-09-01 Board Of Regents, The University Of Texas System 99m Tc labeled liposomes
US5158760A (en) * 1990-05-30 1992-10-27 Board Of Regents, The University Of Texas System 99m TC labeled liposomes
US5407653A (en) * 1991-06-26 1995-04-18 Brigham And Women's Hospital Evaluation of the multidrug resistance phenotype
US5210270A (en) * 1991-11-25 1993-05-11 Institute Of Nuclear Energy Research Method for synthesis and 99m C labelling of 2-alkoxyisobutylisonitrile
US5420321A (en) * 1993-08-03 1995-05-30 The Du Pont Merck Pharmaceutical Company Tris(isonitrile)copper(i) sulfates for preparing radionuclide complexes
CA2190727C (en) * 1994-05-19 2006-07-18 Sudhakar Kasina Aromatic amine substituted bridged nitrogen and sulfur donor atom ligands for imaging
AU2251197A (en) * 1996-01-24 1997-08-20 Du Pont Merck Pharmaceutical Company, The 99m tc-tertiary-butyl isonitrile and analogs as breast tumor imaging agents
US5961952A (en) * 1996-01-24 1999-10-05 Dupont Pharmaceuticals Company 99m Tc-tertiary-butyl isonitrile as breast tumor imaging agents
US5766952A (en) * 1996-07-25 1998-06-16 Regents Of The University Of Minnesota Vapochromic platinum-complexes and salts
US6416733B1 (en) 1996-10-07 2002-07-09 Bristol-Myers Squibb Pharma Company Radiopharmaceuticals for imaging infection and inflammation
US5900377A (en) * 1997-03-03 1999-05-04 Syncor International Corporation Method for isolating and radiolabeling leukocytes for use in vivo
US6005083A (en) 1997-03-28 1999-12-21 Neorx Corporation Bridged aromatic substituted amine ligands with donor atoms
US6537520B1 (en) 1998-03-31 2003-03-25 Bristol-Myers Squibb Pharma Company Pharmaceuticals for the imaging of angiogenic disorders
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US6589503B1 (en) 1998-06-20 2003-07-08 Washington University Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy
US6348185B1 (en) 1998-06-20 2002-02-19 Washington University School Of Medicine Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy
US7306784B2 (en) 1998-06-20 2007-12-11 Washington University Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy
US8038984B2 (en) 1998-06-20 2011-10-18 Washington University Membrane-permeant peptide complexes for treatment of sepsis
CA2727746A1 (en) 1998-12-18 2000-06-22 Bristol-Myers Squibb Pharma Company Quinolone vitronectin receptor antagonist pharmaceuticals
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US6794518B1 (en) 1998-12-18 2004-09-21 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
US6656448B1 (en) 2000-02-15 2003-12-02 Bristol-Myers Squibb Pharma Company Matrix metalloproteinase inhibitors
CA2379445C (en) 2000-06-01 2007-08-21 Bristol-Myers Squibb Pharma Company Lactams substituted by cyclic succinates as inhibitors of a.beta. protein production
CA2427911A1 (en) 2000-11-03 2002-05-10 Bristol Myers Squibb Company Simultaneous dual isotope imaging of cardiac perfusion and cardiac inflammation
CN1136921C (zh) * 2001-04-27 2004-02-04 北京师范大学 一种心肌显像剂及其制备方法
US6838074B2 (en) 2001-08-08 2005-01-04 Bristol-Myers Squibb Company Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent
AU2002331042B2 (en) 2001-08-08 2007-10-25 Bristol-Myers Squibb Pharma Company Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent
US20050106100A1 (en) * 2003-09-03 2005-05-19 Harris Thomas D. Compounds containing matrix metalloproteinase substrates and methods of their use
US20070189965A1 (en) * 2004-06-17 2007-08-16 Kuperus John H Copper-complex isonitrile positron emission tomography (pet) imaging agent and method
US7229603B2 (en) * 2004-06-17 2007-06-12 Anazaohealth Corporation Stablilized and lyophilized radiopharmaceutical agents
KR20080022588A (ko) * 2005-06-30 2008-03-11 브리스톨-마이어스 스퀴브 파마 컴퍼니 영상화제로서의 히드라지드 컨쥬게이트
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Also Published As

Publication number Publication date
EP0107734A4 (en) 1984-11-22
US4452774A (en) 1984-06-05
DK257183A (da) 1984-12-07
WO1983003761A1 (en) 1983-11-10
EP0107734B1 (en) 1987-07-29
NL950023I2 (nl) 1997-12-01
DK172154B1 (da) 1997-12-01
DE3372709D1 (en) 1987-09-03
CA1218666A (en) 1987-03-03
NL950023I1 (da) 1996-01-02
EP0107734A1 (en) 1984-05-09

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Legal Events

Date Code Title Description
A0 Application filed
B1 Patent granted (law 1993)
PUP Patent expired