DK2575463T3 - Apoptose-inducerende midler til behandling af cancer og immunsygdomme og autoimmune sygdomme - Google Patents

Apoptose-inducerende midler til behandling af cancer og immunsygdomme og autoimmune sygdomme Download PDF

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Publication number
DK2575463T3
DK2575463T3 DK11787299.4T DK11787299T DK2575463T3 DK 2575463 T3 DK2575463 T3 DK 2575463T3 DK 11787299 T DK11787299 T DK 11787299T DK 2575463 T3 DK2575463 T3 DK 2575463T3
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cancer
formula
compounds
nhc
heterocycloalkane
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DK11787299.4T
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Zhi-Fu Tao
Xilu Wang
Gerard Sullivan
Andrew J Souers
Nathaniel D Catron
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Abbvie Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/36—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
    • A01N43/38—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A01N43/42—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Claims (4)

1
1. Forbindelse med formlen (Illa): ener ei lerapeunsK
accepiaDen san aeraf, hvor A1 er C(A2); A2 er H; B1 er OR1 eller NHR1, hvor R1 er (CrC^-alkyl, som er substitueret med R10; D1 erH: E1 erH: Y1 er N02; G1 er alkyl, som er substitueret med 0P(0)(0H)(0H); R10 er (C3-C10)-cycloalkyl med en eller to CH2-dele, som er uerstattede eller erstattet med O; hvor den del, som er repræsenteret ved R10, er usubstitueret eller substitueret med en eller to eller tre eller fire eller fem substituenter, som er uafhængigt valgt fra gruppen bestående af R50, OR50, F, Cl, Br og I; og R50 er (Ci-Cio)-alkyl.
2. Forbindelse eller terapeutisk acceptabelt salt ifølge krav 1, hvor forbindelsen er valgt fra gruppen bestående af: (5-{5-(4-{[2-(4-chlorphenyl)-4,4-dimethylcyclohex-1 -en-1 -yl]methyl}piperazin-1-yl)-2-[({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)carbamoyl]phenoxy}-7H-pyrrolo[2,3-b]pyridin-7-yl)methyl-dihydrogenphosphat; 2 {5-[5-(4-{[2-(4-chlorphenyl)-4,4-dimethylcyclohex-1 -en-1 - yl]methyl}piperazin-1-yl)-2-{[(4-{[(trans-4- methoxycyclohexyl)methyl]amino}-3- nitrophenyl)sulfonyl]carbamoyl}phenoxy]-7H-pyrrolo[2,3-b]pyridin-7-yljmethyl-dihydrogenphosphat og (5-{5-(4-{[2-(4-chlorphenyl)-4,4-dimethylcyclohex-1 -en-1 -yl]methyl}piperazin-1-yl)-2-[({4-[(4-fluortetrahydro-2H-pyran-4-yl)methoxy]-3-nitrophenyl}sulfonyl)carbamoyl]phenoxy}-7H-pyrrolo[2,3-b]pyridin-7-yl)methyl-dihydrogenphosphat.
3. Farmaceutisk sammensætning, som omfatter en excipiens og en terapeutisk effektiv mængde af forbindelsen eller det terapeutisk acceptable salt ifølge krav 1 eller krav 2.
4. Forbindelse eller terapeutisk acceptabelt salt ifølge krav 1 eller krav 2 til anvendelse til behandling af blærecancer, hjernecancer, brystcancer, knoglemarvscancer, cervixcancer, kronisk lymfatisk leukæmi, kolorektal cancer, øsofaguscancer, hepatocellulær cancer, lymfoblastisk leukæmi, follikulært lymfom, en lymfoid malignitet af T-celle- eller B-celleoprindelse, melanom, myeloid leukæmi, myelom, oral cancer, ovariecancer, ikke-småcellet lungecancer, prostatacancer, småcellet lungecancer eller miltcancer hos en patient ved at administrere en terapeutisk effektiv mængde af forbindelsen eller det terapeutisk acceptable salt deraf til patienten.
DK11787299.4T 2010-05-26 2011-05-25 Apoptose-inducerende midler til behandling af cancer og immunsygdomme og autoimmune sygdomme DK2575463T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34842210P 2010-05-26 2010-05-26
PCT/US2011/037849 WO2011150016A1 (en) 2010-05-26 2011-05-25 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases

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DK2575463T3 true DK2575463T3 (da) 2016-07-25

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DK11787299.4T DK2575463T3 (da) 2010-05-26 2011-05-25 Apoptose-inducerende midler til behandling af cancer og immunsygdomme og autoimmune sygdomme

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US (5) US9006247B2 (da)
EP (3) EP3091017B1 (da)
JP (1) JP5782508B2 (da)
KR (2) KR101800167B1 (da)
CN (2) CN104961771B (da)
AR (1) AR081552A1 (da)
AU (1) AU2011258350B2 (da)
BR (1) BR112012029733B1 (da)
CA (1) CA2798765C (da)
CL (1) CL2012003285A1 (da)
CO (1) CO6640275A2 (da)
CR (2) CR20180222A (da)
CY (1) CY1117655T1 (da)
DK (1) DK2575463T3 (da)
DO (3) DOP2012000298A (da)
EC (1) ECSP12012348A (da)
ES (2) ES2666181T3 (da)
GT (1) GT201200315A (da)
HR (1) HRP20160714T1 (da)
HU (1) HUE029231T2 (da)
IL (2) IL222831A (da)
ME (1) ME02452B (da)
MX (1) MX337104B (da)
MY (1) MY165427A (da)
NZ (1) NZ603284A (da)
PE (2) PE20130221A1 (da)
PH (3) PH12012502277A1 (da)
PL (1) PL2575463T3 (da)
PT (1) PT2575463T (da)
RS (1) RS54892B1 (da)
RU (1) RU2567857C2 (da)
SG (3) SG185447A1 (da)
SI (1) SI2575463T1 (da)
TW (1) TWI520960B (da)
UA (1) UA109278C2 (da)
UY (1) UY33408A (da)
WO (1) WO2011150016A1 (da)
ZA (1) ZA201208727B (da)

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