DK2575463T3 - Apoptose-inducerende midler til behandling af cancer og immunsygdomme og autoimmune sygdomme - Google Patents

Apoptose-inducerende midler til behandling af cancer og immunsygdomme og autoimmune sygdomme Download PDF

Info

Publication number
DK2575463T3
DK2575463T3 DK11787299.4T DK11787299T DK2575463T3 DK 2575463 T3 DK2575463 T3 DK 2575463T3 DK 11787299 T DK11787299 T DK 11787299T DK 2575463 T3 DK2575463 T3 DK 2575463T3
Authority
DK
Denmark
Prior art keywords
cancer
formula
compounds
nhc
heterocycloalkane
Prior art date
Application number
DK11787299.4T
Other languages
English (en)
Inventor
Zhi-Fu Tao
Xilu Wang
Gerard Sullivan
Andrew J Souers
Nathaniel D Catron
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45004346&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2575463(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbvie Inc filed Critical Abbvie Inc
Application granted granted Critical
Publication of DK2575463T3 publication Critical patent/DK2575463T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/36—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
    • A01N43/38—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A01N43/42—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Agronomy & Crop Science (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Claims (4)

1
1. Forbindelse med formlen (Illa): ener ei lerapeunsK
accepiaDen san aeraf, hvor A1 er C(A2); A2 er H; B1 er OR1 eller NHR1, hvor R1 er (CrC^-alkyl, som er substitueret med R10; D1 erH: E1 erH: Y1 er N02; G1 er alkyl, som er substitueret med 0P(0)(0H)(0H); R10 er (C3-C10)-cycloalkyl med en eller to CH2-dele, som er uerstattede eller erstattet med O; hvor den del, som er repræsenteret ved R10, er usubstitueret eller substitueret med en eller to eller tre eller fire eller fem substituenter, som er uafhængigt valgt fra gruppen bestående af R50, OR50, F, Cl, Br og I; og R50 er (Ci-Cio)-alkyl.
2. Forbindelse eller terapeutisk acceptabelt salt ifølge krav 1, hvor forbindelsen er valgt fra gruppen bestående af: (5-{5-(4-{[2-(4-chlorphenyl)-4,4-dimethylcyclohex-1 -en-1 -yl]methyl}piperazin-1-yl)-2-[({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)carbamoyl]phenoxy}-7H-pyrrolo[2,3-b]pyridin-7-yl)methyl-dihydrogenphosphat; 2 {5-[5-(4-{[2-(4-chlorphenyl)-4,4-dimethylcyclohex-1 -en-1 - yl]methyl}piperazin-1-yl)-2-{[(4-{[(trans-4- methoxycyclohexyl)methyl]amino}-3- nitrophenyl)sulfonyl]carbamoyl}phenoxy]-7H-pyrrolo[2,3-b]pyridin-7-yljmethyl-dihydrogenphosphat og (5-{5-(4-{[2-(4-chlorphenyl)-4,4-dimethylcyclohex-1 -en-1 -yl]methyl}piperazin-1-yl)-2-[({4-[(4-fluortetrahydro-2H-pyran-4-yl)methoxy]-3-nitrophenyl}sulfonyl)carbamoyl]phenoxy}-7H-pyrrolo[2,3-b]pyridin-7-yl)methyl-dihydrogenphosphat.
3. Farmaceutisk sammensætning, som omfatter en excipiens og en terapeutisk effektiv mængde af forbindelsen eller det terapeutisk acceptable salt ifølge krav 1 eller krav 2.
4. Forbindelse eller terapeutisk acceptabelt salt ifølge krav 1 eller krav 2 til anvendelse til behandling af blærecancer, hjernecancer, brystcancer, knoglemarvscancer, cervixcancer, kronisk lymfatisk leukæmi, kolorektal cancer, øsofaguscancer, hepatocellulær cancer, lymfoblastisk leukæmi, follikulært lymfom, en lymfoid malignitet af T-celle- eller B-celleoprindelse, melanom, myeloid leukæmi, myelom, oral cancer, ovariecancer, ikke-småcellet lungecancer, prostatacancer, småcellet lungecancer eller miltcancer hos en patient ved at administrere en terapeutisk effektiv mængde af forbindelsen eller det terapeutisk acceptable salt deraf til patienten.
DK11787299.4T 2010-05-26 2011-05-25 Apoptose-inducerende midler til behandling af cancer og immunsygdomme og autoimmune sygdomme DK2575463T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34842210P 2010-05-26 2010-05-26
PCT/US2011/037849 WO2011150016A1 (en) 2010-05-26 2011-05-25 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases

Publications (1)

Publication Number Publication Date
DK2575463T3 true DK2575463T3 (da) 2016-07-25

Family

ID=45004346

Family Applications (1)

Application Number Title Priority Date Filing Date
DK11787299.4T DK2575463T3 (da) 2010-05-26 2011-05-25 Apoptose-inducerende midler til behandling af cancer og immunsygdomme og autoimmune sygdomme

Country Status (38)

Country Link
US (5) US9006247B2 (da)
EP (3) EP2575463B1 (da)
JP (1) JP5782508B2 (da)
KR (2) KR101850679B1 (da)
CN (2) CN102939009B (da)
AR (1) AR081552A1 (da)
AU (1) AU2011258350B2 (da)
BR (1) BR112012029733B1 (da)
CA (1) CA2798765C (da)
CL (1) CL2012003285A1 (da)
CO (1) CO6640275A2 (da)
CR (2) CR20180222A (da)
CY (1) CY1117655T1 (da)
DK (1) DK2575463T3 (da)
DO (3) DOP2012000298A (da)
EC (1) ECSP12012348A (da)
ES (2) ES2666181T3 (da)
GT (1) GT201200315A (da)
HR (1) HRP20160714T1 (da)
HU (1) HUE029231T2 (da)
IL (2) IL222831A (da)
ME (1) ME02452B (da)
MX (1) MX337104B (da)
MY (1) MY165427A (da)
NZ (1) NZ603284A (da)
PE (2) PE20130221A1 (da)
PH (3) PH12012502277A1 (da)
PL (1) PL2575463T3 (da)
PT (1) PT2575463T (da)
RS (1) RS54892B1 (da)
RU (1) RU2567857C2 (da)
SG (3) SG185447A1 (da)
SI (1) SI2575463T1 (da)
TW (1) TWI520960B (da)
UA (1) UA109278C2 (da)
UY (1) UY33408A (da)
WO (1) WO2011150016A1 (da)
ZA (1) ZA201208727B (da)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120156134A1 (en) 2007-12-20 2012-06-21 Shayne Squires Compositions and methods for detecting or eliminating senescent cells to diagnose or treat disease
US8563735B2 (en) 2008-12-05 2013-10-22 Abbvie Inc. Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
US20220315555A1 (en) 2009-05-26 2022-10-06 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
KR102001418B1 (ko) * 2009-05-26 2019-07-19 애브비 아일랜드 언리미티드 컴퍼니 암，면역 질환 및 자가면역 질환의 치료를 위한 아폽토시스-유도제
US8546399B2 (en) * 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
CA2811805A1 (en) 2010-10-29 2012-05-03 Abbvie Inc. Solid dispersions containing an apoptosis-inducing agent
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
EP2642999B1 (en) 2010-11-23 2016-09-28 AbbVie Bahamas Ltd. Methods of treatment using selective bcl-2 inhibitors
WO2012177927A1 (en) 2011-06-21 2012-12-27 Mayo Foundation For Medical Education And Research Transgenic animals capable of being induced to delete senescent cells
RU2014128010A (ru) 2011-12-13 2016-02-10 Бак Инститьют Фо Рисерч Он Эйджин Способы улучшения средств консервативной терапии
WO2013158664A2 (en) 2012-04-17 2013-10-24 Kythera Biopharmaceuticals, Inc. Use of engineered viruses to specifically kill senescent cells
EP2882439B1 (en) * 2012-08-13 2018-04-11 AbbVie Inc. Apoptosis-inducing agents
US9901081B2 (en) 2012-08-23 2018-02-27 Buck Institute For Research On Aging Transgenic mouse for determining the role of senescent cells in cancer
US9901080B2 (en) 2012-08-23 2018-02-27 Buck Institute For Research On Aging Transgenic mouse having a transgene that converts a prodrug into a cytotoxic compound in senescent cells
RU2648476C2 (ru) 2012-09-07 2018-03-26 Дженентек, Инк. Комбинированная терапия с использованием антитела против cd20 типа ii и селективного ингибитора bcl-2
SMT201800561T1 (it) 2012-11-01 2018-11-09 Infinity Pharmaceuticals Inc Trattamento di cancri usando modulatori di isoforme di pi3 chinasi
TWI631121B (zh) * 2013-03-13 2018-08-01 艾伯維有限公司 製備細胞凋亡誘導劑的方法
AR095265A1 (es) 2013-03-13 2015-09-30 Abbvie Inc Procesos para la preparación de un agente inductor de la apoptosis
FR3008979B1 (fr) * 2013-07-23 2015-07-24 Servier Lab Nouveaux derives phosphates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2015116735A1 (en) 2014-01-28 2015-08-06 Mayo Foundation For Medical Education And Research Methods and combinations for killing senescent cells and for treating senescence-associated diseases and disorders
US20190269675A1 (en) 2014-01-28 2019-09-05 Buck Institute for Research and Aging Treatment of parkinson's disease and other conditions caused or mediated by senescent astrocytes using small molecule senolytic agents
IL286427B2 (en) 2014-01-28 2024-08-01 Mayo Found Medical Education & Res Inhibitors bcl-2 anti-apoptotic protein family members for treatment of non cancer pulmonary disease or an opthalmic disease
US10328058B2 (en) 2014-01-28 2019-06-25 Mayo Foundation For Medical Education And Research Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques
US9238652B2 (en) 2014-03-04 2016-01-19 Abbvie Inc. Processes for the preparation of an apoptosis-inducing agent
CN112250627B (zh) 2014-10-06 2024-02-02 弗特克斯药品有限公司 囊性纤维化跨膜转导调节因子调节剂
US10195213B2 (en) 2015-03-13 2019-02-05 Unity Biotechnology, Inc. Chemical entities that kill senescent cells for use in treating age-related disease
WO2017063572A1 (zh) * 2015-10-13 2017-04-20 苏州晶云药物科技有限公司 细胞凋亡诱导剂的新晶型及其制备方法
CN106957315B (zh) * 2016-01-08 2019-08-13 中国人民解放军第二军医大学 N-取代苯磺酰基-氮杂吲哚氧基苯甲酰胺类化合物及其制备药物的用途
PL3436446T3 (pl) 2016-03-31 2023-09-11 Vertex Pharmaceuticals Incorporated Modulatory mukowiscydozowego przezbłonowego regulatora przewodnictwa
US20170300968A1 (en) * 2016-04-14 2017-10-19 Nb Portals, Llc Method and system for disseminating information over a communication network
WO2018027097A1 (en) * 2016-08-05 2018-02-08 The Regents Of The University Of Michigan N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors
PT3519401T (pt) 2016-09-30 2021-12-27 Vertex Pharma Modulador de regulador de condutância transmembranar de fibrose quística, composições farmacêuticas, métodos de tratamento e processo para fazer o modulador
EA202192783A1 (ru) 2016-12-09 2022-02-24 Вертекс Фармасьютикалз Инкорпорейтед Модулятор регулятора трансмембранной проводимости при муковисцидозе, фармацевтические композиции, способы лечения и способ получения указанного модулятора
CN110177788B (zh) 2017-01-07 2023-03-24 重庆复创医药研究有限公司 作为bcl-2选择性凋亡诱导剂的化合物
WO2018157803A1 (zh) * 2017-02-28 2018-09-07 苏州科睿思制药有限公司 维奈妥拉的晶型及其制备方法
HRP20221158T1 (hr) 2017-04-18 2022-12-09 Shanghai Fochon Pharmaceutical Co., Ltd. Sredstva za izazivanje apoptoze
CN108794358B (zh) * 2017-04-27 2022-08-12 中国人民解放军第二军医大学 取代苯磺酰基类化合物及其制备药物的用途
EP3634402B1 (en) 2017-06-08 2026-01-21 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
WO2019018395A1 (en) 2017-07-17 2019-01-24 Vertex Pharmaceuticals Incorporated METHODS OF TREATING CYSTIC FIBROSIS
JP7121794B2 (ja) 2017-08-02 2022-08-18 バーテックス ファーマシューティカルズ インコーポレイテッド ピロリジン化合物を調製するためのプロセス
CN107501260B (zh) * 2017-08-14 2019-08-13 郑州大学第一附属医院 一种Bcl-2抑制剂venetoclax以及中间体的制备方法
FI3672976T3 (fi) 2017-08-23 2024-02-21 Guangzhou Lupeng Pharmaceutical Company Ltd Bcl-2-inhibiittoreita
CN107445958A (zh) * 2017-09-19 2017-12-08 上海泓博智源医药股份有限公司 一种abt‑199中间体的制备方法
IL273831B2 (en) 2017-10-19 2024-10-01 Vertex Pharma Crystalline forms and compositions of cftr modulators
US11465985B2 (en) 2017-12-08 2022-10-11 Vertex Pharmaceuticals Incorporated Processes for making modulators of cystic fibrosis transmembrane conductance regulator
EP3737672A4 (en) 2018-01-10 2021-09-15 Recurium IP Holdings, LLC Benzamide compounds
TWI810243B (zh) 2018-02-05 2023-08-01 美商維泰克斯製藥公司 用於治療囊腫纖化症之醫藥組合物
JP2021513978A (ja) * 2018-02-16 2021-06-03 アッヴィ・インコーポレイテッド がん治療における選択的ｂｃｌ−２阻害剤及び抗ｐｄ−１抗体又は抗ｐｄ−ｌ１抗体の併用
WO2019200246A1 (en) 2018-04-13 2019-10-17 Alexander Russell Abela Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
US11420968B2 (en) 2018-04-29 2022-08-23 Beigene, Ltd. Bcl-2 inhibitors
GEP20237458B (en) 2018-07-31 2023-01-10 Ascentage Pharma Suzhou Co Ltd Combination product of bcl-2 inhibitor and mdm2 inhibitor and use thereof in the prevention and/or treatment of diseases
CN110772521A (zh) 2018-07-31 2020-02-11 苏州亚盛药业有限公司 Bcl-2抑制剂或Bcl-2/Bcl-xL抑制剂与BTK抑制剂的组合产品及其用途
GEP20237460B (en) 2018-07-31 2023-01-25 Ascentage Pharma Suzhou Co Ltd Synergistic antitumor effect of bcl-2 inhibitor combined with rituximab and/or bendamustine or bcl-2 inhibitor combined with chop
WO2020024834A1 (en) 2018-07-31 2020-02-06 Ascentage Pharma (Suzhou) Co., Ltd. Combination product of bcl-2 inhibitor and chemotherapeutic agent and use thereof in the prevention and/or treatment of diseases
WO2020041406A1 (en) 2018-08-22 2020-02-27 Newave Pharmaceutical Inc. Bcl-2 inhibitors
WO2020140005A2 (en) 2018-12-29 2020-07-02 Newave Pharmaceutical Inc. Bcl-2 inhibitors
CN112661751B (zh) * 2019-10-16 2024-06-14 南京天印健华医药科技有限公司 作为bcl-2抑制剂的杂环化合物
EP4051676A4 (en) 2019-10-28 2023-11-22 BeiGene, Ltd. BCL-2 INHIBITORS
WO2021110102A1 (en) * 2019-12-02 2021-06-10 Beigene, Ltd. Methods of cancer treatment using bcl-2 inhibitor
US12552784B2 (en) 2019-12-27 2026-02-17 Newave Pharmaceutical Inc. 1H-pyrrolo[2,3-b]pyridine derivatives as BCL-2 inhibitors for the treatment of neoplastic and autoimmune diseases
AU2021256580A1 (en) 2020-04-15 2022-09-29 Beone Medicines I Gmbh Bcl-2 inhibitor
WO2021231486A1 (en) * 2020-05-13 2021-11-18 Unity Biotechnology, Inc. Cancer treatment by senescence induction followed by a senolytic
CN114736203A (zh) * 2021-01-07 2022-07-12 南京天印健华医药科技有限公司 作为bcl-2抑制剂的杂环化合物
EP4353722A4 (en) * 2021-06-04 2025-06-18 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Phosphate of trifluoromethyl-substituted sulfonamide compound

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY115155A (en) 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
JPH11512429A (ja) 1995-09-15 1999-10-26 ファルマシア・アンド・アップジョン・カンパニー アミノアリールオキサゾリジノン ｎ−オキシド
US20030220234A1 (en) 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
DE19830430A1 (de) * 1998-07-08 2000-01-13 Hoechst Marion Roussel De Gmbh Schwefelsubstituierte Sulfonylamino-carbonsäure-N-arylamide, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
GB9918037D0 (en) 1999-07-30 1999-09-29 Biochemie Gmbh Organic compounds
US6720338B2 (en) 2000-09-20 2004-04-13 Abbott Laboratories N-acylsulfonamide apoptosis promoters
UY26942A1 (es) 2000-09-20 2002-04-26 Abbott Lab N-acilsulfonamidas promotoras de la apoptosis
WO2005024636A1 (ja) 2003-09-04 2005-03-17 Hitachi Ulsi Systems Co., Ltd. 半導体装置
US8614318B2 (en) * 2003-11-13 2013-12-24 Abbvie Inc. Apoptosis promoters
US7973161B2 (en) 2003-11-13 2011-07-05 Abbott Laboratories Apoptosis promoters
WO2005049593A2 (en) * 2003-11-13 2005-06-02 Abbott Laboratories N-acylsulfonamide apoptosis promoters
ES2294494T3 (es) 2004-04-19 2008-04-01 Symed Labs Limited Un nuevo procedimiento para la preparacion de linezolid y compuestos relacionados.
WO2006008754A1 (en) 2004-07-20 2006-01-26 Symed Labs Limited Novel intermediates for linezolid and related compounds
US7511013B2 (en) 2004-09-29 2009-03-31 Amr Technology, Inc. Cyclosporin analogues and their pharmaceutical uses
WO2007040650A2 (en) 2005-05-12 2007-04-12 Abbott Laboratories Apoptosis promoters
TW200716636A (en) 2005-05-31 2007-05-01 Speedel Experimenta Ag Heterocyclic spiro-compounds
US7514068B2 (en) 2005-09-14 2009-04-07 Concert Pharmaceuticals Inc. Biphenyl-pyrazolecarboxamide compounds
EP2061560A2 (en) 2006-09-05 2009-05-27 Abbott Laboratories Bcl inhibitors for treating platelet excess
US8796267B2 (en) 2006-10-23 2014-08-05 Concert Pharmaceuticals, Inc. Oxazolidinone derivatives and methods of use
US20080182845A1 (en) 2006-11-16 2008-07-31 Abbott Laboratories Method of preventing or treating organ, hematopoietic stem cell or bone marrow transplant rejection
AU2008214774A1 (en) 2007-02-15 2008-08-21 F. Hoffmann-La Roche Ag 2-aminooxazolines as TAAR1 ligands
US8536157B2 (en) 2007-04-13 2013-09-17 The University Of Melbourne Non-steroidal compounds
KR20100105802A (ko) 2007-04-19 2010-09-29 콘서트 파마슈티컬즈, 인크. 중수소화된 모르폴리닐 화합물
US7531685B2 (en) 2007-06-01 2009-05-12 Protia, Llc Deuterium-enriched oxybutynin
WO2009035598A1 (en) 2007-09-10 2009-03-19 Concert Pharmaceuticals, Inc. Deuterated pirfenidone
US20090118238A1 (en) 2007-09-17 2009-05-07 Protia, Llc Deuterium-enriched alendronate
US20090088416A1 (en) 2007-09-26 2009-04-02 Protia, Llc Deuterium-enriched lapaquistat
US20090082471A1 (en) 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched fingolimod
JP2010540635A (ja) 2007-10-02 2010-12-24 コンサート ファーマシューティカルズ インコーポレイテッド ピリミジンジオン誘導体
US8410124B2 (en) 2007-10-18 2013-04-02 Concert Pharmaceuticals Inc. Deuterated etravirine
US20090105338A1 (en) 2007-10-18 2009-04-23 Protia, Llc Deuterium-enriched gabexate mesylate
AU2008317375B2 (en) 2007-10-26 2013-02-28 Concert Pharmaceuticals, Inc. Deuterated darunavir
KR101585848B1 (ko) 2007-11-16 2016-01-15 애브비 인코포레이티드 관절염의 치료 방법
US20100160322A1 (en) * 2008-12-04 2010-06-24 Abbott Laboratories Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
UA108193C2 (uk) * 2008-12-04 2015-04-10 Апоптозіндукуючий засіб для лікування раку і імунних і аутоімунних захворювань
PE20120119A1 (es) * 2008-12-05 2012-03-18 Abbvie Inc AGENTES INDUCTORES DE APOPTOSIS CON SELECTIVIDAD POR Bcl-2
US8563735B2 (en) * 2008-12-05 2013-10-22 Abbvie Inc. Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
CA2747835A1 (en) * 2009-01-19 2010-07-22 Abbott Laboratories Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
KR102001418B1 (ko) * 2009-05-26 2019-07-19 애브비 아일랜드 언리미티드 컴퍼니 암，면역 질환 및 자가면역 질환의 치료를 위한 아폽토시스-유도제
US8546399B2 (en) * 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases

Also Published As

Publication number Publication date
SI2575463T1 (sl) 2016-11-30
PH12016501126A1 (en) 2017-06-14
ECSP12012348A (es) 2013-04-30
CA2798765C (en) 2018-10-23
CN104961771A (zh) 2015-10-07
UY33408A (es) 2011-12-30
HK1182593A1 (zh) 2013-12-06
IL222831A (en) 2014-08-31
KR20130086954A (ko) 2013-08-05
DOP2012000298A (es) 2018-04-30
CR20180222A (es) 2018-06-05
AU2011258350B2 (en) 2015-04-09
GT201200315A (es) 2014-07-11
EP3091017A1 (en) 2016-11-09
DOP2017000186A (es) 2017-09-15
SG10201700112VA (en) 2017-03-30
UA109278C2 (uk) 2015-08-10
AU2011258350A1 (en) 2012-11-22
EP2575463A4 (en) 2013-11-27
EP3091017B1 (en) 2018-01-17
IL233832B (en) 2018-05-31
CN104961771B (zh) 2018-02-02
WO2011150016A1 (en) 2011-12-01
EP3312178A1 (en) 2018-04-25
US9403822B2 (en) 2016-08-02
HRP20160714T1 (hr) 2016-07-15
ES2666181T3 (es) 2018-05-03
CA2798765A1 (en) 2011-12-01
US20150246914A1 (en) 2015-09-03
KR20170083164A (ko) 2017-07-17
US9006247B2 (en) 2015-04-14
US20200277291A1 (en) 2020-09-03
CN102939009A (zh) 2013-02-20
TWI520960B (zh) 2016-02-11
RU2567857C2 (ru) 2015-11-10
KR101800167B1 (ko) 2017-11-22
US20170096424A1 (en) 2017-04-06
IL222831A0 (en) 2012-12-31
AR081552A1 (es) 2012-10-03
BR112012029733B1 (pt) 2020-12-01
PT2575463T (pt) 2016-07-13
SG10201700115RA (en) 2017-02-27
PL2575463T3 (pl) 2016-10-31
US20190315737A1 (en) 2019-10-17
IL233832A0 (en) 2014-09-30
JP5782508B2 (ja) 2015-09-24
TW201141862A (en) 2011-12-01
CO6640275A2 (es) 2013-03-22
CN102939009B (zh) 2015-03-25
ES2574855T3 (es) 2016-06-22
PH12012502277A1 (en) 2013-02-11
JP2013526612A (ja) 2013-06-24
NZ603284A (en) 2015-01-30
PE20170465A1 (es) 2017-05-18
RU2012156940A (ru) 2014-07-10
CR20120648A (es) 2013-04-03
EP2575463A1 (en) 2013-04-10
US20120028925A1 (en) 2012-02-02
HUE029231T2 (en) 2017-02-28
ME02452B (me) 2016-09-20
PH12018501264A1 (en) 2019-07-01
MX337104B (es) 2016-02-09
PE20130221A1 (es) 2013-04-04
MY165427A (en) 2018-03-22
DOP2016000100A (es) 2016-05-31
SG185447A1 (en) 2012-12-28
ZA201208727B (en) 2013-07-31
EP2575463B1 (en) 2016-03-30
BR112012029733A2 (pt) 2017-06-13
PH12016501126B1 (en) 2017-06-14
CY1117655T1 (el) 2017-05-17
MX2012013704A (es) 2013-03-21
KR101850679B1 (ko) 2018-04-20
CL2012003285A1 (es) 2013-10-04
RS54892B1 (sr) 2016-10-31

Similar Documents

Publication Publication Date Title
DK2575463T3 (da) Apoptose-inducerende midler til behandling af cancer og immunsygdomme og autoimmune sygdomme
US8426422B2 (en) Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
CA2744708C (en) Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US9156856B2 (en) Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
CA2799280A1 (en) Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
CA2759182A1 (en) (hetero)aryl substituted sulfonyl-2-(1h-pyrrolo[2,3-b]pyridine-5-oxy) benzamide compounds and their use as apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
HK1231047A1 (en) Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
HK1231047A (en) Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
HK1182593B (en) Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
HK1177206B (en) Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases