DK2579927T3 - Drivmekanisme til en lægemiddeldispenseringsanordning og lægemiddeldispenseringsanordning - Google Patents

Drivmekanisme til en lægemiddeldispenseringsanordning og lægemiddeldispenseringsanordning Download PDF

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DK2579927T3
DK2579927T3 DK11724421.0T DK11724421T DK2579927T3 DK 2579927 T3 DK2579927 T3 DK 2579927T3 DK 11724421 T DK11724421 T DK 11724421T DK 2579927 T3 DK2579927 T3 DK 2579927T3
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housing
dose
drive
drive mechanism
rotation
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DK11724421.0T
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Stephen David Butler
Mark Philip Horlock
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Sanofi Aventis Deutschland
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31525—Dosing
    • A61M5/31528—Dosing by means of rotational movements, e.g. screw-thread mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31555—Mechanically operated dose setting member by purely axial movement of dose setting member, e.g. during setting or filling of a syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16H—GEARING
    • F16H25/00—Gearings comprising primarily only cams, cam-followers and screw-and-nut mechanisms
    • F16H25/08—Gearings comprising primarily only cams, cam-followers and screw-and-nut mechanisms for interconverting rotary motion and reciprocating motion
    • F16H25/12—Gearings comprising primarily only cams, cam-followers and screw-and-nut mechanisms for interconverting rotary motion and reciprocating motion with reciprocation along the axis of rotation, e.g. gearings with helical grooves and automatic reversal
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T74/00—Machine element or mechanism
    • Y10T74/18—Mechanical movements
    • Y10T74/18568—Reciprocating or oscillating to or from alternating rotary
    • Y10T74/18576—Reciprocating or oscillating to or from alternating rotary including screw and nut

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Claims (16)

1. Drivmekanisme til en lægemiddeldispenseringsanordning (1), der omfatter: - et hus (13, 17), - en stempelstang (12), der er anbragt inde i huset (13, 17), - en drivdel (20), der er anbragt inde i huset (13, 17), hvilken drivdel (20) kan rotere i forhold til huset (13, 17), - en rotationsdel (21) , der kan rotere i forhold til huset (13, 17), - en dosisdel (34), der kan bevæges mellem en første aksial position (60) i forhold til huset (13, 17) og en anden aksial position (61), der er adskilt aksialt fra den første aksiale position (60), - et indgreb mellem dosisdelen (34) og huset (13, 17), hvilket indgreb åbner mulighed for, at dosisdelen (34) kan bevæges ad en indstillings-/dispenseringsbane (62) mellem den første aksiale position (60) og den anden aksiale position (61) i den ene eller den anden retning eller bevæges ad en annulleringsbane (63) fra den anden aksiale position (61) til den første aksiale position (60), og et indgreb mellem dosisdelen (34) og rotationsdelen (21) samt et ensrettet rotationsindgreb mellem rotationsdelen (21) og drivdelen (20) ved hjælp af et koblingsmiddel på en sådan måde, at rotationsdelen (21) roteres, når dosisdelen (34) bevæges ad indstillings-/dispenseringsbanen (62), og drivdelen (20) ikke roteres, når dosisdelen (34) bevæges ad annulleringsbanen (63), der er kendetegnet ved, at stempelstangen (12) omfatter et gevind (49), der er i indgreb med huset (13,17), således at en rotationsbevægelse af stempelstangen (12) omdannes til en bevægelse af stempelstangen (12) i forhold til huset (13, 17) i en distal retning, - stempelstangen (12) omfatter et spor (37), der er i indgreb med drivdelen (20), således at en aksial bevægelse af stempelstangen (12) i forhold til drivdelen (20) er mulig, og en rotationsbevægelse af drivdelen (20) i forhold til huset (13, 17) omdannes til en rotationsbevægelse af stempelstangen (12) i forhold til huset (13, 17), og - dosisdelen (34) er i gevindindgreb med rotationsdelen (21).
2. Drivmekanisme ifølge krav 1, hvor annulleringsbanen (63) medfører en spiralformet bevægelse af dosisdelen (34) i forhold til huset (13, 17).
3. Drivmekanisme ifølge krav 1, hvor annulleringsbanen (63) medfører en spiralformet bevægelse af dosisdelen (34) i forhold til huset (13,17) og en efterfølgende rotation af dosisdelen (34) i den første aksiale position (60).
4. Drivmekanisme ifølge et af kravene 1 til 3, hvor indstillings-/dispenseringsbanen (62) er forbundet med annulleringsbanen (63) via en startbane (58), der er placeret mellem den anden aksiale position (61) og annulleringsbanen (63), og/eller via en slutbane (59), der er placeret mellem annulleringsbanen (63) og den første aksiale position (60).
5. Drivmekanisme ifølge et af kravene 1 til 4, der yderligere omfatter: en indgrebsdel (50), der er tilvejebragt på rotationsdelen (21) eller på dosisdelen (34), idet dosisdelen (34) er i indgreb med rotationsdelen (21) via indgrebsdelen (50), der styres i et gevind (51).
6. Drivmekanisme ifølge et af kravene 1 til 5, der yderligere omfatter: en knap-ind/ud-not (52) og en annulleringsnot (53), hvor dosisdelen (34) er i indgreb med huset (13, 17) ved hjælp af knap-ind/ud-noten (52) og annulleringsnoten (53), hvor knap-ind/ud-noten (52) er indrettet til at styre bevægelsen af dosisdelen (34) ad indstillings- /dispenseringsbanen (62), og annulleringsnoten (53) er indrettet til at styre bevægelsen af dosisdelen (34) ad annulleringsbanen (63).
7. Drivmekanisme ifølge krav 6, der yderligere omfatter: mindst ét bumptræk (55, 55') på annulleringsnoten (53), hvilket bumptræk (55) hæmmer indgang i annulleringsbanen (63) eller udgang fra annulleringsbanen (63).
8. Drivmekanisme ifølge et af kravene 1 til 7, der yderligere omfatter: at koblingsmidlet er dannet af en azimut-anbragt serie af rampetænder (24) på drivdelen (20) og en tilsvarende azimutanbragt yderligere serie af rampetænder (25) på rotationsdelen (21) .
9. Drivmekanisme ifølge et af kravene 1 til 8, der yderligere omfatter: - en stopdel (26), der er rotationslåst med huset (13, 17), - hvilken stopdel (26) er i ensrettet rotationsindgreb med drivdelen (20) ved hjælp af et yderligere koblingsmiddel, der åbner mulighed for en rotation af drivdelen (20) , der frembringes ved en bevægelse af dosisdelen (34) fra den anden aksiale position (61) til den første aksiale position (60) ad indstillings-/dispenseringsbanen (62).
10. Drivmekanisme ifølge krav 9, der yderligere omfatter: at det yderligere koblingsmiddel er dannet af en yderligere azimut-anbragt serie af rampetænder (28) på drivdelen (20) og en tilsvarende azimut-anbragt yderligere serie af rampetænder (27) på stopdelen (26) .
11. Drivmekanisme ifølge krav 9 eller 10, der yderligere omfatter: en elastisk del (31), der udøver en kraft, der påvirker mod at holde drivdelen (20) og stopdelen (26) i kontakt og holde drivdelen (20) og rotationsdelen (21) i kontakt.
12. Drivmekanisme ifølge et af kravene 1 til 11, hvor indstillings-/dispenseringsbanen (62) er aksialt rettet, og annulleringsbanen (63) er spiralsnoet.
13. Drivmekanisme ifølge krav 12, hvor bevægelsen af dosisdelen (34) fra den anden aksiale position (61) til den første aksiale position (60) ad indstillings-/dispenseringsbanen (62) frembringer en aksial forskydning af stempelstangen (12) i forhold til huset (13, 17) med en fast forudbestemt afstand.
14. Drivmekanisme ifølge et af kravene 1 til 13, der yderligere omfatter: et ensrettet rotationsindgreb (56, 57) mellem dosisdelen (34) eller en knap (41), der er fastgjort til dosisdelen (34) og huset (13, 17), eller en indsats (46), der er fastgjort til huset.
15. Drivmekanisme ifølge krav 14, der yderligere omfatter: en klinkeindsats (66), der omfatter mindst én klinkehage (56), hvilken klinkeindsats (66) er rotationslåst med dosisdelen (34), og en klinke (57) på huset (13, 17) eller indsatsen (46), hvor klinkehagen (56) og klinken (57) tilvejebringer et ensrettet rotationsindgreb.
16. Lægemiddeldispenseringsanordning i form af en pentype-injektor, der omfatter en drivmekanisme ifølge et af kravene 1 til 15.
DK11724421.0T 2010-06-11 2011-06-09 Drivmekanisme til en lægemiddeldispenseringsanordning og lægemiddeldispenseringsanordning DK2579927T3 (da)

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EP10165635 2010-06-11
PCT/EP2011/059562 WO2011154479A1 (en) 2010-06-11 2011-06-09 Drive mechanism for a drug delivery device and drug delivery device

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JP (1) JP5868391B2 (da)
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WO2011154479A1 (en) 2011-12-15
EP2579927A1 (en) 2013-04-17
JP5868391B2 (ja) 2016-02-24
US9408977B2 (en) 2016-08-09
JP2013528083A (ja) 2013-07-08
US20130204204A1 (en) 2013-08-08
TR201807048T4 (tr) 2018-06-21
EP2579927B1 (en) 2018-02-21
CA2801158A1 (en) 2011-12-15

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