DK2582794T4 - Generering af inducerede pluripotente stamceller fra små volumener af perifert blod - Google Patents
Generering af inducerede pluripotente stamceller fra små volumener af perifert blod Download PDFInfo
- Publication number
- DK2582794T4 DK2582794T4 DK11796290.2T DK11796290T DK2582794T4 DK 2582794 T4 DK2582794 T4 DK 2582794T4 DK 11796290 T DK11796290 T DK 11796290T DK 2582794 T4 DK2582794 T4 DK 2582794T4
- Authority
- DK
- Denmark
- Prior art keywords
- generation
- stem cells
- peripheral blood
- pluripotent stem
- induced pluripotent
- Prior art date
Links
- 210000004263 induced pluripotent stem cell Anatomy 0.000 title 1
- 210000005259 peripheral blood Anatomy 0.000 title 1
- 239000011886 peripheral blood Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/98—Xeno-free medium and culture conditions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/145—Thrombopoietin [TPO]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2303—Interleukin-3 (IL-3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2306—Interleukin-6 (IL-6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/602—Sox-2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/603—Oct-3/4
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/604—Klf-4
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/605—Nanog
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/606—Transcription factors c-Myc
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/608—Lin28
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases [EC 2.]
- C12N2501/727—Kinases (EC 2.7.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Transplantation (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35504610P | 2010-06-15 | 2010-06-15 | |
| US38894910P | 2010-10-01 | 2010-10-01 | |
| PCT/US2011/040323 WO2011159684A2 (en) | 2010-06-15 | 2011-06-14 | Generation of induced pluripotent stem cells from small volumes of peripheral blood |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK2582794T3 DK2582794T3 (da) | 2018-05-22 |
| DK2582794T4 true DK2582794T4 (da) | 2024-07-22 |
Family
ID=45348816
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11796290.2T DK2582794T4 (da) | 2010-06-15 | 2011-06-14 | Generering af inducerede pluripotente stamceller fra små volumener af perifert blod |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US8691574B2 (da) |
| EP (2) | EP3382008A1 (da) |
| JP (4) | JP5984217B2 (da) |
| KR (1) | KR101861168B1 (da) |
| CN (1) | CN103003416B (da) |
| AU (1) | AU2011267849B2 (da) |
| CA (1) | CA2802249A1 (da) |
| DK (1) | DK2582794T4 (da) |
| ES (1) | ES2670842T5 (da) |
| IL (1) | IL223527B (da) |
| WO (1) | WO2011159684A2 (da) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2438160T3 (da) | 2009-06-05 | 2016-01-11 | Cellular Dynamics Int Inc | Reprogrammering af t-celler og hæmatopoietiske celler |
| US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| JP5984217B2 (ja) * | 2010-06-15 | 2016-09-06 | セルラー ダイナミクス インターナショナル, インコーポレイテッド | 少量の末梢血からの人工多能性幹細胞の作製 |
| WO2012087965A2 (en) | 2010-12-22 | 2012-06-28 | Fate Therapauetics, Inc. | Cell culture platform for single cell sorting and enhanced reprogramming of ipscs |
| WO2013177228A1 (en) | 2012-05-22 | 2013-11-28 | Loma Linda University | Generation of integration/transgene-free stem cells |
| WO2014071219A1 (en) * | 2012-11-01 | 2014-05-08 | Factor Bioscience Inc. | Methods and products for expressing proteins in cells |
| US20150247125A1 (en) * | 2012-11-02 | 2015-09-03 | Lonza Walkersville | Micrornas and cellular reprogramming |
| CN103088065B (zh) * | 2013-01-25 | 2014-12-10 | 北京银杏德济生物技术有限公司 | 一种能够大规模并快速高纯度地诱导间充质干细胞转决定成造血干细胞的方法 |
| ES2491491B1 (es) * | 2013-03-05 | 2015-06-16 | Vodafone España, S.A.U. | Método para asociar de manera anónima mediciones de un dispositivo de monitorización sanitaria con un ID de usuario |
| EP2986711A1 (en) * | 2013-04-16 | 2016-02-24 | Universiteit Maastricht | Blastoid, cell line based artificial blastocyst |
| WO2014201154A1 (en) * | 2013-06-14 | 2014-12-18 | Microstem, Inc. | Matrix combinations support hematopoietic stem cell in vitro culturing |
| WO2015006725A2 (en) | 2013-07-12 | 2015-01-15 | Cedars-Sinai Medical Center | Generation of induced pluripotent stem cells from normal human mammary epithelial cells |
| KR101655383B1 (ko) | 2013-07-27 | 2016-09-08 | 고려대학교 산학협력단 | 소분자 화합물을 포함하는 만능성 줄기세포의 염색체 안정성 유지용 조성물 |
| SG11201606934SA (en) | 2014-03-04 | 2016-09-29 | Fate Therapeutics Inc | Improved reprogramming methods and cell culture platforms |
| US20160376558A1 (en) * | 2014-03-11 | 2016-12-29 | Agency For Science, Technology And Research | Method for inducing pluripotency in a hematopoietic cell |
| CN106661548B (zh) | 2014-05-28 | 2020-12-11 | 儿童医院医疗中心 | 用于经由定向分化将前体细胞转化为胃组织的方法和系统 |
| US10023879B2 (en) | 2014-06-04 | 2018-07-17 | Fate Therapeutics, Inc. | Minimal volume reprogramming of mononuclear cells |
| US20170107498A1 (en) * | 2014-06-05 | 2017-04-20 | Cedars-Sinai Medical Center | Novel and efficient method for reprogramming immortalized lymphoblastoid cell lines to induced pluripotent stem cells |
| AU2016211671B2 (en) | 2015-01-26 | 2022-05-26 | Fate Therapeutics, Inc. | Methods and compositions for inducing hematopoietic cell differentiation |
| CN107438669B (zh) * | 2015-04-09 | 2022-09-27 | 拜奥拉米那公司 | 用于治疗神经退行性疾病的干细胞衍生多巴胺能细胞的生产方法和组合物 |
| KR20260003355A (ko) | 2015-09-08 | 2026-01-06 | 후지필름 셀룰러 다이내믹스, 인코포레이티드 | 줄기 세포에서 유래된 망막색소상피의 macs 기반 정제 |
| CN114807035B (zh) | 2015-09-08 | 2024-02-02 | (由卫生与公众服务部部长代表的)美利坚合众国 | 临床级别视网膜色素上皮细胞的可再现的分化方法 |
| US9762563B2 (en) | 2015-10-14 | 2017-09-12 | FullArmor Corporation | Resource access system and method |
| US9509684B1 (en) * | 2015-10-14 | 2016-11-29 | FullArmor Corporation | System and method for resource access with identity impersonation |
| US9450944B1 (en) | 2015-10-14 | 2016-09-20 | FullArmor Corporation | System and method for pass-through authentication |
| SG10202111851YA (en) | 2015-10-16 | 2021-12-30 | Fate Therapeutics Inc | Platform for the Induction & Maintenance of Ground State Pluripotency |
| CN108431211B (zh) * | 2015-10-20 | 2026-03-24 | 富士胶片细胞动力公司 | 通过遗传编程的多谱系造血前体细胞产生 |
| CA3003152A1 (en) | 2015-11-04 | 2017-05-11 | Fate Therapeutics, Inc. | Methods and compositions for inducing hematopoietic cell differentiation |
| JP6928604B2 (ja) | 2015-11-04 | 2021-09-01 | フェイト セラピューティクス,インコーポレイテッド | 万能性細胞のゲノム改変 |
| US10221395B2 (en) | 2016-06-16 | 2019-03-05 | Cedars-Sinai Medical Center | Efficient method for reprogramming blood to induced pluripotent stem cells |
| US11572545B2 (en) | 2016-06-16 | 2023-02-07 | Cedars-Sinai Medical Center | Efficient method for reprogramming blood to induced pluripotent stem cells |
| EP3478325B1 (en) | 2016-07-01 | 2024-07-17 | Research Development Foundation | Elimination of proliferating cells from stem cell-derived grafts |
| EP3510145A4 (en) * | 2016-09-06 | 2020-03-25 | The Children's Medical Center Corporation | IMMUNCELLS FROM INDUCED PLURIPOTENT STEM CELLS |
| EP3523422B1 (en) | 2016-10-05 | 2024-12-25 | FUJIFILM Cellular Dynamics, Inc. | Generating mature lineages from induced pluripotent stem cells with mecp2 disruption |
| KR102729404B1 (ko) | 2016-11-04 | 2024-11-14 | 칠드런즈 호스피탈 메디칼 센터 | 간 유사 장기 조성물 및 이를 제조 및 사용하는 방법 |
| JP7068305B2 (ja) | 2016-12-05 | 2022-05-16 | チルドレンズ ホスピタル メディカル センター | 結腸オルガノイドならびにその作製方法および使用方法 |
| US12281334B2 (en) | 2017-04-14 | 2025-04-22 | Children's Hospital Medical Center | Multi donor stem cell compositions and methods of making same |
| WO2018195175A1 (en) | 2017-04-18 | 2018-10-25 | FUJIFILM Cellular Dynamics, Inc. | Antigen-specific immune effector cells |
| US20200155609A1 (en) * | 2017-05-22 | 2020-05-21 | Transfusion Health Llc | Compositions and methods of making expanded hematopoietic stem cells using pten inhibitors |
| GB201708554D0 (en) * | 2017-05-30 | 2017-07-12 | Queens Univ Of Belfast | A method for the generation of induced pluirpotent stem cells |
| CN107245474A (zh) * | 2017-06-07 | 2017-10-13 | 北京呈诺医学科技有限公司 | 一种无饲养层无血清的人类诱导性多能干细胞分离培养方法 |
| EP3621630A4 (en) | 2017-06-14 | 2021-03-10 | The Children's Medical Center | HEMATOPOIETIC STEM AND PRECURSOR CELLS FROM HEMOGENIC ENDOTHELIAL CELLS BY EPISOMAL PLASMID GENERAL TRANSFER |
| EP3694603B1 (en) | 2017-10-10 | 2026-04-08 | Children's Hospital Medical Center | Esophageal tissue and/or organoid compositions and methods of making same |
| AU2018354418B2 (en) | 2017-10-27 | 2025-09-11 | Immunebridge Inc. | Compositions and methods of making expanded hematopoietic stem cells using derivatives of fluorene |
| US12379372B2 (en) | 2017-12-21 | 2025-08-05 | Children's Hospital Medical Center | Digitalized human organoids and methods of using same |
| KR102887406B1 (ko) | 2018-07-26 | 2025-11-19 | 칠드런즈 호스피탈 메디칼 센터 | 간-담도-췌장 조직 및 이를 제조하는 방법 |
| AU2019339410A1 (en) | 2018-09-12 | 2021-04-15 | Children's Hospital Medical Center | Organoid compositions for the production of hematopoietic stem cells and derivatives thereof |
| KR20210076048A (ko) * | 2018-10-12 | 2021-06-23 | 라이프 테크놀로지스 코포레이션 | 조혈 줄기 및 전구 세포 확장 시스템 |
| WO2020113029A2 (en) | 2018-11-28 | 2020-06-04 | Board Of Regents, The University Of Texas System | Multiplex genome editing of immune cells to enhance functionality and resistance to suppressive environment |
| MX2021006393A (es) | 2018-11-29 | 2021-10-13 | Univ Texas | Metodos para expansion ex vivo de celulas exterminadoras naturales y uso de las mismas. |
| WO2020160371A1 (en) | 2019-02-01 | 2020-08-06 | The University Of Hong Kong | Innervated organoid compositions and methods of making same |
| WO2020203712A1 (ja) * | 2019-03-29 | 2020-10-08 | 富士フイルム株式会社 | 特定細胞に分化する能力を有する多能性幹細胞の製造方法およびその応用 |
| WO2020223303A1 (en) * | 2019-04-29 | 2020-11-05 | The Children's Hospital Of Philadelphia | Compositions and methods for increasing megakaryocyte production |
| WO2020243613A1 (en) | 2019-05-31 | 2020-12-03 | Children's Hospital Medical Center | Methods of generating and expanding hematopoietic stem cells |
| WO2020243633A1 (en) | 2019-05-31 | 2020-12-03 | Children's Hospital Medical Center | Shaped organoid compositions and methods of making same |
| EP4043864A4 (en) | 2019-10-28 | 2022-11-30 | FUJIFILM Corporation | METHOD FOR SORTING PLURIPOTENT STEM CELLS, METHOD FOR PREDICTING RESULTS OF INDUCTION OF DIFFERENTIATION, AND METHOD FOR MANUFACTURING CELLULAR PRODUCT |
| WO2021085034A1 (ja) | 2019-10-28 | 2021-05-06 | 富士フイルム株式会社 | 多能性幹細胞の選別方法、分化誘導結果の予測方法及び細胞製品の製造方法 |
| CN110669732B (zh) * | 2019-11-05 | 2021-05-04 | 清华大学 | 组合物在将造血祖细胞重编程为造血干细胞中的用途 |
| EP4092107A4 (en) | 2020-01-16 | 2023-12-06 | FUJIFILM Corporation | METHOD FOR PRODUCING PLURIPOTENT STEM CELLS WITH CAPACITY OF DIFFERENTIATION INTO SPECIFIC CELLS AND USE THEREOF |
| AU2021211713A1 (en) | 2020-01-23 | 2022-08-25 | The Children's Medical Center Corporation | Stroma-free T cell differentiation from human pluripotent stem cells |
| US11091524B1 (en) | 2020-04-22 | 2021-08-17 | Houston Gene Therapeutics Llc | Compositions for treatment of vascular disease |
| WO2021256078A1 (ja) | 2020-06-19 | 2021-12-23 | 富士フイルム株式会社 | バイオマーカー特定方法及び細胞の製造方法 |
| EP4172319A4 (en) * | 2020-06-23 | 2024-08-28 | Tithon Biotech, Inc. | SMALL PLURIPOTENT CELLS FROM PERIPHERAL BLOOD |
| GB2607514B (en) | 2020-07-20 | 2023-06-21 | Enanta Pharm Inc | Functionalized peptides as antiviral agents |
| CA3201499A1 (en) | 2020-11-13 | 2022-05-19 | Catamaran Bio, Inc. | Genetically modified natural killer cells and methods of use thereof |
| US11384090B2 (en) | 2020-11-23 | 2022-07-12 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| US11352363B1 (en) | 2020-11-23 | 2022-06-07 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| US12540141B2 (en) | 2020-11-23 | 2026-02-03 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| KR20230124583A (ko) | 2020-11-23 | 2023-08-25 | 이난타 파마슈티칼스, 인코포레이티드 | 신규한 스피로피롤리딘 유래 항바이러스제 |
| WO2022115611A1 (en) | 2020-11-25 | 2022-06-02 | Catamaran Bio, Inc. | Cellular therapeutics engineered with signal modulators and methods of use thereof |
| US11319325B1 (en) | 2021-05-11 | 2022-05-03 | Enanta Pharmaceuticals, Inc. | Macrocyclic spiropyrrolidine derived antiviral agents |
| US11325916B1 (en) | 2021-07-29 | 2022-05-10 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| US11339170B1 (en) | 2021-07-23 | 2022-05-24 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| AU2022343749A1 (en) | 2021-09-13 | 2024-03-28 | FUJIFILM Cellular Dynamics, Inc. | Methods for the production of committed cardiac progenitor cells |
| WO2023053220A1 (ja) | 2021-09-28 | 2023-04-06 | 公益財団法人京都大学iPS細胞研究財団 | 多能性幹細胞の製造方法 |
| WO2023086352A1 (en) | 2021-11-12 | 2023-05-19 | Enanta Pharmaceuticals, Inc. | Novel spiropyrrolidine derived antiviral agents |
| WO2023086350A1 (en) | 2021-11-12 | 2023-05-19 | Enanta Pharmaceuticals, Inc. | Alkyne-containing antiviral agents |
| US11919910B2 (en) | 2021-11-12 | 2024-03-05 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| WO2023172514A1 (en) | 2022-03-07 | 2023-09-14 | Catamaran Bio, Inc. | Engineered immune cell therapeutics targeted to her2 and methods of use thereof |
| WO2023196307A1 (en) | 2022-04-05 | 2023-10-12 | Enanta Pharmaceuticals, Inc. | Novel spiropyrrolidine derived antiviral agents |
| CN114958771B (zh) * | 2022-06-27 | 2023-12-05 | 广东康盾创新产业集团股份公司 | 一种ipsc-car-nk细胞的制备方法 |
| KR20250075707A (ko) | 2022-09-30 | 2025-05-28 | 후지필름 셀룰러 다이내믹스, 인코포레이티드 | 심장 섬유아세포의 제조 방법 |
| WO2025259202A1 (en) * | 2024-06-12 | 2025-12-18 | Chiang Mai University | A method of reprogramming human somatic cells and reprogrammed cells derived thereof |
Family Cites Families (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8200523A (nl) | 1982-02-11 | 1983-09-01 | Univ Leiden | Werkwijze voor het in vitro transformeren van planteprotoplasten met plasmide-dna. |
| US4714680B1 (en) | 1984-02-06 | 1995-06-27 | Univ Johns Hopkins | Human stem cells |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4952500A (en) | 1988-02-01 | 1990-08-28 | University Of Georgia Research Foundation, Inc. | Cloning systems for Rhodococcus and related bacteria |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5302523A (en) | 1989-06-21 | 1994-04-12 | Zeneca Limited | Transformation of plant cells |
| US5550318A (en) | 1990-04-17 | 1996-08-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
| US7705215B1 (en) | 1990-04-17 | 2010-04-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
| US5322783A (en) | 1989-10-17 | 1994-06-21 | Pioneer Hi-Bred International, Inc. | Soybean transformation by microparticle bombardment |
| US5484956A (en) | 1990-01-22 | 1996-01-16 | Dekalb Genetics Corporation | Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin |
| US5384253A (en) | 1990-12-28 | 1995-01-24 | Dekalb Genetics Corporation | Genetic transformation of maize cells by electroporation of cells pretreated with pectin degrading enzymes |
| WO1993004169A1 (en) | 1991-08-20 | 1993-03-04 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
| DK0641781T3 (da) | 1991-09-06 | 2000-09-18 | Yoshitomi Pharmaceutical | 4-Amino(alkyl)cyclohexan-1-carboxamidforbindelser og anvendelse af disse |
| US5610042A (en) | 1991-10-07 | 1997-03-11 | Ciba-Geigy Corporation | Methods for stable transformation of wheat |
| DE69334225D1 (de) | 1992-07-07 | 2008-07-31 | Japan Tobacco Inc | Verfahren zur transformation einer monokotyledon pflanze |
| US5702932A (en) | 1992-07-20 | 1997-12-30 | University Of Florida | Microinjection methods to transform arthropods with exogenous DNA |
| WO1994002620A2 (en) | 1992-07-27 | 1994-02-03 | Pioneer Hi-Bred International, Inc. | An improved method of agrobacterium-mediated transformation of cultured soybean cells |
| DE4228457A1 (de) | 1992-08-27 | 1994-04-28 | Beiersdorf Ag | Herstellung von heterodimerem PDGF-AB mit Hilfe eines bicistronischen Vektorsystems in Säugerzellen |
| GB9222888D0 (en) | 1992-10-30 | 1992-12-16 | British Tech Group | Tomography |
| GB9223084D0 (en) | 1992-11-04 | 1992-12-16 | Imp Cancer Res Tech | Compounds to target cells |
| CA2168348A1 (en) | 1993-07-29 | 1995-02-09 | Bruno Peault | Novel stem cell marker |
| CA2170357A1 (en) | 1993-08-25 | 1995-03-02 | David Digiusto | Method for producing a highly enriched population of hematopoietic stem cells |
| AU7798294A (en) | 1993-09-17 | 1995-04-03 | Systemix, Inc. | Method for obtaining a cell population enriched in stem cells and compositions derived therefrom |
| US5656610A (en) | 1994-06-21 | 1997-08-12 | University Of Southern California | Producing a protein in a mammal by injection of a DNA-sequence into the tongue |
| FR2722208B1 (fr) | 1994-07-05 | 1996-10-04 | Inst Nat Sante Rech Med | Nouveau site interne d'entree des ribosomes, vecteur le contenant et utilisation therapeutique |
| US5736524A (en) | 1994-11-14 | 1998-04-07 | Merck & Co.,. Inc. | Polynucleotide tuberculosis vaccine |
| ATE195555T1 (de) | 1994-11-29 | 2000-09-15 | Takara Shuzo Co | Verfahren zur herstellung transformierter zellen |
| US5728581A (en) | 1995-06-07 | 1998-03-17 | Systemix, Inc. | Method of expanding hematopoietic stem cells, reagents and bioreactors for use therein |
| US5780448A (en) | 1995-11-07 | 1998-07-14 | Ottawa Civic Hospital Loeb Research | DNA-based vaccination of fish |
| US20030059913A1 (en) | 1995-11-20 | 2003-03-27 | Walter Weyler | Novel Microorganisms with ability to degrade indole and novel enzymes therefrom |
| GB9807935D0 (en) | 1998-04-14 | 1998-06-10 | Univ Edinburgh | Lineage specific cells and progenitor cells |
| ES2202581T3 (es) * | 1996-03-14 | 2004-04-01 | The Governors Of The University Of Alberta | Uso de hialuronan (ha) para la movilizacion celular. |
| US5928906A (en) | 1996-05-09 | 1999-07-27 | Sequenom, Inc. | Process for direct sequencing during template amplification |
| US5945100A (en) | 1996-07-31 | 1999-08-31 | Fbp Corporation | Tumor delivery vehicles |
| US5981274A (en) | 1996-09-18 | 1999-11-09 | Tyrrell; D. Lorne J. | Recombinant hepatitis virus vectors |
| CA2277278A1 (en) | 1997-01-10 | 1998-07-16 | Life Technologies, Inc. | Embryonic stem cell serum replacement |
| US5994624A (en) | 1997-10-20 | 1999-11-30 | Cotton Incorporated | In planta method for the production of transgenic plants |
| AU729377B2 (en) | 1997-10-23 | 2001-02-01 | Asterias Biotherapeutics, Inc. | Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture |
| US7410798B2 (en) | 2001-01-10 | 2008-08-12 | Geron Corporation | Culture system for rapid expansion of human embryonic stem cells |
| US6667176B1 (en) | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
| CA2369085A1 (en) | 1999-05-14 | 2000-11-23 | City Of Hope | Ex vivo expansion of mammalian hematopoietic stem cells |
| JP2002184539A (ja) | 2000-12-14 | 2002-06-28 | Auto Network Gijutsu Kenkyusho:Kk | コネクタ |
| MXPA03008659A (es) | 2001-03-23 | 2005-04-08 | Bayer Ag | Inhibidores de rho-cinasa. |
| US20030125344A1 (en) | 2001-03-23 | 2003-07-03 | Bayer Corporation | Rho-kinase inhibitors |
| JPWO2002100889A1 (ja) | 2001-06-08 | 2004-09-24 | 麒麟麦酒株式会社 | ヒトパピローマウイルスe7抗原の新規エピトープおよびそのエピトープにより活性化されたcd4陽性t細胞 |
| US20030211603A1 (en) | 2001-08-14 | 2003-11-13 | Earp David J. | Reprogramming cells for enhanced differentiation capacity using pluripotent stem cells |
| DE60320933D1 (de) | 2002-01-10 | 2008-06-26 | Bayer Healthcare Ag | Rho-kinase inhibitoren |
| MXPA04007196A (es) | 2002-01-23 | 2005-06-08 | Bayer Pharmaceuticals Corp | Inhibidores de rho-quinasa. |
| JP4469179B2 (ja) | 2002-01-23 | 2010-05-26 | バイエル ファーマセチカル コーポレーション | Rhoキナーゼ阻害剤としてのピリミジン誘導体 |
| WO2004098490A2 (en) | 2002-05-17 | 2004-11-18 | Mount Sinai School Of Medicine Of New York University | Mesoderm and definitive endoderm cell populations |
| US20040039796A1 (en) | 2002-08-08 | 2004-02-26 | Virtual Radio, Inc. | Personalized cyber disk jockey and Internet radio advertising |
| ES2273047T3 (es) | 2002-10-28 | 2007-05-01 | Bayer Healthcare Ag | Fenilaminopirimidinas sustituidas con heteroariloxi como inhibidores de rho-cinasa. |
| US7986994B2 (en) | 2002-12-04 | 2011-07-26 | Medtronic, Inc. | Method and apparatus for detecting change in intrathoracic electrical impedance |
| US20050123902A1 (en) | 2003-05-21 | 2005-06-09 | President And Fellows Of Harvard College | Human papillomavirus inhibitors |
| US20090155218A1 (en) | 2004-03-10 | 2009-06-18 | Alberto Hayek | Compositions and methods for growth of embryonic stem cells |
| US7452718B2 (en) | 2004-03-26 | 2008-11-18 | Geron Corporation | Direct differentiation method for making cardiomyocytes from human embryonic stem cells |
| EP1783205B1 (en) | 2004-06-18 | 2024-02-21 | Riken | Method of inducing the differentiation of embryonic stem cells into nerve by serum-free suspension culture |
| US20080038820A1 (en) | 2004-06-22 | 2008-02-14 | Rudy-Reil Diane E | Induction of pluripotent stem cells into mesodermal lineages |
| AU2005282414C1 (en) | 2004-09-08 | 2011-04-07 | Wisconsin Alumni Research Foundation | Culturing human embryonic stem cells |
| WO2006066320A1 (en) | 2004-12-22 | 2006-06-29 | Es Cell International Pte Ltd | Differentiation of human embryonic stem cells and cardiomyocytes and cardiomyocyte progenitors derived therefrom |
| US7606580B2 (en) | 2005-05-11 | 2009-10-20 | Aol Llc | Personalized location information for mobile devices |
| US7599295B2 (en) | 2005-09-20 | 2009-10-06 | Futurewei Technologies, Inc. | System for passive alarm propagation and suppression for packet based networks |
| US20070116680A1 (en) | 2005-11-18 | 2007-05-24 | Rensselaer Polytechnic Institute | Stem cells within gel microenvironments |
| EP2457995A1 (en) | 2006-03-30 | 2012-05-30 | The University Court of The University of Edinburgh | Culture medium containing kinase inhibitors, and uses thereof |
| CN101595107A (zh) | 2006-06-30 | 2009-12-02 | 先灵公司 | 能提高p53活性的有取代哌啶及其用途 |
| BRPI0714409A2 (pt) | 2006-07-14 | 2013-03-12 | Novartis Ag | derivados de pirimidina como inibidores de alk-5 |
| CN103627671A (zh) | 2007-01-30 | 2014-03-12 | 佐治亚大学研究基金会 | 产生中内胚层细胞及多能游走细胞的方法与细胞群及用途 |
| DK3399025T3 (da) | 2007-03-23 | 2025-06-16 | Wisconsin Alumni Res Found | Omprogrammering af somatiske celler |
| CN101100655B (zh) * | 2007-06-15 | 2011-08-03 | 中国人民解放军第二军医大学 | 胚胎源性多能干细胞向心脏起搏细胞定向诱导分化的方法 |
| WO2009032456A2 (en) | 2007-08-01 | 2009-03-12 | Primegen Biotech Llc | Non-viral delivery of transcription factors that reprogram human somatic cells into a stem cell-like state |
| WO2009091543A1 (en) | 2008-01-14 | 2009-07-23 | Lindner Scott E | An efficient orip/ebna-1 plasmid vector |
| JP2011160661A (ja) * | 2008-06-02 | 2011-08-25 | Kyowa Hakko Kirin Co Ltd | 血球細胞の初期化法 |
| EP3279314A1 (en) | 2008-06-04 | 2018-02-07 | Cellular Dynamics International, Inc. | Methods for the production of ips cells using non-viral approach |
| DE102008040322A1 (de) | 2008-07-10 | 2010-09-16 | Dilo Trading Ag | Energiespeicher-Kreislaufsystem unter Verwendung von Lithium-Ionen-Zellen |
| US8288513B2 (en) | 2008-07-25 | 2012-10-16 | Becton, Dickinson And Company | Defined cell culturing surfaces and methods of use |
| WO2010013845A1 (en) * | 2008-07-30 | 2010-02-04 | Kyoto University | Method of efficiently establishing induced pluripotent stem cells |
| JP2012500005A (ja) | 2008-08-12 | 2012-01-05 | セルラー ダイナミクス インターナショナル, インコーポレイテッド | iPS細胞を生成するための方法 |
| CA2741090C (en) | 2008-10-24 | 2018-10-16 | Wisconsin Alumni Research Foundation | Pluripotent stem cells obtained by non-viral reprogramming |
| KR101720961B1 (ko) | 2009-02-27 | 2017-03-29 | 셀룰러 다이내믹스 인터내셔널, 인코포레이티드 | 다능성 세포의 분화 |
| EP2434012B1 (en) † | 2009-05-18 | 2017-12-13 | National Institute of Advanced Industrial Science And Technology | Vector material for creating pluripotent stem cells, and pluripotent stem cell creation method using said vector material |
| US8496941B2 (en) | 2009-06-03 | 2013-07-30 | National Institute Of Advanced Industrial Science And Technology | Vectors for generating pluripotent stem cells and methods of producing pluripotent stem cells using the same |
| DK2438160T3 (da) * | 2009-06-05 | 2016-01-11 | Cellular Dynamics Int Inc | Reprogrammering af t-celler og hæmatopoietiske celler |
| KR101774206B1 (ko) * | 2009-08-07 | 2017-09-04 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 유도된 다능성 줄기 세포의 효율적인 확립 방법 |
| CN102803476A (zh) | 2009-09-14 | 2012-11-28 | 程临钊 | 血细胞重编程产生多潜能干细胞和多功能干细胞 |
| ES2539487T3 (es) | 2009-11-04 | 2015-07-01 | Cellular Dynamics International, Inc. | Reprogramación episómica con compuestos químicos |
| US8048675B1 (en) * | 2010-05-12 | 2011-11-01 | Ipierian, Inc. | Integration-free human induced pluripotent stem cells from blood |
| JP5984217B2 (ja) * | 2010-06-15 | 2016-09-06 | セルラー ダイナミクス インターナショナル, インコーポレイテッド | 少量の末梢血からの人工多能性幹細胞の作製 |
| US9409760B1 (en) | 2013-12-05 | 2016-08-09 | Paul Lichtefeld, Sr. | Fluid dispenser |
| US9410501B2 (en) | 2014-04-25 | 2016-08-09 | Rohr, Inc. | Translating sleeve actuation system and apparatus |
-
2011
- 2011-06-14 JP JP2013515431A patent/JP5984217B2/ja active Active
- 2011-06-14 CA CA2802249A patent/CA2802249A1/en not_active Abandoned
- 2011-06-14 AU AU2011267849A patent/AU2011267849B2/en active Active
- 2011-06-14 EP EP18159786.5A patent/EP3382008A1/en active Pending
- 2011-06-14 KR KR1020137000892A patent/KR101861168B1/ko active Active
- 2011-06-14 WO PCT/US2011/040323 patent/WO2011159684A2/en not_active Ceased
- 2011-06-14 ES ES11796290T patent/ES2670842T5/es active Active
- 2011-06-14 US US13/160,076 patent/US8691574B2/en active Active
- 2011-06-14 CN CN201180029389.7A patent/CN103003416B/zh active Active
- 2011-06-14 DK DK11796290.2T patent/DK2582794T4/da active
- 2011-06-14 EP EP11796290.2A patent/EP2582794B2/en active Active
-
2012
- 2012-12-09 IL IL223527A patent/IL223527B/en active IP Right Grant
-
2014
- 2014-02-12 US US14/179,547 patent/US9447382B2/en active Active
-
2015
- 2015-08-21 JP JP2015163425A patent/JP2015211695A/ja not_active Withdrawn
-
2016
- 2016-08-10 US US15/233,925 patent/US10260048B2/en active Active
-
2017
- 2017-11-10 JP JP2017217269A patent/JP2018019725A/ja active Pending
-
2020
- 2020-12-04 JP JP2020201481A patent/JP2021035399A/ja active Pending
-
2023
- 2023-08-14 US US18/449,100 patent/US20240228977A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3382008A1 (en) | 2018-10-03 |
| ES2670842T5 (en) | 2024-12-16 |
| US9447382B2 (en) | 2016-09-20 |
| JP2021035399A (ja) | 2021-03-04 |
| JP2013528397A (ja) | 2013-07-11 |
| EP2582794A2 (en) | 2013-04-24 |
| ES2670842T3 (es) | 2018-06-01 |
| DK2582794T3 (da) | 2018-05-22 |
| AU2011267849A1 (en) | 2013-01-10 |
| CN103003416A (zh) | 2013-03-27 |
| US8691574B2 (en) | 2014-04-08 |
| CN103003416B (zh) | 2016-11-16 |
| US20120009676A1 (en) | 2012-01-12 |
| US20240228977A1 (en) | 2024-07-11 |
| JP5984217B2 (ja) | 2016-09-06 |
| IL223527B (en) | 2018-05-31 |
| JP2015211695A (ja) | 2015-11-26 |
| AU2011267849B2 (en) | 2015-02-05 |
| US20140234973A1 (en) | 2014-08-21 |
| EP2582794B2 (en) | 2024-04-24 |
| CA2802249A1 (en) | 2011-12-22 |
| EP2582794A4 (en) | 2013-12-11 |
| WO2011159684A3 (en) | 2012-04-19 |
| KR101861168B1 (ko) | 2018-05-31 |
| KR20130087009A (ko) | 2013-08-05 |
| US20170088818A1 (en) | 2017-03-30 |
| US10260048B2 (en) | 2019-04-16 |
| EP2582794B1 (en) | 2018-03-07 |
| WO2011159684A2 (en) | 2011-12-22 |
| JP2018019725A (ja) | 2018-02-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK2582794T4 (da) | Generering af inducerede pluripotente stamceller fra små volumener af perifert blod | |
| HUS1900001I1 (hu) | Transztiretin expressziójának módosítása | |
| EP2414510A4 (en) | INDUCED PLURIPOTENTIAL STEM CELLS | |
| HUE037448T2 (hu) | Pluripotens õssejt, amely izolálható testi szövetbõl | |
| EP2611907A4 (en) | DIFFERENTIATION OF PLURIPOTENTAL STEM CELLS | |
| EP2639296A4 (en) | STEM CELL SUSPENSION | |
| HUE037140T2 (hu) | Humán GDF8-hoz kötõdõ ellenanyagok | |
| DK3498225T3 (da) | Hjerteklapprotese | |
| EP2611910A4 (en) | Differentiation of human embryonic stem cells | |
| LT2494039T (lt) | Ląstelių perprogramavimo būdai ir jų panaudojimas | |
| DK2456853T3 (da) | Anvendelse af stamceller til reduktion af leukocyt-ekstravasation | |
| DK2569154T3 (da) | Flerlags støbt legeme af træfiner | |
| PL2611909T3 (pl) | Zróżnicowanie ludzkich embrionalnych komórek macierzystych | |
| EP2749641A4 (en) | CANCER STEM CELLS ISOLATION | |
| IL217063A0 (en) | Generation of induced pluripotent stem cells from cord blood | |
| EP2643012A4 (en) | PROTEIN RELIEF FROM STEM CELL MICRO-SUPPLIES | |
| EP2376908A4 (en) | SIMULATION OF NORMAL FRESH THROMBOCYTES | |
| EP2531853A4 (en) | USING NEW MARKERS FOR PLURIPOTENTIAL STEM CELLS | |
| EP2683814A4 (en) | PERIPHERAL BLOOD PERFECT PERFORMER | |
| EP2539437A4 (en) | HUMAN MUSCLE SIMILAR CELLS OBTAINED FROM HUMAN PLURIPOTENTIAL STEM CELLS | |
| FI20096402A0 (fi) | Veriryhmästatuksen käyttö II | |
| SG11201403370YA (en) | Induced pluripotent stem cells prepared from human kidney-derived cells | |
| EP2762310A4 (en) | POWER BODY | |
| EP2446020A4 (en) | RE-PROGRAMMING OF DENTAL STEM CELLS | |
| FI20095792L (fi) | Ihmissolujen käyttö |