DK2593792T3 - Proteinbindingsdomæner, der stabiliserer funktionelle konformationelle tilstande af GPCR'er og anvendelser deraf - Google Patents

Proteinbindingsdomæner, der stabiliserer funktionelle konformationelle tilstande af GPCR'er og anvendelser deraf Download PDF

Info

Publication number
DK2593792T3
DK2593792T3 DK11734078.6T DK11734078T DK2593792T3 DK 2593792 T3 DK2593792 T3 DK 2593792T3 DK 11734078 T DK11734078 T DK 11734078T DK 2593792 T3 DK2593792 T3 DK 2593792T3
Authority
DK
Denmark
Prior art keywords
gpcrs
applications
binding domains
protein binding
conformational states
Prior art date
Application number
DK11734078.6T
Other languages
English (en)
Inventor
Jan Steyaert
Els Pardon
Toon Laeremans
Juan Fung
Brian Kobilka
Søren Rasmussen
Original Assignee
Vib Vzw
Univ Brussel Vrije
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vib Vzw, Univ Brussel Vrije, Univ Leland Stanford Junior filed Critical Vib Vzw
Application granted granted Critical
Publication of DK2593792T3 publication Critical patent/DK2593792T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/20—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by using diffraction of the radiation by the materials, e.g. for investigating crystal structure; by using scattering of the radiation by the materials, e.g. for investigating non-crystalline materials; by using reflection of the radiation by the materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/6857—Antibody fragments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
DK11734078.6T 2010-07-16 2011-07-18 Proteinbindingsdomæner, der stabiliserer funktionelle konformationelle tilstande af GPCR'er og anvendelser deraf DK2593792T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39978110P 2010-07-16 2010-07-16
GBGB1014715.5A GB201014715D0 (en) 2010-09-06 2010-09-06 Nanobodies stabilizing functional conformational states of GPCRS
PCT/EP2011/062287 WO2012007593A1 (en) 2010-07-16 2011-07-18 Protein binding domains stabilizing functional conformational states of gpcrs and uses thereof

Publications (1)

Publication Number Publication Date
DK2593792T3 true DK2593792T3 (da) 2020-02-03

Family

ID=43037319

Family Applications (5)

Application Number Title Priority Date Filing Date
DK19169005.6T DK3557255T3 (da) 2010-07-16 2011-07-18 Proteinbindingsdomæner, der stabiliserer funktionelle konformationelle tilstande af GPCR'er, og anvendelser deraf
DK23185997.6T DK4273549T3 (da) 2010-07-16 2011-07-18 Proteinbindingsdomæner til stabilisering af funktionelle konformationstilstande af GPCRS og anvendelser deraf
DK11732498.8T DK2593791T3 (da) 2010-07-16 2011-07-18 Proteinbindingsdomæner, som stabiliserer funktionelle konformationstilstande af GPCR, og anvendelser deraf
DK11734078.6T DK2593792T3 (da) 2010-07-16 2011-07-18 Proteinbindingsdomæner, der stabiliserer funktionelle konformationelle tilstande af GPCR'er og anvendelser deraf
DK19169004.9T DK3557254T3 (da) 2010-07-16 2011-07-18 Proteinbindingsdomæner, der stabiliserer funktionelle konformationelle tilstande af GPCR'er, og anvendelser deraf

Family Applications Before (3)

Application Number Title Priority Date Filing Date
DK19169005.6T DK3557255T3 (da) 2010-07-16 2011-07-18 Proteinbindingsdomæner, der stabiliserer funktionelle konformationelle tilstande af GPCR'er, og anvendelser deraf
DK23185997.6T DK4273549T3 (da) 2010-07-16 2011-07-18 Proteinbindingsdomæner til stabilisering af funktionelle konformationstilstande af GPCRS og anvendelser deraf
DK11732498.8T DK2593791T3 (da) 2010-07-16 2011-07-18 Proteinbindingsdomæner, som stabiliserer funktionelle konformationstilstande af GPCR, og anvendelser deraf

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK19169004.9T DK3557254T3 (da) 2010-07-16 2011-07-18 Proteinbindingsdomæner, der stabiliserer funktionelle konformationelle tilstande af GPCR'er, og anvendelser deraf

Country Status (15)

Country Link
US (16) US9453065B2 (da)
EP (7) EP2593791B1 (da)
JP (4) JP6302248B2 (da)
CN (1) CN103180734B (da)
BR (1) BR112013001180B1 (da)
CA (1) CA2805560C (da)
DK (5) DK3557255T3 (da)
ES (5) ES3007288T3 (da)
FI (1) FI4273549T3 (da)
GB (1) GB201014715D0 (da)
HR (3) HRP20220326T1 (da)
HU (2) HUE031572T2 (da)
PL (5) PL2593791T3 (da)
PT (5) PT3557254T (da)
WO (2) WO2012007594A1 (da)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201014715D0 (en) 2010-09-06 2010-10-20 Vib Vzw Nanobodies stabilizing functional conformational states of GPCRS
WO2012175643A2 (en) * 2011-06-21 2012-12-27 Vib Vzw Binding domains directed against gpcr:g protein complexes and uses derived thereof
WO2013126856A1 (en) 2012-02-23 2013-08-29 Vanderbilt University Substituted 5-aminothieno[2,3-c]pyridazine-6-carboxamide analogs as positive allosteric modulators of the muscarinic acetylcholine receptor m4
CN103509115B (zh) * 2012-06-21 2016-03-23 中国科学院上海生命科学研究院 人胱抑素c纳米抗体及其应用
WO2014001557A1 (en) 2012-06-28 2014-01-03 Ucb Pharma S.A. A method for identifying compounds of therapeutic interest
WO2014035829A1 (en) * 2012-08-31 2014-03-06 Vanderbilt University Substituted 3-aminothieno[2,3-c]pyridine-2-carboxamide analogs as positive allosteric modulators
CN112858672A (zh) * 2013-01-30 2021-05-28 弗拉芒区生物技术研究所 用于筛选和药物发现目的的新型嵌合多肽
PL2953973T3 (pl) * 2013-02-05 2020-01-31 Vib Vzw Środki wiążące muskarynowy receptor acetylocholiny i ich zastosowania
US9880179B2 (en) * 2013-02-05 2018-01-30 The Board Of Trustees Of The Leland Stanford Junior University Method for selecting agents that bind to transmembrane receptors in a conformationally selective manner
WO2014153044A1 (en) * 2013-03-14 2014-09-25 Temple University Of The Commonwealth System Of Higher Education Treatment of patients with hyponatremia and cardiac disease
MY191368A (en) 2013-06-28 2022-06-20 X Body Inc Target antigen discovery, phenotypic screens and use thereof for identification of target cell specific target epitopes
US9637498B2 (en) 2013-08-23 2017-05-02 Vanderbilt University Substituted thieno[2,3-C]pyridazine-6-carboxamide analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M4
CN103454413B (zh) * 2013-09-04 2015-03-11 吉日木图 双峰驼特异性抗体制备及免疫检测方法
US10519436B2 (en) 2013-09-23 2019-12-31 X-Body, Inc. Methods and compositions for generation of binding agents against cell surface antigens
WO2016012363A1 (en) 2014-07-22 2016-01-28 Vib Vzw Methods to select for agents that stabilize protein complexes
GB201601690D0 (en) 2016-01-29 2016-03-16 Heptares Therapeutics Ltd G proteins
DE102016116391B3 (de) * 2016-09-01 2018-02-01 Gea Mechanical Equipment Gmbh Verfahren zum Überwachen einer Schneckenzentrifuge
WO2018208877A1 (en) * 2017-05-09 2018-11-15 Yale University Basehit, a high-throughput assay to identify proteins involved in host-microbe interaction
WO2018207950A1 (ja) * 2017-05-12 2018-11-15 横山　茂之 クラスａ ｇｐｃｒ結合性化合物改変体
CN107423555B (zh) * 2017-06-09 2020-06-30 王�忠 一种探索药物新适应症的方法
WO2019032661A1 (en) * 2017-08-09 2019-02-14 Orionis Biosciences Inc. CD8 LIAISON AGENTS
CN113501881B (zh) * 2017-09-27 2023-07-28 北京大学 融合蛋白
EP3691684A1 (en) * 2017-10-02 2020-08-12 VIB vzw Compounds to inhibit bacterial s-layer protein assembly
EP4635987A3 (en) 2017-10-31 2026-01-14 Vib Vzw Novel antigen-binding chimeric proteins and methods and uses thereof
KR102485253B1 (ko) * 2017-11-10 2023-01-06 현대자동차주식회사 대화 시스템 및 그 제어방법
CN112703201A (zh) * 2018-07-05 2021-04-23 诺沃班德畜牧业治疗公司 针对家禽致病原的抗体和其用途
CN110759998A (zh) * 2018-07-27 2020-02-07 深圳康体生命科技有限公司 一种gfp抗体制备方法及其dna序列
CN114041057A (zh) 2019-04-29 2022-02-11 康福治疗有限公司 嵌合蛋白和筛选与gpcr结合的化合物和配体的方法
CA3138608A1 (en) * 2019-05-01 2020-11-05 Commonwealth Scientific And Industrial Research Organisation Immunosensor
CN113891896B (zh) * 2019-05-07 2023-09-26 庄亚(北京)生物科技有限公司 单域抗体融合蛋白及其在止血中的应用
WO2021140205A1 (en) 2020-01-10 2021-07-15 Confo Therapeutics N.V. Methods for generating antibodies and antibody fragments and libraries comprising same
CN115996754A (zh) 2020-02-21 2023-04-21 免疫之源生物技术有限公司 痤疮丙酸杆菌的预防性和治疗性免疫治疗
CN115884988A (zh) * 2020-05-28 2023-03-31 小利兰·斯坦福大学托管委员会 防止封闭和半封闭空间中病毒和微生物污染的雾化粘液抑制纳米抗体
CA3193537A1 (en) * 2020-09-25 2022-03-31 The Board Of Trustees Of The Leland Stanford Junior University Potent binding agents for activation of the hedgehog signaling pathway
CN112843222B (zh) * 2021-01-21 2023-01-31 暨南大学 Ankrd22蛋白在制备治疗或延缓自身免疫性疾病的产品中的应用
CN112851811B (zh) * 2021-01-28 2022-08-09 姜国胜 一种cd44v6纳米抗体及其作为白血病研究试剂的应用
US12282027B2 (en) 2021-02-19 2025-04-22 University Of South Florida High-throughput NMR approach for in-membrane protein ligand screening
WO2022258437A1 (en) * 2021-06-07 2022-12-15 Paul Scherrer Institut Quantification of protein-protein interaction of membrane proteins using high-mass mass spectrometry
CN113717874B (zh) * 2021-09-27 2023-04-11 四川大学 一种耐高温、耐高糖的酿酒酵母菌株及其构建方法和应用
JP2023107630A (ja) * 2022-01-24 2023-08-03 国立大学法人横浜国立大学 抗体を製造するための方法及び抗体を評価するための方法並びにこれらに関連するキット
WO2023168429A2 (en) * 2022-03-04 2023-09-07 Coagulant Therapeutics Corporation Camelid antibodies against activated protein c and uses thereof
US20250242062A1 (en) * 2022-04-11 2025-07-31 Vanderbilt University Anti-cox-2 nanobodies for endoscopic visualization of colorectal adenomas
JP2023178884A (ja) * 2022-06-06 2023-12-18 国立大学法人千葉大学 膜タンパク質のＣ末端に付加したＨｉｓ－ｔａｇに対する高親和性モノクローナル抗体
WO2024192704A1 (en) * 2023-03-22 2024-09-26 Biofront Therapeutics (Beijing) Co., Ltd. Nanobodies that bind to gprc5d and uses thereof
CN116813781B (zh) * 2023-07-29 2024-01-12 十堰市太和医院（湖北医药学院附属医院） 一种靶向β2AR的纳米抗体及其制备方法和应用
WO2025100417A1 (ja) * 2023-11-06 2025-05-15 株式会社ダイセル Ａａｖのフルカプシドに対するアフィニティポリペプチド
WO2025111553A2 (en) * 2023-11-22 2025-05-30 The General Hospital Corporation Antibody-based human lamp-1 composition and its uses
EP4620523A1 (en) * 2024-03-22 2025-09-24 Genome Research Limited Mutants of the beta2-adrenergic receptor with altered activity and their use in disease treatment.
CN118324905B (zh) * 2024-06-14 2024-09-03 广州明药科技有限公司 抗人β2微球蛋白的纳米抗体及其应用
CN118894930A (zh) * 2024-07-31 2024-11-05 演生潮(北京)生物科技有限公司 一种基于生物学活性评价的纳米抗体快速筛查方法
CN119912560B (zh) * 2025-01-24 2026-01-02 深圳市捷博生物科技有限公司 一种AVRcap1b纳米抗体及其应用

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0437547B1 (en) 1988-10-03 1999-12-29 The Scripps Research Institute Monoclonal antibodies against receptor-induced binding sites on ligands binding to proteins of the cytoadhesin super family
CA2000044A1 (en) * 1988-10-03 1990-04-03 Edward F. Plow Monoclonal antibodies against receptor induced binding sites
PT1621554E (pt) 1992-08-21 2009-07-13 Univ Bruxelles Imunoglobtainas desprovidas de cadeias leves
WO1999037681A2 (en) 1998-01-26 1999-07-29 Unilever Plc Method for producing antibody fragments
AU2291700A (en) 1999-01-19 2000-08-07 Unilever Plc Method for producing antibody fragments
US20030190598A1 (en) 2000-05-26 2003-10-09 Jasmid Tanha Single-domain antigen-binding antibody fragments derived from llama antibodies
US7294472B2 (en) * 2001-03-14 2007-11-13 Caden Biosciences Method for identifying modulators of G protein coupled receptor signaling
US7208279B2 (en) 2001-03-14 2007-04-24 Caden Biosciences, Inc. Method for identifying inhibitors of G protein coupled receptor signaling
US20020192711A1 (en) * 2001-04-20 2002-12-19 Nestor John J. Methods for identifying ligands of G-Protein-Coupled receptors
US20030129649A1 (en) 2001-04-24 2003-07-10 Kobilka Brian K. Conformational assays to detect binding to G protein-coupled receptors
GB0110029D0 (en) 2001-04-24 2001-06-13 Grosveld Frank Transgenic animal
WO2004035614A1 (en) * 2001-07-11 2004-04-29 Karo Bio Ab Synthetic or partially purified peptides which can bind to specific subunits of g proteins and uses thereof
US7371849B2 (en) 2001-09-13 2008-05-13 Institute For Antibodies Co., Ltd. Methods of constructing camel antibody libraries
JP2005289809A (ja) 2001-10-24 2005-10-20 Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) 突然変異重鎖抗体
GB0228210D0 (en) 2002-12-03 2003-01-08 Babraham Inst Single chain antibodies
JP4490290B2 (ja) 2002-12-31 2010-06-23 ネクター セラピューティクス アラバマ，コーポレイション 加水分解安定性マレイミド末端ポリマー
WO2006086883A1 (en) * 2005-02-16 2006-08-24 Universite De Montreal Biosensors for monitoring receptor-mediated g-protein activation
EP1874950B1 (en) * 2005-04-05 2015-06-03 Corning Incorporated Label free biosensors
WO2007042289A2 (en) * 2005-10-11 2007-04-19 Ablynx N.V. Nanobodies™ and polypeptides against egfr and igf-ir
CN101389963A (zh) * 2006-02-22 2009-03-18 菲洛根有限公司 血管性肿瘤标志物
CA2673331A1 (en) * 2006-12-19 2008-06-26 Ablynx N.V. Amino acid sequences directed against gpcrs and polypeptides comprising the same for the treatment of gpcr-related diseases and disorders
US8785135B2 (en) * 2007-03-22 2014-07-22 Heptares Therapeutics Limited Mutant G-protein coupled receptors and methods for selecting them
EP2152752B1 (en) * 2007-05-15 2017-11-08 F. Hoffmann-La Roche AG Antibody directed to g protein coupled receptors (gpcr)
US7947807B2 (en) * 2007-10-15 2011-05-24 The Board Of Trustees Of The Leland Stanford Junior University Method for obtaining G protein-coupled receptor (GPCR) diffraction-quality crystals employing a monoclonal antibody that binds to the third intracellular loop (IL3)
GB0724860D0 (en) 2007-12-20 2008-01-30 Heptares Therapeutics Ltd Screening
NZ589036A (en) * 2008-05-16 2012-07-27 Ablynx Nv AMINO ACID SEQUENCES DIRECTED AGAINST CXCR4 AND OTHER GPCRs AND COMPOUNDS COMPRISING THE SAME
HUE042053T2 (hu) * 2008-06-05 2019-06-28 Ablynx Nv Vírus burokfehérjéi elleni aminosav-szekvenciák és az azokat tartalmazó polipeptidek virális betegségek kezelésére
EP2328929A2 (en) * 2008-09-10 2011-06-08 Bac Ip B.V. Antigen-binding proteins that inhibit superantigens for the treatment of skin diseases
WO2010043650A2 (en) * 2008-10-14 2010-04-22 Ablynx Nv Amino acid sequences directed against cellular receptors for viruses and bacteria
CA2749558C (en) 2008-12-08 2019-01-15 Complix Nv Single-chain antiparallel coiled coil proteins
GB201014715D0 (en) 2010-09-06 2010-10-20 Vib Vzw Nanobodies stabilizing functional conformational states of GPCRS
WO2012175643A2 (en) 2011-06-21 2012-12-27 Vib Vzw Binding domains directed against gpcr:g protein complexes and uses derived thereof
PL2953973T3 (pl) 2013-02-05 2020-01-31 Vib Vzw Środki wiążące muskarynowy receptor acetylocholiny i ich zastosowania
CA2936728C (en) 2014-01-30 2023-06-20 Vib Vzw Opioid receptor binding agents and uses thereof

Also Published As

Publication number Publication date
HRP20220326T1 (hr) 2022-05-13
GB201014715D0 (en) 2010-10-20
ES2613532T3 (es) 2017-05-24
EP3557257A1 (en) 2019-10-23
US20190383828A1 (en) 2019-12-19
EP4273549B1 (en) 2024-11-06
PL3557255T3 (pl) 2022-06-20
EP2593791A1 (en) 2013-05-22
CN103180734A (zh) 2013-06-26
HUE031572T2 (en) 2017-07-28
US11162954B2 (en) 2021-11-02
PT2593791T (pt) 2017-02-01
EP3557254A1 (en) 2019-10-23
HRP20170201T1 (hr) 2017-04-07
JP6302248B2 (ja) 2018-03-28
HUE070205T2 (hu) 2025-05-28
PT3557255T (pt) 2022-01-20
US20190041400A1 (en) 2019-02-07
US20130183287A1 (en) 2013-07-18
AU2011278244B2 (en) 2016-01-28
DK3557255T3 (da) 2022-01-24
WO2012007593A1 (en) 2012-01-19
US20240103013A1 (en) 2024-03-28
US10436796B2 (en) 2019-10-08
JP2013536173A (ja) 2013-09-19
WO2012007594A1 (en) 2012-01-19
EP3557254B1 (en) 2021-12-15
US20170153245A1 (en) 2017-06-01
US20190383825A1 (en) 2019-12-19
PL2593792T3 (pl) 2020-05-18
US20180067126A1 (en) 2018-03-08
AU2011278244A8 (en) 2016-02-11
PT2593792T (pt) 2020-01-29
PL4273549T3 (pl) 2025-03-03
US11162953B2 (en) 2021-11-02
EP3557256A1 (en) 2019-10-23
US20130137856A1 (en) 2013-05-30
US9863959B2 (en) 2018-01-09
US20190049463A1 (en) 2019-02-14
AU2011278244A1 (en) 2013-02-28
PL2593791T3 (pl) 2017-08-31
JP6859229B2 (ja) 2021-04-14
DK2593791T3 (da) 2017-02-06
US12092646B2 (en) 2024-09-17
JP2018027936A (ja) 2018-02-22
US9689872B2 (en) 2017-06-27
DK3557254T3 (da) 2022-01-24
PL3557254T3 (pl) 2022-05-23
US20200025773A1 (en) 2020-01-23
CN103180734B (zh) 2016-03-02
BR112013001180A2 (pt) 2016-05-31
PT4273549T (pt) 2025-01-03
EP3557255B1 (en) 2021-11-17
US20190383829A1 (en) 2019-12-19
CA2805560A1 (en) 2012-01-19
US20190383826A1 (en) 2019-12-19
EP2593792B1 (en) 2019-11-13
JP7248637B2 (ja) 2023-03-29
FI4273549T3 (fi) 2025-02-05
CA2805560C (en) 2019-10-29
US20180100865A1 (en) 2018-04-12
EP3557255A1 (en) 2019-10-23
US20160347842A1 (en) 2016-12-01
ES2907049T3 (es) 2022-04-21
US10054598B2 (en) 2018-08-21
EP4273549A1 (en) 2023-11-08
US20190383827A1 (en) 2019-12-19
US9453065B2 (en) 2016-09-27
US10078088B2 (en) 2018-09-18
ES2905455T3 (es) 2022-04-08
EP2593791B1 (en) 2016-11-23
HRP20220204T1 (hr) 2022-04-29
JP2021042209A (ja) 2021-03-18
US20220099683A1 (en) 2022-03-31
AU2011278244B8 (en) 2016-02-11
BR112013001180B1 (pt) 2022-01-11
EP2593792A1 (en) 2013-05-22
PT3557254T (pt) 2022-01-20
DK4273549T3 (da) 2024-12-02
JP2023085340A (ja) 2023-06-20
ES2771479T3 (es) 2020-07-06
ES3007288T3 (en) 2025-03-19

Similar Documents

Publication Publication Date Title
DK3557254T3 (da) Proteinbindingsdomæner, der stabiliserer funktionelle konformationelle tilstande af GPCR'er, og anvendelser deraf
HUE036982T2 (hu) GPCR:G-fehérje komplexek ellen irányuló kötõdomének és alkalmazások
DK2913344T3 (da) Specifikke bindingsproteiner og anvendelser deraf
DK3168229T3 (da) Fremstilling af proteiner og polypeptider.
DK3339323T3 (da) Anti-n3pglu-amyloid-beta-peptid-antistoffer og anvendelser deraf
DK3199547T3 (da) Antistoflignende bindingsproteiner med dobbelt variabel region og overkrydsende orientering af bindingsregion
IL222961B (en) Dna-binding proteins and uses thereof
DK3091034T3 (da) Anti-CD40-antistoffer og anvendelser deraf
ME03075B (me) Prolaktin receptor vezujući proteini i njihova upotreba
DK3275899T3 (da) Optimering af antistoffer, der binder lymfocytaktiveringsgen-3 (lag-3), og anvendelser deraf
EP2426557A4 (en) Light-sensitive modified polyimide resin composition and use
DK2157967T3 (da) Suspensionsformuleringer af insulinotropiske peptider og anvendelser deraf
DK2209806T3 (da) Anti-hepcidin-antistoffer og anvendelser deraf
DK2352756T3 (da) Højaffin T-cellereceptor og anvendelse af denne
SG10201504971QA (en) Mice that make binding proteins comprising vl domains
DK2142529T3 (da) Trpv1-antagonister og anvendelser deraf
DK2570467T4 (da) Anvendelse af en sammensætning af tetrafluorpropen og carbonhydrider
DK3725330T3 (da) Stabile formuleringer af polypeptider og anvendelser heraf
DK2240203T3 (da) Alfa5-beta1-antistoffer og deres anvendelser
DK2917229T3 (da) Antistoffer og fragmenter, der er mod alfa-3-domænerne af hla-g-protein, fremgangsmåder og midler til deres forberedelse, og anvendelsen deraf
DK2118140T3 (da) Humancytomegalovirus-neutraliserende antistoffer og anvendelse deraf
DK2531181T3 (da) Formuleringer af rasagilin med forlænget afgivelse og anvendelser deraf
DK2513193T3 (da) Forbedrede blends af polyarylenethere og polyarylensulfider
PT2580240T (pt) Anticorpos as100a4 e utilizações terapêuticas dos mesmos
DK2557924T3 (da) Dermale farmaceutiske sammensætninger af 1-methyl-2',6'-pipecoloxylidid og fremgangsmåde til deres anvendelse