DK2675504T3 - Autoinjektor - Google Patents

Autoinjektor Download PDF

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Publication number
DK2675504T3
DK2675504T3 DK12703839.6T DK12703839T DK2675504T3 DK 2675504 T3 DK2675504 T3 DK 2675504T3 DK 12703839 T DK12703839 T DK 12703839T DK 2675504 T3 DK2675504 T3 DK 2675504T3
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DK
Denmark
Prior art keywords
carrier
chassis
auto
injector
collar
Prior art date
Application number
DK12703839.6T
Other languages
English (en)
Inventor
Simon Francis Brereton
Thomas Kemp
Matthew Ekman
Rosie Burnell
Original Assignee
Sanofi Sa
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Publication date
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Publication of DK2675504T3 publication Critical patent/DK2675504T3/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/3157—Means providing feedback signals when administration is completed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2422—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
    • A61M5/2429—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by telescoping of ampoules or carpules with the syringe body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31501—Means for blocking or restricting the movement of the rod or piston
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
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    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202—Devices for protection of the needle before use, e.g. caps
    • A—HUMAN NECESSITIES
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    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
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    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202—Devices for protection of the needle before use, e.g. caps
    • A61M5/3204—Needle cap remover, i.e. devices to dislodge protection cover from needle or needle hub, e.g. deshielding devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A61M5/3257—Semi-automatic sleeve extension, i.e. in which triggering of the sleeve extension requires a deliberate action by the user, e.g. manual release of spring-biased extension means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A61M5/326—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2006—Having specific accessories
    • A61M2005/2013—Having specific accessories triggering of discharging means by contact of injector with patient body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/206—With automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
    • A61M2005/208—Release is possible only when device is pushed against the skin, e.g. using a trigger which is blocked or inactive when the device is not pushed against the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
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    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A61M5/3245—Constructional features thereof, e.g. to improve manipulation or functioning
    • A61M2005/3247—Means to impede repositioning of protection sleeve from needle covering to needle uncovering position
    • A—HUMAN NECESSITIES
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    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
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    • A61M2205/582—Means for facilitating use, e.g. by people with impaired vision by tactile feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/50—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
    • A61M5/5086—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile for indicating if defective, used, tampered with or unsterile
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04C—ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT PUMPS
    • F04C2270/00—Control; Monitoring or safety arrangements
    • F04C2270/04—Force
    • F04C2270/042—Force radial
    • F04C2270/0421—Controlled or regulated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T403/00—Joints and connections
    • Y10T403/32—Articulated members
    • Y10T403/32254—Lockable at fixed position
    • Y10T403/32467—Telescoping members
    • Y10T403/32475—Telescoping members having detent
    • Y10T403/32501—Cam or wedge

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Environmental & Geological Engineering (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Claims (14)

1. Autoinjektor (1) til administrering af en dosis af et væskeformigt medikament (M), der omfatter: - et rørformet chassis (2), der kan skydes sammen i en aflangt hylster (12) , - en medbringerdel, der omfatter en rørformet medbringer (7) , der er forskydeligt anbragt delvist inde i chassiset (2) og inde i hylsteret (12), hvilken medbringer (7) er indrettet til at indeholde en sprøjte (3) med en hul injektionskanyle (4), en drivfjeder (8) og et stempel (9) til f remadbelastning af drivfjederen (8) mod en prop (6) i sprøjten (3), hvor sprøjten (3) er låsbar til samlet aksial translation med medbringeren (7) , - en kontrolfjeder (19), der er anbragt omkring medbringeren (7) , der er kendetegnet ved, at autoinjektoren (1) yderligere omfatter: - en kontrolmekanisme til kanyleindføring (24) til kobling af en proksimal ende af kontrolfjederen (19) til enten medbringeren (7) til fremføring af denne til kanyleindføring eller til chassiset (2), hvor kontrolmekanismen til kanyleindføring (24) omfatter en første krave (20), der påvirkes af kontrolfjederen i en proksimal retning (P) , hvor mindst én femte klemme (2.10) er anbragt på den ene af chassiset (2) eller den første krave (20), der indledningsvis støder op mod en blok (20.7) på den anden af chassiset (2) eller den første krave (20), hvor der er tilvejebragt et rampe-indgreb mellem den femte klemme (2.10) og medbringeren (7) til udadrettet afledning af den femte klemme (2.10) ved translation af medbringeren (7) i den proksimale retning (P), hvor udadrettet afledning af den femte klemme (2.10) og translation of medbringeren (7) i den proksimale retning (P) indledningsvis forhindres af hylsteret (12), der udad støder mod den femte klemme (2.10), hvor hylsteret (12) mindst indledningsvis påvirkes i den distale retning (D) , hvor hylsteret (12) er indrettet til at translatere mod påvirkningen i den proksimale retning (P) i forhold til chassiset (2) til en fremskudt position til derved translatering af et andet vindue (12.8) i hylsteret (12) udad bag den femte klemme (2.10), hvorved der åbnes mulighed for udadrettet afledning til afkobling af den femte klemme (2.10) fra blokken (20.7) og til muliggørelse af, at den første krave (20) kan støde op mod medbringeren (7) og skyde den frem under belastning af kontrolfjederen (19) .
2. Autoinjektor (1) ifølge krav 1, der er kendetegnet ved, at den første krave (20) omfatter en fjerde klemme (20.5) til at gå i indgreb med en fjerde ribbe (7.18) på medbringeren (7) til kanyleindføring, hvor mindst den ene af den fjerde klemme (20.5) og fjerde ribbe (7.18) skråner til udadrettet afledning af den fjerde klemme (20.5) til afkobling af den fjerde klemme (20.5) fra den fjerde ribbe (7.18) under belastning af kontrolfjederen (19), hvor udadrettet afledning af den fjerde klemme (20.5) indledningsvis forhindres af hylsteret (12), hvor hylsteret (12) har mulighed for at translatere fra den fremskudte position i den distale retning (D) drevet af kontrolfjederen (19), når autoinjektoren (1) løftes fra injektionsstedet til derved translatering af en sjette forsænkning (12.7) i hylsteret udad bag den fjerde klemme (20.5) til således muliggørelse af udadrettet afledning til afkobling af den første krave (20) fra medbringeren (7) og efterfølgende muliggørelse af, at den første krave (20) kan støde op mod chassiset (2) .
3. Autoinjektor (1) ifølge et af ovennævnte krav, der er kendetegnet ved: - en udløserknap (13), der er anbragt distalt eller lateralt i eller på hylsteret (12), en stempeludløsningsmekanisme (27), der er indrettet til udløsning af stemplet (9) til injektion, når medbringeren (7) har i det mindste næsten nået en injektionsdybde under kanyleindføring, - en kontrolmekanisme til sprøjtetilbagetrækning (25), der er indrettet til kobling af en distal ende af kontrolfjederen (19) til enten medbringeren (7) til kanyletilbagetrækning eller ellers til hylsteret (12).
4. Autoinjektor (1) ifølge krav 3, der er kendetegnet ved, at stempeludløsningsmekanismen (27) omfatter mindst én fjedrende arm (15) på medbringeren (7) , der er indrettet, så den er i rampe-indgreb med stemplet (9) til afkobling af disse under belastning af drivfjederen (8) , hvor en tap (14) rager frem fra en distal endeflade af udløserknappen (13) i den proksimale retning (P) på en måde til understøtning af den fjedrende arm (15), hvilket forhindrer afkobling af medbringeren (7) fra stemplet (9) og således udløsning af drivfjederen (8) , når medbringeren (7) er i en distal position, hvor udløserknappen (13) er indrettet til at forblive i position i forhold til hylsteret (12), når medbringeren (7) translateres til fremføring af kanylen (4) , så den fjedrende arm (15) trækkes væk fra tappen (14) til således muliggørelse af afledning af den fjedrende arm (15) som følge af rampe-indgrebet under belastning af drivfjederen (8) til afkobling af stemplet (9) fra medbringeren (7) og udløsning af drivfjederen (8) til lægemiddelfremføring, når medbringeren (7) har nået en forudbestemt position under kanylefremføring.
5. Autoinjektor (1) ifølge krav 3, der er kendetegnet ved, at stemplet (9) i stempeludløsningsmekanismen (27) i en indledende tilstand er låst til medbringeren (7) ved hjælp af et rampe-indgreb og ved at blive forhindret i at rotere ud af rampe-indgrebet afhængig af en relativ position i længderetningen af medbringeren (7) i hylsteret (12), hvor stemplet (9) er indrettet til at blive frigjort til rotering ud af rampe-indgrebet, når kanylen (4) når i det mindste næsten en forudbestemt injektionsdybde ved translation af medbringeren (7) i den proksimale retning (P) til fremføring af kanylen (4) forbi en proksimal ende af autoinjektoren (1).
6. Autoinjektor (1) ifølge krav 5, der er kendetegnet ved, at medbringeren (7) har et længdegående hul (7.9), hvor et udadrettet fremspring (9.1) er anbragt på stemplet (9) på en måde, så det går i indgreb med en flade (7.8) på medbringeren (7) i hullet (7.9), hvor mindst den ene af det udadrettede fremspring (9.1) eller fladen (7.8) på medbringeren (7) skråner, så stemplet (9) tvinges til at rotere, når det translateres, hvor en indadrettet længdegående ribbe (21.5), der er forbundet til hylsteret (12), rager indad i det længdegående hul (7.9) på en måde, der forhindrer afkobling af det udadrettede fremspring (9.1) fra fladen (7.8) på medbringeren (7) før translation af medbringeren (7) til fremføring af kanylen (4), og hvor det udadrettede fremspring (9.1) kommer fri af den indadrettede længdegående ribbe (21.5) ved translation af medbringeren (7) til fremføring af kanylen (4), så den roterer forbi en proksimal ende af den indadrettede længdegående ribbe (21.5) som følge af dens rampe-indgreb med medbringeren (7) under belastning af drivfjederen (8).
7. Autoinjektor (1) ifølge krav 6, der er kendetegnet ved, at den indadrettede længdegående ribbe (21.5) er anbragt på en anden krave (21), der er anbragt i hylsteret (12) og indledningsvis låst til hylsteret (12) til samlet aksial translation, hvor den anden krave (21) er en del af en kontrolmekanisme til sprøjtetilbagetrækning (25), hvor kontrolmekanismen til sprøjtetilbagetrækning (25) er indrettet til at koble fra hylsteret (12) og koble til medbringeren (7), når hylsteret (12) bevæges i den distale retning (D) fra en position med kanylen (4) i injektionsdybden, hvor en kontrolfjeder (19) er anbragt i hylsteret (12) omkring medbringeren (7), hvilken kontrolfjeder (19) virker mellem den anden krave (21) og en proksimal første krave (20) til påvirkning af hylsteret (12) eller medbringeren (7) i den distale retning (D).
8. Autoinjektor (1) ifølge et af kravene 3 til 7, der er kendetegnet ved, at den distalt anbragte udløserknap (13) mindst indlednings er koblet til medbringeren (7), hvor hylsteret (12) er indrettet til at støde op mod udløserknappen (13) i den indledende tilstand, hvilket forhindrer nedtrykning af udløserknappen (13), hvor udløserknappen (13) ved translation af hylsteret (12) til den fremskudte position forbliver koblet til medbringeren (7) og således dukker frem fra hylsteret (12) til muliggørelse af nedtrykning af udløserknappen (13) .
9. Autoinjektor (1) ifølge et af kravene 3 til 8, der er kendetegnet ved, at kontrolmekanismen til sprøjtetilbagetrækning (25) omfatter en anden krave (21), der ligger op mod den distale ende af kontrolfjederen (19) og har en fjedrende proksimal bjælke (21.1) med et andet bjælkehoved (21.2), der har en indadrettet knap (21.3), hvor det andet bjælkehoved (21.2) er indrettet til at være i rampe-indgreb med en anden hylstergriber (12.2) i hylsteret (12) på en måde, hvor det andet bjælkehoved (21.1) skråner i retningen indad (I) under belastning af kontrolfjederen (19) i den distale retning (D) , hvor den indadrettede knap (21.3) er indrettet til indad at støde op mod medbringeren (7) til forhindring af indadrettet afledning af det andet bjælkehoved (21.1) og holde den anden krave (21) låst til hylsteret (12), hvor en tredje forsænkning (7.7) er anbragt i medbringeren (7) til muliggørelse af, at den indadrettede knap (21.3) kan afledes indad ved translation af hylsteret (12) i den distale retning (D) i forhold til medbringeren (7).
10. Autoinjektor (1) ifølge et af kravene 3 til 7 eller 9, der er kendetegnet ved, at udløserknappen (13) er anbragt distalt, hvor hylsteret (12) er indrettet som en overfaldsmuffeudløser med en lukket distal endeflade (12.10), der dækker udløserknappen (13), hvor der i en indledende tilstand tilvejebringes et frirum (33) mellem den distale endeflade (12.10) af muffeudløseren (12) og udløserknappen (13) til muliggørelse af en vis vandring af muffeudløseren (12) mod påvirkningen af kontrolfjederen (19) i den proksimale retning (P) i en første fase, før den støder mod udløserknappen (13) .
11. Autoinjektor (1) ifølge et af ovennævnte krav, der er kendetegnet ved, at der er tilvejebragt en udløselig støj komponent (28), der ved udløsning er i stand til at frembringe et hørligt og/eller føleligt feedback til en bruger, hvor støj komponenten (28) er indrettet til at blive udløst, når stemplet (9) når en position i forhold til sprøjten (3), hvor proppen (4) er placeret i nærheden af en proksimal ende af sprøjten (3), og hvor den udløste støj komponent (28) påvirker en huskomponent (12, 13).
12. Autoinjektor (1) ifølge krav 11, der er kendetegnet ved, at huskomponenten i autoinjektoren (1) omfatter mindst en del af chassiset (2), hylsteret (12), udløserknappen (13), medbringeren (7) og/eller stemplet (9).
13. Autoinjektor (1) ifølge et af ovennævnte krav, der er kendetegnet ved, at der er tilvejebragt en visuel brugsindikator, der omfatter mindst ét indikatorvindue (32) i hylsteret (12), hvor en del af chassiset (2) er indrettet til at blive placeret bag indikatorvinduet (32), når hylsteret (12) er i dets distale position, der påvirkes af kontrolfjederen (19), hvor en tap (20.4) på den første krave (20) placeres udad fra delen af chassiset (2), efter at kraven (20) er blevet translateret i den proksimale retning (P) under kanyleindføring, hvor tappen (20.4) og delen af chassiset (2) fremviser et visuelt særskilt træk.
14. Autoinjektor (1) ifølge et af kravene 3 til 7, 9 eller 11 til 13, der er kendetegnet ved, at udløserknappen (13) indledningsvis er koblet til hylsteret (12) på en måde, så den rager frem distalt fra hylsteret (12) og er låst til chassiset (2) på en måde, der forhindrer, at udløserknappen (13) kobles fra hylsteret (12), og således forhindrer aktivering af udløserknappen (13) i en indledende position, hvor hylsteret (12) er indrettet til at translatere i den proksimale retning (P) mod påvirkningen i forhold til chassiset (2) , når chassiset (2) trykkes mod et injektionssted, hvorved udløserknappen (13) også translateres til frigørelse af låsningen til chassiset (2) , hvorved der åbnes mulighed for aktivering af udløserknappen (13), hvor udløserknappen (13) er indrettet til at låse i en mere proksimal position ved aktivering.
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IL227806A (en) 2017-04-30
US10384015B2 (en) 2019-08-20
HK1188161A1 (en) 2014-04-25
EP2675504A1 (en) 2013-12-25
TW201247272A (en) 2012-12-01
WO2012110583A1 (en) 2012-08-23
AR085264A1 (es) 2013-09-18
AU2012217087A1 (en) 2013-09-05
JP5881745B2 (ja) 2016-03-09
JP2014513565A (ja) 2014-06-05
US20130317428A1 (en) 2013-11-28
BR112013020848A2 (pt) 2016-10-18
EP2489388A1 (en) 2012-08-22
EP2675504B1 (en) 2015-06-24
TWI555545B (zh) 2016-11-01
CN103492001A (zh) 2014-01-01
AU2012217087B2 (en) 2016-02-25
US9636459B2 (en) 2017-05-02
US20170197036A1 (en) 2017-07-13
CN103492001B (zh) 2016-04-06
CA2826620A1 (en) 2012-08-23

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