DK267689A - Ikke-beta-oxiderbare fede syrer analoge med blodcholesterol- og -triglyceridsaenkende evne og praeparater indeholdende saadanne forbindelser - Google Patents

Ikke-beta-oxiderbare fede syrer analoge med blodcholesterol- og -triglyceridsaenkende evne og praeparater indeholdende saadanne forbindelser Download PDF

Info

Publication number: DK267689A
Authority: DK; Denmark
Prior art keywords: compounds; triglyceride; beta; preparations containing; blood cholesterol
Prior art date: 1988-06-02

Application number

DK267689A

Other languages

English (en)

Other versions

DK267689D0 (da

Inventor

Rolf K Berge

Jon Bremer

Original Assignee

Norsk Hydro As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-06-02

Filing date

1989-06-01

Publication date

1989-12-03

1989-06-01 Application filed by Norsk Hydro As filed Critical Norsk Hydro As

1989-06-01 Publication of DK267689D0 publication Critical patent/DK267689D0/da

1989-12-03 Publication of DK267689A publication Critical patent/DK267689A/da

Links

HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title abstract 6
239000008280 blood Substances 0.000 title abstract 3
210000004369 blood Anatomy 0.000 title abstract 3
150000001875 compounds Chemical class 0.000 title abstract 2
239000002253 acid Substances 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
241000124008 Mammalia Species 0.000 abstract 2
235000012000 cholesterol Nutrition 0.000 abstract 2
239000003814 drug Substances 0.000 abstract 2
230000000055 hyoplipidemic effect Effects 0.000 abstract 2
238000004519 manufacturing process Methods 0.000 abstract 2
150000003626 triacylglycerols Chemical class 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
229930195734 saturated hydrocarbon Natural products 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
229930195735 unsaturated hydrocarbon Natural products 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Emergency Medicine (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK267689A 1988-06-02 1989-06-01 Ikke-beta-oxiderbare fede syrer analoge med blodcholesterol- og -triglyceridsaenkende evne og praeparater indeholdende saadanne forbindelser DK267689A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB888813012A GB8813012D0 (en)	1988-06-02	1988-06-02	Non-b-oxidizable fatty acid analogues to reduce concentration of cholesterol & triglycerides in blood of mammals

Publications (2)

Publication Number	Publication Date
DK267689D0 DK267689D0 (da)	1989-06-01
DK267689A true DK267689A (da)	1989-12-03

Family

ID=10637920

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK267689A DK267689A (da)	1988-06-02	1989-06-01	Ikke-beta-oxiderbare fede syrer analoge med blodcholesterol- og -triglyceridsaenkende evne og praeparater indeholdende saadanne forbindelser

Country Status (8)

Country	Link
US (1)	US5093365A (da)
EP (1)	EP0345038B1 (da)
AT (1)	ATE96664T1 (da)
CA (1)	CA1329550C (da)
DE (1)	DE68910386T2 (da)
DK (1)	DK267689A (da)
ES (1)	ES2059749T3 (da)
GB (1)	GB8813012D0 (da)

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JPH10507179A (ja) *	1994-10-13	1998-07-14	ペプチドテクノロジーリミテッド	修飾ポリ不飽和脂肪酸
NO952796D0 (no) *	1995-07-14	1995-07-14	Rolf Berge	Fettsyre analoger med ikkeoksyderbart B-sete, fremstilling og anvendelse i krapeutiske preparater
WO1999058120A1 (en) *	1998-05-08	1999-11-18	Rolf Berge	USE OF NON-β-OXIDIZABLE FATTY ACID ANALOGUES FOR TREATMENT OF SYNDROME-X CONDITIONS
US20020074691A1 (en) *	1999-09-14	2002-06-20	Robert M Mortellite	High speed method of making plastic film and nonwoven laminates
AUPQ291499A0 (en) *	1999-09-17	1999-10-07	Women's And Children's Hospital Adelaide	Novel nitro and sulphur containing compounds
NO328803B1 (no)	2000-03-03	2010-05-18	Thia Medica	Nye fettsyreanaloger
US6982251B2 (en) *	2000-12-20	2006-01-03	Schering Corporation	Substituted 2-azetidinones useful as hypocholesterolemic agents
PL364178A1 (en) *	2001-01-26	2004-12-13	Schering Corporation	Combinations of sterol absorption inhibitor(s) with blood modifier(s) for treating vascular conditions
US7071181B2 (en) *	2001-01-26	2006-07-04	Schering Corporation	Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
AU2002241956A1 (en) *	2001-01-26	2002-08-06	Schering Corporation	Combinations of bile acid sequestrant(s) and sterol absorption inhibitor(s) and treatments for vascular indications
US20020183305A1 (en) *	2001-01-26	2002-12-05	Schering Corporation	Combinations of nicotinic acid and derivatives thereof and sterol absorption inhibitor(s) and treatments for vascular indications
EP1911462A3 (en)	2001-01-26	2011-11-30	Schering Corporation	Compositions comprising a sterol absorption inhibitor
US20060287254A1 (en) *	2001-01-26	2006-12-21	Schering Corporation	Use of substituted azetidinone compounds for the treatment of sitosterolemia
IL156585A0 (en) *	2001-01-26	2004-01-04	Schering Corp	Combinations of sterol absorption inhibitor(s) with cardiovascular agent(s) for the treatment of vascular conditions
HU230253B1 (hu) *	2001-01-26	2015-11-30	Merck Sharp & Dohme Corp	Peroxiszóma proliferátor-aktivált receptor (PPAR) aktivátor(ok) és szterin-abszorpció inhibitor(ok) kombinációi és alkalmazásuk vaszkuláris indikációk kezelésére
DK1355644T3 (da) *	2001-01-26	2006-10-23	Schering Corp	Anvendelse af substituerede azetidinonforbindelser til behandling af sitosterolæmi
JP2004532868A (ja) *	2001-05-25	2004-10-28	シェーリング　コーポレイション	アルツハイマー病の処置におけるアゼチジノン置換誘導体の使用
FR2828487B1 (fr) *	2001-08-09	2005-05-27	Genfit S A	Nouveaux composes derives d'acides gras, preparation et utilisations
US7056906B2 (en) *	2001-09-21	2006-06-06	Schering Corporation	Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
US20030119808A1 (en) *	2001-09-21	2003-06-26	Schering Corporation	Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects
JP2005504091A (ja) *	2001-09-21	2005-02-10	シェーリング　コーポレイション	ステロール吸収阻害剤としてアゼチジノンを用いる黄色腫の処置
US7053080B2 (en) *	2001-09-21	2006-05-30	Schering Corporation	Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
AU2002335770B2 (en) *	2001-09-21	2005-08-18	Merck Sharp & Dohme Corp.	Methods for treating or preventing vascular inflammation using sterol absorption inhibitor(s)
NZ537762A (en) *	2002-06-20	2007-02-23	Thia Medica As	Sulfur-containing phospholipid derivatives
US20040067267A1 (en) *	2002-10-08	2004-04-08	Murthy Pothapragada Suryanarayana	Process for preparation of cholesterol lowering compositions from garlic
WO2004043457A1 (en) *	2002-11-06	2004-05-27	Schering Corporation	Cholesterol absorptions inhibitors for the treatment of autoimmune disorders
CA2517571C (en)	2003-03-07	2011-07-05	Schering Corporation	Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
JP4589919B2 (ja) *	2003-03-07	2010-12-01	シェーリングコーポレイション	高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用
US7459442B2 (en) *	2003-03-07	2008-12-02	Schering Corporation	Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
JP2006519869A (ja)	2003-03-07	2006-08-31	シェーリング　コーポレイション	置換アゼチジノン化合物、置換アゼチジノン化合物を調製するためのプロセス、それらの処方物および使用
EP1680189A2 (en) *	2003-11-05	2006-07-19	Schering Corporation	Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions
US20090215895A1 (en) *	2004-01-30	2009-08-27	Peplin Biolipids Pty Ltd	Therapeutic and carrier molecules
JP2008506774A (ja) *	2004-07-19	2008-03-06	ティアメディカアクスイェセルスカプ	タンパク質材料と非酸化性脂肪酸体を含む組成物
WO2012027331A1 (en)	2010-08-27	2012-03-01	Ironwood Pharmaceuticals, Inc.	Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
AU2014229506B2 (en)	2013-03-11	2017-04-13	Nobesita As	Natural lipids containing non-oxidizable fatty acids
CA2904898C (en)	2013-03-11	2019-10-15	Jan Remmereit	Lipid compositions containing bioactive fatty acids

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2208533A1 (de) *	1972-02-23	1973-09-27	Kolmar Laboratories	Neue alkylthioaether
NL7405744A (en) *	1974-04-29	1975-10-31	Dow Chemical Co	Butylphenyl-thioalkane carboxylic acids - as hypocholesterolaemics and antilipaemics from corresp. thiophenols and haloalkane carboxylic acids
DE2515146A1 (de) *	1975-04-08	1976-10-21	Bayer Ag	Carbonsaeureamide, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2856683A1 (de) *	1978-12-29	1980-07-17	Nattermann A & Cie	Entzuendungshemmende und antiatherosklerotisch wirkende arzneimittel
CH661207A5 (en) *	1980-06-30	1987-07-15	Hoerrmann Wilhelm	Pharmaceutical composition containing long-chain aldehydes or carboxylic acids

1988
- 1988-06-02 GB GB888813012A patent/GB8813012D0/en active Pending
1989
- 1989-05-31 EP EP89305478A patent/EP0345038B1/en not_active Expired - Lifetime
- 1989-05-31 ES ES89305478T patent/ES2059749T3/es not_active Expired - Lifetime
- 1989-05-31 AT AT89305478T patent/ATE96664T1/de not_active IP Right Cessation
- 1989-05-31 DE DE68910386T patent/DE68910386T2/de not_active Expired - Lifetime
- 1989-06-01 DK DK267689A patent/DK267689A/da not_active Application Discontinuation
- 1989-06-01 CA CA000601425A patent/CA1329550C/en not_active Expired - Lifetime
- 1989-06-02 US US07/360,870 patent/US5093365A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE68910386D1 (de)	1993-12-09
US5093365A (en)	1992-03-03
EP0345038A2 (en)	1989-12-06
EP0345038B1 (en)	1993-11-03
ES2059749T3 (es)	1994-11-16
GB8813012D0 (en)	1988-07-06
CA1329550C (en)	1994-05-17
EP0345038A3 (en)	1991-06-12
DK267689D0 (da)	1989-06-01
ATE96664T1 (de)	1993-11-15
DE68910386T2 (de)	1994-06-09

Legal Events

Date	Code	Title	Description
1999-06-14	AHS	Application shelved for other reasons than non-payment

Publication	Publication Date	Title
DK267689D0 (da)	1989-06-01	Ikke-beta-oxiderbare fede syrer analoge med blodcholesterol- og -triglyceridsaenkende evne og praeparater indeholdende saadanne forbindelser
HUT43599A (en)	1987-11-30	Process for production of derivatives of thiazolidindion and medical compounds containing those
DK139287A (da)	1987-03-18	Tertiaere hydroxyalkylxanthiner, deres fremstilling og anvendelse som laegemidler
SE8703625D0 (sv)	1987-09-18	New medical use
DK0430045T3 (da)	1995-07-17	Ascorbinsyretocopherylphosphatdiestere til hæmning af Maillards reaktion
AU6567086A (en)	1987-05-28	Compositions and methods for the treatment of bleeding disorders
ZA899673B (en)	1991-07-31	Pyridinium polymers and their use as cholesterol lowering agents
GR3002618T3 (en)	1993-01-25	Solutions of oxazaphosphorins with enhanced stability and process for their preparation
DK337589A (da)	1990-01-09	3r,s- og 3r-formerne af 3-substuerede 1-(2-aryl -eller heteroarylethyl)piperidin-forbindelser og deres anvendelse til fremstilling af et laegemiddel til behandling af sygdommme forbundet med aendret motilitet og/eller tonus af glatmuskel samt farmaceutiske praeparater indeholdende disse forbindelser
AU2158688A (en)	1989-05-25	Use of bezafibrate for treating diabetes
DK562488A (da)	1989-04-09	Farmaceutisk praeparat indeholdende polyminderivater, samt nogle af disse polyaminderivater
ATE71092T1 (de)	1992-01-15	Hydroxybutenolid-derivate, ihre herstellung und ihre verwendung.
PH21450A (en)	1987-10-28	N-(6-methoxy-5(perfluoroalkyl)-1-naphthoyl)-n-methylglycines and their thionaphthoyl analogs
ZA842166B (en)	1984-10-31	Chromone-and thiochromone-substituted 1,4-dihydro-pyridinelactones,several processes for their preparation and their use in medicaments
DK248886A (da)	1986-11-30	Spiro-imidazolidin-forbindelser og farmaceutiske praeparater indeholdende disse
DE3665320D1 (en)	1989-10-05	Stabilization of peroxidase activity in solution
DK165981C (da)	1993-07-26	Isoxazolderivater, fremgangsmaade til deres fremstilling og laegemidler indeholdende disse forbindelser
DK302486A (da)	1986-12-28	11-substituerede 5,11-dihydro-6h-pyrido(2,3-b)(1,4)benzodiazepin-6-oner
ATE86498T1 (de)	1993-03-15	Verminderung des gehaltes an lipoproteine mit geringer dichte in biologischen fluessigkeiten.
IL89324A0 (en)	1989-09-10	Therapeutic agents for the treatment of peptic ulcer disease containing xanthine derivatives
KR910002456A (ko)	1991-02-25	당뇨병 치료용 제약 조성물
NO931752D0 (no)	1993-05-14	Oktahydronaftalenoksimderivater til inhibering av kolesterolbiosyntese, samt fremgangsmaate til fremstilling og anvendelse derav
AU584098B2 (en)	1989-05-18	Substituted azabicycloheptanes, the use thereof, pharmaceutical preparations that contain these compounds, and processes for the manufacture of these compounds
GB2152508A (en)	1985-08-07	Pyrimidine derivatives
FR2558161B1 (fr)	1987-01-23	3-alkoxy 2-(n-pyrrolidino) n-furylmethyl ou n-thienylmethyl n-pyridyl propylamines, leur preparation et leur application en therapeutique