DK268484A - Substituerede phenylalkyl-(piperazinyl eller homopiperazinyl)-alkylthioler og -thiocarbamater, salte deraf samt fremgangsmaade til deres fremstilling - Google Patents

Substituerede phenylalkyl-(piperazinyl eller homopiperazinyl)-alkylthioler og -thiocarbamater, salte deraf samt fremgangsmaade til deres fremstilling Download PDF

Info

Publication number: DK268484A
Authority: DK; Denmark
Prior art keywords: carbon atoms; hydrogen; alkyl; salts; alkoxy
Prior art date: 1983-05-31

Application number

DK268484A

Other languages

English (en)

Other versions

DK163921B (da

DK268484D0 (da

DK163921C (da

Inventor

Karl D Hargrave

John P Devlin

Edward L Barsumian

Original Assignee

Boehringer Ingelheim Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-05-31

Filing date

1984-05-30

Publication date

1984-12-01

1984-05-30 Application filed by Boehringer Ingelheim Ltd filed Critical Boehringer Ingelheim Ltd

1984-05-30 Publication of DK268484D0 publication Critical patent/DK268484D0/da

1984-12-01 Publication of DK268484A publication Critical patent/DK268484A/da

1992-04-21 Publication of DK163921B publication Critical patent/DK163921B/da

1992-09-21 Application granted granted Critical

1992-09-21 Publication of DK163921C publication Critical patent/DK163921C/da

Links

-1 PIPERAZINYL Chemical class 0.000 title abstract 3
150000003839 salts Chemical class 0.000 title abstract 3
150000001356 alkyl thiols Chemical class 0.000 title 1
238000000034 method Methods 0.000 title 1
150000003558 thiocarbamic acid derivatives Chemical class 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 12
229910052739 hydrogen Inorganic materials 0.000 abstract 6
239000001257 hydrogen Substances 0.000 abstract 6
125000000217 alkyl group Chemical group 0.000 abstract 5
125000003545 alkoxy group Chemical group 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000004093 cyano group Chemical group *C#N 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
125000004953 trihalomethyl group Chemical group 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
230000000172 allergic effect Effects 0.000 abstract 1
208000010668 atopic eczema Diseases 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000001900 immune effect Effects 0.000 abstract 1
230000002757 inflammatory effect Effects 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK268484A 1983-05-31 1984-05-30 Substituerede (piperazinyl eller homopiperazinyl)alkylthioler og -thiocarbamater og salte deraf, fremgangsmaade til deres fremstilling og immunologisk, antiallergisk eller antiinflammatorisk praeparat indeholdende dem DK163921C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US49918883A	1983-05-31	1983-05-31
US49918883		1983-05-31

Publications (4)

Publication Number	Publication Date
DK268484D0 DK268484D0 (da)	1984-05-30
DK268484A true DK268484A (da)	1984-12-01
DK163921B DK163921B (da)	1992-04-21
DK163921C DK163921C (da)	1992-09-21

Family

ID=23984207

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK268484A DK163921C (da)	1983-05-31	1984-05-30	Substituerede (piperazinyl eller homopiperazinyl)alkylthioler og -thiocarbamater og salte deraf, fremgangsmaade til deres fremstilling og immunologisk, antiallergisk eller antiinflammatorisk praeparat indeholdende dem

Country Status (24)

Country	Link
EP (1)	EP0127182B1 (da)
JP (1)	JPS59227868A (da)
KR (1)	KR900001188B1 (da)
AT (1)	ATE24502T1 (da)
AU (1)	AU566668B2 (da)
CA (1)	CA1215979A (da)
CS (1)	CS245792B2 (da)
DD (1)	DD224591A5 (da)
DE (1)	DE3461797D1 (da)
DK (1)	DK163921C (da)
ES (1)	ES532930A0 (da)
FI (1)	FI77238C (da)
GR (1)	GR82001B (da)
HU (1)	HU192405B (da)
IE (1)	IE57841B1 (da)
IL (1)	IL71970A (da)
NO (1)	NO169895C (da)
NZ (1)	NZ208334A (da)
PH (1)	PH21555A (da)
PL (1)	PL142332B1 (da)
PT (1)	PT78667B (da)
SU (1)	SU1355128A3 (da)
YU (1)	YU43569B (da)
ZA (1)	ZA844101B (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4692448A (en) *	1984-11-20	1987-09-08	Boehringer Ingelheim Pharmaceuticals, Inc.	Bis(arylpiperazinyl)sulfur compounds
CA2180190A1 (en) *	1995-07-10	1997-01-11	Kazumi Ogata	Benzylpiperazine derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1286198A (fr) *	1961-04-07	1962-03-02	Bayer Ag	Procédé de fabrication d'esters s-alkyliques, à substituants basiques, de l'acide phénylthiocarbamique
GB952142A (en) *	1961-05-26	1964-03-11	Miles Lab	Phenylpiperazinylalkyl carbamates

1984
- 1984-05-29 FI FI842141A patent/FI77238C/fi not_active IP Right Cessation
- 1984-05-29 GR GR74863A patent/GR82001B/el unknown
- 1984-05-30 NO NO842154A patent/NO169895C/no unknown
- 1984-05-30 PH PH30739A patent/PH21555A/en unknown
- 1984-05-30 DE DE8484106160T patent/DE3461797D1/de not_active Expired
- 1984-05-30 PL PL1984247953A patent/PL142332B1/pl unknown
- 1984-05-30 CS CS844059A patent/CS245792B2/cs unknown
- 1984-05-30 ES ES532930A patent/ES532930A0/es active Granted
- 1984-05-30 CA CA000455423A patent/CA1215979A/en not_active Expired
- 1984-05-30 DD DD84263572A patent/DD224591A5/de not_active IP Right Cessation
- 1984-05-30 YU YU925/84A patent/YU43569B/xx unknown
- 1984-05-30 IE IE1346/84A patent/IE57841B1/en not_active IP Right Cessation
- 1984-05-30 EP EP84106160A patent/EP0127182B1/en not_active Expired
- 1984-05-30 DK DK268484A patent/DK163921C/da not_active IP Right Cessation
- 1984-05-30 HU HU842102A patent/HU192405B/hu not_active IP Right Cessation
- 1984-05-30 AT AT84106160T patent/ATE24502T1/de not_active IP Right Cessation
- 1984-05-30 KR KR1019840003003A patent/KR900001188B1/ko not_active Expired
- 1984-05-30 IL IL71970A patent/IL71970A/xx unknown
- 1984-05-30 ZA ZA844101A patent/ZA844101B/xx unknown
- 1984-05-30 SU SU843745557A patent/SU1355128A3/ru active
- 1984-05-31 PT PT78667A patent/PT78667B/pt not_active IP Right Cessation
- 1984-05-31 AU AU28878/84A patent/AU566668B2/en not_active Ceased
- 1984-05-31 NZ NZ208334A patent/NZ208334A/en unknown
- 1984-05-31 JP JP59109807A patent/JPS59227868A/ja active Pending

Also Published As

Publication number	Publication date
PT78667A (en)	1984-06-01
GR82001B (da)	1984-12-12
ES8505981A1 (es)	1985-06-16
PL142332B1 (en)	1987-10-31
HUT34740A (en)	1985-04-28
KR900001188B1 (ko)	1990-02-27
CS245792B2 (en)	1986-10-16
IE841346L (en)	1984-11-30
EP0127182B1 (en)	1986-12-30
FI842141A7 (fi)	1984-12-01
IL71970A0 (en)	1984-09-30
AU566668B2 (en)	1987-10-29
ES532930A0 (es)	1985-06-16
ZA844101B (en)	1986-02-26
PH21555A (en)	1987-12-11
HU192405B (en)	1987-06-29
IL71970A (en)	1988-02-29
NO842154L (no)	1984-12-03
DK163921B (da)	1992-04-21
CS405984A2 (en)	1985-09-17
DD224591A5 (de)	1985-07-10
DK268484D0 (da)	1984-05-30
YU43569B (en)	1989-08-31
AU2887884A (en)	1984-12-20
DE3461797D1 (en)	1987-02-05
CA1215979A (en)	1986-12-30
FI842141A0 (fi)	1984-05-29
NO169895B (no)	1992-05-11
IE57841B1 (en)	1993-04-21
NO169895C (no)	1992-08-19
FI77238C (fi)	1989-02-10
NZ208334A (en)	1987-02-20
PT78667B (en)	1986-09-08
JPS59227868A (ja)	1984-12-21
FI77238B (fi)	1988-10-31
KR840009089A (ko)	1984-12-24
ATE24502T1 (de)	1987-01-15
DK163921C (da)	1992-09-21
PL247953A1 (en)	1985-03-26
YU92584A (da)	1986-06-30
SU1355128A3 (ru)	1987-11-23
EP0127182A1 (en)	1984-12-05

Legal Events

Date	Code	Title	Description
1996-01-22	PBP	Patent lapsed

Publication	Publication Date	Title
BR8403068A (pt)	1985-05-28	Compostos,processo para sua preparacao,composicoes farmaceuticas e uso dos ditos compostos
DK436081A (da)	1982-04-04	Substituerede acyl-derivater af 1,2,3,4-tetrahydroisoquinolin-3-carboxylsyrer og farmaceutisk acceptable salte deraf fremgangsmaade til deres fremstilling og deres anvendelse
ES2059069T3 (es)	1994-11-01	Nuevos derivados de 1-alcoxi-(2-acilamino-etil)-naftalenos y su procedimiento de preparacion.
ATE33133T1 (de)	1988-04-15	Alpha-alkyl-polyencarbonsaeuren, ihre derivate und ihre verwendung in der behandlung von psoriasis.
DK268484A (da)	1984-12-01	Substituerede phenylalkyl-(piperazinyl eller homopiperazinyl)-alkylthioler og -thiocarbamater, salte deraf samt fremgangsmaade til deres fremstilling
MX7122E (es)	1987-06-29	Procedimiento para la preparacion de derivados de tiometilpiridina
ES539160A0 (es)	1985-11-01	Un procedimiento para preparar derivados de penem
ES516554A0 (es)	1983-06-16	Procedimiento para preparar nuevos derivados de etenilimidazol.
ES320729A1 (es)	1966-05-16	Procedimiento para la sintesis de nuevos derivados de acido antranilico.
BR8401710A (pt)	1984-11-20	Processo para a preparacao de fenetilsulfonamidas n-sulfeniladas,composicoes praguicidas e processos para o combate as pragas e para a preparacao de composicoes
GB1037013A (en)	1966-07-20	Naphthylacetamide derivatives