DK2721152T3 - Dimere bindingsproteiner baseret på modificerede ubiquitiner - Google Patents
Dimere bindingsproteiner baseret på modificerede ubiquitiner Download PDFInfo
- Publication number
- DK2721152T3 DK2721152T3 DK12729509.5T DK12729509T DK2721152T3 DK 2721152 T3 DK2721152 T3 DK 2721152T3 DK 12729509 T DK12729509 T DK 12729509T DK 2721152 T3 DK2721152 T3 DK 2721152T3
- Authority
- DK
- Denmark
- Prior art keywords
- ubiquitines
- dimere
- modified
- binding proteins
- proteins based
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/95—Fusion polypeptide containing a motif/fusion for degradation (ubiquitin fusions, PEST sequence)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Mycology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Plant Pathology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Botany (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- General Physics & Mathematics (AREA)
- Bioinformatics & Computational Biology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11170054 | 2011-06-15 | ||
| PCT/EP2012/061455 WO2012172055A1 (en) | 2011-06-15 | 2012-06-15 | Dimeric binding proteins based on modified ubiquitins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2721152T3 true DK2721152T3 (da) | 2019-07-01 |
Family
ID=44680786
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12729509.5T DK2721152T3 (da) | 2011-06-15 | 2012-06-15 | Dimere bindingsproteiner baseret på modificerede ubiquitiner |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9492572B2 (da) |
| EP (1) | EP2721152B1 (da) |
| JP (1) | JP6146821B2 (da) |
| AU (1) | AU2012268970B2 (da) |
| CA (1) | CA2837804C (da) |
| DK (1) | DK2721152T3 (da) |
| IL (1) | IL229722A (da) |
| WO (1) | WO2012172055A1 (da) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4088742B2 (ja) | 2000-12-26 | 2008-05-21 | 信越化学工業株式会社 | フォトマスクブランクス、フォトマスク及びフォトマスクブランクスの製造方法 |
| JP2002244274A (ja) | 2001-02-13 | 2002-08-30 | Shin Etsu Chem Co Ltd | フォトマスクブランク、フォトマスク及びこれらの製造方法 |
| EP1859028B1 (en) * | 2005-02-10 | 2015-12-02 | Regents Of The University Of Minnesota | Vascular endothelial cells |
| DK3253795T3 (da) | 2015-02-06 | 2019-07-29 | Navigo Proteins Gmbh | Hidtil ukendte bindende proteiner, der omfatter et ubiquitin-mutein, og antistoffer eller antistoffragmenter |
| EP3253785B1 (en) | 2015-02-06 | 2019-04-10 | Navigo Proteins Gmbh | Novel egfr binding proteins |
| CN107922483B (zh) | 2015-07-16 | 2021-07-30 | 纳维格蛋白质有限公司 | 新型免疫球蛋白结合蛋白及其在亲和纯化中的用途 |
| WO2017013136A1 (en) | 2015-07-20 | 2017-01-26 | Scil Proteins Gmbh | Novel binding proteins based on di-ubiquitin muteins and methods for generation |
| AU2017260274A1 (en) | 2016-05-04 | 2018-11-01 | Navigo Proteins Gmbh | Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker |
| CA3030208A1 (en) | 2016-08-11 | 2018-02-15 | Navigo Proteins Gmbh | Novel alkaline stable immunoglobulin binding proteins |
| US11414466B2 (en) | 2017-11-07 | 2022-08-16 | Navigo Proteins Gmbh | Fusion proteins with specificity for ED-B and long serum half-life for diagnosis or treatment of cancer |
| CA3123986A1 (en) | 2018-12-18 | 2020-06-25 | Navigo Proteins Gmbh | Novel folr1 specific binding proteins for cancer diagnosis and treatment |
| US20230416345A1 (en) * | 2020-11-09 | 2023-12-28 | Navigo Proteins Gmbh | New type ii collagen binding proteins |
| EP4608853A1 (en) * | 2022-10-24 | 2025-09-03 | Navigo Proteins Gmbh | Novel proteins with high binding affinity to programmed death ligand 1 (pd-l1) |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4873192A (en) | 1987-02-17 | 1989-10-10 | The United States Of America As Represented By The Department Of Health And Human Services | Process for site specific mutagenesis without phenotypic selection |
| SE9103701D0 (sv) | 1991-12-13 | 1991-12-13 | Kabi Pharmacia Ab | Apolipoprotein |
| WO1997012992A2 (en) | 1995-10-02 | 1997-04-10 | Royal Netherlands Academy Of Arts And Sciences | Diagnosis method for a disease caused by a frameshift mutation in a gene and reagents therefore |
| CA2235223A1 (en) | 1995-10-30 | 1997-05-09 | Massachusetts Institute Of Technology | Rationally designed polysaccharide lyases derived from heparinase i |
| US5789166A (en) | 1995-12-08 | 1998-08-04 | Stratagene | Circular site-directed mutagenesis |
| GB9610967D0 (en) | 1996-05-24 | 1996-07-31 | Cambridge Antibody Tech | Specific binding members,materials and methods |
| FR2761689B1 (fr) | 1997-04-02 | 1999-06-25 | Transgene Sa | Fibre adenovirale modifiee et adenovirus cibles |
| ATE250668T1 (de) | 1997-05-28 | 2003-10-15 | Discerna Ltd | Ribosom-komplexe als selektionspartikel für die in vitro anzeige und evolution von proteinen |
| JP3614866B2 (ja) | 1997-06-12 | 2005-01-26 | リサーチ コーポレイション テクノロジーズ，インコーポレイティド | 人工抗体ポリペプチド |
| DE19742706B4 (de) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
| US20030045681A1 (en) | 1998-05-11 | 2003-03-06 | Anthony J. Zelano | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
| TWI259837B (en) | 1998-05-11 | 2006-08-11 | Eidgenossische Tech Hochscule | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
| DE19932688B4 (de) | 1999-07-13 | 2009-10-08 | Scil Proteins Gmbh | Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen |
| PT1257297E (pt) | 2000-02-24 | 2006-12-29 | Philogen Spa | Composições e método para tratamento da angiogénese em lesões patológicas |
| AU4243201A (en) | 2000-02-24 | 2001-09-03 | Eidgenoess Tech Hochschule | Antibody specific for the ed-b domain of fibronectin, conjugates comprising saidantibody, and their use for the detection and treatment of angiogenesis |
| US6799121B2 (en) | 2000-03-30 | 2004-09-28 | York University | Sequencing of peptides by mass spectrometry |
| US20110179531A1 (en) | 2000-05-09 | 2011-07-21 | Kovalic David K | Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement |
| US20030073623A1 (en) | 2001-07-30 | 2003-04-17 | Drmanac Radoje T. | Novel nucleic acid sequences obtained from various cDNA libraries |
| US20040043386A1 (en) | 2002-08-30 | 2004-03-04 | Todd Pray | Methods and compositions for functional ubiquitin assays |
| DE10324447A1 (de) | 2003-05-28 | 2004-12-30 | Scil Proteins Gmbh | Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin |
| AU2003250972A1 (en) | 2003-07-14 | 2005-01-28 | Mattex Leisure Industries | Artificial turf filament and artificial turf system |
| CA2544764A1 (en) | 2003-11-04 | 2005-05-19 | Yale University | Protein binding miniature proteins |
| US7393918B2 (en) | 2003-12-11 | 2008-07-01 | Yale University | Protein binding miniature proteins and uses thereof |
| DE10360483B4 (de) | 2003-12-22 | 2007-11-15 | Scil Proteins Gmbh | Expressionsvektor und dessen Verwendung |
| DE102004049479A1 (de) | 2004-10-11 | 2006-04-13 | Scil Proteins Gmbh | Proteinkonjugate zur Verwendung in Therapie, Diagnose und Chromatographie |
| KR101281208B1 (ko) | 2005-05-11 | 2013-07-26 | 필로겐 에스.피.에이. | 피브로넥틴 ｅｄ-ｂ에 대한 항체 ｌ１９ 및 인터루킨１２의 융합 단백질 |
| EP1945767B1 (de) | 2005-11-09 | 2010-04-07 | MorphoSys AG | Identifizierung und charakterisierung von funktionsblockierenden anti-ed-b-fibronektin antikörpern |
| EP1842553A1 (en) | 2006-04-07 | 2007-10-10 | Bayer Schering Pharma Aktiengesellschaft | Combination of an anti-EDb fibronectin domain antibody/IL2 fusion protein and a further small molecule |
| KR20090008467A (ko) | 2006-05-08 | 2009-01-21 | 필로겐 에스.피.에이. | 치료용의 항체표적 사이토카인 |
| EP1892248A1 (en) | 2006-08-21 | 2008-02-27 | Eidgenössische Technische Hochschule Zürich | Specific and high affinity binding proteins comprising modified SH3 domains of FYN kinase |
| EP1925664A1 (en) | 2006-11-15 | 2008-05-28 | Scil proteins GmbH | Artificial binding proteins based on a modified alpha helical region of ubiquitin |
| EP1955712A1 (en) | 2007-02-09 | 2008-08-13 | Scil proteins GmbH | Multimeric conjugate |
| KR101436222B1 (ko) * | 2009-12-14 | 2014-09-01 | 쉴 프로테인즈 게엠베하 | 리간드 결합능력을 가진 헤테로-다량체 변형 유비퀴틴 단백질을 확인하는 방법 |
| WO2012171541A1 (en) | 2011-06-15 | 2012-12-20 | Scil Proteins Gmbh | Human fusion proteins comprising interferons and hetero-dimeric modified ubiquitin proteins |
| WO2013186329A1 (en) | 2012-06-13 | 2013-12-19 | Scil Proteins Gmbh | Human fusion proteins comprising single chain tnfalpha and targeting domains |
-
2012
- 2012-06-15 EP EP12729509.5A patent/EP2721152B1/en active Active
- 2012-06-15 AU AU2012268970A patent/AU2012268970B2/en not_active Ceased
- 2012-06-15 JP JP2014515207A patent/JP6146821B2/ja active Active
- 2012-06-15 CA CA2837804A patent/CA2837804C/en active Active
- 2012-06-15 US US14/126,358 patent/US9492572B2/en active Active
- 2012-06-15 DK DK12729509.5T patent/DK2721152T3/da active
- 2012-06-15 WO PCT/EP2012/061455 patent/WO2012172055A1/en not_active Ceased
-
2013
- 2013-11-28 IL IL229722A patent/IL229722A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CA2837804A1 (en) | 2012-12-20 |
| WO2012172055A1 (en) | 2012-12-20 |
| US20140127129A1 (en) | 2014-05-08 |
| JP6146821B2 (ja) | 2017-06-14 |
| EP2721152B1 (en) | 2019-03-27 |
| AU2012268970B2 (en) | 2016-01-28 |
| EP2721152A1 (en) | 2014-04-23 |
| IL229722A (en) | 2017-03-30 |
| IL229722A0 (en) | 2014-01-30 |
| CA2837804C (en) | 2018-03-20 |
| JP2014526881A (ja) | 2014-10-09 |
| US9492572B2 (en) | 2016-11-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUS2300021I1 (hu) | Anti-IL-36R antitestek | |
| IL288203A (en) | Meditopes and meditope-binding antibodies and uses thereof | |
| LTC2521568I2 (lt) | Plazmos kalikreiną surišantys baltymai | |
| DK2723771T3 (da) | Serumalbuminbindende proteiner | |
| DK2850103T3 (da) | ST2-antigenbindende proteiner | |
| IL310186B2 (en) | Plasma kallikrein binding proteins | |
| PL3415531T3 (pl) | Białka wiążące antygen | |
| HUE033063T2 (hu) | IL-1 kötõ fehérjék | |
| HRP20150241T1 (xx) | Antikancerogeni fuzijski protein | |
| DK2970464T3 (da) | Anti-lag-3-bindende proteiner | |
| DK2606061T3 (da) | Bindingsproteiner til hepcidin | |
| CO6811812A2 (es) | Anticuerpo anti-b7-h3 | |
| CO7020862A2 (es) | Proteinas de unión al antígeno cd27l | |
| EP2723379A4 (en) | ANTI-ALPHA-SYNUCLEIN BINDING MOLECULES | |
| BR112014004902A2 (pt) | peptídeos | |
| HUE041958T2 (hu) | 4-IBB-t kötõ molekulák | |
| BR112013030352A2 (pt) | proteínas de ligação do receptor fc | |
| CO6900146A2 (es) | Imidazopiridazinas sustituidas con amino | |
| CR20140127A (es) | Anticuerpo anti-abtcr | |
| DK3431492T3 (da) | Humane cd30-ligandantigen-bindende proteiner | |
| ZA201404481B (en) | Il-1 binding proteins | |
| CO6791565A2 (es) | Anticuerpos anti-notch1 | |
| ME02224B (me) | Antikancerski fuzioni protein | |
| EP2733327A4 (en) | TURBO | |
| FI20116212L (fi) | Polypeptidi |