DK2734547T3 - Anvendelse af c-fms-antistoffer - Google Patents

Anvendelse af c-fms-antistoffer Download PDF

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Publication number
DK2734547T3
DK2734547T3 DK12735555.0T DK12735555T DK2734547T3 DK 2734547 T3 DK2734547 T3 DK 2734547T3 DK 12735555 T DK12735555 T DK 12735555T DK 2734547 T3 DK2734547 T3 DK 2734547T3
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DK
Denmark
Prior art keywords
pain
leu
ser
fms
pro
Prior art date
Application number
DK12735555.0T
Other languages
English (en)
Inventor
Stefan Steidl
John Allan Hamilton
Andrew David Cook
Original Assignee
Univ Melbourne
Morphosys Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Melbourne, Morphosys Ag filed Critical Univ Melbourne
Application granted granted Critical
Publication of DK2734547T3 publication Critical patent/DK2734547T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/243—Colony Stimulating Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/249—Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (7)

1. Antagonist af c-Fms til anvendelse i behandling af osteoarthritis eller smerte, hvor antagonisten er et antistof, der er specifikt for M-CSF, c-FMS eller IL-34.
2. Antagonist ifølge krav 1 til anvendelse ifølge krav 1, hvor smerten er postoperativ smerte.
3. Antagonist ifølge krav 1 til anvendelse ifølge krav 1, hvor smerten skyldes knoglecancer.
4. Antagonist ifølge krav 1 til anvendelse ifølge krav 1, hvor smerten skyldes rheumatoid arthritis.
5. Antagonist ifølge krav 1 til anvendelse ifølge krav 1, hvor smerten skyldes osteoarthritis.
6. Antagonist ifølge krav 1 til anvendelse ifølge krav 1, hvor smerten skyldes inflammation.
7. Antagonist ifølge et hvilket som helst af de foregående krav til anvendelse ifølge krav 1, hvor antagonisten anvendes til et menneske.
DK12735555.0T 2011-07-18 2012-07-17 Anvendelse af c-fms-antistoffer DK2734547T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161508717P 2011-07-18 2011-07-18
EP11174305 2011-07-18
PCT/EP2012/063998 WO2013011021A1 (en) 2011-07-18 2012-07-17 Use of c-fms antagonists

Publications (1)

Publication Number Publication Date
DK2734547T3 true DK2734547T3 (da) 2017-04-03

Family

ID=47557687

Family Applications (1)

Application Number Title Priority Date Filing Date
DK12735555.0T DK2734547T3 (da) 2011-07-18 2012-07-17 Anvendelse af c-fms-antistoffer

Country Status (8)

Country Link
US (3) US9243066B2 (da)
EP (1) EP2734547B1 (da)
JP (2) JP2014520873A (da)
AU (1) AU2012285875B2 (da)
CA (1) CA2841013C (da)
DK (1) DK2734547T3 (da)
ES (1) ES2618828T3 (da)
WO (1) WO2013011021A1 (da)

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ES2722300T3 (es) 2009-12-10 2019-08-09 Hoffmann La Roche Anticuerpos que se unen preferentemente al dominio extracelular 4 de CSF1R y su uso
RU2658603C2 (ru) 2011-12-15 2018-06-21 Ф.Хоффманн-Ля Рош Аг Антитела против человеческого csf-1r и их применения
AR095882A1 (es) 2013-04-22 2015-11-18 Hoffmann La Roche Terapia de combinación de anticuerpos contra csf-1r humano con un agonista de tlr9
WO2014189832A1 (en) * 2013-05-22 2014-11-27 Albert Einstein College Of Medicine Of Yeshiva University Il-34 receptor assays and uses thereof
AR097584A1 (es) 2013-09-12 2016-03-23 Hoffmann La Roche Terapia de combinación de anticuerpos contra el csf-1r humano y anticuerpos contra el pd-l1 humano
US10155025B2 (en) 2014-07-17 2018-12-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for inhibiting or reducing transplant rejection by adminstration of interleukin-34
JP6723230B2 (ja) * 2014-10-09 2020-07-15 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 神経障害性疼痛を治療するためのｃｓｆ１−ｄａｐ１２経路のメンバー遺伝子の標的破壊
JP6621252B2 (ja) * 2015-06-17 2019-12-18 国立大学法人北海道大学 治療耐性がんに対する治療耐性低減剤
PT3380615T (pt) * 2015-11-25 2021-04-01 Nogra Pharma Ltd Oligonucleótidos antissentido il-34 e métodos de utilização dos mesmos
CN109790220A (zh) 2016-08-25 2019-05-21 豪夫迈·罗氏有限公司 与巨噬细胞激活剂组合的抗csf-1r抗体的间歇给药
CN110072553B (zh) 2016-12-22 2023-09-15 豪夫迈·罗氏有限公司 在抗pd-l1/pd1治疗失败之后抗csf-1r抗体与抗pd-l1抗体组合对肿瘤的治疗
AU2022276078A1 (en) 2021-05-17 2024-01-04 Nogra Pharma Limited Il-34 antisense agents and methods of using same

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Also Published As

Publication number Publication date
US9243066B2 (en) 2016-01-26
WO2013011021A1 (en) 2013-01-24
CA2841013A1 (en) 2013-01-24
JP2014520873A (ja) 2014-08-25
US20180237531A1 (en) 2018-08-23
ES2618828T3 (es) 2017-06-22
US10005840B2 (en) 2018-06-26
CA2841013C (en) 2020-04-21
US20160185867A1 (en) 2016-06-30
US20140205608A1 (en) 2014-07-24
AU2012285875A1 (en) 2014-01-16
JP6313481B2 (ja) 2018-04-18
AU2012285875A8 (en) 2016-11-03
EP2734547B1 (en) 2016-12-21
EP2734547A1 (en) 2014-05-28
JP2017095484A (ja) 2017-06-01
AU2012285875B2 (en) 2016-11-10

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