ES2091816T3 - Anticuerpos monoclonales del factor estimulador de colonias de macrofagos (m-csf) que reconocen un epitope conformacional neutralizante. - Google Patents

Anticuerpos monoclonales del factor estimulador de colonias de macrofagos (m-csf) que reconocen un epitope conformacional neutralizante.

Info

Publication number
ES2091816T3
ES2091816T3 ES90902943T ES90902943T ES2091816T3 ES 2091816 T3 ES2091816 T3 ES 2091816T3 ES 90902943 T ES90902943 T ES 90902943T ES 90902943 T ES90902943 T ES 90902943T ES 2091816 T3 ES2091816 T3 ES 2091816T3
Authority
ES
Spain
Prior art keywords
monoclonal antibodies
csf
conformational epitope
macrophagus
recognizing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90902943T
Other languages
English (en)
Inventor
Robert F Halenbeck
Kirston E Koths
Joseph W Wrin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cetus Oncology Corp
Original Assignee
Cetus Oncology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cetus Oncology Corp filed Critical Cetus Oncology Corp
Application granted granted Critical
Publication of ES2091816T3 publication Critical patent/ES2091816T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/243—Colony Stimulating Factors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

SE DESCRIBEN ANTICUERPOS MONOCLONALES, Y SUS METODOS DE UTILIZACION, QUE SE UNEN A UN EPITOPE CONFORMACIONAL APARENTE ASOCIADO CON M-CSF DIMERICO RECOMBINANTE O INNATO CON NEUTRALIZACION CONCOMITANTE DE ACTIVIDAD BIOLOGICA, ESTOS ANTICUERPOS MONOCLONALES SON SUSTANCIALMENTE NO REACTIVOS CON FORMAS INACTIVAS DE M-CSF INCLUYENDO M-CSF DIMERICO DERIVATIZADO QUIMICAMENTE Y MONOMERICO.
ES90902943T 1989-02-10 1990-01-17 Anticuerpos monoclonales del factor estimulador de colonias de macrofagos (m-csf) que reconocen un epitope conformacional neutralizante. Expired - Lifetime ES2091816T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31004289A 1989-02-10 1989-02-10

Publications (1)

Publication Number Publication Date
ES2091816T3 true ES2091816T3 (es) 1996-11-16

Family

ID=23200753

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90902943T Expired - Lifetime ES2091816T3 (es) 1989-02-10 1990-01-17 Anticuerpos monoclonales del factor estimulador de colonias de macrofagos (m-csf) que reconocen un epitope conformacional neutralizante.

Country Status (9)

Country Link
US (1) US5491065A (es)
EP (1) EP0457804B1 (es)
JP (1) JP3001969B2 (es)
AT (1) ATE141290T1 (es)
CA (1) CA2008817C (es)
DE (1) DE69028095T2 (es)
DK (1) DK0457804T3 (es)
ES (1) ES2091816T3 (es)
WO (1) WO1990009400A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6096540A (en) * 1996-09-30 2000-08-01 Becton Dickinson And Company Differentiation of granulocytic and monocytic progenitor cells
US6363129B1 (en) 1998-11-09 2002-03-26 Broadcom Corporation Timing recovery system for a multi-pair gigabit transceiver
WO2001034177A2 (en) * 1999-11-08 2001-05-17 The Government Of The United States Of America, A S Represented By The Secretary, Department Of Hea Lth & Human Services, The National Institutes Of Health Method of treating a viral infection using antagonists of macrophage colony stimulating factor
US7108852B2 (en) 2000-03-20 2006-09-19 Warner-Lambert Company Llc Methods of treating inflammation using antibodies to M-CSF
US20110091451A1 (en) * 2002-11-15 2011-04-21 Kavanaugh William M Methods for preventing and treating cancer metastasis and bone loss associated with cancer metastasis
CN1787837A (zh) * 2002-11-15 2006-06-14 希龙公司 防止和治疗癌转移以及与癌转移相关的骨质损失的方法
AR045563A1 (es) 2003-09-10 2005-11-02 Warner Lambert Co Anticuerpos dirigidos a m-csf
AU2005205533B2 (en) 2004-01-07 2012-03-22 Novartis Vaccines And Diagnostics, Inc. M-CSF-specific monoclonal antibody and uses thereof
AU2005255019B2 (en) * 2004-06-12 2011-05-19 Oregon Health And Science University Compositions and methods for diagnosis and treatment of orthopoxviruses
AR054428A1 (es) * 2005-03-08 2007-06-27 Pharmacia & Upjohn Co Llc Composiciones de anticuerpos anti factor estimulante de colonia de macrofagos (anti-m-csf) que tienen menores niveles de endotoxina
WO2007016285A2 (en) * 2005-07-28 2007-02-08 Novartis Ag M-csf specific monoclonal antibody and uses thereof
WO2007016240A2 (en) * 2005-07-28 2007-02-08 Novartis Ag Use of antibody to m-csf
EP1984024A2 (en) 2006-01-05 2008-10-29 Novartis AG Methods for preventing and treating cancer metastasis and bone loss associated with cancer metastasis
CA2841013C (en) 2011-07-18 2020-04-21 Morphosys Ag Use of c-fms antagonists
KR20150140752A (ko) 2013-04-12 2015-12-16 모르포시스 아게 M-csf를 표적으로 하는 항체

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4504586A (en) * 1983-02-03 1985-03-12 Amgen Hybridoma tumor cell lines and their monoclonal antibodies to human colony stimulating factor subclass number 1
AU588819B2 (en) * 1984-10-29 1989-09-28 Immunex Corporation Cloning of human granulocyte-macrophage colony stimulating factor gene
HU212277B (en) * 1986-05-06 1996-04-29 Genetics Inst Process for producing m-csf
GB8624899D0 (en) * 1986-10-17 1986-11-19 Sandoz Ltd Monoclonal antibodies
US4929700A (en) * 1987-04-16 1990-05-29 Cetus Corporation Production of purified, biologically active, bacterially produced recombinant human CSF-1

Also Published As

Publication number Publication date
DK0457804T3 (da) 1996-09-23
EP0457804B1 (en) 1996-08-14
CA2008817A1 (en) 1990-08-10
ATE141290T1 (de) 1996-08-15
JP3001969B2 (ja) 2000-01-24
WO1990009400A1 (en) 1990-08-23
DE69028095D1 (de) 1996-09-19
CA2008817C (en) 2000-03-14
DE69028095T2 (de) 1997-02-06
JPH04503155A (ja) 1992-06-11
US5491065A (en) 1996-02-13
EP0457804A1 (en) 1991-11-27

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