DK276289A - 9-r-azacykliske erythromycinantibiotika - Google Patents

9-r-azacykliske erythromycinantibiotika Download PDF

Info

Publication number: DK276289A
Authority: DK; Denmark
Prior art keywords: azacyclic; erythromycinantibiotics; derivatives; erythromycin; salts
Prior art date: 1988-06-07

Application number

DK276289A

Other languages

English (en)

Other versions

DK172754B1 (da

DK276289D0 (da

Inventor

Richard J Pariza

Paul A Lartey

Clarence J Maring

Larry L Klein

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-06-07

Filing date

1989-06-06

Publication date

1989-12-08

1989-06-06 Application filed by Abbott Lab filed Critical Abbott Lab

1989-06-06 Publication of DK276289D0 publication Critical patent/DK276289D0/da

1989-12-08 Publication of DK276289A publication Critical patent/DK276289A/da

1999-06-28 Application granted granted Critical

1999-06-28 Publication of DK172754B1 publication Critical patent/DK172754B1/da

Links

ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
230000000845 anti-microbial effect Effects 0.000 abstract 1
229940088710 antibiotic agent Drugs 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
239000003120 macrolide antibiotic agent Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/08—Ethers or acetals acyclic, e.g. paraformaldehyde
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Pharmacology & Pharmacy (AREA)
Biochemistry (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Cephalosporin Compounds (AREA)

DK198902762A 1988-06-07 1989-06-06 9-R-azacykliske erythromycinantibiotika og farmaceutisk middel indeholdende disse antibiotika DK172754B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US20340088		1988-06-07
US07/203,400 US5075289A (en)	1988-06-07	1988-06-07	9-r-azacyclic erythromycin antibiotics

Publications (3)

Publication Number	Publication Date
DK276289D0 DK276289D0 (da)	1989-06-06
DK276289A true DK276289A (da)	1989-12-08
DK172754B1 DK172754B1 (da)	1999-06-28

Family

ID=22753840

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198902762A DK172754B1 (da)	1988-06-07	1989-06-06	9-R-azacykliske erythromycinantibiotika og farmaceutisk middel indeholdende disse antibiotika

Country Status (13)

Country	Link
US (1)	US5075289A (da)
EP (1)	EP0345627B1 (da)
JP (1)	JP2922922B2 (da)
KR (1)	KR0132671B1 (da)
AT (1)	ATE151772T1 (da)
AU (1)	AU609307B2 (da)
CA (1)	CA1328258C (da)
DE (1)	DE68927967T2 (da)
DK (1)	DK172754B1 (da)
ES (1)	ES2103257T3 (da)
GR (1)	GR3023617T3 (da)
IL (1)	IL90434A0 (da)
NZ (1)	NZ229328A (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5217960A (en) *	1991-05-03	1993-06-08	Abbott Laboratories	Erythromycin derivatives
EP0549040A1 (en) *	1991-12-20	1993-06-30	Merck & Co. Inc.	Methods of making 4" derivatives of 9-deoxo-8a-aza-8a-alkyl-8a-homoerythromycin A
US5527780A (en) *	1992-11-05	1996-06-18	Roussel Uclaf	Erythromycin derivatives
AU704596B2 (en) *	1995-06-29	1999-04-29	Texas Biotechnology Corporation	Di- and trivalent small molecule selectin inhibitors
HRP960497B1 (en) *	1996-10-28	2003-08-31	Pliva Pharm & Chem Works	9-n-ethenyl derivatives of 9(s)-erythromycylamine
US6436906B1 (en)	2001-04-02	2002-08-20	Enanta Pharmaceuticals, Inc.	9-amino-14-membered macrolides derived from leucomycins
UA85937C2 (uk)	2004-12-21	2009-03-10	Пфайзер Продактс Інк.	Макроліди

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
YU31319B (en) *	1967-08-03	1973-04-30	Pliva Pharm & Chem Works	Postupak za dobijanje acil derivata eritromicin oksima
US3652537A (en) *	1969-11-21	1972-03-28	Lilly Co Eli	Epierythromycylamine and epierythromycyl b amine
GB1341022A (en) *	1970-04-13	1973-12-19	Lilly Industries Ltd	Erythromycylamine compounds
US3681322A (en) *	1970-04-13	1972-08-01	Lilly Co Eli	Adducts of aliphatic and araliphatic aldehydes and erythromycylamine or erythromycyl b amine
ZA71763B (en) *	1970-04-13	1972-03-29	Lilly Industries Ltd	Erythromycylamines via hydrazones
US3660376A (en) *	1970-09-30	1972-05-02	Lilly Co Eli	N-arylidene erythromycylamines
GB1345524A (en) *	1970-09-30	1974-01-30	Lilly Industries Ltd	N-heteroarylidene erythomycylamines
GB1344629A (en) *	1970-09-30	1974-01-23	Lilly Industries Ltd	Erythromycin azine derivatives
US3983103A (en) *	1973-01-19	1976-09-28	Pliva Pharmaceutical And Chemical Works	N-(Benzenesulfonyl)-erythromycylamine derivatives
US3923784A (en) *	1973-09-10	1975-12-02	Hoffmann La Roche	Erythromycin a derivatives
YU35363B (en) *	1974-01-14	1980-12-31	Pliva Zagreb	Process for obtaining n-(benzene-sulfonyl)-5-0desosaminyl-erythromycilamine derivatives
US4070376A (en) *	1974-02-04	1978-01-24	Hoffmann-La Roche, Inc.	Antibiotic 1745A/X and methods for the production thereof
US3928387A (en) *	1974-02-04	1975-12-23	Hoffmann La Roche	Antibiotic 1745A/X and methods for the production thereof
US3992264A (en) *	1974-02-04	1976-11-16	Hoffmann-La Roche Inc.	Antibiotic 1745A/X and methods for the production thereof
AT342770B (de) *	1975-04-07	1978-04-25	Thomae Gmbh Dr K	Verfahren zur herstellung neuer erythromycinderivate
DK139522C (da) *	1975-04-07	1979-08-20	Thomae Gmbh Dr K	Analogifremgangsmaade til fremstilling af 9-iminoalkylamino-erythromyciner eller syreadditionssalte deraf
DE2750288A1 (de) *	1977-11-10	1979-05-17	Thomae Gmbh Dr K	Neue 9-(omega-heteroarylamino- alkylamino)-erythromycine, ihre salze, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4180654A (en) *	1978-01-03	1979-12-25	Pfizer Inc.	4"-Deoxy-4"-acylamido derivatives of oleandomycin, erythromycin and erythromycin carbonate
SI7910768A8 (en) *	1979-04-02	1996-06-30	Pliva Pharm & Chem Works	Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
FR2473525A1 (fr) *	1980-01-11	1981-07-17	Roussel Uclaf	Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments
US4283527A (en) *	1980-04-01	1981-08-11	Pfizer Inc.	Erythromycylamine 11,12-carbonate and derivatives thereof
FR2534588B2 (fr) *	1982-10-15	1985-09-20	Roussel Uclaf	Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments
PH19293A (en) *	1982-11-15	1986-03-04	Pfizer	Epimeric azahomoerythromycin,pharmaceutical composition containing the same and method of use thereof
US4492688A (en) *	1983-11-25	1985-01-08	Pfizer Inc.	Antibacterial cyclic ethers of 9-deoxo-9a-aza-9a-homoerythromycin A and intermediates therefor
US4465674A (en) *	1983-09-06	1984-08-14	Pfizer Inc.	Azahomoerythromycin D derivative and intermediates therefor
DE3475073D1 (en) *	1983-09-06	1988-12-15	Pfizer	Azahomoerythromycin b derivatives and intermediates thereof
US4518590A (en) *	1984-04-13	1985-05-21	Pfizer Inc.	9α-Aza-9α-homoerythromycin compounds, pharmaceutical compositions and therapeutic method
US4512982A (en) *	1984-04-13	1985-04-23	Pfizer Inc.	9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
GB8421429D0 (en) *	1984-08-23	1984-09-26	Beecham Group Plc	Chemical compounds
JPS61103890A (ja) *	1984-10-26	1986-05-22	Taisho Pharmaceut Co Ltd	６−０−メチルエリスロマイシンａ誘導体
GB8506380D0 (en) *	1985-03-12	1985-04-11	Beecham Group Plc	Chemical compounds
EP0201166B1 (en) *	1985-03-12	1990-02-07	Beecham Group Plc	Erythromycin derivatives
US4670549A (en) *	1985-03-18	1987-06-02	Taisho Pharmaceutical Co., Ltd.	Method for selective methylation of erythromycin a derivatives
JPS61229895A (ja) *	1985-04-03	1986-10-14	Nippon Zeon Co Ltd	保護化デス−ｎ−メチルエリスロマイシン誘導体
GB8521402D0 (en) *	1985-08-28	1985-10-02	Beecham Group Plc	Chemical compounds
ZA87591B (en) *	1986-02-03	1988-09-28	Lilly Co Eli	Novel derivatives of eryhromycylamine
DE3782994T2 (de) *	1986-09-18	1993-04-08	Taisho Pharma Co Ltd	Erythromycin-a-derivate und verfahren zu ihrer herstellung.

1988
- 1988-06-07 US US07/203,400 patent/US5075289A/en not_active Expired - Fee Related
1989
- 1989-05-28 IL IL90434A patent/IL90434A0/xx not_active IP Right Cessation
- 1989-05-29 NZ NZ229328A patent/NZ229328A/xx unknown
- 1989-06-01 EP EP89109890A patent/EP0345627B1/en not_active Expired - Lifetime
- 1989-06-01 DE DE68927967T patent/DE68927967T2/de not_active Expired - Fee Related
- 1989-06-01 AT AT89109890T patent/ATE151772T1/de not_active IP Right Cessation
- 1989-06-01 ES ES89109890T patent/ES2103257T3/es not_active Expired - Lifetime
- 1989-06-03 KR KR1019890007655A patent/KR0132671B1/ko not_active Expired - Fee Related
- 1989-06-06 CA CA000601931A patent/CA1328258C/en not_active Expired - Fee Related
- 1989-06-06 AU AU36102/89A patent/AU609307B2/en not_active Ceased
- 1989-06-06 DK DK198902762A patent/DK172754B1/da not_active IP Right Cessation
- 1989-06-06 JP JP1146556A patent/JP2922922B2/ja not_active Expired - Lifetime
1997
- 1997-05-30 GR GR970401261T patent/GR3023617T3/el unknown

Also Published As

Publication number	Publication date
JPH0267294A (ja)	1990-03-07
GR3023617T3 (en)	1997-08-29
NZ229328A (en)	1991-04-26
IL90434A0 (en)	1990-01-18
EP0345627B1 (en)	1997-04-16
ES2103257T3 (es)	1997-09-16
EP0345627A3 (en)	1991-09-11
CA1328258C (en)	1994-04-05
DK172754B1 (da)	1999-06-28
AU3610289A (en)	1989-12-14
ATE151772T1 (de)	1997-05-15
US5075289A (en)	1991-12-24
DE68927967D1 (de)	1997-05-22
KR910000785A (ko)	1991-01-29
DE68927967T2 (de)	1997-10-02
EP0345627A2 (en)	1989-12-13
KR0132671B1 (ko)	1998-04-14
DK276289D0 (da)	1989-06-06
AU609307B2 (en)	1991-04-26
JP2922922B2 (ja)	1999-07-26

Legal Events

Date	Code	Title	Description
1999-06-28	B1	Patent granted (law 1993)
2004-02-02	PBP	Patent lapsed	Country of ref document: DK

Publication	Publication Date	Title
FR2696176B1 (fr)	1994-11-10	Dérivés de pipéridine, leur préparation et leur application en thérapeutique.
ATE66001T1 (de)	1991-08-15	Makrolid-antibiotikaderivate.
ATE162200T1 (de)	1998-01-15	Bisaminierte zyklohexapeptide
FR2681325B1 (fr)	1993-12-17	Derives de l'aminomethyl-4 piperidine, leur preparation et leur application en therapeutique.
DK276289A (da)	1989-12-08	9-r-azacykliske erythromycinantibiotika
DK0797579T3 (da)	2000-06-05	Erythromycin A-9-O-oxim-derivater udstyret med antibiotisk aktivitet
DK71786A (da)	1986-08-16	1,8-naphthyridinderivater med antibakteriel aktivitet
DK254588A (da)	1988-11-12	Antibiotika
FI910303A7 (fi)	1991-07-23	Tiatsolidinin johdannaiset, joilla on verenpainetta alentava vaikutus ja niiden terapeuttinen käyttö
MA22981A1 (fr)	1994-04-01	Derives de piperidine, leur preparation et leur application en therapeutique.
FR2567126B1 (fr)	1986-12-12	Derives de pyrrolo(1,2,3-de) benzoxazine et benzothiazine, leur preparation et leur application en therapeutique
MY104067A (en)	1993-11-30	Epipodophyllotoxin glucoside 4''-acyl derivatives
FR2638747B1 (fr)	1993-12-24	Derives de phenyloxypropanolamines, leur preparation et leur application en therapeutique
AU1887788A (en)	1989-01-12	Anthracycline derivatives having cytostatic activity
IT8921262A0 (it)	1989-07-21	Copolimeri saccaridici aventi attivita' antibatterica.
FR2606409B1 (fr)	1989-05-05	Derives d'imidazopyridine, leur preparation et leur application en therapeutique
DE3867780D1 (de)	1992-02-27	4-h-chinolizin-4-on-derivate mit therapeutischer aktivitaet.
FR2637595B1 (fr)	1990-11-30	Derives de benzimidazole, leur preparation et leur application en therapeutique
FR2618151B1 (fr)	1991-01-11	Derives de piperidine, leur preparation et leur application en therapeutique
AU616366B2 (en)	1991-10-24	Anthracycline derivatives having cytostatic activity
FR2684379B1 (fr)	1995-04-28	Derives de piperidine, leur preparation et leur application en therapeutique.
IT8722156A0 (it)	1987-10-06	Derivati pirido benzoiazinici dotati di elevata attivita'antibatterica e di elevata biodisponibilita' tissutale.
AU5380590A (en)	1990-11-01	Rhodomycin derivatives with cytostatic activity
FR2621584B1 (fr)	1991-05-24	Derives de benzothiazepine-1,5, leur preparation et leur application en therapeutique
FR2679233B1 (fr)	1993-10-15	Derives d'imidazo [2,1-b] benzothiazole-3-acetamide, leur preparation et leur application en therapeutique.