DK278879A - Fremgangsmaade til fremstilling af krystallinsk n-formimidoylthienamycin - Google Patents

Fremgangsmaade til fremstilling af krystallinsk n-formimidoylthienamycin

Info

Publication number
DK278879A
DK278879A DK278879A DK278879A DK278879A DK 278879 A DK278879 A DK 278879A DK 278879 A DK278879 A DK 278879A DK 278879 A DK278879 A DK 278879A DK 278879 A DK278879 A DK 278879A
Authority
DK
Denmark
Prior art keywords
formimidoylthienamycine
procedure
preparing crystalline
crystalline
preparing
Prior art date
Application number
DK278879A
Other languages
English (en)
Other versions
DK153486B (da
DK153486C (da
Inventor
T W Miller
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK278879A publication Critical patent/DK278879A/da
Publication of DK153486B publication Critical patent/DK153486B/da
Application granted granted Critical
Publication of DK153486C publication Critical patent/DK153486C/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D477/00Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20Sulfur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK278879A 1978-07-03 1979-07-02 Analogifremgangsmaade til fremstilling af krystallinsk n-formimidoyl-thienamycin-monohydrat DK153486C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92137978A 1978-07-03 1978-07-03
US92137978 1978-07-03

Publications (3)

Publication Number Publication Date
DK278879A true DK278879A (da) 1980-01-04
DK153486B DK153486B (da) 1988-07-18
DK153486C DK153486C (da) 1988-11-28

Family

ID=25445341

Family Applications (1)

Application Number Title Priority Date Filing Date
DK278879A DK153486C (da) 1978-07-03 1979-07-02 Analogifremgangsmaade til fremstilling af krystallinsk n-formimidoyl-thienamycin-monohydrat

Country Status (6)

Country Link
EP (1) EP0006639B1 (da)
JP (1) JPS559090A (da)
AT (1) ATE1676T1 (da)
DE (1) DE2963882D1 (da)
DK (1) DK153486C (da)
IE (1) IE48356B1 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE50333B1 (en) * 1979-11-02 1986-04-02 Merck & Co Inc Antibacterial compositions comprising a beta-lactam-type compound and a 3-substituted propenoate
US4374772A (en) * 1981-03-19 1983-02-22 Merck & Co., Inc. Process for the preparation of N-formimidoyl thienamycin and reagents therefor
US4713451A (en) * 1984-04-09 1987-12-15 Merck & Co., Inc. Crystalline dimethyliminothienamycin
JPS61207617A (ja) * 1985-03-05 1986-09-16 Toyobo Co Ltd ポリエステル繊維の製造方法
IE60588B1 (en) * 1986-07-30 1994-07-27 Sumitomo Pharma Carbapenem compound in crystalline form, and its production and use
DK168047B1 (da) * 1987-12-07 1994-01-24 Lederle Japan Ltd (1r,5s,6s)-2-substitueret thio-6-oe(r)-1-hydroxyethylaa-1-methyl-carbapenem-3-carboxylsyrederivater, fremgangsmaade til remstilling deraf, midler og praeparater indeholdende den krystallinske forbindelse samt dens anvendelse.
US5317016A (en) * 1991-08-20 1994-05-31 Shionogi Seiyaku Kabushiki Kaisha Pyrrolidylthiocarbapenem derivative
HUP0402112A2 (hu) * 2001-11-16 2005-02-28 Ranbaxy Laboratories Limited Eljárás kristályos imipenem előállítására
CN100497338C (zh) * 2006-01-05 2009-06-10 上海医药工业研究院 4-甲基-7-氧-1-氮杂双环[3.2.0]庚-2-烯-2-羧酸类衍生物的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL50911A (en) * 1975-11-21 1981-01-30 Merck & Co Inc Substituted n-methylene derivatives of thienamycin
CS226166B2 (cs) * 1975-11-21 1984-03-19 Merck & Co Inc Způsob přípravy derivátů thienamycinu

Also Published As

Publication number Publication date
IE48356B1 (en) 1984-12-26
IE791191L (en) 1980-01-03
EP0006639B1 (en) 1982-10-20
DE2963882D1 (en) 1982-11-25
JPH0248557B2 (da) 1990-10-25
EP0006639A1 (en) 1980-01-09
DK153486B (da) 1988-07-18
DK153486C (da) 1988-11-28
ATE1676T1 (de) 1982-11-15
JPS559090A (en) 1980-01-22

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