PT69955B - Process for preparing a combination of thienamycin-type anibiotics with dipeptidase inhibitors - Google Patents

Process for preparing a combination of thienamycin-type anibiotics with dipeptidase inhibitors

Info

Publication number
PT69955B
PT69955B PT69955A PT6995579A PT69955B PT 69955 B PT69955 B PT 69955B PT 69955 A PT69955 A PT 69955A PT 6995579 A PT6995579 A PT 6995579A PT 69955 B PT69955 B PT 69955B
Authority
PT
Portugal
Prior art keywords
anibiotics
thienamycin
preparing
combination
type
Prior art date
Application number
PT69955A
Other languages
English (en)
Other versions
PT69955A (en
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26728043&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT69955(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of PT69955A publication Critical patent/PT69955A/pt
Publication of PT69955B publication Critical patent/PT69955B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT69955A 1978-07-24 1979-07-20 Process for preparing a combination of thienamycin-type anibiotics with dipeptidase inhibitors PT69955B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92721378A 1978-07-24 1978-07-24
US5023279A 1979-06-22 1979-06-22

Publications (2)

Publication Number Publication Date
PT69955A PT69955A (en) 1979-08-01
PT69955B true PT69955B (pt) 1981-06-11

Family

ID=26728043

Family Applications (1)

Application Number Title Priority Date Filing Date
PT69955A PT69955B (pt) 1978-07-24 1979-07-20 Process for preparing a combination of thienamycin-type anibiotics with dipeptidase inhibitors

Country Status (19)

Country Link
EP (1) EP0007614B1 (pt)
AR (1) AR244550A1 (pt)
AU (1) AU529315B2 (pt)
CA (1) CA1136549A (pt)
CZ (1) CZ280583B6 (pt)
DD (1) DD145059A5 (pt)
DE (1) DE2964609D1 (pt)
EG (1) EG14367A (pt)
ES (1) ES482774A1 (pt)
FI (1) FI792282A7 (pt)
GR (1) GR69997B (pt)
HK (1) HK23286A (pt)
HU (1) HU182973B (pt)
IE (1) IE51691B1 (pt)
IL (1) IL57798A (pt)
NZ (1) NZ190993A (pt)
PH (1) PH16620A (pt)
PT (1) PT69955B (pt)
SK (1) SK513779A3 (pt)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880793A (en) * 1978-07-24 1989-11-14 Merck & Co., Inc. Combination of thienamycin-type antibiotics with dipeptidase inhibitors
US5071843A (en) * 1978-07-24 1991-12-10 Merck & Co., Inc. Combination of 2-substituted carbapenems with dipeptidase inhibitors
GR70784B (pt) * 1979-11-02 1983-03-23 Merck & Co Inc
DE3173503D1 (en) * 1980-09-17 1986-02-27 Merck & Co Inc Antibacterial composition of thienamycin type compound and a dipeptidase inhibitor
PT73640B (en) * 1980-09-17 1983-10-19 Merck & Co Inc Process for preparing chemical compounds selectively inhibit the metabolism of dipeptidase
DE48301T1 (de) * 1980-09-24 1983-01-20 Merck & Co., Inc., 07065 Rahway, N.J. 2-(cyclopropancarboxamido)-2-alkensaeuren, deren ester und salze und daraus bestehende bakterienhemmende zusammensetzungen mit einer verbindung des typs thienamycin.
NZ201471A (en) * 1981-08-10 1985-09-13 Merck & Co Inc Antibacterial compositions containing penems and dipeptidase inhibitors
JPS6025952A (ja) * 1983-07-20 1985-02-08 Sumitomo Chem Co Ltd 光学活性2,2−ジメチルシクロプロパン−1−カルボン酸誘導体の製造法
EP0161546B1 (en) * 1984-04-30 1989-12-13 Merck & Co. Inc. Combination of 2-substituted carbapenems with dipeptidase inhibitors
CA1273012A (en) * 1984-07-02 1990-08-21 Burton G. Christensen 1-methylcarbapenems having an externally alkylated mono- of bicyclic 2-quarternary heteroarylalkylthio substituent
IE851586L (en) * 1984-07-02 1986-01-02 Interchem Internat S A I methylcarbapenems having a 2-quaternary¹heteroarylalkylthio substituent
CA1273011A (en) * 1984-07-02 1990-08-21 Susan M. Schmitt Carbapenems having an externally alkylated mono- or bicyclic 2-quaternary heteroarylalkylthio substituent
NO172099C (no) * 1984-10-15 1993-06-09 Sankyo Co Fremgangsmaate til fremstilling av et preparat som inneholder et penem -eller karbapenemantibiotikum og en n-acetylert aminosyre
US4680292A (en) * 1984-12-13 1987-07-14 Merck & Co., Inc. Carbapenems and 1-methylcarbapenems having a 2-heteroaryliumaliphatic substituent
US4739113A (en) * 1986-05-30 1988-04-19 Merck & Co., Inc. Bis(cyclopropanecarboxamido)alkadienedioic acids as renal dipeptidase inhibitors
EP0464900A3 (en) 1990-06-26 1992-07-22 Merck & Co. Inc. 2-biphenyl-carbapenems
CA2052730A1 (en) 1990-10-11 1992-04-12 Frank P. Dininno 2-(substituted-dibenzofuranyl and dibenzothienyl) carbapenem antibacterial agents
ATE217195T1 (de) * 1991-02-01 2002-05-15 Suntory Ltd Verwendung von cilastatin, glutathione und n- acetyl-l-cysteine zur herstellung eines arzneimittels zur verbesserung der resorption von carbapenem oder penem antibiotika im magen-darm- trakt
US6297231B1 (en) 1996-10-28 2001-10-02 Merck & Co., Inc. Stabilized carbapenem antibiotic compositions and method of making
US6255300B1 (en) 1997-09-09 2001-07-03 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
US6277843B1 (en) 1997-09-17 2001-08-21 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
US6271222B1 (en) 1998-05-28 2001-08-07 Merck & Co., Inc. Penem antibacterial compounds, compositions and methods of treatment
US6288054B1 (en) 1998-06-02 2001-09-11 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
US6310055B2 (en) 1998-06-02 2001-10-30 Merck & Co., Inc. Halophenoxy substituted carbapenem antibacterial compounds
US6284753B2 (en) 1998-06-02 2001-09-04 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
WO1999067241A1 (en) 1998-06-25 1999-12-29 Merck & Co., Inc. (heterocyclic) methyl substituted carbapenem antibacterials
CA2335538A1 (en) 1998-06-25 1999-12-29 Merck & Co., Inc. (heterocyclic)methyl substituted carbapenem antibacterials
WO1999066928A1 (en) 1998-06-25 1999-12-29 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
US6346526B1 (en) 1998-06-25 2002-02-12 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
US6265395B1 (en) 1998-06-25 2001-07-24 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
US6316488B1 (en) 1999-06-17 2001-11-13 Merck & Co., Inc. Antibiotic compound
US6221859B1 (en) 1999-08-27 2001-04-24 Merck & Co., Inc. Carbapenem antibacterial compositions and methods of the treatment
WO2012104793A1 (en) * 2011-02-02 2012-08-09 Indian Council Of Medical Research An antibacterial and antiviral compound
AU2012275499A1 (en) 2011-06-27 2013-12-19 Kyorin Pharmaceutical Co., Ltd. Bridged bicyclic compounds for the treatment of bacterial infections

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2272684A1 (en) * 1975-01-07 1975-12-26 Ito Shojiro Antibiotic-unsaturated acid compsns. - having a synergistic effect against gram positive and negative bacteria

Also Published As

Publication number Publication date
CA1136549A (en) 1982-11-30
GR69997B (pt) 1982-07-23
SK278357B6 (en) 1997-01-08
EG14367A (en) 1984-09-30
AR244550A1 (es) 1993-11-30
HK23286A (en) 1986-04-11
PH16620A (en) 1983-11-28
SK513779A3 (en) 1997-01-08
AU529315B2 (en) 1983-06-02
NZ190993A (en) 1981-10-19
EP0007614A1 (en) 1980-02-06
AU4893279A (en) 1980-01-31
CZ513779A3 (en) 1995-10-18
DD145059A5 (de) 1980-11-19
ES482774A1 (es) 1980-09-01
IL57798A0 (en) 1979-11-30
EP0007614B1 (en) 1983-01-26
FI792282A7 (fi) 1981-01-01
IL57798A (en) 1986-11-30
HU182973B (en) 1984-03-28
PT69955A (en) 1979-08-01
DE2964609D1 (en) 1983-03-03
CZ280583B6 (cs) 1996-02-14
IE51691B1 (en) 1987-02-18
IE791388L (en) 1980-01-24

Similar Documents

Publication Publication Date Title
EG14367A (en) Process for preparing a combination of thienamycin-type antibiotics with dipeptidase inhibitors
YU42172B (en) Process for obtaining new derivatives of 4-amino-5-alkyl-sulphonyl-orthdanizamide
YU42655B (en) Process for obtaining derivatives of carboxialkyldipeptides
RO81857A (ro) Procedeu de preparare a unor 6-n-propil-8-metoximetilergoline sau 6-n-propil-8-metilmercaptometilergoline
ES490114A0 (es) Metodo de preparar nuevas aril-3 eter-5 oxazolidinonas-2
YU128879A (en) Process for obtaining new aminothiazoles
RO83454A (ro) Procedeu pentru prepararea unor pirimidoane
RO81114A (ro) Procedeu de preparare a unor 4-desacetilvincalencoblastin-c3-carboxihidracide
RO79700A (ro) Procedeu de obtinere a vinilpolibutadienei
NO150286C (no) Fremgangsmaate for fremstilling av en pulverformig vaskemiddelblanding
ES492972A0 (es) Un metodo de preparar nuevos derivados de pirazolina
RO73516A (ro) Procedeu pentru prepararea unor glicozide a 2-dezoxistreptaminei
RO84536A (ro) Procedeu de sinteza a amoniacului
IT1122026B (it) Procedimento per preparare poliolefine
ES484446A0 (es) Un procedimiento de preparacion de derivados del jurano
PT69607A (en) Process for preparing di-o-n-alkyl glycerol derivatives asimmune stimulants
IT1122386B (it) Procedimento per preparare isopropenil-fenolo
JPS5548324A (en) Sprouting process for regular shimejiimushroom
RO77032A (ro) Procedeu de preparare a 3-amino-5-tert-butilizoxazolului
KE3294A (en) Process for preparing thiazoles
YU41072B (en) Process for the cultivation of basidionycetes
NO791994L (no) Fremgangsmaate for fremstilling av 2-isopropylamino-pyrimidin
PT66747A (en) Process for preparing of optically active trans-hexahydro-dibenzopyranones
AT378588B (de) Gasversorgungsverfahren
IT7950308A0 (it) Procedimento per preparare cefalosporine