DK2795A - Fremgangsmåde til fremstilling af 4-substituerede 3-(1'-hydroxyethyl)-azetidin-2-oner samt azetidin-2-on-derivat - Google Patents

Fremgangsmåde til fremstilling af 4-substituerede 3-(1'-hydroxyethyl)-azetidin-2-oner samt azetidin-2-on-derivat Download PDF

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Publication number
DK2795A
DK2795A DK002795A DK2795A DK2795A DK 2795 A DK2795 A DK 2795A DK 002795 A DK002795 A DK 002795A DK 2795 A DK2795 A DK 2795A DK 2795 A DK2795 A DK 2795A
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DK
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Prior art keywords
azetidin
hydroxyethyl
ones
derivative
substituted
Prior art date
Application number
DK002795A
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English (en)
Other versions
DK171985B1 (da
Inventor
Peter Schneider
Gerardo Ramos
Jacques Bersier
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DK2795A publication Critical patent/DK2795A/da
Application granted granted Critical
Publication of DK171985B1 publication Critical patent/DK171985B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
    • C07D265/08—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/94—Saccharomyces
    • Y10S435/942—Saccharomyces cerevisiae

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Electrolytic Production Of Non-Metals, Compounds, Apparatuses Therefor (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK002795A 1987-05-04 1995-01-10 Fremgangsmåde til fremstilling af 4-substituerede 3-(1'-hydroxyethyl)-azetidin-2-oner samt azetidin-2-on-derivat DK171985B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH168387 1987-05-04
CH168387 1987-05-04

Publications (2)

Publication Number Publication Date
DK2795A true DK2795A (da) 1995-01-10
DK171985B1 DK171985B1 (da) 1997-09-08

Family

ID=4216154

Family Applications (2)

Application Number Title Priority Date Filing Date
DK238988A DK170856B1 (da) 1987-05-04 1988-05-03 Fremgangsmåde til fremstilling af 4-substituerede 3-(1'-hydroxyethyl)-azetidin-2-oner, alfa-aminomethyl-beta-hydroxy-carboxylsyre og derivater og salte deraf samt 5,6-dihydro-1,3,4H-oxaziner og salte deraf
DK002795A DK171985B1 (da) 1987-05-04 1995-01-10 Fremgangsmåde til fremstilling af 4-substituerede 3-(1'-hydroxyethyl)-azetidin-2-oner samt azetidin-2-on-derivat

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK238988A DK170856B1 (da) 1987-05-04 1988-05-03 Fremgangsmåde til fremstilling af 4-substituerede 3-(1'-hydroxyethyl)-azetidin-2-oner, alfa-aminomethyl-beta-hydroxy-carboxylsyre og derivater og salte deraf samt 5,6-dihydro-1,3,4H-oxaziner og salte deraf

Country Status (9)

Country Link
US (2) US4927507A (da)
EP (1) EP0290385B1 (da)
JP (2) JP2520447B2 (da)
CA (1) CA1335971C (da)
DE (1) DE3875373D1 (da)
DK (2) DK170856B1 (da)
ES (1) ES2045180T3 (da)
HK (1) HK99795A (da)
IE (1) IE62804B1 (da)

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EP0279781A3 (de) * 1987-02-17 1989-07-26 Ciba-Geigy Ag Verfahren zur Herstellung von 4-Acetoxy-3-hydroxyethyl-azetidinon
US5274188A (en) * 1987-05-04 1993-12-28 Ciba-Geigy Corporation Process for the manufacture of 4-acyloxy-3-hydroxyethyl-azetidinones
JPH0623150B2 (ja) * 1988-11-15 1994-03-30 高砂香料工業株式会社 光学活性３−ヒドロキシブタン酸類の製造方法
US5204460A (en) * 1988-11-29 1993-04-20 Takasago International Corporation Ruthenium catalyzed process for preparing 4-acetoxyazetidinones
US5241064A (en) * 1989-10-02 1993-08-31 Fujisawa Pharmaceutical Co., Ltd. Enzymatic process for preparing optically active 3-substituted azetidinones
JP2640986B2 (ja) * 1990-11-08 1997-08-13 高砂香料工業株式会社 （１′ｒ，３ｓ）―３―（１′―ヒドロキシエチル）―アゼチジン―２―オン又はその誘導体の製造法
JP2787248B2 (ja) * 1990-11-30 1998-08-13 高砂香料工業株式会社 ４―アセトキシアゼチジノン類の製造方法
US5420337A (en) * 1992-11-12 1995-05-30 E. R. Squibb & Sons, Inc. Enzymatic reduction method for the preparation of compounds useful for preparing taxanes
US5631363A (en) * 1992-11-13 1997-05-20 Tanabe Seiyaku Co., Ltd. Azetidinone compound and process for preparation thereof
US5346983A (en) * 1993-05-28 1994-09-13 Hoechst Celanese Corporation Substituted phenyl compounds and processes for preparing the same
US5602272A (en) * 1994-06-21 1997-02-11 Bristol-Myers Squibb Company Reduction and resolution methods for the preparation of compounds useful as intemediates for preparing taxanes
KR19990058545A (ko) * 1997-12-30 1999-07-15 유현식 메틸(2에스,3알)-2-(엔-벤조일아미노)메티래-3-히드록시부타노에이트의 합성방법
JP4854136B2 (ja) * 2001-06-20 2012-01-18 和光純薬工業株式会社 ハロアルキルスルホン化合物及びビニルスルホン化合物の製造方法
KR100451413B1 (ko) * 2001-12-28 2004-10-06 한국과학기술연구원 클루이베로마이시스 마르시아누스의 카르보닐 환원효소를이용한 카르보닐 화합물의 환원반응
KR100522133B1 (ko) 2002-01-26 2005-10-18 한국과학기술연구원 클루이베로마이세스 마르시아누스로부터 분리 및 정제된 카르보닐 환원효소 및 그 제조 방법
KR20080036098A (ko) * 2005-07-20 2008-04-24 가부시키가이샤 가네카 광학 활성 2-(ｎ-치환 아미노메틸)-3-히드록시부티르산에스테르류의 제조 방법
CN1940079B (zh) * 2006-09-08 2010-10-13 鲁南制药集团股份有限公司 利用酵母细胞不对称合成(2s,3s)-2-苯甲酰氨甲基-3-羟基丁酸酯系列化合物
HUE027683T2 (en) 2007-10-01 2016-10-28 Codexis Inc Ketoreductase polypeptides for the production of azetidinone
WO2010025287A2 (en) * 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
EP2329013B1 (en) * 2008-08-27 2015-10-28 Codexis, Inc. Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
US8273554B2 (en) 2008-08-29 2012-09-25 Codexis, Inc. Ketoreductase polypeptides for the stereoselective production of (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one
ES2575560T3 (es) 2009-08-19 2016-06-29 Codexis, Inc. Polipéptidos cetorreductasa para preparar fenilefrina
HUE026367T2 (en) 2010-05-04 2016-06-28 Codexis Inc Biocatalysts for ezetimibe synthesis
CN103045504B (zh) * 2012-12-05 2014-06-04 浙江工业大学 微生物催化制备(2s, 3r)-2-苯甲酰氨甲基-3-羟基丁酸酯及菌株
CN105624125B (zh) * 2014-11-26 2020-03-17 上海弈柯莱生物医药科技有限公司 醛酮还原酶及其在合成(2s,3r)-2-苯甲酰氨甲基-3-羟基丁酸酯中的应用
CN113272347B (zh) * 2018-11-21 2024-05-14 株式会社可乐丽 单分散性水凝胶颗粒
CN113528592B (zh) * 2021-06-08 2022-08-19 复旦大学 酶催化的(2s,3r)-2-取代氨基甲基-3-羟基丁酸酯的合成方法

Family Cites Families (19)

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US3681333A (en) * 1967-07-24 1972-08-01 Allied Chem Process for the preparation of cyclic iminoethers
US4138400A (en) * 1975-12-20 1979-02-06 Hoechst Aktiengesellschaft Omega-alkoxy derivatives of lactams
US4138408A (en) * 1975-12-20 1979-02-06 Hoechst Aktiengesellschaft ω-Alkoxy derivatives of lactams and process for their manufacture
US4400323A (en) * 1979-07-23 1983-08-23 Merck & Co., Inc. 3-[1-Hydroxyethyl]-4-carboxymethyl-azetidin-2-one
US4467107A (en) * 1981-04-08 1984-08-21 Merck & Co., Inc. 1-Hydroxyethyl-2-amino pentanedioic acid derivatives
US4473502A (en) * 1981-04-08 1984-09-25 Merck & Co., Inc. Synthesis of thienamycin via (3SR, 4RS)-3-[1 (SR)-hydroxyethyl]-2-oxo-4-azetidineacetic acid
CA1190236A (en) 1981-10-23 1985-07-09 Edward J.J. Grabowski Antibiotic synthesis
EP0106652B1 (en) * 1982-10-13 1988-01-27 Sumitomo Pharmaceuticals Company, Limited Beta-lactam compounds and production thereof
GB8321004D0 (en) * 1983-08-04 1983-09-07 Erba Farmitalia Azetidinones
US4656165A (en) 1983-09-02 1987-04-07 Ciba-Geigy Corporation Aminomethyl penem compounds
DE3340006A1 (de) * 1983-11-04 1985-05-23 Hans Rudolf Prof. Dipl.-Chem. Dr. 8000 München Pfaendler Verfahren zur herstellung von azetidin-2-onen
US4596677A (en) * 1984-04-06 1986-06-24 Bristol-Myers Company Anhydropenicillin intermediates
CA1256443A (en) * 1984-07-05 1989-06-27 Takehisa Ohashi Process for preparing 4-acetoxy-3- hydroxyethylazetidin-2-one derivatives
EP0171064B1 (en) 1984-08-06 1995-07-12 Fujisawa Pharmaceutical Co., Ltd. Azetidinone derivative and processes for production thereof
DE3587546D1 (de) 1984-10-01 1993-09-30 Ciba Geigy Verfahren zur Herstellung von optisch aktiven Acyloxyazetidinonen.
EP0180398A1 (en) * 1984-10-26 1986-05-07 The Regents Of The University Of California Synthesis of beta-lactam
US4892961A (en) * 1985-07-31 1990-01-09 Sumitomo Pharmaceuticals Company, Limited Amino acid derivatives, and their production
EP0215739B1 (de) 1985-09-11 1993-09-01 Ciba-Geigy Ag Synthese von Beta-Lactamverbindungen
US4882429A (en) * 1986-03-03 1989-11-21 Schering Corporation Stereospecific preparation of (3S,4R,5R)-3-(1-hydroxyethyl)-4-benzoyloxy-azeridinones from L-(-)-theonine

Also Published As

Publication number Publication date
JPS63297360A (ja) 1988-12-05
DK238988A (da) 1988-11-05
US5064761A (en) 1991-11-12
IE881327L (en) 1988-11-04
ES2045180T3 (es) 1994-01-16
JP2520447B2 (ja) 1996-07-31
EP0290385A1 (de) 1988-11-09
DK171985B1 (da) 1997-09-08
DE3875373D1 (de) 1992-11-26
JPH09104678A (ja) 1997-04-22
IE62804B1 (en) 1995-03-08
US4927507A (en) 1990-05-22
HK99795A (en) 1995-06-30
JP2711244B2 (ja) 1998-02-10
DK170856B1 (da) 1996-02-12
EP0290385B1 (de) 1992-10-21
DK238988D0 (da) 1988-05-03
CA1335971C (en) 1995-06-20

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