DK2825309T3 - Prøvepatron med integreret overførselsmodul - Google Patents

Prøvepatron med integreret overførselsmodul Download PDF

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Publication number
DK2825309T3
DK2825309T3 DK13711332.0T DK13711332T DK2825309T3 DK 2825309 T3 DK2825309 T3 DK 2825309T3 DK 13711332 T DK13711332 T DK 13711332T DK 2825309 T3 DK2825309 T3 DK 2825309T3
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Denmark
Prior art keywords
chamber
transfer module
sample
port
ports
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DK13711332.0T
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English (en)
Inventor
Fabra Jordi Carrera
Cases Anna Comenges
Gibert Rafael Bru
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Stat Diagnostica & Innovation Sl
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Publication of DK2825309T3 publication Critical patent/DK2825309T3/da

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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Clinical Laboratory Science (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Sustainable Development (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Sampling And Sample Adjustment (AREA)

Claims (65)

  1. P a t e n t k r a v
    1. Patronsystem (100) omfattende: et patronhus (102) omfattende: mindst ét prøveindløb (114); en flerhed af lagerkamre (116); en flerhed af reaktionskamre (216); og et fluidnetværk, der forbinder det mindst ene prøveindløb (114), i det mindste en del af flerheden af lagerkamre (116) og i det mindste en del af flerheden af reaktionskamre (216) med en første flerhed af porte (210) placeret på en indre overflade af patronhuset (102); og et hult overførselsmodul (104) anbragt inden i patronhuset (102), der omfatter en eftergivelig kappe (108) omkring et hus (110), og en anden flerhed af porte (312) langs en ydre overflade af overførselsmodulet (104), som fører til et centralt kammer (316) af overførselsmodulet (104), hvor overførselsmodulet (104) er indrettet til at bevæge sig sideværts langs en længde af patronhuset (102), hvor sideværts bevægelse af overførselsmodulet (104) justerer mindst en del af den første flerhed af porte (210) med i det mindste en del af den anden flerhed af porte (312).
  2. 2. System ifølge krav 1, hvor patronhuset (102) endvidere omfatter en flerhed af behandlingskamre, og hvor fluidnetværket også forbinder i det mindste en del af flerheden af behandlingskamre med den første flerhed af porte (210).
  3. 3. System ifølge krav 2, hvor flerheden af behandlingskamre er anbragt langs en sideflade af patronhuset (102).
  4. 4. System ifølge krav 1, der yderligere omfatter et sæt af ventilkanaler dannet af en grænseflade mellem patronhuset (102) og det hule overførselsmodul (104).
  5. 5. System ifølge krav 1, hvor en ydre overflade af det hule overførselsmodul (104) omfatter højdekamme.
  6. 6. System ifølge krav 5, hvor højdekammene har en toroidform.
  7. 7. System ifølge krav 5, hvor højdekammene definerer et område på overførselsmodulets (104) ydre overflade, der er konfigureret til at være justeret med mindst to af de første flerheder af porte (210) og tillade fluid at strømme mellem de mindst to af den første flerhed af porte (210).
  8. 8. System ifølge krav 5, hvor højdekammene definerer en flerhed af ventilområder koblet til fluidnetværket via overførselsmodulet (104).
  9. 9. System ifølge krav 8, hvor ventilområderne er konfigureret til at definere en overførselsbane for væskeprøver blandt prøveindløbet (114), flerheden af opbevaringskamre (116), flerheden af reaktionskamre (216) og det centrale kammer (316).
  10. 10. System ifølge krav 1, hvor mindst et af flerheden af lagerkamre (116) indbefatter en åbning konfigureret til at udlufte lagerkammeret (116).
  11. 11. System ifølge krav 1, der yderligere omfatter en flerhed af forblandingskamre placeret langs en sideflade af patronhuset (102).
  12. 12. System ifølge krav 11, der yderligere omfatter et eller flere reagenser forseglet i mindst ét af flere lagerkamre (116), flerheden af reaktionskamre (216) og flerheden af forblandingskamre.
  13. 13. System ifølge krav 12, hvor det ene eller flere reagenser frysetørres.
  14. 14. System ifølge krav 1, hvor flerheden af opbevaringskamre (116) er anbragt langs en topflade af patronhuset (102).
  15. 15. System ifølge krav 1, hvor flerheden af reaktionskamre (216) er anbragt langs en sideflade af patronhuset (102).
  16. 16. System ifølge krav 15, hvor patronhuset (102) endvidere omfatter et eller flere optiske adgangsvinduer placeret under flerheden af reaktionskamre (216).
  17. 17. System ifølge krav 1, der yderligere omfatter en første film, som forsegler flerheden af lagerkamre (116), og en flerhed af film, der forsegler flerheden af reaktionskamre (216).
  18. 18. System ifølge krav 17, hvor den første film, der forsegler flerheden af lagerkamre (116), er i kontakt med en termisk styret overflade.
  19. 19. System ifølge krav 17, hvor flerheden af film, som forsegler flerheden af reaktionskamre (216), er i kontakt med en termisk styret overflade.
  20. 20. System ifølge krav 19, hvor en temperatur på den termisk styrede overflade er påvirket af enten et termoelektrisk system eller af et resistivt varmesystem eller ved opvarmning af luft eller ved afkøling af luft.
  21. 21. System ifølge krav 1, hvor det mindst ene prøveindløb (114) er dimensioneret til at modtage en prøve via en svaberpind.
  22. 22. System ifølge krav 1, hvor det mindst ene prøveindløb (114) er konfigureret til at modtage faste og flydende prøver.
  23. 23. System ifølge krav 1, hvor patronhuset (102) endvidere omfatter mindst en luftindløbsport.
  24. 24. System ifølge krav 23, hvor den mindst ene luftindløbsport er konfigureret til forbindelse til en ekstern trykkilde.
  25. 25. System ifølge krav 23, der yderligere omfatter et filter koblet til den mindst ene luftindløbsport.
  26. 26. System ifølge krav 23, der yderligere omfatter et bufferkammer koblet til den mindst ene luftindløbsport og konfigureret til at holde en væske, inden væsken undslipper gennem den mindst ene luftindløbsport.
  27. 27. System ifølge krav 1, hvor det hule overførselsmodul (104) er konfigureret til at bevæge sig sideværts via en lineær aktuator.
  28. 28. System ifølge krav 27, hvor den lineære aktuator er konfigureret til at bevæge overførselsmodulet (104) mellem diskrete trin.
  29. 29. System ifølge krav 1, hvor patronhuset (102) endvidere omfatter et middel til centrering af systemet inden i en analysator.
  30. 30. System ifølge krav 1, hvor mindst en af den anden flerhed af porte (312) er placeret i det væsentlige ved et laveste punkt i det centrale kammer (316).
  31. 31. System ifølge krav 30, hvor vægge i det centrale kammer (316) er skrånende for derved at afdræne en væske tilstrækkeligt i det centrale kammer (316) gennem den mindst ene af den anden flerhed af porte (312).
  32. 32. System ifølge krav 1, hvor patronhuset (102) endvidere omfatter et filter koblet til fluidnetværket.
  33. 33. System ifølge krav 32, hvor filteret er en silikat-matrice eller omfatter en flerhed af silika-perler.
  34. 34. System ifølge krav 1, der yderligere omfatter en omrøringsstang anbragt inden i det centrale kammer (316).
  35. 35. System ifølge krav 1, hvor patronhuset (102) endvidere omfatter en flerhed af væskefølsomme områder.
  36. 36. System ifølge krav 35, hvorved en tilstedeværelse af væske detekteres ved de væskefølsomme områder under anvendelse af en optisk sensor.
  37. 37. System ifølge krav 1, hvor patronhuset (102) endvidere omfatter en flerhed af fritter koblet til fluidnetværket.
  38. 38. Overførselsmodul (104), der er hensigtsmæssigt til anvendelse i systemet ifølge krav 1 og konfigureret til at opbevare og transportere flydende prøver, hvor overførselsmodulet (104) omfatter: et indre hus, der omslutter et centralt kammer (316); en eftergivelig kappe (108) dannet omkring det indre hus, hvilken kappe (108) omfatter: mønstrede højdekamme langs den ydre overflade af kappen (108), hvor de mønstrede højdekamme er konfigureret til at definere en flerhed af ventilområder langs den ydre overflade af kappen (108), når overførselsmodulet (104) er anbragt inden i en omslutning, der kommer i kontakt med de mønstrede højdekamme; og en flerhed af porte, der strækker sig gennem kappen (108) og det indre hus ind i det centrale kammer (316), hvor et af flerheden af ventilområder er konfigureret til at blive trykt separat fra andre områder i flerheden af ventilområder.
  39. 39. Overførselsmodul (104) ifølge krav 38, hvor en fluidstrøm forekommer enten ind i eller ud af det centrale kammer (316) via en eller flere af flerheden af porte, når ét af flerheden af ventilområder er under tryk.
  40. 40. Overførselsmodul (104) ifølge krav 38, hvor de mønstrede højdekamme er yderligere konfigureret til at definere et område på ydersiden af kappen (108), som er justeret med mindst to porte i et hus, der i det væsentlige omgiver overførselsmodulet og tillader væske at strømme mellem de mindst to porte.
  41. 41. Overførselsmodul (104) ifølge krav 38, hvor det indre hus og kappen (108) er dannet som en enkelt sprøjtestøbt enhed.
  42. 42. Overførselsmodul (104) ifølge krav 38, hvor flerheden af porte er anbragt langs en side af overførsel s modul et og langs en top af overførselsmodulet.
  43. 43. Overførselsmodul (104) ifølge krav 38, hvor en flerhed af de mønstrede højdekamme er toroidformede.
  44. 44. Overførselsmodul (104) ifølge krav 38, hvor mindst en af flerheden af porte er placeret i det væsentlige ved et laveste punkt i det centrale kammer (316).
  45. 45. Overførselsmodul (104) ifølge krav 44, hvor vægge i det centrale kammer (316) er skrånende for i tilstrækkelig grad at dræne en væske i det centrale kammer (316) gennem den mindst ene af flerheden af porte.
  46. 46. Overførselsmodul (104) ifølge krav 38, der yderligere omfatter en omrøringsstang anbragt inden i det centrale kammer (316).
  47. 47. Overførselsmodul (104) ifølge krav 38, der yderligere omfatter et låg, der er konfigureret til at forsegle den ene ende af det centrale kammer (316) og har en skrånende konstruktion inde i det centrale kammer (316).
  48. 48. Overførselsmodul (104) ifølge krav 47, hvor den skrånende konstruktion omfatter en flerhed af kanaler konfigureret til at lede væske inde i det centrale kammer (316) til en eller flere af flerheden af porte.
  49. 49. Fremgangsmåde til anvendelse af systemet ifølge krav 1, hvilken fremgangsmåde omfatter: sideværts bevægelse af et overførselsmodul til at justere en første port af overførselsmodulet med et centralt kammer (316) med en port i et første kammer; sugning af en prøve ind i det centrale kammer (316) fra det første kammer via en første trykforskel; sideværts bevægelse af overførselsmodulet for at justere en anden port i overførselsmodulet med en port i et andet kammer; og sugning af prøven ind i det andet kammer fra det centrale kammer (316) via en anden trykforskel.
  50. 50. Fremgangsmåde ifølge krav 49, der yderligere omfatter blanding af prøven indført i det første kammer med en buffer placeret i det første kammer.
  51. 51. Fremgangsmåde ifølge krav 49, der yderligere omfatter blanding af prøven suget ind i det centrale kammer (316) fra det første kammer med en væske, som allerede er til stede i det centrale kammer (316).
  52. 52. Fremgangsmåde ifølge krav 49, der yderligere omfatter indføring af prøven i det første kammer via en svaberpind, der bærer prøven.
  53. 53. Fremgangsmåde ifølge krav 49, der yderligere omfatter: behandling af prøven i det andet kammer; sugning af prøven ind i det centrale kammer (316) fra det andet kammer via en tredje trykforskel; sideværts bevægelse af overførselsmodulet for at justere den anden port af overførselsmodulet med en port i et tredje kammer; sugning af prøven ind i det tredje kammer fra det centrale kammer (316) via en fjerde trykforskel; og måling af en eller flere kvaliteter af prøven, mens denne befinder sig i det tredje kammer.
  54. 54. Fremgangsmåde ifølge krav 53, hvorved måling omfatter optisk måling af et fluorescenssignal.
  55. 55. Fremgangsmåde ifølge krav 53, hvorved måling omfatter optisk måling af en absorbans.
  56. 56. Fremgangsmåde ifølge krav 53, der yderligere omfatter opvarmning af prøven efter enten sugning af prøven ind i det andet kammer eller sugning af prøven ind i det tredje kammer.
  57. 57. Fremgangsmåde ifølge krav 49, der yderligere omfatter gentagelse af sideværts bevægelse af overførselsmodulet til at justere den første port af overførselsmodulet med forskellige porte i et eller flere kamre.
  58. 58. Fremgangsmåde ifølge krav 57, der yderligere omfatter sugning af en eller flere væsker ind i det centrale kammer (316) fra det ene eller flere kamre via en eller flere trykforskelle.
  59. 59. Fremgangsmåde ifølge krav 49, der yderligere omfatter gentagelse af sideværts bevægelse af overførselsmodulet for at justere den anden port af overførselsmodulet med forskellige porte i et eller flere kamre.
  60. 60. Fremgangsmåde ifølge krav 59, der yderligere omfatter sugning af en eller flere væsker ind i det centrale kammer (316) fra det ene eller flere kamre via en eller flere trykforskelle.
  61. 61. Fremgangsmåde ifølge krav 59, der yderligere omfatter sugning af en eller flere væsker ind i det ene eller flere kamre fra det centrale kammer (316) via en eller flere trykforskelle.
  62. 62. Fremgangsmåde ifølge krav 49, der yderligere omfatter: behandling af prøven i det andet kammer; sugning af prøven ind i det centrale kammer (316) fra det andet kammer via en tredje trykforskel; sideværts bevægelse af overførselsmodulet for at justere den anden port af overførselsmodulet med en port i et tredje kammer; sugning af prøven ind i det tredje kammer fra det centrale kammer (316) via en fjerde trykforskel; behandling af prøven i det tredje kammer; sideværts bevægelse af overførselsmodulet for at justere den anden port af overførselsmodulet med en port i et fjerde kammer; sugning af prøven ind i det fjerde kammer fra det centrale kammer (316) via en femte trykforskel; og måling af en eller flere kvaliteter af prøven, mens denne befinder sig i det fjerde kammer.
  63. 63. Fremgangsmåde ifølge krav 49, hvorved sugning af prøven ind i det andet kammer omfatter, at prøven strømmer gennem et filter.
  64. 64. Fremgangsmåde ifølge krav 49, hvorved sugning af prøven ind i det andet kammer omfatter, at prøven strømmer gennem en fluidopdeler ind i et eller flere underkamre.
  65. 65. Fremgangsmåde ifølge krav 49, der yderligere omfatter blanding af prøven inde i det centrale kammer (316) med en magnetisk omrøringsstang.
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Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8448499B2 (en) 2008-12-23 2013-05-28 C A Casyso Ag Cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method
DK2825309T3 (da) 2012-03-16 2018-07-30 Stat Diagnostica & Innovation Sl Prøvepatron med integreret overførselsmodul
DE102012222828B4 (de) * 2012-12-11 2025-05-28 Agilent Technologies, Inc. - A Delaware Corporation - Probentrenngerät, Anordnung und Verfahren zur Flüssigkeitsversorgung eines Probentrenngeräts
US11187713B2 (en) * 2013-01-14 2021-11-30 Stratec Se Laboratory module for storing and feeding to further processing of samples
AU2014248813B2 (en) 2013-03-11 2016-05-19 Cue Health Inc. Systems and methods for detection and quantification of analytes
KR20160049001A (ko) * 2013-09-06 2016-05-04 테라노스, 인코포레이티드 면봉(swab) 수납용 기기, 시스템, 방법 및 키트
EP3594360B1 (en) 2014-04-24 2021-06-23 Lucira Health, Inc. Colorimetric detection of nucleic acid amplification
USD745423S1 (en) 2014-05-12 2015-12-15 Cue Inc. Automated analyzer test cartridge and sample collection device for analyte detection
CN107148479A (zh) 2014-09-04 2017-09-08 赛拉诺斯股份有限公司 病原体和抗微生物剂抗性检测
JP6823589B2 (ja) * 2014-09-11 2021-02-03 キュー ヘルス インコーポレイテッド 被分析物の検出および定量のためのシステム
US10816559B2 (en) 2014-09-29 2020-10-27 Ca Casyso Ag Blood testing system and method
US10539579B2 (en) 2014-09-29 2020-01-21 C A Casyso Gmbh Blood testing system and method
KR102604091B1 (ko) 2015-07-17 2023-11-22 큐 헬스 인코퍼레이티드 분석물질의 증진된 검출 및 정량을 위한 시스템 및 방법
US10300486B2 (en) 2015-07-17 2019-05-28 Stat-Diagnostica & Innovation, S.L. Dry chemistry container
US10775370B2 (en) 2015-07-17 2020-09-15 Stat-Diagnostica & Innovation, S.L. Fluidic system for performing assays
US10413902B2 (en) 2015-07-17 2019-09-17 Stat-Diagnostica & Innovation, S.L. Apparatus for sample separation and collection
EP3429543B1 (en) 2016-03-14 2024-11-20 Pfizer Inc. Selectively vented biological assay devices and associated methods
JP6949864B2 (ja) 2016-03-14 2021-10-13 ルシラ ヘルス インコーポレイテッド 生物学的アッセイ試料調製および送り出しのための装置および方法
ES2927062T3 (es) 2016-03-14 2022-11-02 Lucira Health Inc Dispositivos y procedimientos para modificar propiedades ópticas
AU2017232340B2 (en) 2016-03-14 2022-04-28 Pfizer Inc. Systems and methods for performing biological assays
WO2017180909A1 (en) 2016-04-13 2017-10-19 Nextgen Jane, Inc. Sample collection and preservation devices, systems and methods
DE112016006830B4 (de) * 2016-05-02 2024-02-22 Integriculture Inc. System zur intelligenten induktion, steuervorrichtung zur alterungsinduktion, verfahren zur steuerung der alterungsinduktion und programm zur steuerung von alterungsinduktion
WO2017201049A1 (en) * 2016-05-17 2017-11-23 Integrated Nano-Technologies, Inc. Flow control system for diagnostic assay system
US10450144B2 (en) * 2016-05-27 2019-10-22 Biomerieux, Inc. System and method for transferring specimen containers between detection instruments
CN106226254B (zh) * 2016-08-03 2019-06-07 天津喜诺生物医药有限公司 一种用于生物检测的微流控芯片及其制备方法
US11237161B2 (en) 2017-01-25 2022-02-01 Cue Health Inc. Systems and methods for enhanced detection and quantification of analytes
EP3354342A1 (en) * 2017-01-26 2018-08-01 Eidgenössische Anstalt für Wasserversorgung, Abwasserreinigung und Gewässerschutz, Eawag Device and method for producing individually processed fluid samples
US11080848B2 (en) 2017-04-06 2021-08-03 Lucira Health, Inc. Image-based disease diagnostics using a mobile device
USD839447S1 (en) * 2017-04-20 2019-01-29 Hemosonics Llc Hemostasis measurement cartridge
USD841184S1 (en) * 2017-06-06 2019-02-19 Hemosonics Llc Transparent hemostasis measurement cartridge
US10549275B2 (en) 2017-09-14 2020-02-04 Lucira Health, Inc. Multiplexed biological assay device with electronic readout
CN113777011B (zh) 2017-09-14 2024-11-19 辉瑞公司 具有电子读出的复用生物测定装置
US12042793B2 (en) * 2018-01-18 2024-07-23 Qiagen Gmbh Dry chemistry container
USD878622S1 (en) * 2018-04-07 2020-03-17 Precision Nanosystems Inc. Microfluidic chip
EP3556840A1 (en) * 2018-04-19 2019-10-23 Aglaris Ltd Disposable cartridge cooperating with a platform for a system and installation for monitoring and controlling fluids
WO2020018074A1 (en) 2018-07-17 2020-01-23 Hewlett-Packard Development Company, L.P. Droplet ejectors to provide fluids to droplet ejectors
US20210031188A1 (en) 2018-04-24 2021-02-04 Hewlett-Packard Development Company, L.P. Droplet ejectors to draw fluids through microfluidic networks
US11925932B2 (en) 2018-04-24 2024-03-12 Hewlett-Packard Development Company, L.P. Microfluidic devices
WO2020018073A1 (en) 2018-07-17 2020-01-23 Hewlett-Packard Development Company, L.P. Droplet ejectors with target media
DE102018111822B4 (de) 2018-05-16 2021-10-07 Microfluidic Chipshop Gmbh Fluidisches System zur Aufnahme, Abgabe und Bewegung von Flüssigkeiten, Verfahren zur Verarbeitung von Fluiden in einem fluidischen System
DE102018111834A1 (de) * 2018-05-16 2019-11-21 Mildendo Gesellschaft für mikrofluidische Systeme mbH Mikrofluidische Vorrichtung und Verfahren zur Nutzung derselben zur Trennung, Aufreinigung und Konzentration von Komponenten von fluidischen Medien,
EP3647781B1 (en) 2018-10-29 2024-05-01 EXIAS Medical GmbH Measuring cartridge for measuring a liquid sample
USD910200S1 (en) 2018-12-21 2021-02-09 Lucira Health, Inc. Test tube
JP2023514660A (ja) * 2020-02-27 2023-04-07 ワン バイオメッド ピーティーイー リミテッド 生物学的物質を単離するための装置、システム、及び方法
WO2021219533A1 (en) 2020-04-29 2021-11-04 Boehringer Ingelheim Vetmedica Gmbh Cartridge, system and method for amplification of at least one analyte
USD953561S1 (en) 2020-05-05 2022-05-31 Lucira Health, Inc. Diagnostic device with LED display
USD962470S1 (en) 2020-06-03 2022-08-30 Lucira Health, Inc. Assay device with LCD display
CN113917164A (zh) * 2020-07-10 2022-01-11 深圳市帝迈生物技术有限公司 Poct样本分析仪及试剂盒
WO2022132134A1 (en) * 2020-12-15 2022-06-23 Hewlett-Packard Development Company, L.P. Sample swab including a heating instrument
WO2022139812A1 (en) * 2020-12-22 2022-06-30 Hp Health Solutions Inc. Dual mechanical heating control
EP4267009A4 (en) * 2020-12-23 2024-11-20 NextGen Jane, Inc. SYSTEMS AND METHODS FOR PRESERVING A CERVICOVAGINAL FLUID SAMPLE
WO2022251508A1 (en) * 2021-05-28 2022-12-01 Proof Diagnostics Reaction cartridge
CN115725403B (zh) * 2021-08-27 2025-12-09 广州万孚生物技术股份有限公司 体外分析诊断检测装置及pcr模组
KR102483098B1 (ko) * 2022-04-06 2023-01-02 남택신 검체 삽입형 진단키트
WO2024150241A1 (en) * 2023-01-12 2024-07-18 Sigtuple Technologies Private Limited A cartridge for analysis of a biological fluid
USD1069156S1 (en) 2023-04-10 2025-04-01 Becton, Dickinson And Company Dispensing device

Family Cites Families (217)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE454115B (sv) 1982-09-13 1988-03-28 Wallac Oy Homogenfasanalys med lantanidkelat som merksubstans
SE8301395L (sv) 1983-03-15 1984-09-16 Wallac Oy Kelatiserande foreningar med funktionella grupper vilka tillater kovalent koppling till bio-organiska molekyler
US4680275A (en) 1985-02-11 1987-07-14 Becton, Dickinson And Company Homogeneous fluorescence immunoassay using a light absorbing material
US5144139A (en) 1985-08-05 1992-09-01 Biotrack, Inc. Capillary flow device
WO1987002708A1 (en) 1985-10-24 1987-05-07 Siska Diagnostics, Inc. Lanthanide chelate-tagged nucleic acid probes
AU604684B2 (en) 1986-03-20 1991-01-03 Gen-Probe Incorporated Method for releasing RNA and DNA from cells
WO1988000767A1 (fr) 1986-06-09 1988-01-28 Kabushiki Kaisha Komatsu Seisakusho Laser multi-mode a bande etroite
US4729875A (en) * 1986-06-26 1988-03-08 Allelix Inc. Device for performing immunochemical assays
SE454781B (sv) 1986-10-17 1988-05-30 Wallac Oy Hybridiseringsforfarande for detektion av polynukleotidsekvens
US4923819A (en) 1987-03-27 1990-05-08 Chimerix Corporation Time-resolved fluorescence immunoassay
US4855930A (en) 1987-03-27 1989-08-08 Chimerix Corporation Method and appartatus for improved time-resolved fluorescence spectroscopy
WO1988007670A2 (en) 1987-03-27 1988-10-06 Chimerix Corporation Time-resolved fluorescence apparatus and immunoassay
SE8703682L (sv) 1987-09-24 1989-03-25 Wallac Oy Homogen bestaemningsmetod som utnyttjar affinitetsreaktioner
AU2714988A (en) 1987-10-23 1989-06-01 Siska Diagnostics, Inc. Lanthanide chelate-tagged nucleic acid probes
GB8728639D0 (en) 1987-12-08 1988-01-13 Scient Generics Ltd Device for analytical determinations
US5162237A (en) 1988-04-11 1992-11-10 Miles Inc. Reaction cassette for preforming sequential analytical assays by noncentrifugal and noncapillary manipulations
SE8801702D0 (sv) 1988-05-05 1988-05-05 Pharmacia Ab Sett vid bestemning av enzymatisk aktivitet
SE8802575D0 (sv) 1988-07-08 1988-07-08 Wallac Oy Terpyridine derivatives
SE8802573D0 (sv) 1988-07-08 1988-07-08 Wallac Oy Multi-label time-resolved fluorescence analysis of nucleic acid sequences using lanthanide chelates
US5096669A (en) 1988-09-15 1992-03-17 I-Stat Corporation Disposable sensing device for real time fluid analysis
US5061076A (en) 1989-01-31 1991-10-29 Enzo Diagnostics, Inc. Time-resolved fluorometer
US5219526A (en) 1990-04-27 1993-06-15 Pb Diagnostic Systems Inc. Assay cartridge
RU1778693C (ru) * 1990-09-12 1992-11-30 Конструкторское Проектно-Технологическое Бюро Росплемобъединения Устройство дл внесени жидких компонентов в лунки пластины
AU653012B2 (en) 1991-02-14 1994-09-15 Microscan, Inc. Novel lanthanide chelate-conjugated oligonucleotides
FI88654C (fi) 1991-03-15 1993-06-10 Datacity Center Oy Fluorescenshoejningsmetod
EP0515211A3 (en) 1991-05-23 1993-04-07 Becton Dickinson And Company Apparatus and method for phase resolved fluorescence lifetimes of independent and varying amplitude pulses
WO1993011433A1 (en) 1991-12-05 1993-06-10 Wallac Oy Luminescent lanthanide chelates
CA2082770A1 (en) 1992-02-25 1993-08-26 Denis Banville Engineered protein chelates suitable for fluorescent lanthanide (e.g. terbium (iii)) based time resolved fluorescence assays
DE4210970C2 (de) 1992-04-02 1996-10-17 Markus Dipl Chem Sauer Verfahren zur simultanen optischen qualitativen und quantitativen Erfassung von verschiedenen mit Fluorochromen oder Fluorogenen markierten Molekülen eines Gemisches mittels Laserspektroskopie
US5223219A (en) 1992-04-10 1993-06-29 Biotrack, Inc. Analytical cartridge and system for detecting analytes in liquid samples
US5397539A (en) 1992-04-23 1995-03-14 Toray Industries, Inc. Automatic analyzing apparatus
DE69433688T2 (de) 1993-10-28 2005-04-28 I-Stat Corp. Vorrichtung zur abnahme und einleitung von flüssigkeitsproben
US5464773A (en) 1994-03-14 1995-11-07 Amoco Corporation Cell disrupting apparatus
PT703454E (pt) 1994-09-23 2002-05-31 Unilever Nv Metodos de monitorizacao e dispositivos para utilizacao nessa monitorizacao
US6455287B1 (en) 1995-02-23 2002-09-24 Wyeth Mechanical disruption of bacterial cells for plasmid recovery
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
CN1095693C (zh) 1996-09-16 2002-12-11 阿尔法海利克斯股份公司 存储和发放试剂用的药筒和方法
US5744096A (en) 1997-02-21 1998-04-28 Cholestech Corporation Automated immunoassay cassette
US6143496A (en) * 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
WO1998050147A1 (en) 1997-05-09 1998-11-12 The Regents Of The University Of California Peltier-assisted microfabricated reaction chambers for thermal cycling
US5961925A (en) * 1997-09-22 1999-10-05 Bristol-Myers Squibb Company Apparatus for synthesis of multiple organic compounds with pinch valve block
FR2768743B1 (fr) 1997-09-23 2001-09-14 Bio Merieux Procede de lyse de micro-organisme
US5971941A (en) 1997-12-04 1999-10-26 Hewlett-Packard Company Integrated system and method for sampling blood and analysis
US6036924A (en) 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
US6394952B1 (en) 1998-02-03 2002-05-28 Adeza Biomedical Corporation Point of care diagnostic systems
US6267722B1 (en) 1998-02-03 2001-07-31 Adeza Biomedical Corporation Point of care diagnostic systems
US9066695B2 (en) * 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
FR2781500B1 (fr) 1998-07-23 2000-09-08 Bio Merieux Dispositif perfectionne et procede de lyse de micro-organismes
FR2783321B1 (fr) 1998-09-11 2000-11-24 Biotrol Diagnostic Cuvettes de reaction, ensemble de telles cuvettes, appareil de dosage immunologique et procede mettant en oeuvre de tels ensembles de cuvettes
US6431476B1 (en) 1999-12-21 2002-08-13 Cepheid Apparatus and method for rapid ultrasonic disruption of cells or viruses
US6531095B2 (en) 1999-02-11 2003-03-11 Careside, Inc. Cartridge-based analytical instrument with optical detector
US6942771B1 (en) * 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
EP1181529A4 (en) 1999-04-23 2002-07-03 Surromed Inc DISPOSABLE OPTICAL CARTRIDGE WITH WC
US20020106787A1 (en) 1999-04-29 2002-08-08 James Benn Device for repid DNA sample processing with integrated liquid handling, thermocycling, and purification
US20040200909A1 (en) 1999-05-28 2004-10-14 Cepheid Apparatus and method for cell disruption
US6818185B1 (en) 1999-05-28 2004-11-16 Cepheid Cartridge for conducting a chemical reaction
CA2373198C (en) 1999-05-28 2011-10-11 Cepheid Cartridge for conducting a chemical reaction
JP4078073B2 (ja) 1999-05-28 2008-04-23 シーフィード 流体試料分析装置および方法
FR2795476B1 (fr) * 1999-06-22 2001-07-27 Biomerieux Sa Vanne permettant de diriger un fluide dans une carte d'analyse
JP3823053B2 (ja) 1999-08-06 2006-09-20 サーモ エレクトロン コーポレイション−ポイント オブ ケア エンド ラピッド ダイアグノスティックス 完全サンプル処理能力を備える、医療現場用検出自動化装置
KR20020021810A (ko) 1999-08-11 2002-03-22 야마모토 카즈모토 분석용 카트리지 및 송액 제어 장치
DE60011274T2 (de) 1999-09-03 2005-07-07 Roche Diagnostics Corp., Indianapolis Verfahren, reagenz und messkartusche zur bestimmung der gerinnungszeit
EP1080785A1 (en) 1999-09-04 2001-03-07 F. Hoffmann-La Roche Ag System for thermocycling of fluids in cartridges
US6743399B1 (en) 1999-10-08 2004-06-01 Micronics, Inc. Pumpless microfluidics
KR20020065519A (ko) 1999-11-15 2002-08-13 아이-스탯 코오포레이션 유체 샘플 중의 응고물을 분석하기 위한 장치 및 방법
US6403037B1 (en) 2000-02-04 2002-06-11 Cepheid Reaction vessel and temperature control system
MXPA02008290A (es) * 2000-02-23 2004-09-10 Caliper Technologies Inc Sistema de control de presion de multi-reserva-.
EP1263533B1 (en) 2000-03-14 2010-03-03 Micronics, Inc. Microfluidic analysis cartridge
US7553453B2 (en) 2000-06-02 2009-06-30 Honeywell International Inc. Assay implementation in a microfluidic format
FR2812303B1 (fr) 2000-07-27 2002-12-06 Biomerieux Sa Procede de lyse cellulaire de procaryotes ou d'eucaryotes ou de lyse cellulaire simultanee de procaryotes et d'eucaryotes
WO2002015949A2 (en) 2000-08-25 2002-02-28 Genome Therapeutics Corporation Device for identifying the presence of a nucleotide sequence in a dna sample
US8048386B2 (en) 2002-02-25 2011-11-01 Cepheid Fluid processing and control
US6374684B1 (en) 2000-08-25 2002-04-23 Cepheid Fluid control and processing system
FR2813207B1 (fr) 2000-08-28 2002-10-11 Bio Merieux Carte reactionnelle et utilisation d'une telle carte
US6349546B1 (en) 2000-09-06 2002-02-26 Wafermasters Incorporated Liquid gas exchanger
US7232109B2 (en) 2000-11-06 2007-06-19 California Institute Of Technology Electrostatic valves for microfluidic devices
JP4442035B2 (ja) * 2001-01-11 2010-03-31 株式会社島津製作所 マイクロチャンネル型チップ
WO2002064253A2 (en) 2001-02-09 2002-08-22 Microchem Solutions Method and apparatus for sample injection in microfabricated devices
US7223363B2 (en) 2001-03-09 2007-05-29 Biomicro Systems, Inc. Method and system for microfluidic interfacing to arrays
US6942169B2 (en) 2001-06-06 2005-09-13 Integrated Sensing Systems Micromachined lysing device and method for performing cell lysis
FR2826454B1 (fr) 2001-06-26 2003-10-17 Bio Merieux Cartes d'analyse
CA2451985C (en) 2001-07-19 2012-03-13 Infectio Diagnostic (I.D.I.) Inc. Universal method and composition for the rapid lysis of cells for the release of nucleic acids and their detection
US6942836B2 (en) * 2001-10-16 2005-09-13 Applera Corporation System for filling substrate chambers with liquid
US6966880B2 (en) 2001-10-16 2005-11-22 Agilent Technologies, Inc. Universal diagnostic platform
EP1446669A1 (en) * 2001-10-26 2004-08-18 Advion BioSciences, Inc. Method and device for chemical analysis
US6893613B2 (en) 2002-01-25 2005-05-17 Bristol-Myers Squibb Company Parallel chemistry reactor with interchangeable vessel carrying inserts
US7622083B2 (en) 2002-01-28 2009-11-24 Biocal Technology, Inc. Multi-capillary electrophoresis cartridge interface mechanism
US7419821B2 (en) 2002-03-05 2008-09-02 I-Stat Corporation Apparatus and methods for analyte measurement and immunoassay
US7141058B2 (en) 2002-04-19 2006-11-28 Pelikan Technologies, Inc. Method and apparatus for a body fluid sampling device using illumination
JP4625693B2 (ja) 2002-05-08 2011-02-02 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 診療現場診断及び／又は分析用のシステム
US7238519B2 (en) 2002-06-07 2007-07-03 Cholestech Corporation Automated immunoassay cassette, apparatus and method
DE60230966D1 (de) 2002-06-07 2009-03-12 Cholestech Corp Automatisierte Kassette für eine Vorrichtung zur Durchführung von immunoanalytischen Tests und Verfahren zu ihrer Verwendung
CA2489176C (en) 2002-06-11 2013-10-15 Chempaq A/S Lysing reagent, cartridge and automatic electronic cell counter for simultaneous enumeration of different types of white blood cells
EP1385006A3 (en) 2002-07-24 2004-09-01 F. Hoffmann-La Roche Ag System and cartridge for processing a biological sample
US7244961B2 (en) * 2002-08-02 2007-07-17 Silicon Valley Scientific Integrated system with modular microfluidic components
ES2282682T3 (es) * 2002-08-02 2007-10-16 Ge Healthcare (Sv) Corp. Diseño integrado de microchips.
WO2004020590A2 (en) * 2002-08-27 2004-03-11 Vanderbilt University Bioreactors with multiple chambers
US6905585B2 (en) 2002-09-11 2005-06-14 Temple University Of The Commonwealth System Of Higher Education Automated system for high-throughput electrophoretic separations
TW590982B (en) 2002-09-27 2004-06-11 Agnitio Science & Technology I Micro-fluid driving device
AU2003299541A1 (en) 2002-10-02 2004-05-25 California Institute Of Technology Microfluidic nucleic acid analysis
US7319021B2 (en) 2002-11-01 2008-01-15 Promega Corporation Cell lysis composition, methods of use, apparatus and kit
US7842234B2 (en) 2002-12-02 2010-11-30 Epocal Inc. Diagnostic devices incorporating fluidics and methods of manufacture
US7238520B2 (en) 2002-12-04 2007-07-03 Smiths Detection Inc. PCR sample preparation holder and method
EP1583950B1 (en) * 2002-12-26 2017-04-05 Meso Scale Technologies, LLC. Assay cartridges and methods of using the same
US20040176705A1 (en) 2003-03-04 2004-09-09 Stevens Timothy A. Cartridge having an integrated collection element for point of care system
DE10315074A1 (de) 2003-04-02 2004-10-14 Clondiag Chip Technologies Gmbh Vorrichtung zur Vervielfältigung und zum Nachweis von Nukleinsäuren
US20050019757A1 (en) 2003-06-12 2005-01-27 Stolarchuk Danylo J. Contaminant detection apparatus
US7604592B2 (en) 2003-06-13 2009-10-20 Pelikan Technologies, Inc. Method and apparatus for a point of care device
US8409528B2 (en) 2003-06-19 2013-04-02 Abbott Laboratories Apparatus and method for handling fluids for analysis
EP3718635A1 (en) * 2003-07-31 2020-10-07 Handylab, Inc. Processing particle-containing samples
US7413712B2 (en) 2003-08-11 2008-08-19 California Institute Of Technology Microfluidic rotary flow reactor matrix
JP4146780B2 (ja) 2003-10-17 2008-09-10 株式会社日立ハイテクノロジーズ 試薬カセット及びそれを用いる自動分析装置
US7601300B2 (en) 2003-10-28 2009-10-13 BIOMéRIEUX, INC. Compact, integrated system for processing test samples
RU2265194C2 (ru) * 2003-11-11 2005-11-27 ФГУП "Производственное объединение "Маяк" Транспортирующее устройство
EP1541991A1 (en) 2003-12-12 2005-06-15 STMicroelectronics S.r.l. Integrated semiconductor chemical microreactor for real-time monitoring of biological reactions
EP2187201B1 (en) 2003-12-16 2012-02-15 Dynabyte Informationssysteme GmbH Cartridge device for blood analysis
JP2005180983A (ja) 2003-12-17 2005-07-07 Hitachi High-Technologies Corp 化学分析装置および化学分析用構造体
DE10360786B4 (de) 2003-12-23 2005-12-22 Roche Diagnostics Gmbh Analysehandgerät
WO2005094981A1 (en) 2004-03-29 2005-10-13 Agilent Technologies, Inc. Cyclic pcr system
CA2562517A1 (en) 2004-04-16 2005-10-27 Spartan Bioscience Inc. System for rapid nucleic acid amplification and detection
DE102004021822B3 (de) 2004-04-30 2005-11-17 Siemens Ag Verfahren und Anordnung zur DNA-Amplifikation mittels PCR unter Einsatz von Trockenreagenzien
US9101302B2 (en) 2004-05-03 2015-08-11 Abbott Diabetes Care Inc. Analyte test device
US7887750B2 (en) 2004-05-05 2011-02-15 Bayer Healthcare Llc Analytical systems, devices, and cartridges therefor
WO2005118144A1 (en) 2004-06-04 2005-12-15 Abacus Diagnostica Oy Temperature control of reaction vessel, system with reaction vessel, software product for system and use of system
US7785535B2 (en) 2004-06-07 2010-08-31 Iquum, Inc. Sample multiprocessing
WO2006005347A1 (en) 2004-07-13 2006-01-19 Radiometer Medical Aps A container comprising a reference gas, a set of reference fluids, a cassette comprising the reference fluids, and an apparatus comprising the reference fluids
WO2006018044A1 (en) * 2004-08-18 2006-02-23 Agilent Technologies, Inc. Microfluidic assembly with coupled microfluidic devices
JP4742544B2 (ja) 2004-09-08 2011-08-10 凸版印刷株式会社 遺伝子チェック装置及び方法
EP1650297B1 (en) 2004-10-19 2011-04-13 Samsung Electronics Co., Ltd. Method and apparatus for the rapid disruption of cells or viruses using micro magnetic beads and laser
GB2433993B (en) 2004-10-19 2010-04-28 Wallac Oy Single molecule TR-FRET probe
JP2008527312A (ja) 2004-12-31 2008-07-24 メムズフロウ エイピーエス たとえば細胞溶解のための脈動圧力波の生成
DE102005013685A1 (de) 2005-03-18 2006-09-28 Roche Diagnostics Gmbh Bandmagazin für ein Handgerät zur Untersuchung einer Körperflüssigkeit, sowie Handgerät
DE102005015005A1 (de) 2005-04-01 2006-10-05 Qiagen Gmbh Verfahren zur Behandlung einer Biomoleküle enthaltenden Probe
DE212006000036U1 (de) 2005-04-30 2008-02-21 Oakville Hong Kong Co., Ltd. Vorrichtungen zum Probensammeln und zur Analyse
WO2006122312A2 (en) 2005-05-11 2006-11-16 The Trustees Of The University Of Pennsylvania Methods of testing using a microfluidic cassette
US8206974B2 (en) * 2005-05-19 2012-06-26 Netbio, Inc. Ruggedized apparatus for analysis of nucleic acid and proteins
DK1883474T3 (da) 2005-05-25 2021-06-21 Boehringer Ingelheim Vetmedica Gmbh System til integreret og automatiseret dna- eller proteinanalyse og fremgangsmåde til at drive et sådan system
CN101253401B (zh) 2005-07-01 2013-01-02 霍尼韦尔国际公司 带三维流体动力学集中的模制标本盒
JP2007021351A (ja) 2005-07-15 2007-02-01 Yokogawa Electric Corp 化学反応用カートリッジおよび化学反応処理システム
US20070031914A1 (en) 2005-08-05 2007-02-08 Wei Zhu Devices for analyte assays and methods of use
AU2006283177B2 (en) 2005-08-23 2011-11-17 University Of Virginia Patent Foundation Passive components for micro-fluidic flow profile shaping and related method thereof
US20070053800A1 (en) 2005-09-02 2007-03-08 Applera Corporation Fluid processing device comprising sample transfer feature
WO2007047336A2 (en) 2005-10-12 2007-04-26 University Of Virginia Patent Foundation Integrated microfluidic analysis systems
US7754148B2 (en) * 2006-12-27 2010-07-13 Progentech Limited Instrument for cassette for sample preparation
DE102005054924B4 (de) 2005-11-17 2012-06-14 Siemens Ag Vorrichtung und Verfahren zum Extrahieren einer Abstrichprobe
EP1951860A4 (en) 2005-11-21 2012-06-06 Life Technologies Corp PORTABLE PREPARATION, ANALYSIS AND DETECTION APPARATUS FOR THE TREATMENT OF NUCLEIC ACIDS
JP2009521684A (ja) 2005-12-22 2009-06-04 ハネウェル・インターナショナル・インコーポレーテッド 携帯用サンプル分析装置のカートリッジ
JP5175213B2 (ja) * 2005-12-22 2013-04-03 ハネウェル・インターナショナル・インコーポレーテッド 携帯用サンプル分析システム
CA2634735A1 (en) 2005-12-29 2007-07-12 I-Stat Corporation Molecular diagnostics amplification system and methods
US20070152683A1 (en) 2005-12-30 2007-07-05 Karl Werner Electronic device for analysis of a body fluid
US7888130B2 (en) * 2006-01-03 2011-02-15 Dräger Safety AG & Co. KGaA Test cassette for fluid analyses
KR100790880B1 (ko) 2006-07-05 2008-01-02 삼성전자주식회사 자성 비드가 결합되어 있는 소수성 다공성 중합체가 벽면에결합되어 있는 마이크로채널 또는 마이크로챔버를포함하는 미세유동장치 및 그를 이용하는 방법
EP1878496A1 (en) 2006-07-14 2008-01-16 Roche Diagnostics GmbH Apparatus for performing nucleic acid analysis
US7888107B2 (en) 2006-07-24 2011-02-15 Nanosphere, Inc. System using self-contained processing module for detecting nucleic acids
US8807164B2 (en) 2006-08-30 2014-08-19 Semba Biosciences, Inc. Valve module and methods for simulated moving bed chromatography
WO2008030433A2 (en) 2006-09-06 2008-03-13 Canon U.S. Life Sciences, Inc. Chip and cartridge design configuration for performing micro-fluidic assays
GB0618966D0 (en) * 2006-09-26 2006-11-08 Iti Scotland Ltd Cartridge system
GB0619008D0 (en) 2006-09-27 2006-11-08 Akubio Ltd Cartridge for a fluid sample analyser
KR20080029233A (ko) 2006-09-28 2008-04-03 삼성전자주식회사 핵산 증폭 및 혼성화를 단일 고체 지지체에서 수행하는방법 및 장치
US8765076B2 (en) 2006-11-14 2014-07-01 Handylab, Inc. Microfluidic valve and method of making same
WO2008060604A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8895295B2 (en) 2006-11-15 2014-11-25 Biofire Diagnostics, Llc High density self-contained biological analysis
GB2446204A (en) * 2007-01-12 2008-08-06 Univ Brunel A Microfluidic device
WO2008101196A1 (en) 2007-02-15 2008-08-21 Osmetech Molecular Diagnostics Fluidics devices
CA2680558A1 (en) 2007-03-13 2008-09-18 The Governors Of The University Of Alberta Clinical sample preparation on a microfluidic platform
US8702976B2 (en) 2007-04-18 2014-04-22 Ondavia, Inc. Hand-held microfluidic testing device
EP2015067A1 (de) 2007-06-15 2009-01-14 Roche Diagnostics GmbH System zur Messung einer Analytkonzentration einer Körperflüssigkeitsprobe
CA2754884C (en) * 2007-06-21 2013-04-30 Gen-Probe Incorporated Methods of concentrating an analyte
GB0715171D0 (en) 2007-08-03 2007-09-12 Enigma Diagnostics Ltd Sample processor
WO2009019452A1 (en) 2007-08-03 2009-02-12 Enigma Diagnostics Limited Reaction vessel
US8658110B2 (en) * 2007-08-13 2014-02-25 Hewlett-Packard Development Company, L.P. Fluid delivery system
EP2030567A1 (de) 2007-08-31 2009-03-04 Roche Diagnostics GmbH Analysegerät zur Bestimmung eines Analyten in einer Körperflüssigkeit, Magazin für ein Analysegerät und Verfahren zur Erzeugung einer Wunde und zum Untersuchen einer austretenden Körperflüssigkeit
WO2009027935A2 (en) 2007-08-31 2009-03-05 Koninklijke Philips Electronics N. V. Biochemical sensor cartridge
WO2009038628A2 (en) 2007-09-19 2009-03-26 Claros Diagnostics, Inc. Liquid containment for integrated assays
GB0720264D0 (en) 2007-10-17 2007-11-28 Smiths Detection Watford Ltd Sample preparation devices and analyzers
US20090104076A1 (en) 2007-10-19 2009-04-23 Los Alamos National Security Llc Sample preparation cartridge and system
EP2056114A1 (en) 2007-10-29 2009-05-06 Koninklijke Philips Electronics N.V. Automatic detection of infectious diseases
EP2077336A1 (en) 2007-12-19 2009-07-08 Koninklijke Philips Electronics N.V. Device and method for parallel quantitative analysis of multiple nucleic acids
ATE489636T1 (de) 2008-01-07 2010-12-15 Hoffmann La Roche Reagenzienkassette
US20090215050A1 (en) 2008-02-22 2009-08-27 Robert Delmar Jenison Systems and methods for point-of-care amplification and detection of polynucleotides
US20090286692A1 (en) 2008-04-15 2009-11-19 Wainwright Norman R Cartridge and Method for Sample Analysis
US8961902B2 (en) * 2008-04-23 2015-02-24 Bioscale, Inc. Method and apparatus for analyte processing
WO2009131677A1 (en) 2008-04-25 2009-10-29 Claros Diagnostics, Inc. Flow control in microfluidic systems
EP2265960A2 (en) 2008-04-25 2010-12-29 Plexigen, Inc. Biochips and related automated analyzers and methods
US8895240B2 (en) 2008-05-19 2014-11-25 E I Du Pont De Nemours And Company Method, kit and system for collecting and processing samples for DNA and RNA detection
WO2009149115A1 (en) 2008-06-04 2009-12-10 Vectrant Technologies Inc. Cartridge for conducting biochemical assays
EP2304445B1 (en) 2008-07-09 2020-06-10 Micropoint Bioscience Inc Analytical cartridge with fluid flow control
EP2143491A1 (en) * 2008-07-10 2010-01-13 Carpegen GmbH Device for analysing a chemical or biological sample
US8021873B2 (en) * 2008-07-16 2011-09-20 Boston Microfluidics Portable, point-of-care, user-initiated fluidic assay methods and systems
US8133451B2 (en) 2008-08-28 2012-03-13 Microfluidic Systems, Inc. Sample preparation apparatus
US8201765B2 (en) 2008-09-08 2012-06-19 California Institute Of Technology Mechanical lysis arrangements and methods
US8216529B2 (en) 2008-09-15 2012-07-10 Abbott Point Of Care Inc. Fluid-containing pouches with reduced gas exchange and methods for making same
GB2464721C (en) 2008-10-23 2013-08-14 Biosurfit Sa Jet deflection device
US7993583B2 (en) 2008-10-29 2011-08-09 Lawrence Livermore National Security, Llc Passive microfluidic array card and reader
EP2187210A1 (en) 2008-11-14 2010-05-19 Koninklijke Philips Electronics N.V. Measurement device for body fluid analysis
EP2191900B1 (en) 2008-11-28 2016-03-30 F. Hoffmann-La Roche AG System and method for nucleic acids containing fluid processing
ES2643134T3 (es) 2008-11-28 2017-11-21 F. Hoffmann-La Roche Ag Sistema y método para el procesamiento de muestras líquidas
WO2010064160A1 (en) 2008-12-05 2010-06-10 Biocartis S.A. Thermal cycling system comprising transport heater
KR20110113610A (ko) 2008-12-05 2011-10-17 나노아이브이디, 인크. 현장진단 분석기를 위한 미세유체 기반의 랩온어 테스트 카드
FR2939445B1 (fr) 2008-12-10 2013-05-03 Biomerieux Sa Systeme automatise de lyse de microorganismes presents dans un echantillon, d'extraction et de purification des acides nucleiques desdits microorganismes aux fins d'analyse.
WO2010080115A2 (en) 2008-12-18 2010-07-15 Claros Diagnostics, Inc. Improved reagent storage in microfluidic systems and related articles and methods
KR101656846B1 (ko) 2008-12-23 2016-09-12 미카티스 엔브이 생물학적 분석들을 수행하기 위한 분석 장치 및 방법
GB2466644B (en) 2008-12-30 2011-05-11 Biosurfit Sa Liquid handling
ES2695039T3 (es) 2009-02-02 2018-12-28 Opko Diagnostics, Llc Estructuras para controlar la interacción de luz con dispositivos microfluídicos
WO2010118427A1 (en) * 2009-04-10 2010-10-14 Canon U.S. Life Sciences, Inc. Fluid interface cartridge for a microfluidic chip
CA2662546A1 (en) 2009-04-15 2010-10-15 Spartan Bioscience Inc. Tube for dna reactions
EP3357579A1 (en) * 2009-04-15 2018-08-08 Biocartis NV Cartridge for optical analysis by a bioanalytical reaction device
JP2012529268A (ja) 2009-06-05 2012-11-22 インテジェンクス，インコーポレイテッド ユニバーサルサンプル調製システムおよび統合解析システムの使用方法
JP5711227B2 (ja) 2009-06-26 2015-04-30 クレアモント バイオソリューソンズ エルエルシー 試料破壊用ビーズを利用した生物検体の捕捉および溶出
EP3078422A1 (en) * 2009-10-21 2016-10-12 Biocartis NV Manifold for a fluidic cartridge
US9132422B2 (en) * 2010-06-03 2015-09-15 Spinomix, S.A. Fluidic interfacing system and assembly
KR20130029128A (ko) * 2010-07-23 2013-03-21 베크만 컬터, 인코포레이티드 실시간 pcr용 용기
EP2747859A4 (en) * 2011-08-22 2015-04-22 Waters Technologies Corp MICROFLUIDIC DEVICE WITH INTERFACE FOR DBS CARD
KR102481494B1 (ko) * 2011-12-22 2022-12-26 아이씨유 메디칼 인코퍼레이티드 의료용 유체 전달 시스템, 유체 전달 방법, 전자 의료용 유체 전달 시스템, 및 전자 의료용 유체 전달 시스템 이용 방법
WO2013123035A1 (en) * 2012-02-13 2013-08-22 Molecular Systems Corporation System and method for processing and detecting nucleic acids
DK2825309T3 (da) 2012-03-16 2018-07-30 Stat Diagnostica & Innovation Sl Prøvepatron med integreret overførselsmodul
US9081001B2 (en) * 2012-05-15 2015-07-14 Wellstat Diagnostics, Llc Diagnostic systems and instruments

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