DK2830595T3 - Ioniserbare kationiske lipider - Google Patents
Ioniserbare kationiske lipider Download PDFInfo
- Publication number
- DK2830595T3 DK2830595T3 DK13768446T DK13768446T DK2830595T3 DK 2830595 T3 DK2830595 T3 DK 2830595T3 DK 13768446 T DK13768446 T DK 13768446T DK 13768446 T DK13768446 T DK 13768446T DK 2830595 T3 DK2830595 T3 DK 2830595T3
- Authority
- DK
- Denmark
- Prior art keywords
- cationic lipids
- ionizable cationic
- ionizable
- lipids
- cationic
- Prior art date
Links
- 150000002632 lipids Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/20—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
- C07C211/21—Monoamines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01023—Beta-galactosidase (3.2.1.23), i.e. exo-(1-->4)-beta-D-galactanase
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dispersion Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261617468P | 2012-03-29 | 2012-03-29 | |
| PCT/US2013/034602 WO2013149140A1 (en) | 2012-03-29 | 2013-03-29 | Ionizable cationic lipids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2830595T3 true DK2830595T3 (da) | 2019-12-02 |
Family
ID=49261289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13768446T DK2830595T3 (da) | 2012-03-29 | 2013-03-29 | Ioniserbare kationiske lipider |
Country Status (11)
| Country | Link |
|---|---|
| US (9) | US9546128B2 (da) |
| EP (2) | EP2830595B1 (da) |
| JP (3) | JP6283655B2 (da) |
| CN (1) | CN104334161A (da) |
| AU (2) | AU2013237873B2 (da) |
| BR (1) | BR112014024131A2 (da) |
| CA (1) | CA2868034C (da) |
| DK (1) | DK2830595T3 (da) |
| ES (2) | ES2762873T3 (da) |
| HK (1) | HK1206645A1 (da) |
| WO (1) | WO2013149140A1 (da) |
Families Citing this family (134)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3338765T3 (pl) | 2009-12-01 | 2019-06-28 | Translate Bio, Inc. | Pochodna steroidowa dla dostarczania mrna w ludzkich chorobach genetycznych |
| US8853377B2 (en) * | 2010-11-30 | 2014-10-07 | Shire Human Genetic Therapies, Inc. | mRNA for use in treatment of human genetic diseases |
| PT2717893T (pt) | 2011-06-08 | 2019-08-20 | Translate Bio Inc | Composições de nanopartículas lipídicas e métodos para transferência de arnm |
| DK3336082T3 (da) | 2011-06-08 | 2020-04-27 | Translate Bio Inc | Spaltelige lipider |
| MX350957B (es) | 2011-11-23 | 2017-09-27 | Medimmune Llc | Moleculas de union especificas para her3 y usos de las mismas. |
| ES2762873T3 (es) | 2012-03-29 | 2020-05-26 | Translate Bio Inc | Lípidos catiónicos ionizables |
| WO2013185069A1 (en) * | 2012-06-08 | 2013-12-12 | Shire Human Genetic Therapies, Inc. | Pulmonary delivery of mrna to non-lung target cells |
| WO2013185067A1 (en) | 2012-06-08 | 2013-12-12 | Shire Human Genetic Therapies, Inc. | Nuclease resistant polynucleotides and uses thereof |
| ES2981185T3 (es) | 2013-03-14 | 2024-10-07 | Translate Bio Inc | Métodos para la purificación de ARN mensajero |
| US10258698B2 (en) | 2013-03-14 | 2019-04-16 | Modernatx, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| EP2968586B1 (en) | 2013-03-14 | 2018-07-25 | Translate Bio, Inc. | Cftr mrna compositions and related methods and uses |
| HUE040425T2 (hu) | 2013-04-30 | 2019-03-28 | Delta Fly Pharma Inc | Liposzóma topikális adagoláshoz és alkalmazása |
| WO2015011633A1 (en) * | 2013-07-23 | 2015-01-29 | Protiva Biotherapeutics, Inc. | Compositions and methods for delivering messenger rna |
| WO2015048008A2 (en) | 2013-09-24 | 2015-04-02 | Medimmune, Llc | Binding molecules specific for her3 and uses thereof |
| US11224642B2 (en) * | 2013-10-22 | 2022-01-18 | Translate Bio, Inc. | MRNA therapy for argininosuccinate synthetase deficiency |
| CA2928040A1 (en) | 2013-10-22 | 2015-04-30 | Shire Human Genetic Therapies, Inc. | Cns delivery of mrna and uses thereof |
| MX2016005239A (es) | 2013-10-22 | 2016-08-12 | Shire Human Genetic Therapies | Tratamiento con acido ribonucleico mensajero para la fenilcetonuria. |
| PT3122878T (pt) * | 2014-03-24 | 2019-02-01 | Translate Bio Inc | Terapia de arnm para o tratamento de doenças oculares |
| US10745490B2 (en) | 2014-04-11 | 2020-08-18 | Celldex Therapeutics, Inc. | Anti-ErbB antibodies and methods of use thereof |
| JP6571679B2 (ja) | 2014-04-25 | 2019-09-04 | トランスレイト バイオ， インコーポレイテッド | メッセンジャーｒｎａの精製方法 |
| US10022455B2 (en) | 2014-05-30 | 2018-07-17 | Translate Bio, Inc. | Biodegradable lipids for delivery of nucleic acids |
| CA2952824C (en) | 2014-06-24 | 2023-02-21 | Shire Human Genetic Therapies, Inc. | Stereochemically enriched compositions for delivery of nucleic acids |
| WO2016068160A1 (ja) * | 2014-10-30 | 2016-05-06 | Ｄｅｌｔａ－Ｆｌｙ Ｐｈａｒｍａ株式会社 | 局所投与用リポプレックスの新規製造方法及び該リポプレックスを使用する抗腫瘍剤 |
| AU2015338923B2 (en) | 2014-11-02 | 2021-10-21 | Arcturus Therapeutics, Inc. | Messenger UNA molecules and uses thereof |
| WO2016079197A1 (en) * | 2014-11-18 | 2016-05-26 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Delivery enhancers for conjugated sirna and lipid nanoparticles |
| MA56412A (fr) * | 2014-12-05 | 2022-05-04 | Translate Bio Inc | Thérapie par l'arn messager pour le traitement des maladies articulaires |
| GB201508025D0 (en) | 2015-05-11 | 2015-06-24 | Ucl Business Plc | Fabry disease gene therapy |
| EP3896164A1 (en) | 2016-05-18 | 2021-10-20 | ModernaTX, Inc. | Polynucleotides encoding alpha-galactosidase a for the treatment of fabry disease |
| AU2017286980B2 (en) | 2016-06-30 | 2023-10-26 | Arbutus Biopharma Corporation | Compositions and methods for delivering messenger RNA |
| CA3054321A1 (en) | 2017-02-27 | 2018-08-30 | Translate Bio, Inc. | Methods for purification of messenger rna |
| AU2018224326B2 (en) | 2017-02-27 | 2024-01-04 | Translate Bio, Inc. | Novel codon-optimized CFTR mRNA |
| ES2925083T3 (es) | 2017-02-27 | 2022-10-13 | Translate Bio Inc | Métodos de purificación de ARN mensajero |
| MX2019013752A (es) | 2017-05-16 | 2020-07-20 | Translate Bio Inc | Tratamiento de la fibrosis quística mediante el suministro de arnm que codifica cftr optimizado en codones. |
| EP3641834B1 (en) | 2017-06-19 | 2023-10-04 | Translate Bio, Inc. | Messenger rna therapy for the treatment of friedreich's ataxia |
| EP3662913A4 (en) | 2017-08-04 | 2021-06-30 | Kyowa Kirin Co., Ltd. | Nucleic-acid-containing lipid nanoparticles |
| EP3714048B1 (en) | 2017-11-22 | 2025-04-09 | ModernaTX, Inc. | Polynucleotides encoding ornithine transcarbamylase for the treatment of urea cycle disorders |
| US11167043B2 (en) | 2017-12-20 | 2021-11-09 | Translate Bio, Inc. | Composition and methods for treatment of ornithine transcarbamylase deficiency |
| WO2019152802A1 (en) | 2018-02-02 | 2019-08-08 | Translate Bio, Inc. | Cationic polymers |
| AU2019271132B2 (en) * | 2018-05-15 | 2026-02-05 | Translate Bio, Inc. | Subcutaneous delivery of messenger RNA |
| US11964051B2 (en) * | 2018-05-16 | 2024-04-23 | Translate Bio, Inc. | Ribose cationic lipids |
| AU2019275068B2 (en) | 2018-05-24 | 2024-09-26 | Translate Bio, Inc. | Thioester cationic lipids |
| AU2019277355A1 (en) | 2018-05-30 | 2020-12-17 | Translate Bio, Inc. | Phosphoester cationic lipids |
| AU2019277361B2 (en) | 2018-05-30 | 2025-04-24 | Translate Bio, Inc. | Messenger RNA vaccines and uses thereof |
| WO2019232095A1 (en) | 2018-05-30 | 2019-12-05 | Translate Bio, Inc. | Vitamin cationic lipids |
| US11547666B2 (en) | 2018-05-30 | 2023-01-10 | Translate Bio, Inc. | Cationic lipids comprising a steroidal moiety |
| US12357580B2 (en) | 2018-06-19 | 2025-07-15 | The Board Of Regents Of The University Of Texas System | Lipid nanoparticle compositions for delivery of mRNA and long nucleic acids |
| EP3810148A4 (en) * | 2018-06-19 | 2022-06-08 | The Board Of Regents Of The University Of Texas System | LIPIDAN NOPARTICLE COMPOSITIONS FOR DELIVERY OF MRNA AND LONG NUCLEIC ACIDS |
| KR20210056331A (ko) | 2018-07-23 | 2021-05-18 | 트랜슬레이트 바이오 인코포레이티드 | 전령 rna의 건조 분말 제형 |
| CN118421617A (zh) | 2018-08-24 | 2024-08-02 | 川斯勒佰尔公司 | 用于纯化信使rna的方法 |
| KR20210091120A (ko) | 2018-08-29 | 2021-07-21 | 트랜슬레이트 바이오 인코포레이티드 | Mrna-로딩된 지질 나노입자를 제조하는 개선된 공정 |
| GB2592504B (en) * | 2018-09-04 | 2023-02-15 | Univ Texas | Compositions and methods for organ specific delivery of nucleic acids |
| EP3846822A4 (en) | 2018-09-04 | 2022-07-06 | The Board Of Regents Of The University Of Texas System | COMPOSITIONS AND METHODS FOR ORGAN-SPECIFIC DELIVERY OF NUCLEIC ACIDS |
| KR102871791B1 (ko) | 2018-09-10 | 2025-10-15 | 미라티 테라퓨틱스, 인크. | 병용 요법 |
| US12564645B2 (en) | 2018-09-14 | 2026-03-03 | Translate Bio, Inc. | Methods for treatment of methylmalonic acidemia |
| CN113166783B (zh) | 2018-10-09 | 2024-10-11 | 不列颠哥伦比亚大学 | 包含无有机溶剂和去污剂的转染活性囊泡的组合物和系统以及与之相关的方法 |
| KR20210090634A (ko) | 2018-10-19 | 2021-07-20 | 트랜슬레이트 바이오 인코포레이티드 | 전령 rna의 무펌프 캡슐화 |
| EP3877538A1 (en) | 2018-11-08 | 2021-09-15 | Translate Bio, Inc. | Methods and compositions for messenger rna purification |
| EP3876914A2 (en) | 2018-11-09 | 2021-09-15 | Translate Bio, Inc. | Messenger rna therapy for treatment of ocular diseases |
| WO2020097376A1 (en) | 2018-11-09 | 2020-05-14 | Translate Bio, Inc. | Multi-peg lipid compounds |
| KR102860605B1 (ko) | 2018-11-09 | 2025-09-15 | 트랜슬레이트 바이오 인코포레이티드 | 에스테르, 티오에스테르, 이황화물, 및 무수물 모이어티가 삽입된 2,5-디옥소피페라진 |
| AU2019374871B2 (en) | 2018-11-09 | 2025-09-11 | Translate Bio, Inc. | PEG lipidoid compounds |
| AU2019378763B2 (en) | 2018-11-12 | 2025-06-26 | Translate Bio, Inc. | Methods for inducing immune tolerance |
| EP3883917B1 (en) | 2018-11-21 | 2024-01-24 | Translate Bio, Inc. | Cationic lipid compounds and compositions thereof for use in the delivery of messenger rna |
| EP3883592A1 (en) | 2018-11-21 | 2021-09-29 | Translate Bio, Inc. | Treatment of cystic fibrosis by delivery of nebulized mrna encoding cftr |
| CN113412273B (zh) | 2019-01-07 | 2025-08-22 | 川斯勒佰尔公司 | 用于治疗原发性纤毛运动障碍的组合物和方法 |
| US20220177423A1 (en) | 2019-04-18 | 2022-06-09 | Translate Bio, Inc. | Cystine cationic lipids |
| ES2972014T3 (es) | 2019-04-22 | 2024-06-10 | Translate Bio Inc | Lípidos catiónicos de tioéster |
| US12453759B2 (en) | 2019-05-03 | 2025-10-28 | Translate Bio, Inc. | Di-thioester cationic lipids |
| WO2020257611A1 (en) | 2019-06-21 | 2020-12-24 | Translate Bio, Inc. | Cationic lipids comprising an hydroxy moiety |
| AU2020297606B2 (en) | 2019-06-21 | 2026-04-02 | Translate Bio, Inc. | Tricine and citric acid lipids |
| ES2992127T3 (es) | 2019-07-08 | 2024-12-09 | Translate Bio Inc | Nanopartículas lipídicas cargadas de ARNm mejoradas y sus procesos de fabricación |
| WO2021016430A1 (en) | 2019-07-23 | 2021-01-28 | Translate Bio, Inc. | Stable compositions of mrna-loaded lipid nanoparticles and processes of making |
| WO2021055609A1 (en) | 2019-09-20 | 2021-03-25 | Translate Bio, Inc. | Mrna encoding engineered cftr |
| US20210145860A1 (en) | 2019-10-21 | 2021-05-20 | Translate Bio, Inc. | Compositions, methods and uses of messenger rna |
| KR20220142432A (ko) | 2019-12-20 | 2022-10-21 | 트랜슬레이트 바이오 인코포레이티드 | 메신저 rna의 직장 전달 |
| US12053551B2 (en) | 2019-12-20 | 2024-08-06 | Translate Bio, Inc. | Process of preparing mRNA-loaded lipid nanoparticles |
| WO2021142245A1 (en) | 2020-01-10 | 2021-07-15 | Translate Bio, Inc. | Compounds, pharmaceutical compositions and methods for modulating expression of muc5b in lung cells and tissues |
| WO2021173840A1 (en) | 2020-02-25 | 2021-09-02 | Translate Bio, Inc. | Improved processes of preparing mrna-loaded lipid nanoparticles |
| US12605399B2 (en) | 2020-05-07 | 2026-04-21 | Translate Bio, Inc. | Compositions for CFTR MRNA therapy |
| EP4146680A1 (en) | 2020-05-07 | 2023-03-15 | Translate Bio, Inc. | Composition and methods for treatment of primary ciliary dyskinesia |
| WO2021226436A1 (en) | 2020-05-07 | 2021-11-11 | Translate Bio, Inc. | Optimized nucleotide sequences encoding sars-cov-2 antigens |
| US12514932B2 (en) | 2020-05-14 | 2026-01-06 | Translate Bio, Inc. | PEG lipidoid compounds |
| EP4149425A1 (en) | 2020-05-15 | 2023-03-22 | Translate Bio, Inc. | Lipid nanoparticle formulations for mrna delivery |
| US20240307556A1 (en) | 2020-07-02 | 2024-09-19 | Maritime Therapeutics, Inc. | Compositions and methods for reverse gene therapy |
| WO2022076562A1 (en) | 2020-10-06 | 2022-04-14 | Translate Bio, Inc. | Improved process and formulation of lipid nanoparticles |
| CN116568334A (zh) * | 2020-10-12 | 2023-08-08 | 加利福尼亚大学董事会 | 用于将大分子递送至细胞中的内体逃逸结构域 |
| US20220110884A1 (en) | 2020-10-12 | 2022-04-14 | Translate Bio, Inc. | Process of preparing mrna-loaded lipid nanoparticles |
| US20220133631A1 (en) | 2020-10-12 | 2022-05-05 | Translate Bio, Inc. | Process of preparing ice-based lipid nanoparticles |
| KR20230118715A (ko) | 2020-10-14 | 2023-08-11 | 조지 메이슨 리서치 파운데이션 인코포레이티드 | 이온화 가능 지질 및 이의 제조 및 사용 방법 |
| AU2021373892A1 (en) | 2020-11-09 | 2023-07-06 | Translate Bio, Inc. | Improved compositions for delivery of codon-optimized mrna |
| CN116723829A (zh) | 2020-11-25 | 2023-09-08 | 翻译生物公司 | 稳定的液体脂质纳米颗粒配制品 |
| CA3200234A1 (en) | 2020-11-25 | 2022-06-02 | Daryl C. Drummond | Lipid nanoparticles for delivery of nucleic acids, and related methods of use |
| JP2024504614A (ja) | 2021-01-14 | 2024-02-01 | トランスレイト バイオ， インコーポレイテッド | ｍＲＮＡがコードする抗体を送達する方法および組成物 |
| CN117157101A (zh) | 2021-02-08 | 2023-12-01 | 德克萨斯大学系统董事会 | 不饱和的树枝状聚合物组合物、有关的制剂、及其使用方法 |
| WO2022204219A1 (en) | 2021-03-22 | 2022-09-29 | Recode Therapeutics, Inc. | Compositions and methods for targeted delivery to cells |
| KR20230175196A (ko) | 2021-03-23 | 2023-12-29 | 리코드 테라퓨틱스, 인크. | 폴리뉴클레오티드 조성물, 관련된 제제, 및 이의 사용 방법 |
| WO2022204549A1 (en) | 2021-03-25 | 2022-09-29 | Translate Bio, Inc. | Optimized nucleotide sequences encoding the extracellular domain of human ace2 protein or a portion thereof |
| WO2022225918A1 (en) | 2021-04-19 | 2022-10-27 | Translate Bio, Inc. | Improved compositions for delivery of mrna |
| CA3215957A1 (en) * | 2021-04-22 | 2022-10-27 | Vishwesh Ashok PATIL | Tissue-specific nucleic acid delivery by mixed cationic lipid particles |
| JP2024527541A (ja) | 2021-07-01 | 2024-07-25 | トランスレイト バイオ， インコーポレイテッド | Ｍｒｎａの送達のための組成物 |
| MX2024000965A (es) * | 2021-07-27 | 2024-02-09 | Toray Industries | Medicamento para el tratamiento y/o prevencion de cancer. |
| IL309505A (en) | 2021-09-03 | 2024-02-01 | CureVac SE | Novel lipid nanoparticles for delivery of nucleic acids |
| EP4412592A4 (en) * | 2021-10-06 | 2025-11-19 | Seqirus Inc | LIPID NANOPARTICLE COMPRISING A NUCLEIC ACID-BINDING PROTEIN |
| AR127312A1 (es) | 2021-10-08 | 2024-01-10 | Suzhou Abogen Biosciences Co Ltd | Compuestos lipídicos ycomposiciones de nanopartículas lipídicas |
| US20250027108A1 (en) | 2021-10-29 | 2025-01-23 | CureVac SE | Improved circular rna for expressing therapeutic proteins |
| AU2022388747A1 (en) | 2021-11-10 | 2024-06-20 | Translate Bio, Inc. | Composition and methods for treatment of primary ciliary dyskinesia |
| WO2023125184A1 (zh) * | 2021-12-29 | 2023-07-06 | 华南理工大学 | 叔胺类脂质化合物及其应用 |
| US20250099614A1 (en) | 2022-01-28 | 2025-03-27 | CureVac SE | Nucleic acid encoded transcription factor inhibitors |
| EP4529472A1 (en) | 2022-05-23 | 2025-04-02 | Logicbio Therapeutics, Inc. | Gene therapy compositions and methods of use thereof |
| EP4531819A2 (en) | 2022-05-25 | 2025-04-09 | Akagera Medicines, Inc. | Lipid nanoparticles for delivery of nucleic acids and methods of use thereof |
| CA3248209A1 (en) | 2022-05-25 | 2023-11-30 | CureVac SE | Escherichia coli Antigenic Polypeptide-Based Nucleic Acid Vaccine (FIMH) |
| US12297285B2 (en) | 2022-06-24 | 2025-05-13 | Orna Therapeutics, Inc. | Circular RNA encoding chimeric antigen receptors targeting BCMA |
| WO2024006960A1 (en) | 2022-06-29 | 2024-01-04 | Juno Therapeutics, Inc. | Lipid nanoparticles for delivery of nucleic acids |
| WO2024038407A1 (en) * | 2022-08-19 | 2024-02-22 | Seqirus Inc. | Lipid nanoparticle comprising a dna-binding protein |
| WO2024091037A1 (ko) * | 2022-10-27 | 2024-05-02 | 에스티팜 주식회사 | 폐를 표적장기로 하는 생분해성 지질나노입자 약물 전달 제형 및 이의 활용 |
| EP4608442A1 (en) | 2022-10-28 | 2025-09-03 | GlaxoSmithKline Biologicals S.A. | Nucleic acid based vaccine |
| EP4622630A1 (en) | 2022-11-21 | 2025-10-01 | Translate Bio, Inc. | Compositions of dry powder formulations of messenger rna and methods of use thereof |
| EP4630057A1 (en) | 2022-12-08 | 2025-10-15 | Recode Therapeutics, Inc. | Lipid nanoparticle compositions and uses thereof |
| WO2024126809A1 (en) | 2022-12-15 | 2024-06-20 | Sanofi | Mrna encoding influenza virus-like particle |
| EP4637813A1 (en) | 2022-12-20 | 2025-10-29 | Sanofi Pasteur | Rhinovirus mrna vaccine |
| JP2026509258A (ja) | 2023-03-08 | 2026-03-17 | キュアバック エスイー | 核酸送達のための新規な脂質ナノ粒子製剤 |
| MX2025012337A (es) | 2023-04-17 | 2026-02-03 | Sanofi Pasteur Inc | Formulaciones de polvo seco reconstituibles y métodos de uso de las mismas |
| AU2024269222A1 (en) | 2023-05-05 | 2025-10-09 | Orna Therapeutics, Inc. | Circular rna compositions and methods |
| WO2024230934A1 (en) | 2023-05-11 | 2024-11-14 | CureVac SE | Therapeutic nucleic acid for the treatment of ophthalmic diseases |
| US12553042B2 (en) | 2023-12-01 | 2026-02-17 | Recode Therapeutics, Inc. | Method for quantifying an amount of capped messenger RNA |
| US12364773B2 (en) | 2023-12-01 | 2025-07-22 | Recode Therapeutics, Inc. | Lipid nanoparticle compositions and uses thereof |
| WO2025137646A1 (en) | 2023-12-22 | 2025-06-26 | Recode Therapeutics, Inc. | Gene editing methods and compositions for treating cystic fibrosis |
| WO2025147545A1 (en) | 2024-01-03 | 2025-07-10 | Juno Therapeutics, Inc. | Lipid nanoparticles for delivery of nucleic acids and related methods and uses |
| WO2025196065A1 (en) | 2024-03-20 | 2025-09-25 | Sanofi | Novel homocysteine based lipids and their use for delivery of nucleic acids |
| WO2025250751A1 (en) | 2024-05-31 | 2025-12-04 | Orna Therapeutics, Inc. | Circular rna compositions and methods |
| WO2025262460A1 (en) * | 2024-06-21 | 2025-12-26 | BioNTech SE | Lipid compositions for nucleic acid delivery |
| WO2026003582A2 (en) | 2024-06-27 | 2026-01-02 | Axelyf ehf. | Lipids and lipid nanoparticles |
| WO2026008743A1 (en) | 2024-07-02 | 2026-01-08 | Sanofi Pasteur Inc. | Water-soluble polyanionic polymer as adjuvant for carrier-formulated nucleic acid |
| WO2026033123A1 (en) | 2024-08-08 | 2026-02-12 | Sanofi Pasteur Inc. | Lipid nanoparticle formulations for mrna delivery |
Family Cites Families (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7214841A (da) | 1971-11-10 | 1973-05-14 | ||
| JPS5710846B2 (da) * | 1974-03-13 | 1982-03-01 | ||
| JPS5475753A (en) | 1977-11-28 | 1979-06-16 | Shinko Electric Co Ltd | Robot controller for laterally symmetrically operating article on conveyor |
| DE2855505C3 (de) | 1978-12-22 | 1981-11-12 | Ruhrchemie Ag, 4200 Oberhausen | Verfahren zur Herstellung von 2-Methylen-aldehyden |
| JPS584748A (ja) * | 1981-06-30 | 1983-01-11 | Takasago Corp | エナミンまたはイミンの製造方法 |
| JPS6127949A (ja) * | 1984-07-17 | 1986-02-07 | Takasago Corp | 光学活性なエナミンの製造法 |
| US4897355A (en) | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US5223263A (en) | 1988-07-07 | 1993-06-29 | Vical, Inc. | Liponucleotide-containing liposomes |
| US4737323A (en) | 1986-02-13 | 1988-04-12 | Liposome Technology, Inc. | Liposome extrusion method |
| JPS63147019A (ja) | 1986-12-08 | 1988-06-20 | Tomoegumi Iron Works Ltd | 鉄塔下部構造の構築方法 |
| US4920016A (en) | 1986-12-24 | 1990-04-24 | Linear Technology, Inc. | Liposomes with enhanced circulation time |
| DE3728917A1 (de) | 1987-08-29 | 1989-03-09 | Roth Hermann J | Neue lipide mit unsymmetrisch substituierter disulfidbruecke |
| US4946683A (en) | 1987-11-18 | 1990-08-07 | Vestar, Inc. | Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes |
| FR2645866B1 (fr) | 1989-04-17 | 1991-07-05 | Centre Nat Rech Scient | Nouvelles lipopolyamines, leur preparation et leur emploi |
| DE59009670D1 (de) * | 1989-05-18 | 1995-10-26 | Hoffmann La Roche | Phosphorverbindungen. |
| US5194654A (en) | 1989-11-22 | 1993-03-16 | Vical, Inc. | Lipid derivatives of phosphonoacids for liposomal incorporation and method of use |
| JP2759546B2 (ja) * | 1990-05-21 | 1998-05-28 | 高砂香料工業株式会社 | （３ｓ）―３，７―ジメチル―２―メチレン―６―オクテン―１―アール及びその製法並びにこれを含有する香料組成物 |
| US5334761A (en) | 1992-08-28 | 1994-08-02 | Life Technologies, Inc. | Cationic lipids |
| US5844107A (en) * | 1994-03-23 | 1998-12-01 | Case Western Reserve University | Compacted nucleic acids and their delivery to cells |
| US5885613A (en) | 1994-09-30 | 1999-03-23 | The University Of British Columbia | Bilayer stabilizing components and their use in forming programmable fusogenic liposomes |
| US5965434A (en) | 1994-12-29 | 1999-10-12 | Wolff; Jon A. | Amphipathic PH sensitive compounds and delivery systems for delivering biologically active compounds |
| JPH0940598A (ja) * | 1995-07-27 | 1997-02-10 | Mitsui Petrochem Ind Ltd | アルデヒド類の製造方法 |
| US5744335A (en) | 1995-09-19 | 1998-04-28 | Mirus Corporation | Process of transfecting a cell with a polynucleotide mixed with an amphipathic compound and a DNA-binding protein |
| JPH09309857A (ja) * | 1996-05-22 | 1997-12-02 | Mitsui Petrochem Ind Ltd | ４−不飽和アルデヒド類の製造方法 |
| US5677124A (en) | 1996-07-03 | 1997-10-14 | Ambion, Inc. | Ribonuclease resistant viral RNA standards |
| US7662409B2 (en) | 1998-09-25 | 2010-02-16 | Gel-Del Technologies, Inc. | Protein matrix materials, devices and methods of making and using thereof |
| US6379698B1 (en) | 1999-04-06 | 2002-04-30 | Isis Pharmaceuticals, Inc. | Fusogenic lipids and vesicles |
| US7112337B2 (en) * | 1999-04-23 | 2006-09-26 | Alza Corporation | Liposome composition for delivery of nucleic acid |
| AU6105300A (en) | 1999-07-16 | 2001-02-05 | Purdue Research Foundation | Vinyl ether lipids with cleavable hydrophilic headgroups |
| CA2401385C (en) | 2000-02-28 | 2011-05-17 | Gel-Del Technologies, Inc. | Protein matrix materials, devices and methods of making and using thereof |
| TW530521B (en) * | 2000-08-28 | 2003-05-01 | Koninkl Philips Electronics Nv | Circuit device for operating a high-pressure discharge lamp with successive current phases |
| CA2456144A1 (en) * | 2001-08-03 | 2003-02-20 | Zhenhua Yang | A group of novel anti-cancer compounds with specific structure |
| US6776861B2 (en) | 2002-06-04 | 2004-08-17 | E. I. Du Pont De Nemours And Company | Tape composition and process for internally constrained sintering of low temperature co-fired ceramic |
| EP1519714B1 (en) | 2002-06-28 | 2010-10-20 | Protiva Biotherapeutics Inc. | Method and apparatus for producing liposomes |
| AU2004268013B2 (en) | 2003-08-29 | 2011-05-12 | Mayo Foundation For Medical Education And Research | Hydrogel porogens for fabricating biodegradable scaffolds |
| CN1882693B (zh) | 2003-09-15 | 2012-08-15 | 普洛体维生物治疗公司 | 聚乙二醇修饰的脂质化合物及其应用 |
| ATE536418T1 (de) | 2004-06-07 | 2011-12-15 | Protiva Biotherapeutics Inc | Lipidverkapselte interferenz-rna |
| JP4314350B2 (ja) * | 2004-12-15 | 2009-08-12 | 独立行政法人科学技術振興機構 | α，β−ジアミノ酸誘導体の製法 |
| WO2007086883A2 (en) | 2005-02-14 | 2007-08-02 | Sirna Therapeutics, Inc. | Cationic lipids and formulated molecular compositions containing them |
| WO2007051303A1 (en) | 2005-11-02 | 2007-05-10 | Protiva Biotherapeutics, Inc. | MODIFIED siRNA MOLECULES AND USES THEREOF |
| FR2904144A1 (fr) | 2006-07-19 | 2008-01-25 | St Microelectronics Rousset | Procede de fabrication d'un wafer de semi-conducteur comprenant un filtre optique integre |
| JP5119561B2 (ja) | 2007-08-10 | 2013-01-16 | シンフォニアテクノロジー株式会社 | エア浮上搬送装置、エア浮上ユニット、エア浮上搬送方法 |
| KR100807060B1 (ko) * | 2007-08-28 | 2008-02-25 | 고려대학교 산학협력단 | 신규한 양이온성 지질, 그의 제조 방법 및 그를 포함하는전달체 |
| CA2707158A1 (en) * | 2007-11-28 | 2009-06-04 | Revision Therapeutics, Inc. | Modulators of ocular oxidative stress |
| US9381273B2 (en) | 2008-01-31 | 2016-07-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Scaffolds with oxygen carriers, and their use in tissue regeneration |
| NZ588583A (en) | 2008-04-15 | 2012-08-31 | Protiva Biotherapeutics Inc | Novel lipid formulations for nucleic acid delivery |
| US20090263407A1 (en) * | 2008-04-16 | 2009-10-22 | Abbott Laboratories | Cationic Lipids and Uses Thereof |
| JP5777519B2 (ja) * | 2008-10-09 | 2015-09-09 | テクミラ ファーマシューティカルズ コーポレイション | 改良されたアミノ脂質および核酸の送達方法 |
| MX2011003618A (es) | 2008-10-09 | 2011-06-16 | Tufts College | Peliculas de seda modificadas que contienen glicerol. |
| EP4241767B1 (en) | 2008-11-10 | 2024-10-23 | Arbutus Biopharma Corporation | Novel lipids and compositions for the delivery of therapeutics |
| ES2443045T5 (es) | 2009-04-20 | 2021-05-10 | Allergan Inc | Hidrogeles de fibroína de seda y usos de éstos |
| SG176553A1 (en) | 2009-05-05 | 2012-01-30 | Muthiah Manoharan | Lipid compositions |
| TR201811076T4 (tr) | 2009-06-10 | 2018-08-27 | Arbutus Biopharma Corp | Geliştirilmiş lipit formulasyonu. |
| US8283333B2 (en) | 2009-07-01 | 2012-10-09 | Protiva Biotherapeutics, Inc. | Lipid formulations for nucleic acid delivery |
| US8236943B2 (en) | 2009-07-01 | 2012-08-07 | Protiva Biotherapeutics, Inc. | Compositions and methods for silencing apolipoprotein B |
| US9018187B2 (en) | 2009-07-01 | 2015-04-28 | Protiva Biotherapeutics, Inc. | Cationic lipids and methods for the delivery of therapeutic agents |
| WO2011011447A1 (en) | 2009-07-20 | 2011-01-27 | Protiva Biotherapeutics, Inc. | Compositions and methods for silencing ebola virus gene expression |
| DE102009043342A1 (de) | 2009-09-29 | 2011-03-31 | Bayer Technology Services Gmbh | Stoffe für selbstorganisierte Träger zur kontrollierten Freisetzung eines Wirkstoffs |
| AU2010334911A1 (en) * | 2009-12-23 | 2012-07-12 | Novartis Ag | Lipids, lipid compositions, and methods of using them |
| US20130123338A1 (en) | 2010-05-12 | 2013-05-16 | Protiva Biotherapeutics, Inc. | Novel cationic lipids and methods of use thereof |
| WO2011141703A1 (en) * | 2010-05-12 | 2011-11-17 | Protiva Biotherapeutics Inc. | Compositions and methods for silencing apolipoprotein b |
| WO2012000104A1 (en) | 2010-06-30 | 2012-01-05 | Protiva Biotherapeutics, Inc. | Non-liposomal systems for nucleic acid delivery |
| TWI504350B (zh) * | 2010-09-01 | 2015-10-21 | Du Pont | 殺真菌吡唑及其混合物 |
| MX349088B (es) | 2010-09-20 | 2017-07-10 | Merck Sharp & Dohme | Lípidos catiónicos novedosos de bajo peso molecular para la entrega de oligonucleótidos. |
| JP2014511687A (ja) | 2011-03-31 | 2014-05-19 | モデルナ セラピューティクス インコーポレイテッド | 工学操作された核酸の送達および製剤 |
| DK3336082T3 (da) | 2011-06-08 | 2020-04-27 | Translate Bio Inc | Spaltelige lipider |
| JP2014530602A (ja) | 2011-10-05 | 2014-11-20 | プロティバ バイオセラピューティクス インコーポレイテッド | アルデヒドデヒドロゲナーゼをサイレンシングするための組成物および方法 |
| MX2014005704A (es) | 2011-11-09 | 2015-02-17 | Tufts College | Espumas de fibroina de seda inyectables y sus usos. |
| ES3065854T3 (en) | 2011-12-07 | 2026-05-08 | Alnylam Pharmaceuticals Inc | Biodegradable lipids for the delivery of active agents |
| EP2791159A4 (en) | 2011-12-14 | 2015-10-14 | Moderna Therapeutics Inc | MODIFIED NUCLEIC ACIDS AND ACUTE TREATMENT USES THEREOF |
| CN104968354A (zh) | 2011-12-21 | 2015-10-07 | 现代治疗公司 | 增加器官或器官外植体的活力或寿命的方法 |
| WO2013116126A1 (en) | 2012-02-01 | 2013-08-08 | Merck Sharp & Dohme Corp. | Novel low molecular weight, biodegradable cationic lipids for oligonucleotide delivery |
| DK2817287T3 (da) | 2012-02-24 | 2019-01-02 | Arbutus Biopharma Corp | Trialkyl kationisk lipid og metoder til anvendelse deraf |
| EP3865123A1 (en) | 2012-03-29 | 2021-08-18 | Translate Bio, Inc. | Lipid-derived neutral nanoparticles |
| ES2762873T3 (es) | 2012-03-29 | 2020-05-26 | Translate Bio Inc | Lípidos catiónicos ionizables |
| US20150050354A1 (en) | 2012-04-02 | 2015-02-19 | Moderna Therapeutics, Inc. | Modified polynucleotides for the treatment of otic diseases and conditions |
| WO2013151663A1 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of membrane proteins |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| WO2013185069A1 (en) * | 2012-06-08 | 2013-12-12 | Shire Human Genetic Therapies, Inc. | Pulmonary delivery of mrna to non-lung target cells |
| EP2929035A1 (en) * | 2012-12-07 | 2015-10-14 | Shire Human Genetic Therapies, Inc. | Lipidic nanoparticles for mrna delivering |
| EP2970940B1 (en) * | 2013-03-14 | 2018-07-25 | Translate Bio, Inc. | Mrna therapeutic compositions and use to treat diseases and disorders |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| HUE056760T2 (hu) | 2013-07-11 | 2022-03-28 | Modernatx Inc | A CRISPR-hez kapcsolódó fehérjéket és a szintetikus SGRNS-ket kódoló szintetikus polinukleotidokat tartalmazó készítmények és felhasználási módjaik |
| WO2015011633A1 (en) | 2013-07-23 | 2015-01-29 | Protiva Biotherapeutics, Inc. | Compositions and methods for delivering messenger rna |
| BR112020021054A2 (pt) | 2018-04-25 | 2021-02-17 | Ethris Gmbh | composição, processo para a preparação de uma composição, e, composições sólida e para uso |
| JP7767376B2 (ja) | 2023-10-31 | 2025-11-11 | オートリブ ディベロップメント エービー | シートベルト用リトラクタシステム |
-
2013
- 2013-03-29 ES ES13768446T patent/ES2762873T3/es active Active
- 2013-03-29 JP JP2015503636A patent/JP6283655B2/ja active Active
- 2013-03-29 WO PCT/US2013/034602 patent/WO2013149140A1/en not_active Ceased
- 2013-03-29 AU AU2013237873A patent/AU2013237873B2/en active Active
- 2013-03-29 BR BR112014024131A patent/BR112014024131A2/pt not_active IP Right Cessation
- 2013-03-29 HK HK15107434.2A patent/HK1206645A1/xx unknown
- 2013-03-29 CN CN201380026332.0A patent/CN104334161A/zh active Pending
- 2013-03-29 US US14/389,023 patent/US9546128B2/en active Active
- 2013-03-29 EP EP13768446.0A patent/EP2830595B1/en active Active
- 2013-03-29 CA CA2868034A patent/CA2868034C/en active Active
- 2013-03-29 EP EP19198309.7A patent/EP3620447B1/en active Active
- 2013-03-29 ES ES19198309T patent/ES2868174T3/es active Active
- 2013-03-29 DK DK13768446T patent/DK2830595T3/da active
-
2016
- 2016-12-02 US US15/368,280 patent/US10065919B2/en active Active
-
2018
- 2018-01-29 JP JP2018012629A patent/JP6585202B2/ja active Active
- 2018-03-13 AU AU2018201766A patent/AU2018201766B2/en active Active
- 2018-08-10 US US16/100,853 patent/US10766852B2/en active Active
- 2018-08-24 US US16/111,724 patent/US20180362443A1/en not_active Abandoned
-
2019
- 2019-09-04 JP JP2019161182A patent/JP6873200B2/ja active Active
-
2020
- 2020-08-03 US US16/983,121 patent/US11999675B2/en active Active
-
2024
- 2024-04-25 US US18/646,567 patent/US20240425442A1/en not_active Abandoned
- 2024-08-07 US US18/797,392 patent/US12331005B2/en active Active
-
2025
- 2025-01-17 US US19/029,962 patent/US12459885B2/en active Active
- 2025-10-07 US US19/351,909 patent/US20260125339A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2830595A4 (en) | IONIZABLE CATIONIC LIPIDS | |
| EP2871178A4 (en) | CATIONIC LIPID | |
| PT2878018T (pt) | Resumo | |
| PT2819623T (pt) | Resumo | |
| PT2674413T (pt) | Resumo | |
| UA24760S (uk) | Шрифт | |
| EP2887958A4 (en) | Liposome formulations | |
| PT2831109T (pt) | Resumo | |
| PT2825212T (pt) | Resumo | |
| EP2836099A4 (en) | INFLATABLE PILLOW | |
| EP2833521A4 (en) | STATOR | |
| DK2660955T3 (da) | En elektrisk maskine | |
| ITMI20132009A1 (it) | Macchina elettrica | |
| EP2905036A4 (en) | IONISER | |
| EP2818541A4 (en) | INSULATOR | |
| BR112014017890A2 (pt) | Máquina elétrica | |
| DK2636312T3 (da) | Glyceridsammensætning | |
| ES1077210Y (es) | Columbario cinerario | |
| ITPO20120010A1 (it) | Trasloelevatore perfezionato | |
| UA23806S (uk) | Літак | |
| FI9903U1 (fi) | Pakkaus | |
| UA23855S (uk) | Літак | |
| UA23749S (uk) | Літак | |
| FI9934U1 (fi) | Pakkaus | |
| FI9974U1 (fi) | Sovitelma |