DK283889A - Nye polypeptider med antikoagulerende virkning - Google Patents

Nye polypeptider med antikoagulerende virkning Download PDF

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Publication number
DK283889A
DK283889A DK283889A DK283889A DK283889A DK 283889 A DK283889 A DK 283889A DK 283889 A DK283889 A DK 283889A DK 283889 A DK283889 A DK 283889A DK 283889 A DK283889 A DK 283889A
Authority
DK
Denmark
Prior art keywords
new polypeptides
anticoagulative effect
anticoagulative
effect
polypeptides
Prior art date
Application number
DK283889A
Other languages
Danish (da)
English (en)
Other versions
DK283889D0 (da
Inventor
Reinhard Maschler
Verena Steiner
Markus Gerhard Gruetter
Fritz Raschdorf
Original Assignee
Ciba Geigy Ag
Ucp Gen Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888813876A external-priority patent/GB8813876D0/en
Application filed by Ciba Geigy Ag, Ucp Gen Pharma Ag filed Critical Ciba Geigy Ag
Publication of DK283889D0 publication Critical patent/DK283889D0/da
Publication of DK283889A publication Critical patent/DK283889A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK283889A 1988-06-11 1989-06-09 Nye polypeptider med antikoagulerende virkning DK283889A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888813876A GB8813876D0 (en) 1988-06-11 1988-06-11 Novel polypeptides with anticoagulant activity
GB888818123A GB8818123D0 (en) 1988-06-11 1988-07-29 Novel polypeptides with anticoagulant activity

Publications (2)

Publication Number Publication Date
DK283889D0 DK283889D0 (da) 1989-06-09
DK283889A true DK283889A (da) 1989-12-12

Family

ID=26294006

Family Applications (1)

Application Number Title Priority Date Filing Date
DK283889A DK283889A (da) 1988-06-11 1989-06-09 Nye polypeptider med antikoagulerende virkning

Country Status (10)

Country Link
US (1) US5114922A (fr)
EP (1) EP0347376B1 (fr)
JP (1) JPH02117697A (fr)
AU (1) AU625375B2 (fr)
CA (1) CA1339106C (fr)
DE (1) DE58907266T2 (fr)
DK (1) DK283889A (fr)
ES (1) ES2052062T3 (fr)
IE (1) IE61809B1 (fr)
PT (1) PT90798B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0286424B1 (fr) * 1987-04-09 1994-03-16 Delta Biotechnology Limited Vecteur de levure
US5192745A (en) * 1987-05-21 1993-03-09 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
US5236898A (en) * 1987-05-21 1993-08-17 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
GB8826428D0 (en) * 1988-11-11 1988-12-14 Biopharm Ltd Antithrombin
US5192747A (en) * 1989-10-03 1993-03-09 Merrell Dow Pharmaceuticals Inc. Anticoagulant peptides
CA2026377A1 (fr) * 1989-10-03 1991-04-04 John L. Krstenansky Peptides anticoagulants avec marqueur radioactif
CA2035917C (fr) * 1990-02-13 2001-10-02 John L. Krstenansky Derives sulfonate, sulfate, phosphonate et phosphate stabilises de hirudine
DK0540574T3 (da) * 1990-07-24 1996-09-30 Merrell Pharma Inc Antikoagulationspeptider
GB9022040D0 (en) * 1990-10-10 1990-11-21 Biopharm Ltd Platelet adhesion inhibitor
ES2129749T3 (es) * 1990-11-08 1999-06-16 Japan Energy Corp Vector de secrecion, microorganismos transformados que contienen el indicado vector y produccion de un producto a partir de dicho microorganismo.
IL101062A0 (en) * 1991-02-28 1992-11-15 Erba Carlo Spa Anti-thrombin polypeptides and their preparation
US6719975B1 (en) * 1991-06-27 2004-04-13 Farmitalia Carlo Erba S.R.L. Anti-hirudin polyclonal antibodies and their use for the identification, immunopurification and quantitative determination of hirudin
US5863534A (en) * 1993-04-09 1999-01-26 Bio-Technology General Corp. Polypeptide having factor Xa inhibitory method of reducing blood coagulation with a novel polypeptide having factor Xa inhibitory activity
ES2155472T3 (es) * 1993-04-09 2001-05-16 Bio Technology General Corp Nuevo polipeptido con actividad inhibidora del factor xa.
GB9309509D0 (en) * 1993-05-07 1993-06-23 Merck Patent Gmbh Thrombin inhibitors
NZ268159A (en) * 1993-06-11 1997-03-24 Merrell Pharma Inc Anticoagulant and antiplatelet peptides and their use
US5661001A (en) * 1993-08-04 1997-08-26 Ciba-Geigy Corporation High molecular weight desulphatohirudin
RU2112528C1 (ru) * 1994-12-23 1998-06-10 Институт биоорганической химии им.М.М.Шемякина и Ю.А.Овчинникова РАН СПОСОБ ПОЛУЧЕНИЯ ФЕРМЕНТА ДЕСТАБИЛАЗЫ, ОБЛАДАЮЩЕГО ФИБРИНОЛИТИЧЕСКОЙ, ТРОМБОЛИТИЧЕСКОЙ, ЭНДО- И ЭКЗО- ε(γ GLY)-LYS-ИЗОПЕПТИДАЗНОЙ И АМИДОЛИТИЧЕСКОЙ АКТИВНОСТЬЮ
GB9509271D0 (en) * 1995-05-05 1995-06-28 Biopharm Res & Dev Ltd Blood clot stabilisation inhibitors
CN102914612B (zh) * 2011-08-06 2015-10-21 河北以岭医药研究院有限公司 一种菲牛蛭药材指纹图谱的测定方法
CN105646702B (zh) * 2016-04-13 2019-03-01 中国科学院昆明动物研究所 菲牛蛭Kazal型胰蛋白酶抑制剂Bdellin-HM及其编码基因和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3324534A1 (de) * 1983-07-07 1985-01-17 Ciba-Geigy Ag, Basel Modifizierte protease-inhibitoren, verfahren zu ihrer herstellung und daraus bereitete pharmazeutische mittel
DE3342139A1 (de) * 1983-11-22 1985-05-30 Ciba-Geigy Ag, Basel Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel
DE3438296A1 (de) * 1984-04-18 1985-11-07 Hoechst Ag, 6230 Frankfurt Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
DE3445532A1 (de) * 1984-12-13 1986-06-19 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
CN86101096A (zh) * 1985-04-26 1986-10-22 株式会社岛津制作所 印字绘图器
EP0209061B1 (fr) * 1985-07-17 1994-01-12 Hoechst Aktiengesellschaft Peptides à activité anticoagulante, leur procédé de préparation, d'obtention, leur application et les agents les contenant
NO170430C (no) * 1986-09-18 1992-10-14 Pennsylvania Hospital Fremgangsmaate for fremstilling av et protein som har antikoagulerende og anti-metastatiske egenskaper
FR2630638B1 (fr) * 1988-05-02 1997-08-08 Inst Nat Sante Rech Med Implant oculaire et son procede de preparation

Also Published As

Publication number Publication date
EP0347376A2 (fr) 1989-12-20
IE61809B1 (en) 1994-11-30
AU625375B2 (en) 1992-07-09
ES2052062T3 (es) 1994-07-01
EP0347376A3 (en) 1990-07-04
PT90798A (pt) 1989-12-29
PT90798B (pt) 1994-10-31
DE58907266D1 (de) 1994-04-28
JPH02117697A (ja) 1990-05-02
EP0347376B1 (fr) 1994-03-23
AU3630189A (en) 1989-12-14
CA1339106C (fr) 1997-07-29
DE58907266T2 (de) 1994-09-29
US5114922A (en) 1992-05-19
DK283889D0 (da) 1989-06-09
IE891856L (en) 1989-12-11

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Legal Events

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AHB Application shelved due to non-payment