DK2844083T3 - Anvendelse af tomatekstrakt som antihypertensivt middel og fremgangsmåde til fremstilling af vandopløseligt sukkerfrit tomatekstrakt - Google Patents

Anvendelse af tomatekstrakt som antihypertensivt middel og fremgangsmåde til fremstilling af vandopløseligt sukkerfrit tomatekstrakt Download PDF

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DK2844083T3
DK2844083T3 DK13719356.1T DK13719356T DK2844083T3 DK 2844083 T3 DK2844083 T3 DK 2844083T3 DK 13719356 T DK13719356 T DK 13719356T DK 2844083 T3 DK2844083 T3 DK 2844083T3
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extract
tomato
composition
use according
tomato extract
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DK13719356.1T
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Asim K Duttaroy
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Univ Oslo
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4875—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/55—Liquid-liquid separation; Phase separation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Botany (AREA)
  • Cardiology (AREA)
  • Mycology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
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  • Polymers & Plastics (AREA)
  • Nutrition Science (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
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  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
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Claims (14)

1. Sammensætning, der omfatter et tomatekstrakt til anvendelse som et lægemiddel til behandling af hypertension, hvor sammensætningen fremstilles ved en fremgangsmåde, der omfatter følgende trin: a) homogenisering af tomater; b) fjernelse af partikelmateriale ved centrifugering og/eller ultrafiltrering og c) fjernelse af opløselige sukkere.
2. Sammensætning til anvendelse ifølge krav 1, hvor sammensætningen er et vandopløseligt, sukkerfrit tomatekstrakt.
3. Sammensætning til anvendelse ifølge krav 1, hvor tomatekstraktet er fremstillet af en koldpresset tomatpasta.
4. Sammensætning til anvendelse ifølge krav 1 fremstillet ved en fremgangsmåde, der omfatter følgende trin: a) fortynding i vand af en koldpresset tomatpasta med 28-30 °Brix og et bruningsindeks på mindre end 0,350 AU; b) fjernelse af partikelmateriale, der er større end 0,2 pm, for at fremstille en opløsning; og c) opkoncentrering af opløsningen for at danne en sirup med 62-65 °Brix.
5. Sammensætning til anvendelse ifølge krav 1, hvor fremgangsmåden endvidere omfatter fraktionering af ikke-sukkerkomponenterne ved anvendelse af højtryksvæskekromatografi.
6. Sammensætning til anvendelse ifølge krav 1, der omfatter et tomatekstrakt, der kan opnås ved en fremgangsmåde, der omfatter følgende trin: a) homogenisering af en tomat for at fremstille et tomathomogenat; b) filtrering af tomathomogenatet gennem et filter med en øvre molekylvægtgrænse på 1000 Da for at fremstille et filtrat; c) opsamling af filtratet for at tilvejebringe et ekstrakt og d) fjernelse af det vanduopløselige sukker fra ekstraktet.
7. Sammensætning til anvendelse ifølge krav 1, hvor tomaten pilles inden homogeniseringstrinnet.
8. Sammensætning til anvendelse ifølge krav 1, hvor tomatekstraktet er i form af et koncentrat eller et dehydrat.
9. Sammensætning til anvendelse ifølge krav 8, hvor tomatekstraktet er i form af et koncentrat, der er mindst 2 gange opkoncentreret.
10. Sammensætning til anvendelse ifølge krav 1, hvor tomatekstraktet er dehydreret for at opnå et tørekstrakt.
11. Sammensætning til anvendelse ifølge krav 10, hvor det tørre ekstrakt er i form af en fast eller en halvfast doseringsform.
12. Sammensætning til anvendelse ifølge krav 1, hvor ekstaktet er indeholdt i en kapselskal.
13. Sammensætning til anvendelse ifølge krav 1, hvor ekstaktet indeholder en i alt væsentligt varmestabil vandopløselig forbindelse eller forbindelser med en molekylvægt på mindre end 1000.
14. Sammensætning til anvendelse som defineret i et hvilket som helst af kravene 1-13, hvor ekstaktet er i form af en aktiv fraktion af tomatfrugten, der kan passere gennem et ultrafiltreringsfilter med en øvre molekylvægtgrænse på 1000, og som indeholder en i alt væsentligt varmestabil, farveløs eller stråfarvet, vandopløselig forbindelse eller forbindelser med en molekylvægt på mindre end 1000.
DK13719356.1T 2012-04-23 2013-04-22 Anvendelse af tomatekstrakt som antihypertensivt middel og fremgangsmåde til fremstilling af vandopløseligt sukkerfrit tomatekstrakt DK2844083T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261636813P 2012-04-23 2012-04-23
PCT/US2013/037524 WO2013163057A1 (en) 2012-04-23 2013-04-22 Use of tomato extract as antihypertensive agent and process for making water soluble sugar free tomato extract

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DK2844083T3 true DK2844083T3 (da) 2018-11-12

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US (3) US20150132371A1 (da)
EP (1) EP2844083B1 (da)
JP (5) JP2015515493A (da)
CN (2) CN107397830A (da)
AU (1) AU2013252637B2 (da)
CA (1) CA2881555C (da)
DK (1) DK2844083T3 (da)
ES (1) ES2692158T3 (da)
IN (1) IN2014MN02392A (da)
NZ (1) NZ630482A (da)
PL (1) PL2844083T3 (da)
PT (1) PT2844083T (da)
TR (1) TR201815457T4 (da)
WO (1) WO2013163057A1 (da)

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JP7104032B2 (ja) 2016-11-02 2022-07-20 プロヴェクシス ナチュラル プロダクツ リミテッド 大気汚染の悪影響に対する水溶性トマト抽出物の保護

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