DK2860179T3 - Pyrazolopyridinderivater som NADPH-oxidase-hæmmere - Google Patents

Pyrazolopyridinderivater som NADPH-oxidase-hæmmere Download PDF

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DK2860179T3
DK2860179T3 DK14190340.1T DK14190340T DK2860179T3 DK 2860179 T3 DK2860179 T3 DK 2860179T3 DK 14190340 T DK14190340 T DK 14190340T DK 2860179 T3 DK2860179 T3 DK 2860179T3
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optionally substituted
pyrazolo
methyl
alkyl
pyridine
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DK14190340.1T
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Patrick Page
Mike Orchard
Francesca Gaggini
Benoît Laleu
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Genkyotex Suisse Sa
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Claims (21)

1. Pyrazolopyridinderivat med formlen I:
hvor Gi er H; G2 er valgt blandt eventuelt substitueret aryl og eventuelt substitueret heteroaryl; G3 er valgt blandt H; eventuelt substitueret amino; eventuelt substitueret aminoalkyl; eventuelt substitueret aminocarbonyl; eventuelt substitueret alkoxy; eventuelt substitueret alkoxy C1-C6 alkyl; eventuelt substitueret carbonyl; eventuelt substitueret C1-C6 alkyl; eventuelt substitueret C2-C6 alkenyl; eventuelt substitueret C2-C6 alkynyl; eventuelt substitueret aryl; eventuelt substitueret aryl C1-C6 alkyl; eventuelt substitueret heteroaryl; eventuelt substitueret C1-C6 alkyl heteroaryl; eventuelt substitueret heteroaryl C1-C6 alkyl; eventuelt substitueret C2-C6 alkenyl aryl; eventuelt substitueret aryl C2-C6 alkenyl; eventuelt substitueret C2-C6 alkenyl heteroaryl; eventuelt substitueret heteroaryl C2-C6 alkenyl; eventuelt substitueret Cs-Ce-cycloalkyl; eventuelt substitueret heterocycloalkyl; eventuelt substitueret C1-C6 alkyl Cs-Ce-cycloalkyl; eventuelt substitueret Cs-Ce-cycloalkyl C1-C6 alkyl; eventuelt substitueret C1-C6 alkyl heterocycloalkyl and eventuelt substitueret heterocycloalkyl C1-C6 alkyl; G4 er valgt blandt -NR2-C(0)-R1 og -(CHR3)m-(CH2)n-R4, hvor R1 er valgt blandt H; amino; -NR5R6; eventuelt substitueret alkoxy; eventuelt substitueret alkoxy C1-C6 alkyl; eventuelt substitueret aryl; eventuelt substitueret C1-C6 alkyl aryl; eventuelt substitueret aryl C1-C6 alkyl; heteroaryl; eventuelt substitueret C1-C6 alkyl heteroaryl; eventuelt substitueret heteroaryl C1-C6 alkyl; eventuelt substitueret Cs-Ce-cycloalkyl; eventuelt substitueret C1-C6 alkyl Cs-Ce-cycloalkyl; eventuelt substitueret C3-Ce-cycloalkyl C1-C6 alkyl; eventuelt substitueret heterocycloalkyl; eventuelt substitueret C1-C6 alkyl heterocycloalkyl; og eventuelt substitueret heterocycloalkyl C1-C6 alkyl; R2 er valgt blandt H; eventuelt substitueret alkoxy C1-C6 alkyl; eventuelt substitueret aryl; eventuelt substitueret C1-C6 alkyl aryl; eventuelt substitueret aryl C1-C6 alkyl; eventuelt substitueret heteroaryl; eventuelt substitueret C1-C6 alkyl heteroaryl; eventuelt substitueret heteroaryl C1-C6 alkyl; eventuelt substitueret Cs-Cs-cycloalkyl; eventuelt substitueret C1-C6 alkyl Cs-Ce-cycloalkyl; eventuelt substitueret Cs-Ce-cycloalkyl C1-C6 alkyl; eventuelt substitueret heterocycloalkyl; eventuelt substitueret C1-C6 alkyl heterocycloalkyl; eventuelt substitueret heterocycloalkyl C1-C6 alkyl; R3 er valgt blandt H; halogen; eventuelt substitueret alkoxy; eventuelt substitueret alkoxy C1-C6 alkyl aryl; eventuelt substitueret C1-C6 alkyl aryl; eventuelt substitueret aryl C1-C6 alkyl; substitueret heteroaryl; eventuelt substitueret C1-C6 alkyl heteroaryl; eventuelt substitueret heteroaryl C1-C6 alkyl; eventuelt substitueret Cs-Cs-cycloalkyl; eventuelt substitueret C1-C6 alkyl Cs-Cs-cycloalkyl; eventuelt substitueret Cs-Cs-cycloalkyl C1-C6 alkyl; eventuelt substitueret heterocycloalkyl; eventuelt substitueret C1-C6 alkyl heterocycloalkyl; og eventuelt substitueret heterocycloalkyl C1-C6 alkyl; R4 er valgt blandt H;-C(0)R7; -A-B; -CHR8R9 og -(CH2)q-E; R5 og R6 er uafhængigt valgt blandt H; eventuelt substitueret alkoxy C1-C6 alkyl; eventuelt substitueret aryl; eventuelt substitueret C1-C6 alkyl aryl; eventuelt substitueret aryl C1-C6 alkyl; eventuelt substitueret heteroaryl; eventuelt substitueret C1-C6 alkyl heteroaryl; eventuelt substitueret heteroaryl C1-C6 alkyl; eventuelt substitueret Cs-Cs-cycloalkyl; eventuelt substitueret C1-C6 alkyl Cs-Cs-cycloalkyl; eventuelt substitueret Cs-Cs-cycloalkyl C1-C6 alkyl; eventuelt substitueret heterocycloalkyl; eventuelt substitueret C1-C6 alkyl heterocycloalkyl; og eventuelt substitueret heterocycloalkyl C1-C6 alkyl eller-NR5R6 danner sammen en ring valgt blandt eventuelt substitueret heteroaryl og eventuelt substitueret heterocycloalkyl; R7 er valgt blandt eventuelt substitueret amino; eventuelt substitueret alkoxy; eventuelt substitueret aminoalkyl; eventuelt substitueret alkoxy C1-C6 alkyl; eventuelt substitueret C1-C6 alkyl; eventuelt substitueret C2-C6 alkenyl; eventuelt substitueret C2-C6 alkynyl; -NR5R6; eventuelt substitueret aryl; eventuelt substitueret C1-C6 alkyl aryl; eventuelt substitueret aryl C1-C6 alkyl; eventuelt substitueret heteroaryl; eventuelt substitueret C1-C6 alkyl heteroaryl; eventuelt substitueret heteroaryl C1-C6 alkyl; eventuelt substitueret Cs-Ce-cycloalkyl; eventuelt substitueret C1-C6 alkyl Cs-Ce-cycloalkyl; eventuelt substitueret C3-Ce-cycloalkyl C1-C6 alkyl; eventuelt substitueret heterocycloalkyl; eventuelt substitueret C1-C6 alkyl heterocycloalkyl; og eventuelt substitueret heterocycloalkyl C1-C6 alkyl; R8 og R9 er uafhængigt valgt blandt eventuelt substitueret aryl; eventuelt substitueret heteroaryl; eventuelt substitueret Cs-Ce-cycloalkyl og eventuelt substitueret heterocycloalkyl; R10 er valgt blandt H; hydroxyl; eventuelt substitueret amino C1-C6 alkyl; eventuelt substitueret alkoxy C1-C6 alkyl; eventuelt substitueret aryl; eventuelt substitueret C1-C6 alkyl aryl; eventuelt substitueret aryl C1-C6 alkyl; heteroaryl; eventuelt substitueret C1-C6 alkyl heteroaryl; eventuelt substitueret heteroaryl Ci-Ce alkyl; eventuelt substitueret Cs-Ce-cycloalkyl; eventuelt substitueret C1-C6 alkyl Cs-Ce-cycloalkyl; eventuelt substitueret C3-Ce-cyclo-alkyl C1-C6 alkyl; eventuelt substitueret heterocycloalkyl; eventuelt substitueret C1-C6 alkyl heterocycloalkyl; og eventuelt substitueret heterocycloalkyl C1-C6 alkyl; R11 og R12 er uafhængigt valgt blandt H; eventuelt substitueret acyl; eventuelt substitueret CrCe alkyl; eventuelt substitueret C2-C6 alkenyl; eventuelt substitueret C2-C6 alkynyl; eventuelt substitueret aryl; eventuelt substitueret CrCe alkyl aryl; eventuelt substitueret aryl C1-C6 alkyl; eventuelt substitueret heteroaryl; eventuelt substitueret C1-C6 alkyl hetero-aryl; eventuelt substitueret heteroaryl CrCe alkyl; eventuelt substitueret Cs-Ce-cycloalkyl; eventuelt substitueret CrCe alkyl Cs-Ce-cycloalkyl; eventuelt substitueret Cs-Ce-cycloalkyl C1-C6 alkyl; eventuelt substitueret heterocycloalkyl; eventuelt substitueret C1-C6 alkyl heterocycloalkyl; og eventuelt substitueret heterocycloalkyl C1-C6 alkyl eller -NR11R12 danner sammen en ring valgt blandt eventuelt substitueret heteroaryl og eventuelt substitueret heterocycloalkyl; R13 er valgt blandt eventuelt substitueret aryl; eventuelt substitueret heteroaryl; eventuelt substitueret C3-C8-cycloalkyl og eventuelt substitueret heterocycloalkyl; R14, R15 og R16 er uafhængigt valgt blandt H og eventuelt substitueret C1-C6 alkyl; R17 er valgt blandt eventuelt substitueret C1-C6 alkyl; eventuelt substitueret C2-C6 alkenyl; eventuelt substitueret C2-C6 alkynyl; eventuelt substitueret aryl; eventuelt substitueret Ci-C6 alkyl aryl; eventuelt substitueret aryl CrCe alkyl; eventuelt substitueret heteroaryl; eventuelt substitueret CrCe alkyl heteroaryl; eventuelt substitueret heteroaryl CrC6 alkyl; eventuelt substitueret Cs-Ce-cycloalkyl; eventuelt substitueret CrC6 alkyl C3-C8-cycloalkyl; eventuelt substitueret Cs-Ce-cycloalkyl Ci-C6 alkyl; eventuelt substitueret heterocycloalkyl; eventuelt substitueret Ci-C6 alkyl heterocycloalkyl; og eventuelt substitueret heterocycloalkyl Ci-C6 alkyl; A er valgt blandt eventuelt substitueret aryl, og eventuelt substitueret heteroaryl; B er valgt blandt-OR10, -NR11R12 og -(CH2)p-R13; E er valgt blandt eventuelt substitueret C3-Ce-cycloalkyl; eventuelt substitueret C2-Ce alkynyl; -NR14R15; -(CH2)r-OR15 og -NR16C(0)-R17; m, n, p og q er heltal valgt blandt 0 til 5; r er et heltal valgt blandt 3 til 5; G5 er valgt blandt H; eventuelt substitueret CrC6 alkyl; eventuelt substitueret C2-C6 alkenyl; eventuelt substitueret C2-Ce alkynyl; eventuelt substitueret aryl; eventuelt substitueret C1-C6 alkyl aryl; eventuelt substitueret aryl C1-C6 alkyl; eventuelt substitueret heteroaryl; eventuelt substitueret C1-C6 alkyl heteroaryl; eventuelt substitueret heteroaryl Ci-C6 alkyl; eventuelt substitueret C2-C6 alkenyl aryl; eventuelt substitueret aryl C2-C6 alkenyl; eventuelt substitueret C2-Ce alkenyl heteroaryl; eventuelt substitueret heteroaryl C2-C6 alkenyl; eventuelt substitueret Cs-Ce-cycloalkyl; eventuelt substitueret heterocycloalkyl; eventuelt substitueret CrCe alkyl C3-Ce-cyclo-alkyl; eventuelt substitueret Cs-Ce-cycloalkyl Ci-Ce alkyl; eventuelt substitueret Ci-Ce alkyl heterocycloalkyl og eventuelt substitueret heterocycloalkyl Ci-Ce alkyl; tauto-merer, geometriske isomerer, optisk aktive former som enantiomerer, diastereomerer og racematformer, samt farmaceutisk acceptable salte deraf.
2. Derivat ifølge krav 1, hvor G2 er eventuelt substitueret phenyl.
3. Derivat ifølge krav 1 eller 2, hvor G3 er eventuelt substitueret aryl.
4. Derivat ifølge ethvert af kravene 1 til 3, hvor G4 er-(CHR3)m-(CH2)n-R4; R3, R4, m og n er som angivet i ethvert af de foregående krav.
5. Derivat ifølge ethvert af de foregående krav, hvor R4 er -(Chbjq-E; E og q er definerede i ethvert af de foregående krav.
6. Derivat ifølge ethvert af de foregående krav, hvor Gs er H.
7. Farmaceutisk sammensætning indeholdende i det mindste ét derivat ifølge ethvert af kravene 1 til 6 og et farmaceutisk acceptabelt bærestof, fortyndingsmiddel eller excipiens for dette.
8. Derivat ifølge ethvert af kravene 1 til 6 til anvendelse som et medikament.
9. Pyrazolopyridinderivat ifølge ethvert af kravene 1 til 6 til anvendelse ved profylakse og/eller behandling af en sygdom eller tilstand valgt blandt hjertekarsygdomme, sygdomme i åndedrætsvejene, stofskifteforstyrrelser, hudlidelser, knoglelidelser, neuro-inflammatoriske og/eller neurodegenerative lidelser, nyresygdomme, forplantningssygdomme, sygdomme, der rammer øjet og/eller linsen og/eller tilstande, der rammer det indre øre, inflammatoriske lidelser, leversygdomme, smerte, cancere, allergiske lidelser, traumatiseringer, septisk, hæmorrhagisk og anafylaktisk chok, sygdomme eller lidelser i mave-tarmsystemet, angiogenese, angiogenese-afhængige tilstande og andre sygdomme og/eller lidelser der står i forbindelse med nikotinamid-adenin-di-nucleotidphosphatoxidase (NADPH Oxidase).
10. Pyrazolopyridinderivat til anvendelse ifølge krav 9, hvor nyrelidelsen eller lidelserne er valgt blandt diabetisk nephropati, nyresvigt, glomerulonephritis, nephro-toksicitet af aminoglycosider og platinforbindelser og hyperaktiv blære.
11. Pyrazolopyridinderivat til anvendelse ifølge krav 9, hvor leversygdommen eller lidelsen er valgt blandt leverfibrose, alkoholinduceret fibrose, steatose og ikke-alko-holisk steatohepatitis.
12. Pyrazolopyridinderivat til anvendelse ifølge krav 9, hvor åndedrætslidelsen er valgt blandt bronchial astma, bronchitis, allergisk rhinitis, voksen respirationssyndrom, viral lungeinfektion (influenza), pulmonær hypertension og kronisk obstruktiv pulmonær lidelse (COPD).
13. Pyrazolopyridinderivat til anvendelse ifølge krav 9, hvor lidelsen knyttet til niko-tinamid-adenin-dinucleotidphosphatoxidase (NADPH Oxidase) er idiopatisk pulmonær fibrose.
14. Pyrazolopyridinderivat til anvendelse ifølge krav 9, hvor forplantningslidelsen eller sygdommen er valgt blandt erektil dysfunktion, fertilitetslidelser, prostatahypertrofi og ondartet prostatahypertrofi.
15. Pyrazolopyridinderivat til anvendelse ifølge krav 9, hvor canceren er valgt blandt fibrosarcoma, myxosarcoma, liposarcoma, chondrosarcoma, osteogenisk sarcoma, chordoma, angiosarcoma, endotheliumsarcoma, lymphangiosarcoma, lymphangioendothelioma, periosteoma, mesothelioma, Ewing's tumor, leiomyosarcoma, rhabdomyosarcoma, colon carcinoma, pankreatisk cancer, brystcancer, ovariecancer, nyrecancer, prostatacarcinoma, pladecellecarcinoma, basal cellecarcinoma, adenocarcinoma, svedkirtelcarcinoma, talgcellecarcinoma, papillær carcinoma, papillær adenocarcinoma, cystadenocarcinoma, medullær carcinoma, bronchogenisk carcinoma, nyrecellecarcinoma, levercellecarcinoma, cholangiocarcinoma, choriocarcinoma, seminoma, embryonal carcinoma, Wilms' tumor, cervical cancer, orchioncus, lungecancer, småcellet lungecancer, lungeadenocarcinoma, blærecancer og epithelial cancer.
16. Pyrazolopyridinderivat til anvendelse ifølge krav 9, hvor smerten er en hyperalgesi associeret med inflammatorisk smerte.
17. Pyrazolopyridinderivat til anvendelse ifølge krav 9, hvor knoglelidelsen er valgt blandt osteoporose, osteoporase, osteosclerose, periodontitis og hyperparathyroi-disme.
18. Pyrazolopyridinderivat til anvendelse ifølge krav 9, hvor sygdommen eller lidelsen, som påvirker øjet og/eller linsen er valgt blandt katarakt omfattende diabetisk katarakt, gen-opacificering af linsen efter katarakt kirurgi, diabetisk og andre former for retino-pati.
19. Pyrazolopyridinderivat til anvendelse ifølge krav 9, hvor den kardiovaskulære lidelse eller sygdom er valgt blandt atherosclerose, især sygdomme eller lidelser knyttet til endothelial dysfunktion inkl. men ikke begrænset til hypertension, kardiovaskulær komplikationer af Type I eller Type II diabetes, intim hyperplasi, koronær hjertesygdom, cerebral, koronær og arterial vasospasme, endothelial dysfunktion, hjerteinsufiens inkl. kongestiv hjerteinsufiens, perifere arteriesygdom, restenose, trauma forårsaget af en stent, slagtilfælde, iskæmisk attack, vaskulære komplikation, såsom efter organtransplantation, myokardiel infarkt, hypertension, dannelse af atherosclerotisk plaq, pladeaggregation, angina pectoris, aneurisme, aortisk dissektion, iskæmisk hjertesygdom, kardial hypertrofi, pulmonær embolus, thrombotiske begivenheder, inkl. dyb venethrombose, skade forårsaget efter iskæmi ved genetablering af blodstrømning eller oxygentilførsel som ved organtransplantation, åben hjertekirurgi, angioplasti, hæmorrhagisk chok, angioplasti af iskæmiske organer inkl. hjerte, hjerne, lever, nyre, nethinde og tarm.
20. Pyrazolopyridinderivat til anvendelse ifølge ethvert af kravene 10 til 19, hvor pyrazolopyridinderivatet er valgt fra følgende gruppe: 2-(2-chlorphenyl)-4-methyl-5-(2-morpholin-4-ylbenzyl)-1H-pyrazolo[4,3-c]pyridin- 3,6(2H,5H)-dion; 2-(2-chlorphenyl)-4-methyl-5-{4-[(4-methylpiperazin-1-yl)methyl]benzyl}-1H-pyrazolo- [4,3-c]pyridin-3,6(2H,5H)-dion; 2-(2-chlorphenyl)-4-methyl-5-(2-morpholin-4-yl-2-phenylethyl)-1H-pyrazolo[4,3-c]- pyridin-3,6(2H,5H)-dion; 2-(2-chlorphenyl)-5-[2-(4-hydroxyphenyl)ethyl]-4-methyl-1H-pyrazolo[4,3-c]pyridin-3,6- (2H,5H)-dion; 5-(3-ethoxypropyl)-4-methyl-2-(4-phenyl-1,3-thiazol-2-yl)-1 H-pyrazolo[4,3-c]pyridin- 3,6-(2H,5H)-dion; 2-(2-chlorphenyl)-4,5-dimethyl-1 H-pyrazolo[4,3-c]pyridin-3,6(2H,5H)-dion; 2-(2-fluorphenyl)-4,5-dimethyl-1H-pyrazolo[4,3-c]pyridin-3,6(2H,5H)-dion; 4- methyl-5-(3-phenoxybenzyl)-2-(4-phenyl-1,3-thiazol-2-yl)-1H-pyrazolo[4,3-c]pyridin-3,6(2H,5H)-dion; 4,5-dimethyl-2-(4-phenyl-1,3-thiazol-2-yl)-1H-pyrazolo[4,3-c]pyridin-3,6(2H,5H)-dion; 2-(3-chlorphenyl)-4,5-dimethyl-1 H-pyrazolo[4,3-c]pyridin-3,6(2H,5H)-dion; N-[2-(2-chlorphenyl)-4-methyl-3,6-dioxo-1,2,3,6-tetrahydro-5H-pyrazolo[4,3-c]pyridin- 5- yl]-2-(4-fluorphenoxy)acetamid; 2-(2-chlorphenyl)-4-methyl-5-(3-phenoxybenzyl)-1 H-pyrazolo[4,3-c]pyridin-3,6-(2H,5H)-dion; 5-(3-ethoxypropyl)-2-(2-fluorphenyl)-4-methyl-1 H-pyrazolo[4,3-c]pyridin-3,6(2H,5H)-dion; 2-(3-chlorphenyl)-5-(3-ethoxypropyl)-4-methyl-1 H-pyrazolo[4,3-c]pyridin-3,6(2H,5H)-dion; 2-(3-chlorphenyl)-4-methyl-5-[2-(morpholin-4-ylmethyl)benzyl]-1H-pyrazolo[4,3-c]- pyridin-3,6(2H,5H)-dion; 2-(2-fluorphenyl)-4-methyl-5-[2-(morpholin-4-ylmethyl)benzyl]-1H-pyrazolo[4,3-c]- pyridin-3,6(2H,5H)-dion; 2-(2-fluorphenyl)-4-methyl-5-[(6-morpholin-4-ylpyridin-2-yl)methyl]-1H-pyrazolo[4,3-c]- pyridin-3,6(2H,5H)-dion; 2-(2-fluorphenyl)-4-methyl-5-[4-(morpholin-4-ylmethyl)benzyl]-1H-pyrazolo[4,3-c]- pyridin-3,6(2H,5H)-dion; 2- (3-chlorphenyl)-4-methyl-5-[(6-morpholin-4-ylpyridin-2-yl)methyl]-1 H-pyrazolo-[4,3-c]pyridin-3,6(2H,5H)-dion; 3- (4,5-dimethyl-3,6-dioxo-1,3,5,6-tetrahydro-2H-pyrazolo[4,3-c]pyridin-2-yl)benzonitril; 2-(2-fluorphenyl)-4-methyl-5-(3-phenoxybenzyl)-1H-pyrazolo[4,3-c]pyridin-3,6 (2H,5H)-dion; 2-(3-chlorphenyl)-4-methyl-5-(3-phenoxybenzyl)-1 H-pyrazolo[4,3-c]pyridin-3,6-(2H,5H)-dion; 2-(2-chlorphenyl)-5-(3-ethoxypropyl)-4-methyl-1 H-pyrazolo[4,3-c]pyridin-3,6(2H,5H)-dion; 2-(2-chlorphenyl)-4-methyl-5-[(6-morpholin-4-ylpyridin-2-yl)methyl]-1 H-pyrazolo[4,3-c]-pyridin-3,6(2H,5H)-dion; 2-(3-chlorphenyl)-4-methyl-5-[4-(4-methylpiperazin-1-yl)-4-oxobutyl]-1 H-pyrazolo- [4,3-c]pyndin-3,6(2H,5H)-dion; 2-(3-chlorphenyl)-4-methyl-5-[4-(morpholin-4-ylmethyl)benzyl]-1H-pyrazolo[4,3-c]- pyridin-3,6(2H,5H)-dion; 2-[2-(2-fluorphenyl)-4-methyl-3,6-dioxo-1,2,3,6-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]-N-(pyridin-2-ylmethyl)acetamid; 2-(2-chlorphenyl)-4-methyl-5-[4-(morpholin-4-ylmethyl)benzyl]-1H-pyrazolo[4,3-c]- pyridin-3,6(2H,5H)-dion; 2- (2-chlorphenyl)-4-methyl-5-[2-(morpholin-4-ylmethyl)benzyl]-1H-pyrazolo[4,3-c]-pyridin-3,6(2H,5H)-dion; 4- methyl-5-(3-phenoxybenzyl)-2-[1,2,4]triazolo[4,3-b]pyridazin-6-yl-1 H-pyrazolo[4,3-c]-pyridin-3,6(2H,5H)-dion; 3- [5-(3-ethoxypropyl)-4-methyl-3,6-dioxo-1,3,5,6-tetrahydro-2H-pyrazolo[4,3-c]pyridin-2-yl]benzonitril; 2-[4-(benzyloxy)phenyl]-4,5-dimethyl-1H-pyrazolo[4,3-c]pyridin-3,6(2H,5H)-dion; 2-[4-(benzyloxy)phenyl]-4-methyl-5-(3-phenoxybenzyl)-1H-pyrazolo[4,3-c]pyridin- 3,6(2H,5H)-dion; 2- [4-(benzyloxy)phenyl]-5-(3-ethoxypropyl)-4-methyl-1H-pyrazolo[4,3-c]pyridin-3,6(2H,5H)-dion; 3- 4-methyl-5-[4-(morpholin-4-ylmethyl)benzyl]-3,6-dioxo-1,3,5,6-tetrahydro-2H-pyrazolo[4,3-c]pyridin-2-yl}benzonitril; 2-(2-chlorphenyl)-5-(3-hydroxypropyl)-4-methyl-1H-pyrazolo[4,3-c]pyridin-3,6 (2H,5H)-dion; 2-[2-(2-chlorphenyl)-4-methyl-3,6-dioxo-1,2,3,6-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]-N-(pyridin-2-ylmethyl)acetamid; 2-[2-(3-cyanophenyl)-4-methyl-3,6-dioxo-1,2,3,6-tetrahydro-5H-pyrazolo[4,3-c]pyridin- 5- yl]-N-(pyridin-2-ylmethyl)acetamid; 2-[2-(3-chlorphenyl)-4-methyl-3,6-dioxo-1,2,3,6-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]-N-(pyridin-2-ylmethyl)acetamid; 2-(2-chlorphenyl)-5-[3-(diethylamino)propyl]-4-methyl-1H-pyrazolo[4,3-c]pyridin-3,6- (2H,5H)-dion; 2-(2-chlorphenyl)-5-(cyclohexylmethyl)-4-methyl-1H-pyrazolo[4,3-c]pyridin-3,6- (2H,5H)-dion; 2-(3-chlorphenyl)-5-(3-hydroxypropyl)-4-methyl-1H-pyrazolo[4,3-c]pyridin-3,6(2H,5H)- dion; 2-(2-chlorphenyl)-4-methyl-5-[4-(4-methylpiperazin-1-yl)-4-oxobutyl]-1 H-pyrazolo-[4,3-c]pyridin-3,6(2H,5H)-dion; 2-(2-chlorphenyl)-5-(3-phenoxybenzyl)-1 H-pyrazolo[4,3-c]pyridin-3,6(2H,5H)-dion; 2-(3-chlorphenyl)-4-methyl-5-(3-morpholin-4-yl-3-phenylpropyl)-1 H-pyrazolo[4,3-c]-pyridin-3,6(2H,5H)-dion; 2-(3-chlorphenyl)-4-methyl-5-(3-phenylprop-2-yn-1-yl)-1H-pyrazolo[4,3-c]pyridin-3,6- (2H,5H)-dion; 2-(2-chlor-4-fluorphenyl)-4-methyl-5-[2-(morpholin-4-ylmethyl)benzyl]-1H-pyrazolo- [4,3-c]pyridin-3,6(2H,5H)-dion; 4,5-dimethyl-2-{5-[(4-methylpiperazin-1-yl)sulfonyl]pyridin-2-yl}-1H-pyrazolo[4,3-c]- pyridin-3,6(2H,5H)-dion; 2-(2-fluorphenyl)-4-methyl-5-(3-morpholin-4-yl-3-phenylpropyl)-1H-pyrazolo[4,3-c]- pyridin-3,6(2H,5H)-dion; 2-(2,5-dichlorphenyl)-4-methyl-5-[2-(morpholin-4-ylmethyl)benzyl]-1 H-pyrazolo[4,3-c]-pyridin-3,6(2H,5H)-dion; 2-[2-(benzyloxy)phenyl]-5-(3-ethoxypropyl)-4-methyl-1H-pyrazolo[4,3-c]pyridin-3,6- (2H,5H)-dion; 2-(2,5-dichlorphenyl)-4-methyl-5-(2-morpholin-4-yl-2-oxoethyl)-1 H-pyrazolo[4,3-c]-pyridin-3,6(2H,5H)-dion; N-{2-[2-(2,5-dichlorphenyl)-4-methyl-3,6-dioxo-1,2,3,6-tetrahydro-5H-pyrazolo[4,3-c]- pyridin-5-yl]ethyl{acetamid; 2-(2-chlor-4-fluorphenyl)-4-(methoxymethyl)-5-[2-(morpholin-4-ylmethyl)benzyl]-1 H-pyrazolo[4,3-c]pyridin-3,6(2H,5H)-dion; 2-(2-chlorphenyl)-5-[2-(dimethylamino)ethyl]-4-methyl-1 H-pyrazolo[4,3-c]pyridin-3,6-(2H,5H)-dion; 2-[4-(benzyloxy)phenyl]-4-methyl-5-[2-(morpholin-4-ylmethyl)benzyl]-1 H-pyrazolo-[4,3-c]pyridin-3,6(2H,5H)-dion; 2-(3-chlorphenyl)-4-methyl-5-[2-(4-methylpiperazin-1-yl)benzyl]-1H-pyrazolo[4,3-c]- pyridin-3,6(2H,5H)-dion; 2-(3,4-dichlorphenyl)-4-methyl-5-[4-(4-methylpiperazin-1-yl)-4-oxobutyl]-1H-pyrazolo- [4,3-c]pyridin-3,6(2H,5H)-dion; 5-[2-(4-benzylpiperazin-1-yl)-2-oxoethyl]-2-(2,5-dichlorphenyl)-4-methyl-1 H-pyrazolo-[4,3-c]pyridin-3,6(2H,5H)-dion; 2-(2-chlorphenyl)-4-methyl-5-(3-phenylprop-2-yn-1-yl)-1H-pyrazolo[4,3-c]pyridin-3,6- (2H,5H)-dion; N-{3-[5-(3-ethoxypropyl)-4-methyl-3,6-dioxo-1,3,5,6-tetrahydro-2H-pyrazolo[4,3-c]- pyridin-2-yl]phenyl}acetamid; 2-benzyl-4-methyl-5-[2-(morpholin-4-ylmethyl)benzyl]-1 H-pyrazolo[4,3-c]pyridin-3,6(2H,5H)-dion; 2-(3,4-dichlorphenyl)-4-methyl-5-[2-(morpholin-4-ylmethyl)benzyl]-1 H-pyrazolo[4,3-c]-pyridin-3,6(2H,5H)-dion; 2-(2-chlor-4-fluorphenyl)-4,5-dimethyl-1 H-pyrazolo[4,3-c]pyridin-3,6(2H,5H)-dion; 2-[4-(benzyloxy)phenyl]-4-methyl-5-(2-morpholin-4-yl-2-oxoethyl)-1H-pyrazolo[4,3-c]- pyridin-3,6(2H,5H)-dion; 2-(3,4-dichlorphenyl)-4-methyl-5-(2-morpholin-4-yl-2-oxoethyl)-1 H-pyrazolo[4,3-c]-pyridin-3,6(2H,5H)-dion; methyl [2-(2,5-dichlorphenyl)-4-methyl-3,6-dioxo-1,2,3,6-tetrahydro-5H-pyrazolo[4,3-c]-pyridin-5-yl]; N-{3-[2-(2,3-dichlorphenyl)-4-methyl-3,6-dioxo-1,2,3,6-tetrahydro-5H-pyrazolo[4,3-c]- pyridin-5-yl]phenyl}acetamid; 2-(2,3-dichlorphenyl)-4-methyl-5-[4-(4-methylpiperazin-1-yl)-4-oxobutyl]-1H-pyrazolo- [4,3-c]pyridin-3,6(2H,5H)-dion; N-{3-[2-(3-chlor-4-fluorphenyl)-4-methyl-3,6-dioxo-1,2,3,6-tetrahydro-5H-pyrazolo-[4,3-c]pyridin-5-yl]phenyl}acetamid; 5-[2-(4-benzylpiperazin-1-yl)-2-oxoethyl]-2-(3,4-dichlorphenyl)-4-methyl-1 H-pyra-zolo[4,3-c]pyridin-3,6(2H,5H)-dion; N-{3-[2-(2-chlor-4-fluorphenyl)-4-methyl-3,6-dioxo-1,2,3,6-tetrahydro-5H-pyrazolo-[4,3-c]pyridin-5-yl]phenyl}acetamid; 2-(3-chlorphenyl)-5-(3-ethoxypropyl)-4-(3-methoxybenzyl)-1 H-pyrazolo[4,3-c]pyridin-3,6(2H,5H)-dion; 2-(3-chlor-4-fluorphenyl)-4-methyl-5-(2-morpholin-4-yl-2-oxoethyl)-1 H-pyrazolo[4,3-c]-pyridin-3,6(2H,5H)-dion; 2-(3-chlor-4-fluorphenyl)-4-methyl-5-[4-(4-methylpiperazin-1-yl)-4-oxobutyl]-1H- pyrazolo[4,3-c]pyridin-3,6(2H,5H)-dion; 2-(2-chlor-4-fluorphenyl)-4-methyl-5-(2-morpholin-4-yl-2-oxoethyl)-1 H-pyrazolo[4,3-c]-pyridin-3,6(2H,5H)-dion; 5-[2-(4-benzylpiperazin-1-yl)-2-oxoethyl]-2-(2-chlor-4-fluorphenyl)-4-methyl-1H-pyra- zolo[4,3-c]pyridin-3,6(2H,5H)-dion; 2-[4-(benzyloxy)phenyl]-4-methyl-5-[4-(4-methylpiperazin-1-yl)-4-oxobutyl]-1 H-pyra-zolo[4,3-c]pyridin-3,6(2H,5H)-dion; 2-(2,3-dichlorphenyl)-4-methyl-5-[2-(morpholin-4-ylmethyl)benzyl]-1 H-pyrazolo[4,3-c]-pyridin-3,6(2H,5H)-dion; 2-(2-chlor-4-fluorphenyl)-4-methyl-5-[2-(4-methylpiperazin-1-yl)benzyl]-1 H-pyra-zolo[4,3-c]pyridin-3,6(2H,5H)-dion; N-(3-{[2-(3-chlor-4-fluorphenyl)-4-methyl-3,6-dioxo-1,2,3,6-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]methyl}phenyl)acetamid; 5-[2-(4-benzylpiperazin-1-yl)-2-oxoethyl]-2-(3-chlor-4-fluorphenyl)-4-methyl-1H-pyra- zolo[4,3-c]pyridin-3,6(2H,5H)-dion N-(3-{[2-(2-chlor-4-fluorphenyl)-4-methyl-3,6-dioxo-1,2,3,6-tetrahydro-5H-pyrazolo-[4,3-c]pyridin-5-yl]methyl}phenyl)acetamid; 2- (2-chlor-4-fluorphenyl)-4-methyl-5-[4-(4-methylpiperazin-1-yl)-4-oxobutyl]-1H-pyra-zolo[4,3-c]pyridin-3,6(2H,5H)-dion; 3- {4-methyl-5-[2-(morpholin-4-ylmethyl)benzyl]-3,6-dioxo-1,3,5,6-tetrahydro-2H-pyrazolo[4,3-c]pyridin-2-yl}benzonitril; N-{2-[2-(3-chlor-4-fluorphenyl)-4-methyl-3,6-dioxo-1,2,3,6-tetrahydro-5H-pyrazolo-[4,3-c]pyridin-5-yl]ethyl}-4-fluorbenzamid; N-{2-[2-(2-chlor-4-fluorphenyl)-4-methyl-3,6-dioxo-1,2,3,6-tetrahydro-5H-pyrazolo-[4,3-c]pyridin-5-yl]ethyl}-4-fluorbenzamid; 2-[2-(2-chlor-4-fluorphenyl)-4-methyl-3,6-dioxo-1,2,3,6-tetrahydro-5H-pyrazolo[4,3-c]- pyridin-5-yl]-N-(pyridin-2-ylmethyl)acetamid; N-(2-{2-[4-(benzyloxy)phenyl]-4-methyl-3,6-dioxo-1,2,3,6-tetrahydro-5H-pyrazolo- [4,3-c]pyridin-5-yl{ethyl)-4-fluorbenzamid; 2-(3-chlor-4-fluorphenyl)-4-methyl-5-[2-(morpholin-4-ylmethyl)benzyl]-1H-pyrazolo- [4,3-c]pyridin-3,6(2H,5H)-dion; N-(3-{4-methyl-5-[2-(morpholin-4-ylmethyl)benzyl]-3,6-dioxo-1,3,5,6-tetrahydro-2H- pyrazolo[4,3-c]pyridin-2-yl}phenyl)acetamid; 2-(4-chlorphenyl)-4-methyl-5-(3-phenoxybenzyl)-1 H-pyrazolo[4,3-c]pyridin-3,6-(2H,5H)-dion; 2-[2-(3-chlor-4-fluorphenyl)-4-methyl-3,6-dioxo-1,2,3,6-tetrahydro-5H-pyrazolo[4,3-c]- pyridin-5-yl]-N-(pyridin-2-ylmethyl)acetamid; 2-[4-butyl-2-(3-chlor-4-fluorphenyl)-3,6-dioxo-1,2,3,6-tetrahydro-5H-pyrazolo[4,3-c]- pyridin-5-yl]-N-(pyridin-2-ylmethyl)acetamid; 2-[2-(2,3-dichlorphenyl)-4-methyl-3,6-dioxo-1,2,3,6-tetrahydro-5H-pyrazolo[4,3-c]-pyridin-5-yl]-N-(pyridin-2-ylmethyl)acetamid; 2-[2,4-bis(3-chlorphenyl)-3,6-dioxo-1,2,3,6-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]-N-(pyridin-2-ylmethyl)acetamid; 2,4-bis(3-chlorphenyl)-5-(3-hydroxypropyl)-1H-pyrazolo[4,3-c]pyridin-3,6(2H,5H)-dion; 2-(2-chlorphenyl)-4-methyl-5-(2-morpholin-4-yl-2-oxoethyl)-1 H-pyrazolo[4,3-c]-pyridin-3,6(2H,5H)-dion; N-{3-[4-(3-chlorphenyl)-5-(3-hydroxypropyl)-3,6-dioxo-1,3,5,6-tetrahydro-2H-pyra- zolo[4,3-c]pyridin-2-yl]phenyl}acetamid; 2-(2-chlorphenyl)-4-methyl-5-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1 H-pyrazolo-[4,3-c]pyridin-3,6(2H,5H)-dion; 2-(2-chlorphenyl)-4-(4-chlorphenyl)-5-(3-ethoxypropyl)-1H-pyrazolo[4,3-c]pyridin- 3,6(2H,5H)-dion; 2-(2-chlorphenyl)-4-(4-chlorphenyl)-5-methyl-1H-pyrazolo[4,3-c]pyridin-3,6(2H,5H)- dion; 2-(2-chlorphenyl)-4-(2-fluorphenyl)-5-methyl-1H-pyrazolo[4,3-c]pyridin-3,6(2H,5H)- dion; 2-(2-chlorphenyl)-4-(4-chlorphenyl)-5-[3-(dimethylamino)propyl]-1H-pyrazolo[4,3-c]- pyridin-3,6(2H,5H)-dion; 2-(2-chlorphenyl)-4-[3-(dimethylamino)phenyl]-5-methyl-1H-pyrazolo[4,3-c]pyridin- 3,6(2H,5H)-dion; 2-(2-chlorphenyl)-5-methyl-4-(3-morpholin-4-ylphenyl)-1H-pyrazolo[4,3-c]pyridin- 3,6(2H,5H)-dion; 2-(2-chlorphenyl)-4-[1-(3,4-difluorphenoxy)ethyl]-5-methyl-1H-pyrazolo[4,3-c]pyridin- 3,6(2H,5H)-dion; 4-[1-(benzyloxy)ethyl]-2-(2-chlorphenyl)-5-methyl-1 H-pyrazolo[4,3-c]pyridin-3,6-(2H,5H)-dion; og 4-[3-(dimethylamino)phenyl]-2-(2-methoxyphenyl)-5-methyl-1H-pyrazolo[4,3-c]pyridin- 3,6(2H,5H)-dion.
21. Pyrazolopyridinderivat til anvendelse ifølge krav 20, hvor pyrazolopyridinderivatet er 2-(2-chlorphenyl)-4-[3-(dimethylamino)phenyl]-5-methyl-1H-pyrazolo[4,3-c]pyridin-3,6(2H,5H)-dion.
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Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2002835A1 (en) 2007-06-04 2008-12-17 GenKyo Tex Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2000176A1 (en) * 2007-06-04 2008-12-10 GenKyo Tex Tetrahydroindole derivatives as NADPH Oxidase inhibitors
EP2166010A1 (en) * 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2165707A1 (en) 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2166008A1 (en) * 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2166009A1 (en) * 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as nadph oxidase inhibitors
EP2305679A1 (en) 2009-09-28 2011-04-06 GenKyoTex SA Pyrazoline dione derivatives as nadph oxidase inhibitors
EP2361911A1 (en) 2010-02-18 2011-08-31 GenKyoTex SA Pyrazolo piperidine derivatives as NADPH oxidase inhibitors
US8877742B2 (en) 2011-06-10 2014-11-04 Glaxosmithkline Intellectual Property Limited Compounds
EP2591782A1 (en) * 2011-11-11 2013-05-15 Johann Wolfgang Goethe-Universität Nadph oxidase 4 inhibitors and use thereof
IN2015DN03761A (da) 2012-10-24 2015-10-02 Glucox Biotech Ab
EP2857399A1 (en) 2013-10-03 2015-04-08 GenKyoTex SA Compounds useful for the treatment of PDE5 inhibitor-poorly responsive erectile dysfunction
EP3258937A4 (en) 2015-02-16 2018-10-31 Glucox Biotech AB N2-(3,4-dimethylphenyl)-6-((4-(p-tolyl)piperazin-1-yl)methyl)-1,3,5-triazine-2,4-diamine
WO2016144647A1 (en) * 2015-03-06 2016-09-15 Stc.Unm Method for treating obesity, diabetes, cardiovascular and kidney diseases by regulating gpr30/gper activity
EP3098220A1 (en) 2015-05-28 2016-11-30 GenKyoTex SA Process for the preparation of a nadph oxidase inhibitor and its polymorphs and uses thereof
US10906899B2 (en) 2016-05-10 2021-02-02 Georgia State University Research Foundation, Inc. Bicyclic fused pyrazole derivatives for the treatment of RSV
US10280164B2 (en) 2016-09-09 2019-05-07 Incyte Corporation Pyrazolopyridone compounds and uses thereof
US20180072718A1 (en) 2016-09-09 2018-03-15 Incyte Corporation Pyrazolopyridine compounds and uses thereof
AR109596A1 (es) 2016-09-09 2018-12-26 Incyte Corp Compuestos pirazolopiridina y sus usos
US20180072741A1 (en) 2016-09-09 2018-03-15 Incyte Corporation Pyrazolopyrimidine compounds and uses thereof
WO2018152220A1 (en) 2017-02-15 2018-08-23 Incyte Corporation Pyrazolopyridine compounds and uses thereof
BR112019023109A2 (pt) 2017-05-04 2020-05-26 Glenmark Pharmaceuticals S.A. Composto, composição farmacêutica e método para tratar uma doença, distúrbio, síndrome ou afecção mediada por nadph oxidase em um indivíduo
CN109562120B (zh) * 2017-08-11 2021-03-19 邦泰生物工程(深圳)有限公司 一种含有nadh和nadph的组合物及其应用
US10722495B2 (en) 2017-09-08 2020-07-28 Incyte Corporation Cyanoindazole compounds and uses thereof
EP3479843A1 (en) * 2017-11-01 2019-05-08 GenKyoTex Suisse SA Use of nox inhibitors for treatment of cancer
KR20200088856A (ko) * 2017-11-15 2020-07-23 벤더르빌트 유니버시티 리소좀 기능의 개선 및 퇴행성 신경 질환의 치료를 위한 방법 및 조성물
DK3755703T3 (da) 2018-02-20 2022-06-27 Incyte Corp N-(phenyl)-2-(phenyl)pyrimidin-4-carboxamidderivater og relaterede forbindelser som hpk1-inhibitorer til behandling af kræft
US10745388B2 (en) 2018-02-20 2020-08-18 Incyte Corporation Indazole compounds and uses thereof
US10752635B2 (en) 2018-02-20 2020-08-25 Incyte Corporation Indazole compounds and uses thereof
US11299473B2 (en) 2018-04-13 2022-04-12 Incyte Corporation Benzimidazole and indole compounds and uses thereof
US10899755B2 (en) 2018-08-08 2021-01-26 Incyte Corporation Benzothiazole compounds and uses thereof
WO2020068729A1 (en) 2018-09-25 2020-04-02 Incyte Corporation Pyrazolo[4,3-d]pyrimidine compounds as alk2 abd/or fgfr modulators
EP3946297A4 (en) 2019-04-01 2023-08-02 Emory University HYALURONIC ACID NANOPARTICLES COMPRISING NADPH OXIDASE INHIBITORS AND THEIR USES IN THE TREATMENT OF CANCER
AU2020289560A1 (en) 2019-06-05 2021-12-23 Emory University Peptidomimetics for the treatment of coronavirus and picornavirus infections
KR20220059480A (ko) 2019-08-06 2022-05-10 인사이트 코포레이션 고체 형태의 hpk1 억제제
KR20220029472A (ko) * 2020-08-28 2022-03-08 (주)셀로스바이오텍 신규 티오히단토인 유도체 및 이의 용도
EP4384168A4 (en) * 2021-08-13 2025-07-09 Univ Georgia State Res Found BICYCLIC FUSED PYRAZOLE DERIVATIVES FOR THE TREATMENT OF RESPIRATORY INFECTIONS INCLUDING RSV
US11896719B2 (en) 2022-01-24 2024-02-13 Calliditas Therapeutics Ab Pharmaceutical compositions
CA3252551A1 (en) 2022-05-09 2023-11-16 Calliditas Therapeutics Suisse Sa NOX INHIBITORS INTENDED FOR USE IN THE TREATMENT OF ALPORT SYNDROME

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3391407A (en) 1966-08-15 1968-07-09 William A. Waters Helmet
US3931407A (en) 1973-03-01 1976-01-06 American Hoechst Corporation Method of treatment with and compositions containing condensed pyrroles bearing an N-phenyl substituent
DE3728278A1 (de) 1986-12-17 1988-06-23 Bayer Ag Herbizide und fungizide mittel auf basis von substituierten pyrazolin-5-on derivaten
DE19518082A1 (de) 1995-05-17 1996-11-21 Merck Patent Gmbh 4(-Arylaminomethylen)-2,4-dihydropyrazol-3-one
US5763496A (en) 1995-11-27 1998-06-09 The Research Foundation Of State University Of New York Prevention of atherosclerosis using NADPH oxidase inhibitors
TW432073B (en) 1995-12-28 2001-05-01 Pfizer Pyrazolopyridine compounds
WO1998037068A1 (en) 1997-02-21 1998-08-27 Bristol-Myers Squibb Company Benzoic acid derivatives and related compounds as antiarrhythmic agents
IL144468A0 (en) 2000-07-27 2002-05-23 Pfizer Prod Inc Use of growth hormone secretagogues for improvement of functional health status
US7902179B2 (en) 2001-04-26 2011-03-08 Ajinomoto Co., Inc. Heterocyclic compounds
EP1291017A3 (en) 2001-09-10 2003-07-02 Warner-Lambert Company Use of statins to inhibit formation of osteoclasts
CA2483306A1 (en) * 2002-04-23 2003-11-06 Shionogi & Co., Ltd. Pyrazolo[1,5-a]pyrimidine derivative and nad(p)h oxidase inhibitor containing the same
WO2004005267A2 (en) 2002-07-03 2004-01-15 Janssen Pharmaceutica, N.V. Heteroaryl compounds useful in treating inflammatory disorders
CN1774243A (zh) 2003-02-28 2006-05-17 霍华德弗洛里实验生理及医药学院 治疗组合物
EP1616576A4 (en) 2003-04-08 2010-02-10 Mitsubishi Tanabe Pharma Corp SPECIFIC NAD (P) H OXIDASE HEMMER
WO2005080378A1 (ja) 2004-02-24 2005-09-01 Mitsubishi Pharma Corporation 縮合ピリダジン誘導体
WO2006041874A2 (en) 2004-10-04 2006-04-20 Myriad Genetics, Inc. Compounds for alzheimer's disease
FR2882654B1 (fr) 2005-03-01 2007-04-27 Servier Lab Utilisation de derives de la diosmetine pour le traitement et la prevention des pathologies thrombotiques
US7759337B2 (en) 2005-03-03 2010-07-20 Amgen Inc. Phthalazine compounds and methods of use
US20070014739A1 (en) * 2005-07-14 2007-01-18 Eldridge Gary R Compositions and methods for controlling biofilms and bacterial infections
DE102005048897A1 (de) 2005-10-12 2007-04-19 Sanofi-Aventis Deutschland Gmbh Diacylindazol-derivate als Inhibitoren von Lipasen und Phospholipasen
JP2009532501A (ja) 2006-04-04 2009-09-10 ミリアド ジェネティクス， インコーポレイテッド 疾患および障害のための化合物
WO2008030887A2 (en) * 2006-09-05 2008-03-13 Bipar Sciences, Inc. Methods for designing parp inhibitors and uses thereof
US8709434B2 (en) * 2006-11-13 2014-04-29 Pcb Associates, Inc. Compositions for inhibiting NADPH oxidase activity
EP2002835A1 (en) 2007-06-04 2008-12-17 GenKyo Tex Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2000176A1 (en) 2007-06-04 2008-12-10 GenKyo Tex Tetrahydroindole derivatives as NADPH Oxidase inhibitors
WO2009072643A1 (en) 2007-12-03 2009-06-11 Takeda Pharmaceutical Company Limited Nitrogen-containing heterocyclic compound and use thereof
US20090163452A1 (en) 2007-12-20 2009-06-25 Schwartz Janice B Compositions and methods for lowering serum cholesterol
FR2929276B1 (fr) 2008-04-01 2010-04-23 Servier Lab Nouveaux derives de diosmetine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP2166009A1 (en) 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as nadph oxidase inhibitors
EP2166010A1 (en) * 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2165707A1 (en) 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2166008A1 (en) 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
AU2009316680B2 (en) * 2008-11-18 2016-03-24 Takeda Vaccines, Inc. RSV F VLPs and methods of manufacture and use thereof
JP5774996B2 (ja) * 2008-11-18 2015-09-09 ソルベイ ユーエスエイ インコーポレイテッド アミノベンゼン組成物ならびに関連する素子および方法
MX2011005250A (es) * 2008-11-19 2011-07-29 Vertex Pharma Inhibidores de triazolotiadiazol de cinasa de proteina c-met.
EP2305679A1 (en) 2009-09-28 2011-04-06 GenKyoTex SA Pyrazoline dione derivatives as nadph oxidase inhibitors
WO2011085293A1 (en) 2010-01-08 2011-07-14 Beth Israel Deaconess Medical Center Methods and compositions for the treatment of migraine headaches
EP2361912A1 (en) 2010-02-18 2011-08-31 GenKyoTex SA Pyrazolo piperidine derivatives as NADPH oxidase inhibitors
EP2361911A1 (en) 2010-02-18 2011-08-31 GenKyoTex SA Pyrazolo piperidine derivatives as NADPH oxidase inhibitors
CN102014373B (zh) 2010-11-22 2015-04-01 中兴通讯股份有限公司 一种激活配置的方法及装置
EP2591782A1 (en) 2011-11-11 2013-05-15 Johann Wolfgang Goethe-Universität Nadph oxidase 4 inhibitors and use thereof

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