BRPI0919330A2 - derivados de pirazolo piridina como inibidores de nadph oxidase - Google Patents

derivados de pirazolo piridina como inibidores de nadph oxidase

Info

Publication number
BRPI0919330A2
BRPI0919330A2 BRPI0919330A BRPI0919330A BRPI0919330A2 BR PI0919330 A2 BRPI0919330 A2 BR PI0919330A2 BR PI0919330 A BRPI0919330 A BR PI0919330A BR PI0919330 A BRPI0919330 A BR PI0919330A BR PI0919330 A2 BRPI0919330 A2 BR PI0919330A2
Authority
BR
Brazil
Prior art keywords
pyridine derivatives
oxidase inhibitors
nadph oxidase
pyrazole pyridine
pyrazole
Prior art date
Application number
BRPI0919330A
Other languages
English (en)
Inventor
Benoit Laleu
Francesa Gaggini
Mike Orchard
Patrick Page
Original Assignee
Genkyotex Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genkyotex Sa filed Critical Genkyotex Sa
Publication of BRPI0919330A2 publication Critical patent/BRPI0919330A2/pt
Publication of BRPI0919330B1 publication Critical patent/BRPI0919330B1/pt

Links

Classifications

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/4965—Non-condensed pyrazines
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
BRPI0919330-8A 2008-09-23 2009-09-22 Derivados de pirazolo piridina como inibidores de nadph oxidase BRPI0919330B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08164857.8 2008-09-23
EP08164857A EP2166010A1 (en) 2008-09-23 2008-09-23 Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
PCT/IB2009/054156 WO2010035221A1 (en) 2008-09-23 2009-09-22 Pyrazolo pyridine derivatives as nadph oxidase inhibitors

Publications (2)

Publication Number Publication Date
BRPI0919330A2 true BRPI0919330A2 (pt) 2016-06-07
BRPI0919330B1 BRPI0919330B1 (pt) 2026-02-03

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KR20170026643A (ko) 2017-03-08
RS53781B1 (sr) 2015-06-30
HRP20150082T1 (hr) 2015-04-10
RU2011116230A (ru) 2012-10-27
US20180235976A1 (en) 2018-08-23
US9974791B2 (en) 2018-05-22
JP2015078222A (ja) 2015-04-23
RU2538041C2 (ru) 2015-01-10
PT2344492E (pt) 2015-02-09
JP5700837B2 (ja) 2015-04-15
EP2166010A1 (en) 2010-03-24
AU2009298008A1 (en) 2010-04-01
DK2860179T3 (en) 2018-06-25
WO2010035221A1 (en) 2010-04-01
CN102159573A (zh) 2011-08-17
IL211892A0 (en) 2011-06-30
US10772891B2 (en) 2020-09-15
JP2012502981A (ja) 2012-02-02
PL2860179T3 (pl) 2018-08-31
EP2344492B1 (en) 2014-10-29
USRE50878E1 (en) 2026-05-05
AU2009298008B2 (en) 2014-07-31
CA2737550A1 (en) 2010-04-01
TR201808380T4 (tr) 2018-07-23
KR20160142419A (ko) 2016-12-12
KR101763096B1 (ko) 2017-07-28
PT2860179T (pt) 2018-05-08
US9096588B2 (en) 2015-08-04
ES2673405T8 (es) 2023-03-15
PL2344492T3 (pl) 2015-04-30
SMT201500070B (it) 2015-05-05
SI2344492T1 (sl) 2015-02-27
JP5932008B2 (ja) 2016-06-08
DK2344492T3 (en) 2015-02-02
US20110269757A1 (en) 2011-11-03
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CY1115952T1 (el) 2017-01-25
EP2860179B1 (en) 2018-03-14
HK1208452A1 (en) 2016-03-04
HK1159107A1 (en) 2012-07-27
CN102159573B (zh) 2015-05-27
ES2528096T3 (es) 2015-02-03
CA2737550C (en) 2020-04-21
EP2344492A1 (en) 2011-07-20
KR20110056387A (ko) 2011-05-27
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US20150290208A1 (en) 2015-10-15
ES2673405T3 (es) 2018-06-21

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