DK2885266T3 - Fremgangsmåde til fremstilling af (2z,5z)-5-(3-chlor-4-((r)-2,3-dihydroxypropoxy)benzyliden)-2-(propylimino)-3-(o-tolyl)thiazolidin-4-on og mellemprodukt, der anvendes i fremgangsmåden - Google Patents
Fremgangsmåde til fremstilling af (2z,5z)-5-(3-chlor-4-((r)-2,3-dihydroxypropoxy)benzyliden)-2-(propylimino)-3-(o-tolyl)thiazolidin-4-on og mellemprodukt, der anvendes i fremgangsmåden Download PDFInfo
- Publication number
- DK2885266T3 DK2885266T3 DK13779378.2T DK13779378T DK2885266T3 DK 2885266 T3 DK2885266 T3 DK 2885266T3 DK 13779378 T DK13779378 T DK 13779378T DK 2885266 T3 DK2885266 T3 DK 2885266T3
- Authority
- DK
- Denmark
- Prior art keywords
- benzylide
- propylimino
- dihydroxypropoxy
- thiazolidin
- chlor
- Prior art date
Links
- -1 (R) -2,3-DIHYDROXYPROPOXY Chemical class 0.000 title 2
- NOLHRFLIXVQPSZ-UHFFFAOYSA-N 1,3-thiazolidin-4-one Chemical compound O=C1CSCN1 NOLHRFLIXVQPSZ-UHFFFAOYSA-N 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/64—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of functional groups containing oxygen only in singly bound form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/77—Preparation of chelates of aldehydes or ketones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
- C07C45/81—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/54—Nitrogen and either oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12180920 | 2012-08-17 | ||
| PCT/IB2013/056662 WO2014027330A1 (en) | 2012-08-17 | 2013-08-15 | Process for the preparation of|(2z,5z)-5-(3-chloro-4-((r)-2,3-dihydroxypropoxy)benzylidene)-2-(propylimino)-3-|(o-tolyl)thiazolidin-4-one and intermediate used in said process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2885266T3 true DK2885266T3 (da) | 2020-06-08 |
Family
ID=46940231
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13779378.2T DK2885266T3 (da) | 2012-08-17 | 2013-08-15 | Fremgangsmåde til fremstilling af (2z,5z)-5-(3-chlor-4-((r)-2,3-dihydroxypropoxy)benzyliden)-2-(propylimino)-3-(o-tolyl)thiazolidin-4-on og mellemprodukt, der anvendes i fremgangsmåden |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9340518B2 (da) |
| EP (1) | EP2885266B1 (da) |
| JP (2) | JP6322630B2 (da) |
| KR (1) | KR101731739B1 (da) |
| CN (1) | CN104540800B (da) |
| CA (1) | CA2895172C (da) |
| CY (1) | CY1123300T1 (da) |
| DK (1) | DK2885266T3 (da) |
| ES (1) | ES2795105T3 (da) |
| HR (1) | HRP20200883T1 (da) |
| HU (1) | HUE050733T2 (da) |
| IL (1) | IL237198A (da) |
| LT (1) | LT2885266T (da) |
| MX (1) | MX350891B (da) |
| PL (1) | PL2885266T3 (da) |
| PT (1) | PT2885266T (da) |
| RS (1) | RS60408B1 (da) |
| SI (1) | SI2885266T1 (da) |
| SM (1) | SMT202000298T1 (da) |
| TW (1) | TWI606036B (da) |
| WO (1) | WO2014027330A1 (da) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2278960T5 (pl) | 2008-03-17 | 2020-06-29 | Actelion Pharmaceuticals Ltd. | Schemat dawkowania dla selektywnego agonisty receptora sip1 |
| SMT202000298T1 (it) * | 2012-08-17 | 2020-07-08 | Actelion Pharmaceuticals Ltd | Processo per la produzione di (2z,5z)-5-(3-cloro-4((r)-2,3-diidrossipropossi) benziliden)-2-(propilimmino)-3-(o-tolil)tiazolidin-4-one e intermedio usato in detto processo |
| KR20200013086A (ko) | 2014-12-11 | 2020-02-05 | 액테리온 파마슈티칼 리미티드 | 선택적 s1p1 수용체 효능제에 대한 투약 섭생 |
| MA41139B1 (fr) | 2014-12-11 | 2026-02-27 | Laboratoires Juvise Pharmaceuticals | Combinaison pharmaceutique comprenant du ponesimod et son utilisation dans le traitement de la sclérose en plaque |
| JP6691218B2 (ja) * | 2015-12-25 | 2020-04-28 | クリスタル ファーマテック カンパニー、リミテッドＣｒｙｓｔａｌ Ｐｈａｒｍａｔｅｃｈ Ｃｏ．， Ｌｔｄ． | 選択的なｓ１ｐ１受容体アゴニストの新規な結晶形及びその製造方法 |
| JOP20190207A1 (ar) | 2017-03-14 | 2019-09-10 | Actelion Pharmaceuticals Ltd | تركيبة صيدلانية تشتمل على بونيسيمود |
| EP3684358A4 (en) | 2017-09-19 | 2021-01-13 | Teva Pharmaceuticals International GmbH | NEW CRYSTALLINE POLYMORPHIC SHAPE OF PONESIMOD |
| US11014940B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Thiazolidinone and oxazolidinone compounds and formulations |
| US11014897B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Solid forms comprising a thiazolidinone compound, compositions and methods of use thereof |
| US11013723B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Solid forms of a thiazolidinone compound, compositions and methods of use thereof |
| US11186556B1 (en) | 2018-10-16 | 2021-11-30 | Celgene Corporation | Salts of a thiazolidinone compound, solid forms, compositions and methods of use thereof |
| KR102365655B1 (ko) | 2018-11-29 | 2022-02-22 | 원광대학교 산학협력단 | 콩 발효 추출물을 유효성분으로 포함하는 피부 주름 예방 또는 개선용 조성물 |
| JP7749552B2 (ja) | 2019-10-31 | 2025-10-06 | イドルシア・ファーマシューティカルズ・リミテッド | Ｃｘｃｒ７アンタゴニストのｓ１ｐ１受容体調節剤との合剤 |
| EP4387960A1 (en) | 2021-08-17 | 2024-06-26 | Teva Czech Industries s.r.o | Polymorphs of ponesimod |
| EP4212156A1 (en) | 2022-01-13 | 2023-07-19 | Abivax | Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a s1p receptor modulator |
| WO2023152691A1 (en) * | 2022-02-10 | 2023-08-17 | Metrochem Api Pvt Ltd | Process for the preparation of ponesimod and its intermediates thereof |
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| PT97507B (pt) | 1990-04-27 | 1998-08-31 | Orion Yhtymae Oy | Processo para apreparacao de novos derivados de catecol farmacologicamente activos |
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| PL2069335T3 (pl) | 2006-09-08 | 2013-05-31 | Actelion Pharmaceuticals Ltd | Pochodne pirydyn-3-ylu jako środki immunomodulujące |
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| PL2278960T5 (pl) | 2008-03-17 | 2020-06-29 | Actelion Pharmaceuticals Ltd. | Schemat dawkowania dla selektywnego agonisty receptora sip1 |
| GB0819182D0 (en) * | 2008-10-20 | 2008-11-26 | Actelion Pharmaceuticals Ltd | Crystalline forms |
| US20100160369A1 (en) | 2008-12-04 | 2010-06-24 | Exelixis, Inc. | S1P1 Agonists and Methods of Making And Using |
| JP5657565B2 (ja) | 2008-12-22 | 2015-01-21 | ノバルティス アーゲー | Ｓ１ｐ受容体アゴニストの投与レジメン |
| TW201028143A (en) | 2008-12-22 | 2010-08-01 | Novartis Ag | Dosage regimen for a S1P receptor agonist |
| SMT202000298T1 (it) * | 2012-08-17 | 2020-07-08 | Actelion Pharmaceuticals Ltd | Processo per la produzione di (2z,5z)-5-(3-cloro-4((r)-2,3-diidrossipropossi) benziliden)-2-(propilimmino)-3-(o-tolil)tiazolidin-4-one e intermedio usato in detto processo |
-
2013
- 2013-08-15 SM SM20200298T patent/SMT202000298T1/it unknown
- 2013-08-15 SI SI201331742T patent/SI2885266T1/sl unknown
- 2013-08-15 EP EP13779378.2A patent/EP2885266B1/en active Active
- 2013-08-15 PL PL13779378T patent/PL2885266T3/pl unknown
- 2013-08-15 LT LTEP13779378.2T patent/LT2885266T/lt unknown
- 2013-08-15 HU HUE13779378A patent/HUE050733T2/hu unknown
- 2013-08-15 ES ES13779378T patent/ES2795105T3/es active Active
- 2013-08-15 HR HRP20200883TT patent/HRP20200883T1/hr unknown
- 2013-08-15 CN CN201380042658.2A patent/CN104540800B/zh active Active
- 2013-08-15 PT PT137793782T patent/PT2885266T/pt unknown
- 2013-08-15 KR KR1020157006474A patent/KR101731739B1/ko active Active
- 2013-08-15 CA CA2895172A patent/CA2895172C/en active Active
- 2013-08-15 WO PCT/IB2013/056662 patent/WO2014027330A1/en not_active Ceased
- 2013-08-15 US US14/422,167 patent/US9340518B2/en active Active
- 2013-08-15 DK DK13779378.2T patent/DK2885266T3/da active
- 2013-08-15 JP JP2015527061A patent/JP6322630B2/ja active Active
- 2013-08-15 RS RS20200642A patent/RS60408B1/sr unknown
- 2013-08-15 MX MX2015002127A patent/MX350891B/es active IP Right Grant
- 2013-08-16 TW TW102129570A patent/TWI606036B/zh not_active IP Right Cessation
-
2015
- 2015-02-12 IL IL237198A patent/IL237198A/en active IP Right Grant
-
2017
- 2017-04-13 JP JP2017079804A patent/JP6424250B2/ja active Active
-
2020
- 2020-06-11 CY CY20201100532T patent/CY1123300T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR101731739B1 (ko) | 2017-05-11 |
| HRP20200883T1 (hr) | 2020-09-04 |
| PL2885266T3 (pl) | 2020-11-16 |
| EP2885266B1 (en) | 2020-03-18 |
| MX350891B (es) | 2017-09-22 |
| TWI606036B (zh) | 2017-11-21 |
| KR20150042277A (ko) | 2015-04-20 |
| LT2885266T (lt) | 2020-07-10 |
| CN104540800A (zh) | 2015-04-22 |
| US9340518B2 (en) | 2016-05-17 |
| PT2885266T (pt) | 2020-05-29 |
| JP2015530373A (ja) | 2015-10-15 |
| WO2014027330A1 (en) | 2014-02-20 |
| RS60408B1 (sr) | 2020-07-31 |
| JP2017160223A (ja) | 2017-09-14 |
| SI2885266T1 (sl) | 2020-10-30 |
| CA2895172A1 (en) | 2014-02-20 |
| HUE050733T2 (hu) | 2021-01-28 |
| CA2895172C (en) | 2020-08-18 |
| CN104540800B (zh) | 2017-05-10 |
| SMT202000298T1 (it) | 2020-07-08 |
| TW201408634A (zh) | 2014-03-01 |
| CY1123300T1 (el) | 2021-12-31 |
| JP6322630B2 (ja) | 2018-05-09 |
| JP6424250B2 (ja) | 2018-11-14 |
| ES2795105T3 (es) | 2020-11-20 |
| US20150203459A1 (en) | 2015-07-23 |
| EP2885266A1 (en) | 2015-06-24 |
| IL237198A (en) | 2017-12-31 |
| IL237198A0 (en) | 2015-04-30 |
| MX2015002127A (es) | 2015-05-11 |
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