DK289087A - Benzo(b)thiophen- og benzo(b)furan-carboxamider, deres fremstilling og laegemidler indeholdende disse forbindelser - Google Patents

Benzo(b)thiophen- og benzo(b)furan-carboxamider, deres fremstilling og laegemidler indeholdende disse forbindelser

Info

Publication number: DK289087A
Authority: DK; Denmark
Prior art keywords: benzo; compounds; thiophene; preparation; medicines containing
Prior art date: 1986-06-05

Application number

DK289087A

Other languages

English (en)

Other versions

DK289087D0 (da

Inventor

Marie-Christine Dubroeucq

Christian Renault

Original Assignee

Rhone Poulenc Sante

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-06-05

Filing date

1987-06-04

Publication date

1987-12-06

1987-06-04 Application filed by Rhone Poulenc Sante filed Critical Rhone Poulenc Sante

1987-06-04 Publication of DK289087D0 publication Critical patent/DK289087D0/da

1987-12-06 Publication of DK289087A publication Critical patent/DK289087A/da

Links

150000001875 compounds Chemical class 0.000 title abstract 2
FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical compound C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 title 1
-1 BENZO (B) FURAN CARBOXAMIDES Chemical class 0.000 title 1
IANQTJSKSUMEQM-UHFFFAOYSA-N benzofuran Natural products C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 title 1
239000003814 drug Substances 0.000 title 1
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical group C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
230000003257 anti-anginal effect Effects 0.000 abstract 1
239000002249 anxiolytic agent Substances 0.000 abstract 1
230000000949 anxiolytic effect Effects 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
230000002519 immonomodulatory effect Effects 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Anesthesiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK289087A 1986-06-05 1987-06-04 Benzo(b)thiophen- og benzo(b)furan-carboxamider, deres fremstilling og laegemidler indeholdende disse forbindelser DK289087A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8608110A FR2599740B1 (fr)	1986-06-05	1986-06-05	Derives de benzo(b)thiophene de benzo(b)furannecarboxamides, leurs procedes de preparation et les medicaments les contenant

Publications (2)

Publication Number	Publication Date
DK289087D0 DK289087D0 (da)	1987-06-04
DK289087A true DK289087A (da)	1987-12-06

Family

ID=9336032

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK289087A DK289087A (da)	1986-06-05	1987-06-04	Benzo(b)thiophen- og benzo(b)furan-carboxamider, deres fremstilling og laegemidler indeholdende disse forbindelser

Country Status (14)

Country	Link
US (1)	US4808599A (da)
EP (1)	EP0248734B1 (da)
JP (1)	JPS6339874A (da)
AT (1)	ATE46157T1 (da)
AU (1)	AU591780B2 (da)
CA (1)	CA1280115C (da)
DE (1)	DE3760532D1 (da)
DK (1)	DK289087A (da)
ES (1)	ES2011296B3 (da)
FR (1)	FR2599740B1 (da)
GR (1)	GR3000148T3 (da)
NZ (1)	NZ220546A (da)
PT (1)	PT85014B (da)
ZA (1)	ZA873978B (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1196849B (it) *	1986-02-16	1988-11-25	Rotta Research Lab	Nuovi derivati degli acidi 5 pentilammino 5 oxo pentaoico e 4 pentilammino 4 oxo butanoico ad attivita antagonista della colecistochinina e procedimento per la loro preparazione
JP3415946B2 (ja) *	1994-10-31	2003-06-09	タイコエレクトロニクスアンプ株式会社	電気コネクタ
US5776946A (en) *	1995-08-28	1998-07-07	Mcgeer; Patrick L.	Peripheral benzodiazepine receptor ligands as antiinflammatory agents
US6110962A (en) *	1998-05-12	2000-08-29	American Home Products Corporation	11-aryl-benzo[B]naphtho[2,3-D]furans and 11-aryl-benzo[B]naphtho[2,3-D]thiophenes useful in the treatment of insulin resistance and hyperglycemia
US6699896B1 (en)	1998-05-12	2004-03-02	Wyeth	Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
US6110963A (en) *	1998-05-12	2000-08-29	American Home Products Corporation	Aryl-oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
EP1077929A1 (en)	1998-05-12	2001-02-28	American Home Products Corporation	2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia
US6221902B1 (en)	1998-05-12	2001-04-24	American Home Products Corporation	Biphenyl sulfonyl aryl carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
HRP20000767A2 (en) *	1998-05-12	2001-10-31	American Home Prod	Benzothiophenes, benzofurans and indoles useful in the treatment of insulin resistance and hyperglycemia
US6232322B1 (en)	1998-05-12	2001-05-15	American Home Products Corporation	Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6251936B1 (en)	1998-05-12	2001-06-26	American Home Products Corporation	Benzothiophenes, benzofurans, and indoles useful in the treatment of insulin resistance and hyperglycemia
US6451827B2 (en) *	1998-05-12	2002-09-17	Wyeth	2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia
WO1999058117A1 (fr) *	1998-05-13	1999-11-18	Sanofi-Synthelabo	Utilisation de composes reduisant l'apoptose
FR2778564B1 (fr) *	1998-05-13	2001-07-13	Sanofi Sa	Utilisation de composes reduisant l'apoptose
EP1140106B1 (en)	1998-12-18	2005-08-03	Scios Inc.	Treatment of diseases involving cyst formation
AU2185100A (en)	1998-12-18	2000-07-12	Scios Inc.	Agonists and antagonists of peripheral-type benzodiazepine receptors
US6310081B1 (en)	1999-05-10	2001-10-30	American Home Products Corporation	Biphenyl sulfonyl aryl carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
JP3745608B2 (ja)	2000-09-27	2006-02-15	矢崎総業株式会社	フロントホルダの係止構造
JP4678139B2 (ja) *	2004-05-10	2011-04-27	トヨタ自動車株式会社	自動車の暖房制御システム
WO2006010379A1 (en) *	2004-07-29	2006-02-02	Actelion Pharmaceuticals Ltd.	Novel thiophene derivatives as immunosuppressive agents
KR20080002850A (ko)	2005-03-23	2008-01-04	액테리온 파마슈티칼 리미티드	신규한 티오펜 유도체
AU2006226018B2 (en) *	2005-03-23	2012-07-12	Idorsia Pharmaceuticals Ltd	Hydrogenated benzo (C) thiophene derivatives as immunomodulators
KR20080092385A (ko)	2006-01-24	2008-10-15	액테리온 파마슈티칼 리미티드	신규한 피리딘 유도체
GB0905328D0 (en) *	2009-03-27	2009-05-13	Ge Healthcare Ltd	Indole derivatives
WO2011117421A1 (en) *	2010-03-26	2011-09-29	Ge Healthcare Limited	Tricyclic indole derivatives as pbr ligands
US9220795B2 (en)	2011-09-22	2015-12-29	Ge Healthcare Limited	Indole derivatives
GB201312768D0 (en)	2013-07-17	2013-08-28	Ge Healthcare Ltd	Work-up procedure

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1297877C (en) *	1983-12-22	1992-03-24	Daniel Lednicer	Benzofurancarboxamides useful as antiemetic or antipsychotic agents

1986
- 1986-06-05 FR FR8608110A patent/FR2599740B1/fr not_active Expired
1987
- 1987-06-03 AU AU73785/87A patent/AU591780B2/en not_active Ceased
- 1987-06-03 NZ NZ220546A patent/NZ220546A/xx unknown
- 1987-06-03 ZA ZA873978A patent/ZA873978B/xx unknown
- 1987-06-04 EP EP87401244A patent/EP0248734B1/fr not_active Expired
- 1987-06-04 DE DE8787401244T patent/DE3760532D1/de not_active Expired
- 1987-06-04 DK DK289087A patent/DK289087A/da not_active Application Discontinuation
- 1987-06-04 PT PT85014A patent/PT85014B/pt not_active IP Right Cessation
- 1987-06-04 CA CA000538850A patent/CA1280115C/fr not_active Expired - Lifetime
- 1987-06-04 ES ES87401244T patent/ES2011296B3/es not_active Expired - Lifetime
- 1987-06-04 AT AT87401244T patent/ATE46157T1/de not_active IP Right Cessation
- 1987-06-05 JP JP62140119A patent/JPS6339874A/ja active Pending
- 1987-06-05 US US07/058,780 patent/US4808599A/en not_active Expired - Fee Related
1989
- 1989-09-07 GR GR89400043T patent/GR3000148T3/el unknown

Also Published As

Publication number	Publication date
AU7378587A (en)	1987-12-10
ES2011296B3 (es)	1990-01-01
DE3760532D1 (en)	1989-10-12
FR2599740A1 (fr)	1987-12-11
ZA873978B (en)	1987-12-02
PT85014B (pt)	1990-03-08
ATE46157T1 (de)	1989-09-15
JPS6339874A (ja)	1988-02-20
GR3000148T3 (en)	1990-11-29
PT85014A (fr)	1987-07-01
EP0248734B1 (fr)	1989-09-06
FR2599740B1 (fr)	1988-08-12
DK289087D0 (da)	1987-06-04
US4808599A (en)	1989-02-28
EP0248734A1 (fr)	1987-12-09
CA1280115C (fr)	1991-02-12
AU591780B2 (en)	1989-12-14
NZ220546A (en)	1989-02-24

Legal Events

Date	Code	Title	Description
1992-02-24	AHB	Application shelved due to non-payment

Publication	Publication Date	Title
DK289087D0 (da)	1987-06-04	Benzo(b)thiophen- og benzo(b)furan-carboxamider, deres fremstilling og laegemidler indeholdende disse forbindelser
ES2059825T3 (es)	1994-11-16	Nuevos inhibidores de agregacion plaquetaria.
ATE233559T1 (de)	2003-03-15	Verwendung von benzothiophene zur behandlung von hypercholesterolämie
FI96204C (fi)	1996-05-27	Menetelmä terapeuttisesti käyttökelpoisten heterosyklisten yhdisteiden valmistamiseksi
DK0483667T3 (da)	1998-09-23	Cykliske iminoderivater, lægemidler indholdende disse forbindelser og fremgangsmåde til fremstilling deraf
DK444581A (da)	1982-04-09	Beta-lactam-forbindelser og farmaceutisk taalelige salte deraf fremgangsmaade til deres fremstilling og deres anvendelse
DK0518558T3 (da)	1999-05-31	1-methylcarbapenemderivater, deres fremstilling og deres anvendelse som antibiotika
ATE144498T1 (de)	1996-11-15	Herstellung von substituierten piperidinen
DK0461986T3 (da)	1996-05-28	Hexahydroazepinderivater, en fremgangsmåde til fremstilling heraf og farmaceutiske midler indeholdende disse
SE8500107D0 (sv)	1985-01-10	Neue 8alfa-acylaminoergoline
ATE40370T1 (de)	1989-02-15	Phenylengruppen-haltige organosilane, verfahren zu ihrer herstellung.
DK282285A (da)	1985-12-23	Hidtil ukendte 8-alkylthio-2-piperazino-pyrimido(5,4-d)pyrimidiner,deres fremstilling og laegemidler indeholdende disse forbindelser
DE59006541D1 (de)	1994-09-01	Mittel zum Schutz von Pflanzen gegen Krankheiten.
DK290086D0 (da)	1986-06-20	I 17-stillingen substituerede sparteinderivater og deres anvendelse som laegemidler
ATE28871T1 (de)	1987-08-15	Disubstituierte piperidine,verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
DK214589A (da)	1989-11-21	3-substituerede 3-(thien-2-yl)-piperazin-2-oner eller farmakologisk acceptable syreadditionsforbindelser deraf, deres fremstilling og anvendelse
NO305556B1 (no)	1999-06-21	Tiokarbamoylforbindelser og anvendelse derav samt middel for beskyttelse av tekniske materialer
ATE7298T1 (de)	1984-05-15	Basisch substituierte 5-phenyltetrazole, verfahren zu ihrer herstellung und ihre verwendung als heilmittel.
DK574582A (da)	1983-06-29	(1,2)-kondenserede 1,4-benzodiazepin-forbindelser og fremgangsmaade til fremstilling deraf
DE69018741D1 (de)	1995-05-24	Konjugierte gamma-Hydroxybutenolid-Derivate und sie als aktiver Wirkstoff enthaltende Mittel gegen Magengeschwüre.
SE7905631L (sv)	1979-12-30	Nya oxotiaforeningar
DK42784A (da)	1984-08-23	Pyridin-pyrimidinon-derivater, fremgangsmaade til deres fremstilling og laegemidler indeholdende disse forbindelser
ATE19077T1 (de)	1986-04-15	Thiophen-derivat mit mucoregulatorischer und anti-husten-wirkung, verfahren zu seiner herstellung und dieses enthaltende pharmazeutische zusammensetzungen.