ZA873978B - Benzo(b)thiophene-and benzo(b)furancarboxamide derivatives,their preparation,and pharmaceutical compositions containing them - Google Patents

Benzo(b)thiophene-and benzo(b)furancarboxamide derivatives,their preparation,and pharmaceutical compositions containing them

Info

Publication number: ZA873978B
Authority: ZA; South Africa
Prior art keywords: benzo; thiophene; preparation; pharmaceutical compositions; compositions containing
Prior art date: 1986-06-05

Application number

ZA873978A

Other languages

English (en)

Inventor

Dubroeucq Marie-Christine

Renault Christian

Original Assignee

Rhone-Poulenc Sante

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-06-05

Filing date

1987-06-03

Publication date

1987-12-02

1987-06-03 Application filed by Rhone-Poulenc Sante filed Critical Rhone-Poulenc Sante

1987-12-02 Publication of ZA873978B publication Critical patent/ZA873978B/xx

Links

CSWYVMIMIIKEEL-UHFFFAOYSA-N C1=CC=C2SC=CC2=C1.C1=CC=C2OC(C(=O)N)=CC2=C1 Chemical class C1=CC=C2SC=CC2=C1.C1=CC=C2OC(C(=O)N)=CC2=C1 CSWYVMIMIIKEEL-UHFFFAOYSA-N 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical group C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
230000003257 anti-anginal effect Effects 0.000 abstract 1
239000002249 anxiolytic agent Substances 0.000 abstract 1
230000000949 anxiolytic effect Effects 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
230000002519 immonomodulatory effect Effects 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Immunology (AREA)
Anesthesiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ZA873978A 1986-06-05 1987-06-03 Benzo(b)thiophene-and benzo(b)furancarboxamide derivatives,their preparation,and pharmaceutical compositions containing them ZA873978B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8608110A FR2599740B1 (fr)	1986-06-05	1986-06-05	Derives de benzo(b)thiophene de benzo(b)furannecarboxamides, leurs procedes de preparation et les medicaments les contenant

Publications (1)

Publication Number	Publication Date
ZA873978B true ZA873978B (en)	1987-12-02

Family

ID=9336032

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA873978A ZA873978B (en)	1986-06-05	1987-06-03	Benzo(b)thiophene-and benzo(b)furancarboxamide derivatives,their preparation,and pharmaceutical compositions containing them

Country Status (14)

Country	Link
US (1)	US4808599A (da)
EP (1)	EP0248734B1 (da)
JP (1)	JPS6339874A (da)
AT (1)	ATE46157T1 (da)
AU (1)	AU591780B2 (da)
CA (1)	CA1280115C (da)
DE (1)	DE3760532D1 (da)
DK (1)	DK289087A (da)
ES (1)	ES2011296B3 (da)
FR (1)	FR2599740B1 (da)
GR (1)	GR3000148T3 (da)
NZ (1)	NZ220546A (da)
PT (1)	PT85014B (da)
ZA (1)	ZA873978B (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1196849B (it) *	1986-02-16	1988-11-25	Rotta Research Lab	Nuovi derivati degli acidi 5 pentilammino 5 oxo pentaoico e 4 pentilammino 4 oxo butanoico ad attivita antagonista della colecistochinina e procedimento per la loro preparazione
JP3415946B2 (ja) *	1994-10-31	2003-06-09	タイコエレクトロニクスアンプ株式会社	電気コネクタ
US5776946A (en) *	1995-08-28	1998-07-07	Mcgeer; Patrick L.	Peripheral benzodiazepine receptor ligands as antiinflammatory agents
CA2331056A1 (en)	1998-05-12	1999-12-02	Wyeth	2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia
US6251936B1 (en)	1998-05-12	2001-06-26	American Home Products Corporation	Benzothiophenes, benzofurans, and indoles useful in the treatment of insulin resistance and hyperglycemia
US6221902B1 (en)	1998-05-12	2001-04-24	American Home Products Corporation	Biphenyl sulfonyl aryl carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
HRP20000767A2 (en) *	1998-05-12	2001-10-31	American Home Prod	Benzothiophenes, benzofurans and indoles useful in the treatment of insulin resistance and hyperglycemia
US6232322B1 (en)	1998-05-12	2001-05-15	American Home Products Corporation	Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6451827B2 (en) *	1998-05-12	2002-09-17	Wyeth	2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia
US6699896B1 (en)	1998-05-12	2004-03-02	Wyeth	Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
US6110963A (en) *	1998-05-12	2000-08-29	American Home Products Corporation	Aryl-oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6110962A (en) *	1998-05-12	2000-08-29	American Home Products Corporation	11-aryl-benzo[B]naphtho[2,3-D]furans and 11-aryl-benzo[B]naphtho[2,3-D]thiophenes useful in the treatment of insulin resistance and hyperglycemia
FR2778564B1 (fr) *	1998-05-13	2001-07-13	Sanofi Sa	Utilisation de composes reduisant l'apoptose
WO1999058117A1 (fr) *	1998-05-13	1999-11-18	Sanofi-Synthelabo	Utilisation de composes reduisant l'apoptose
ATE300947T1 (de)	1998-12-18	2005-08-15	Scios Inc	Behandlung von erkrankungen mit zystenbildung
DE69932449T2 (de)	1998-12-18	2007-03-15	Scios Inc., Fremont	Agonisten und antagonisten von benzodiazepinrezeptoren des peripheren typs
US6310081B1 (en)	1999-05-10	2001-10-30	American Home Products Corporation	Biphenyl sulfonyl aryl carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
JP3745608B2 (ja)	2000-09-27	2006-02-15	矢崎総業株式会社	フロントホルダの係止構造
JP4678139B2 (ja) *	2004-05-10	2011-04-27	トヨタ自動車株式会社	自動車の暖房制御システム
WO2006010379A1 (en) *	2004-07-29	2006-02-02	Actelion Pharmaceuticals Ltd.	Novel thiophene derivatives as immunosuppressive agents
CA2602474C (en) *	2005-03-23	2014-06-10	Actelion Pharmaceuticals Ltd	Hydrogenated benzo (c) thiophene derivatives as immunomodulators
KR20080002850A (ko)	2005-03-23	2008-01-04	액테리온 파마슈티칼 리미티드	신규한 티오펜 유도체
AU2007209051A1 (en) *	2006-01-24	2007-08-02	Actelion Pharmaceuticals Ltd	Novel pyridine derivatives
GB0905328D0 (en) *	2009-03-27	2009-05-13	Ge Healthcare Ltd	Indole derivatives
JP5830519B2 (ja) *	2010-03-26	2015-12-09	ジーイー・ヘルスケア・リミテッド	Ｐｂｒリガンドとしての三環式インドール誘導体
US9220795B2 (en)	2011-09-22	2015-12-29	Ge Healthcare Limited	Indole derivatives
GB201312768D0 (en)	2013-07-17	2013-08-28	Ge Healthcare Ltd	Work-up procedure

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1297877C (en) *	1983-12-22	1992-03-24	Daniel Lednicer	Benzofurancarboxamides useful as antiemetic or antipsychotic agents

1986
- 1986-06-05 FR FR8608110A patent/FR2599740B1/fr not_active Expired
1987
- 1987-06-03 AU AU73785/87A patent/AU591780B2/en not_active Ceased
- 1987-06-03 NZ NZ220546A patent/NZ220546A/xx unknown
- 1987-06-03 ZA ZA873978A patent/ZA873978B/xx unknown
- 1987-06-04 CA CA000538850A patent/CA1280115C/fr not_active Expired - Lifetime
- 1987-06-04 DE DE8787401244T patent/DE3760532D1/de not_active Expired
- 1987-06-04 DK DK289087A patent/DK289087A/da not_active Application Discontinuation
- 1987-06-04 PT PT85014A patent/PT85014B/pt not_active IP Right Cessation
- 1987-06-04 ES ES87401244T patent/ES2011296B3/es not_active Expired - Lifetime
- 1987-06-04 EP EP87401244A patent/EP0248734B1/fr not_active Expired
- 1987-06-04 AT AT87401244T patent/ATE46157T1/de not_active IP Right Cessation
- 1987-06-05 JP JP62140119A patent/JPS6339874A/ja active Pending
- 1987-06-05 US US07/058,780 patent/US4808599A/en not_active Expired - Fee Related
1989
- 1989-09-07 GR GR89400043T patent/GR3000148T3/el unknown

Also Published As

Publication number	Publication date
DK289087D0 (da)	1987-06-04
DE3760532D1 (en)	1989-10-12
NZ220546A (en)	1989-02-24
ES2011296B3 (es)	1990-01-01
AU591780B2 (en)	1989-12-14
DK289087A (da)	1987-12-06
GR3000148T3 (en)	1990-11-29
FR2599740A1 (fr)	1987-12-11
PT85014A (fr)	1987-07-01
JPS6339874A (ja)	1988-02-20
CA1280115C (fr)	1991-02-12
ATE46157T1 (de)	1989-09-15
US4808599A (en)	1989-02-28
AU7378587A (en)	1987-12-10
FR2599740B1 (fr)	1988-08-12
PT85014B (pt)	1990-03-08
EP0248734B1 (fr)	1989-09-06
EP0248734A1 (fr)	1987-12-09

Publication	Publication Date	Title
ZA873978B (en)	1987-12-02	Benzo(b)thiophene-and benzo(b)furancarboxamide derivatives,their preparation,and pharmaceutical compositions containing them
ES2044836T3 (es)	1994-01-16	Derivado de la piperidina, su utilizacion y compuesto farmaceutico que lo contiene.
ATE114463T1 (de)	1994-12-15	Azaspirane mit immunmodulierender wirkung.
DE2960820D1 (en)	1981-12-03	Carbostyrile derivatives, processes for their preparation and pharmaceutical compositions containing them
DK0518558T3 (da)	1999-05-31	1-methylcarbapenemderivater, deres fremstilling og deres anvendelse som antibiotika
IL98479A0 (en)	1992-07-15	Hexahydroazepine derivatives,their preparation and pharmaceutical compositions containing them
NZ248794A (en)	1995-01-27	3-carboxy-(and phosphonoxy-)alkatriene-substituted chromene derivatives and medicaments
DK0564358T3 (da)	1999-07-19	3-aminochroman-spiro-derivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende sådanne
DK282285A (da)	1985-12-23	Hidtil ukendte 8-alkylthio-2-piperazino-pyrimido(5,4-d)pyrimidiner,deres fremstilling og laegemidler indeholdende disse forbindelser
DE3161553D1 (en)	1984-01-05	Thiazolo(3,2-a)pyrimidine derivatives, their preparation and pharmaceutical compositions containing them
GR3023941T3 (en)	1997-09-30	Cyclic derivatives of angiopeptin, their preparation and their pharmaceutical compositions.
DK290086A (da)	1986-12-23	I 17-stillingen substituerede sparteinderivater og deres anvendelse som laegemidler
NO305556B1 (no)	1999-06-21	Tiokarbamoylforbindelser og anvendelse derav samt middel for beskyttelse av tekniske materialer
ATE19077T1 (de)	1986-04-15	Thiophen-derivat mit mucoregulatorischer und anti-husten-wirkung, verfahren zu seiner herstellung und dieses enthaltende pharmazeutische zusammensetzungen.
BG95629A (en)	1994-03-31	Derivatives of 10, 11, 12, 13 - tetrahytdrodesmicozine, method for preparing them, and their use as pharmaceutical preparations
JPS55104266A (en)	1980-08-09	Novel pyridone derivative