DK2895607T3 - Dobbeltstrengede oligonukleotidmolekyler til ddit4 og fremgangsmåder til anvendelse deraf - Google Patents
Dobbeltstrengede oligonukleotidmolekyler til ddit4 og fremgangsmåder til anvendelse deraf Download PDFInfo
- Publication number
- DK2895607T3 DK2895607T3 DK13773450.5T DK13773450T DK2895607T3 DK 2895607 T3 DK2895607 T3 DK 2895607T3 DK 13773450 T DK13773450 T DK 13773450T DK 2895607 T3 DK2895607 T3 DK 2895607T3
- Authority
- DK
- Denmark
- Prior art keywords
- ddit4
- string
- double
- methods
- oligonucleotide molecules
- Prior art date
Links
- 102100026139 DNA damage-inducible transcript 4 protein Human genes 0.000 title 1
- 101000912753 Homo sapiens DNA damage-inducible transcript 4 protein Proteins 0.000 title 1
- 108091034117 Oligonucleotide Proteins 0.000 title 1
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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- C12N2310/31—Chemical structure of the backbone
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- C12N2310/31—Chemical structure of the backbone
- C12N2310/319—Chemical structure of the backbone linked by 2'-5' linkages, i.e. having a free 3'-position
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/321—2'-O-R Modification
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
- C12N2310/3521—Methyl
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- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
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- Biomedical Technology (AREA)
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- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Veterinary Medicine (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Zoology (AREA)
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- Biochemistry (AREA)
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- Endocrinology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261699884P | 2012-09-12 | 2012-09-12 | |
| PCT/US2013/059341 WO2014043289A2 (en) | 2012-09-12 | 2013-09-12 | Double-stranded oligonucleotide molecules to ddit4 and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2895607T3 true DK2895607T3 (da) | 2021-05-25 |
Family
ID=49304313
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13773450.5T DK2895607T3 (da) | 2012-09-12 | 2013-09-12 | Dobbeltstrengede oligonukleotidmolekyler til ddit4 og fremgangsmåder til anvendelse deraf |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US9932578B2 (da) |
| EP (1) | EP2895607B1 (da) |
| JP (1) | JP6364009B2 (da) |
| CN (1) | CN104619844A (da) |
| BR (1) | BR112015004747A2 (da) |
| CA (1) | CA2880290C (da) |
| DK (1) | DK2895607T3 (da) |
| ES (1) | ES2872349T3 (da) |
| HK (1) | HK1210216A1 (da) |
| WO (1) | WO2014043289A2 (da) |
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| US9932578B2 (en) | 2012-09-12 | 2018-04-03 | Quark Pharmaceuticals, Inc. | Double-stranded oligonucleotide molecules to P53 and methods of use thereof |
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| IL316808A (en) | 2014-08-20 | 2025-01-01 | Alnylam Pharmaceuticals Inc | Modified double-stranded RNA materials and their uses |
| JP6982500B2 (ja) | 2015-02-26 | 2021-12-17 | ソニーグループ株式会社 | フェニルエチニルナフタレン染料およびそれらの使用方法 |
| JP6806694B2 (ja) * | 2015-02-26 | 2021-01-06 | ソニー株式会社 | 共役基を含む水溶性蛍光染料または有色染料 |
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| WO2017197014A2 (en) | 2016-05-10 | 2017-11-16 | Sony Corporation | Compositions comprising a polymeric dye and a cyclodextrin and uses thereof |
| US11370922B2 (en) | 2016-05-10 | 2022-06-28 | Sony Corporation | Ultra bright polymeric dyes with peptide backbones |
| KR102526802B1 (ko) | 2016-05-11 | 2023-05-02 | 소니그룹주식회사 | 초고명도 이량체성 또는 중합체성 염료 |
| WO2017214165A1 (en) | 2016-06-06 | 2017-12-14 | Sony Corporation | Ionic polymers comprising fluorescent or colored reporter groups |
| JP7312929B2 (ja) | 2016-07-29 | 2023-07-24 | ソニーグループ株式会社 | 超明色二量体またはポリマー色素およびその調製のための方法 |
| EP4035659A1 (en) | 2016-11-29 | 2022-08-03 | PureTech LYT, Inc. | Exosomes for delivery of therapeutic agents |
| JP7551056B2 (ja) | 2017-10-05 | 2024-09-17 | ソニーグループ株式会社 | プログラマブルなポリマー薬物 |
| CN111093711A (zh) | 2017-10-05 | 2020-05-01 | 索尼公司 | 可编程的树枝状药物 |
| CN111836645A (zh) | 2017-11-16 | 2020-10-27 | 索尼公司 | 可编程的聚合药物 |
| CN111565756A (zh) | 2018-01-12 | 2020-08-21 | 索尼公司 | 包含生物活性化合物的具有刚性间隔基团的聚合物 |
| EP3737419B1 (en) | 2018-01-12 | 2024-04-10 | Sony Group Corporation | Phosphoalkyl polymers comprising biologically active compounds |
| US12194104B2 (en) | 2018-01-12 | 2025-01-14 | Sony Group Corporation | Phosphoalkyl ribose polymers comprising biologically active compounds |
| US11874280B2 (en) | 2018-03-19 | 2024-01-16 | Sony Group Corporation | Use of divalent metals for enhancement of fluorescent signals |
| KR102864292B1 (ko) | 2018-03-21 | 2025-09-26 | 소니그룹주식회사 | 링커 군을 갖는 중합체성 텐덤 염료 |
| US12006438B2 (en) | 2018-06-27 | 2024-06-11 | Sony Group Corporation | Polymeric dyes with linker groups comprising deoxyribose |
| EP3820944A1 (en) | 2018-07-13 | 2021-05-19 | Sony Corporation | Polymeric dyes having a backbone comprising organophosphate units |
| WO2021062176A2 (en) | 2019-09-26 | 2021-04-01 | Sony Corporation | Polymeric tandem dyes with linker groups |
| EP4038081A1 (en) | 2019-09-30 | 2022-08-10 | Sony Group Corporation | Nucleotide probes |
| CN110974804B (zh) * | 2019-11-13 | 2021-09-24 | 杭州师范大学 | p53信使RNA纳米粒及其制备方法和在制备治疗肿瘤药物中的应用 |
| WO2022125564A1 (en) | 2020-12-07 | 2022-06-16 | Sony Group Corporation | Spacing linker group design for brightness enhancement in dimeric or polymeric dyes |
| IL318229A (en) * | 2022-07-27 | 2025-03-01 | E Therapeutics Plc | Nucleic acid compounds |
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-
2013
- 2013-09-12 US US14/421,845 patent/US9932578B2/en not_active Expired - Fee Related
- 2013-09-12 EP EP13773450.5A patent/EP2895607B1/en active Active
- 2013-09-12 CA CA2880290A patent/CA2880290C/en not_active Expired - Fee Related
- 2013-09-12 US US14/426,513 patent/US9611474B2/en not_active Expired - Fee Related
- 2013-09-12 ES ES13773450T patent/ES2872349T3/es active Active
- 2013-09-12 DK DK13773450.5T patent/DK2895607T3/da active
- 2013-09-12 CN CN201380047225.6A patent/CN104619844A/zh active Pending
- 2013-09-12 HK HK15110939.6A patent/HK1210216A1/xx unknown
- 2013-09-12 BR BR112015004747A patent/BR112015004747A2/pt not_active IP Right Cessation
- 2013-09-12 WO PCT/US2013/059341 patent/WO2014043289A2/en not_active Ceased
- 2013-09-12 JP JP2015531340A patent/JP6364009B2/ja not_active Expired - Fee Related
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2017
- 2017-02-15 US US15/433,400 patent/US10421962B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20150267194A1 (en) | 2015-09-24 |
| ES2872349T3 (es) | 2021-11-02 |
| HK1210216A1 (en) | 2016-04-15 |
| EP2895607B1 (en) | 2021-05-05 |
| EP2895607A2 (en) | 2015-07-22 |
| US20180010125A1 (en) | 2018-01-11 |
| US10421962B2 (en) | 2019-09-24 |
| CA2880290C (en) | 2020-10-27 |
| CA2880290A1 (en) | 2014-03-20 |
| US20150203845A1 (en) | 2015-07-23 |
| US9611474B2 (en) | 2017-04-04 |
| CN104619844A (zh) | 2015-05-13 |
| BR112015004747A2 (pt) | 2017-11-21 |
| US20180044671A9 (en) | 2018-02-15 |
| WO2014043289A3 (en) | 2014-06-05 |
| JP2015535174A (ja) | 2015-12-10 |
| WO2014043289A2 (en) | 2014-03-20 |
| US9932578B2 (en) | 2018-04-03 |
| JP6364009B2 (ja) | 2018-07-25 |
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