DK2908871T3 - Fremgangsmåder til behandling af abscesser - Google Patents
Fremgangsmåder til behandling af abscesser Download PDFInfo
- Publication number
- DK2908871T3 DK2908871T3 DK13847381.4T DK13847381T DK2908871T3 DK 2908871 T3 DK2908871 T3 DK 2908871T3 DK 13847381 T DK13847381 T DK 13847381T DK 2908871 T3 DK2908871 T3 DK 2908871T3
- Authority
- DK
- Denmark
- Prior art keywords
- fistula
- therapeutic agent
- abscess
- solid matrix
- abscess cavity
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 43
- 239000003814 drug Substances 0.000 claims description 77
- 229940124597 therapeutic agent Drugs 0.000 claims description 74
- 239000011159 matrix material Substances 0.000 claims description 73
- 206010000269 abscess Diseases 0.000 claims description 65
- 239000000463 material Substances 0.000 claims description 63
- 206010016717 Fistula Diseases 0.000 claims description 58
- 230000003890 fistula Effects 0.000 claims description 58
- 239000007787 solid Substances 0.000 claims description 58
- 239000000945 filler Substances 0.000 claims description 28
- 230000035876 healing Effects 0.000 claims description 22
- 238000011282 treatment Methods 0.000 claims description 18
- 238000002513 implantation Methods 0.000 claims description 11
- 208000004680 Rectal Fistula Diseases 0.000 claims description 10
- 206010002156 anal fistula Diseases 0.000 claims description 10
- 210000000130 stem cell Anatomy 0.000 claims description 10
- 241000124008 Mammalia Species 0.000 claims description 8
- 238000011049 filling Methods 0.000 claims description 4
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- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 208000011231 Crohn disease Diseases 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 108050001049 Extracellular proteins Proteins 0.000 description 1
- 208000034347 Faecal incontinence Diseases 0.000 description 1
- 108010080379 Fibrin Tissue Adhesive Proteins 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 108090000190 Thrombin Proteins 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 230000000735 allogeneic effect Effects 0.000 description 1
- 210000003503 anal sac Anatomy 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
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- 230000000035 biogenic effect Effects 0.000 description 1
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- 229940098773 bovine serum albumin Drugs 0.000 description 1
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- 230000006378 damage Effects 0.000 description 1
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- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 239000012091 fetal bovine serum Substances 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 108091005899 fibrous proteins Proteins 0.000 description 1
- 102000034240 fibrous proteins Human genes 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 238000007455 ileostomy Methods 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 210000002536 stromal cell Anatomy 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 238000011277 treatment modality Methods 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/043—Proteins; Polypeptides; Degradation products thereof
- A61L31/046—Fibrin; Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
- A61L26/0042—Fibrin; Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/005—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/19—Platelets; Megacaryocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/64—Animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Materials Engineering (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Materials For Medical Uses (AREA)
Claims (12)
1. Medicinsk anordning til anvendelse til behandling af en absceshule hos et pattedyr, hvilken anordning omfatter: (a) en stikprop, der omfatter en skivedel og flere ben, der er fastgjort til skivedelen, hvilken skivedel og hvilke ben er konfigureret til implantation i absceshulen, hvor skivedelen og benene er lavet af fast biokompatibelt matrixfyldmateriale, og (b) et terapeutisk middel, hvor det terapeutiske middel er bundet til det faste biokompatible matrixfyldmateriale.
2. Medicinsk anordning ifølge krav 1, hvor pattedyret er et menneske.
3. Medicinsk anordning ifølge krav 1 eller 2, hvor absceshulen er en fistel.
4. Medicinsk anordning ifølge et hvilket som helst af krav 1 til 3, hvor fistlen er en anal fistel.
5. Medicinsk anordning ifølge et hvilket som helst af krav 1 til 4, hvor det terapeutiske middel er a) et stamcellemateriale; eller b) et trombocytderivatmateriale.
6. Medicinsk anordning ifølge krav 5, hvor stamcellematerialet er fedtafledte stamceller, og de fedtafledte stamceller er absorberet i det faste biokompatible matrixfyldmateriale .
7. Fremgangsmåde til opnåelse af en medicinsk anordning til anvendelse til behandling af en absceshule hos et pattedyr, hvilken fremgangsmåde omfatter: (a) tilvejebringelse af en stikprop, der omfatter en skivedel og flere ben, der er fastgjort til skivedelen, hvilken skivedel og hvilke ben er konfigureret til implantation i absceshulen, hvor skivedelen og benene er lavet af fast biokompatibelt matrixfyldmateriale, (b) behandling af det faste biokompatible matrixfyldmateriale med et terapeutisk middel, hvor behandlingen mætter det faste biokompatible matrixfyldmateriale med det terapeutiske middel, og hvor det terapeutiske middel kan fremme heling af absceshulen.
8. Fremgangsmåde ifølge krav 7, hvor pattedyret er et menneske.
9. Fremgangsmåde ifølge krav 7 eller 8, hvor absceshulen er en fistel.
10. Fremgangsmåde ifølge et hvilket som helst af kravene 7 til 9, hvor fistlen er en anal fistel.
11. Fremgangsmåde ifølge et hvilket som helst af kravene 7 til 10, hvor det terapeutiske middel er a) et stamcellemateriale; eller b) et trombocytderivatmateriale.
12. Fremgangsmåde ifølge krav 11, hvor stamcellematerialet er fedtafledte stamceller, og de fedtafledte stamceller er absorberet i det faste biokompatible matrixfyldmateriale.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261715506P | 2012-10-18 | 2012-10-18 | |
| PCT/US2013/065631 WO2014063022A1 (en) | 2012-10-18 | 2013-10-18 | Techniques for treatment of abscesses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2908871T3 true DK2908871T3 (da) | 2018-12-03 |
Family
ID=50488779
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13847381.4T DK2908871T3 (da) | 2012-10-18 | 2013-10-18 | Fremgangsmåder til behandling af abscesser |
| DK18187769.7T DK3473276T3 (da) | 2012-10-18 | 2013-10-18 | Teknikker til behandling af abscesser |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18187769.7T DK3473276T3 (da) | 2012-10-18 | 2013-10-18 | Teknikker til behandling af abscesser |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20150258249A1 (da) |
| EP (2) | EP3473276B1 (da) |
| DK (2) | DK2908871T3 (da) |
| ES (2) | ES2692290T3 (da) |
| FI (1) | FI3473276T3 (da) |
| WO (1) | WO2014063022A1 (da) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3051452A1 (en) * | 2017-03-21 | 2018-09-27 | Mayo Foundation For Medical Education And Research | Methods and materials for treating fistulas |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060045872A1 (en) * | 2004-08-25 | 2006-03-02 | Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco | Use of adipose tissue-derived stromal stem cells in treating fistula |
| JP4995811B2 (ja) * | 2005-04-29 | 2012-08-08 | クック・バイオテック・インコーポレーテッド | 瘻治療用容積式移植片並びに関連の方法及びシステム |
| WO2007002260A2 (en) * | 2005-06-21 | 2007-01-04 | Cook Incorporated | Implantable graft to close a fistula |
| CA2682034C (en) * | 2007-03-26 | 2015-01-27 | Baxter International Inc. | Injectable void filler for soft tissue augmentation |
| US20110293666A1 (en) * | 2007-11-28 | 2011-12-01 | Xianyan Wang | Bioengineered Tissue Constructs and Methods for Production and Use |
| US20110282368A1 (en) * | 2010-05-12 | 2011-11-17 | Swayze Jeffrey S | Fistula Repair Device with Extendable Barbs and Therapeutic Cell Delivery |
| CA3051452A1 (en) * | 2017-03-21 | 2018-09-27 | Mayo Foundation For Medical Education And Research | Methods and materials for treating fistulas |
-
2013
- 2013-10-18 ES ES13847381.4T patent/ES2692290T3/es active Active
- 2013-10-18 EP EP18187769.7A patent/EP3473276B1/en active Active
- 2013-10-18 US US14/435,778 patent/US20150258249A1/en not_active Abandoned
- 2013-10-18 ES ES18187769T patent/ES2968961T3/es active Active
- 2013-10-18 DK DK13847381.4T patent/DK2908871T3/da active
- 2013-10-18 FI FIEP18187769.7T patent/FI3473276T3/fi active
- 2013-10-18 WO PCT/US2013/065631 patent/WO2014063022A1/en not_active Ceased
- 2013-10-18 DK DK18187769.7T patent/DK3473276T3/da active
- 2013-10-18 EP EP13847381.4A patent/EP2908871B1/en active Active
-
2018
- 2018-09-06 US US16/123,555 patent/US20190001028A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20150258249A1 (en) | 2015-09-17 |
| EP3473276B1 (en) | 2023-12-13 |
| US20190001028A1 (en) | 2019-01-03 |
| ES2692290T3 (es) | 2018-12-03 |
| EP2908871A1 (en) | 2015-08-26 |
| EP3473276A1 (en) | 2019-04-24 |
| DK3473276T3 (da) | 2024-01-29 |
| FI3473276T3 (fi) | 2024-01-24 |
| ES2968961T3 (es) | 2024-05-14 |
| EP2908871A4 (en) | 2016-06-29 |
| WO2014063022A1 (en) | 2014-04-24 |
| EP2908871B1 (en) | 2018-08-08 |
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