DK2941483T3 - Fremgangsmåde til at opnå immunstimulerende dendritriske celler - Google Patents

Fremgangsmåde til at opnå immunstimulerende dendritriske celler Download PDF

Info

Publication number
DK2941483T3
DK2941483T3 DK14700025.1T DK14700025T DK2941483T3 DK 2941483 T3 DK2941483 T3 DK 2941483T3 DK 14700025 T DK14700025 T DK 14700025T DK 2941483 T3 DK2941483 T3 DK 2941483T3
Authority
DK
Denmark
Prior art keywords
immunstimulating
procedure
dendritric cells
dendritric
cells
Prior art date
Application number
DK14700025.1T
Other languages
English (en)
Inventor
Karsten Henco
Günter Bauer
Justin Duckworth
Adrian Hayday
Richard Edelson
Robert Tigelaar
Michael Girardi
Original Assignee
Transimmune Ag
Univ Yale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transimmune Ag, Univ Yale filed Critical Transimmune Ag
Application granted granted Critical
Publication of DK2941483T3 publication Critical patent/DK2941483T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/19—Dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/428—Undefined tumor antigens, e.g. tumor lysate or antigens targeted by cells isolated from tumor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
    • C12N2502/115—Platelets, megakaryocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
    • C12N2506/115—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells from monocytes, from macrophages
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2521/00—Culture process characterised by the use of hydrostatic pressure, flow or shear forces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2529/00—Culture process characterised by the use of electromagnetic stimulation
    • C12N2529/10—Stimulation by light

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
DK14700025.1T 2013-01-03 2014-01-02 Fremgangsmåde til at opnå immunstimulerende dendritriske celler DK2941483T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361748546P 2013-01-03 2013-01-03
GBGB1300049.2A GB201300049D0 (en) 2013-01-03 2013-01-03 Method for obtaining immuno-stimulatory dendritic cells
PCT/EP2014/050010 WO2014106629A1 (en) 2013-01-03 2014-01-02 Method for obtaining immuno-stimulatory dendritic cells

Publications (1)

Publication Number Publication Date
DK2941483T3 true DK2941483T3 (da) 2020-06-02

Family

ID=47747911

Family Applications (1)

Application Number Title Priority Date Filing Date
DK14700025.1T DK2941483T3 (da) 2013-01-03 2014-01-02 Fremgangsmåde til at opnå immunstimulerende dendritriske celler

Country Status (12)

Country Link
US (2) US20160298082A1 (da)
EP (2) EP3741843B1 (da)
JP (1) JP6621665B2 (da)
KR (3) KR20200043549A (da)
CN (2) CN105008522A (da)
AU (1) AU2014204344B2 (da)
CA (2) CA2897109C (da)
DK (1) DK2941483T3 (da)
ES (2) ES2987346T3 (da)
GB (1) GB201300049D0 (da)
PL (2) PL2941483T3 (da)
WO (1) WO2014106629A1 (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013059343A1 (en) 2011-10-17 2013-04-25 Massachusetts Institute Of Technology Intracellular delivery
US10124336B2 (en) 2013-08-16 2018-11-13 Massachusetts Institute Of Technology Selective delivery of material to cells
ES2796090T3 (es) * 2014-02-10 2020-11-25 Inst Curie Uso de moduladores MCOLN-1 para regular la migración celular
GB201413665D0 (en) * 2014-07-03 2014-09-17 Transimmune Ag And Yale University Method for obtaining globally activated monocytes
CN122564053A (zh) 2014-10-31 2026-08-14 麻省理工学院 递送生物分子至免疫细胞
WO2016077761A1 (en) 2014-11-14 2016-05-19 Massachusetts Institute Of Technology Disruption and field enabled delivery of compounds and compositions into cells
AU2016206870B2 (en) 2015-01-12 2022-02-17 Massachusetts Institute Of Technology Gene editing through microfluidic delivery
GB201513278D0 (en) * 2015-07-03 2015-09-09 Transimmune Ag And Yale University Device and method for obtaining immunostimulatory antigen-presenting cells
JP6925984B2 (ja) 2015-07-09 2021-08-25 マサチューセッツ インスティテュート オブ テクノロジー 無核細胞への物質の送達
CN105039256A (zh) * 2015-07-13 2015-11-11 中政道和(北京)生物科技有限公司 一种支气管镜下获取肿瘤组织进行树突细胞培养扩增方法
US10946095B2 (en) 2015-09-02 2021-03-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Antibodies specific to human T-cell immunoglobulin and ITIM domain (TIGIT)
EP3518942A4 (en) * 2016-09-29 2020-05-27 Hadasit Medical Research Services&Development Ltd. DENDRITIC CELL PREPARATIONS, COMPOSITIONS AND METHODS OF USE
JP7159299B2 (ja) * 2017-09-05 2022-10-24 メディジーン イミュノテラピーズ ゲーエムベーハー 樹状細胞効力アッセイ
GB201715445D0 (en) * 2017-09-25 2017-11-08 Senzagen Ab Novel cell line and uses thereof
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
BR112021013193A2 (pt) 2019-01-07 2021-09-28 Shattuck Labs, Inc. Proteínas heterodiméricas para modulação de células t gama delta
CN112301057B (zh) * 2019-07-30 2023-02-21 上海市第一人民医院 一种重组腺相关病毒载体及其制备方法与应用
AU2020382701A1 (en) * 2019-11-13 2022-06-02 The Regents Of The University Of Colorado A Body Corporate Identification of host RNA biomarkers of infection
US20250375477A1 (en) 2021-07-29 2025-12-11 Transimmune Ag Selective tolerization - methods of selectively generating tolerogenic dendritic cells
EP4376860A1 (en) 2021-07-29 2024-06-05 Transimmune AG Methods for selectively reducing immunogenicity in a transplant
CN116381247A (zh) * 2022-12-26 2023-07-04 上海生物芯片有限公司 一种同时检测il-6和il-8的试剂盒及方法
CN121335708A (zh) 2023-05-01 2026-01-13 耶鲁大学 用于疫苗接种的抗原特异性生理性树突状细胞
JP2026516460A (ja) 2023-05-01 2026-05-25 エール・ユニバーシティ 療法用の抗原特異的生理的樹状細胞
WO2026074195A1 (en) 2024-10-05 2026-04-09 Yale University Cytokine loaded activated dendritic cells
WO2026074196A1 (en) 2024-10-05 2026-04-09 Yale University Checkpoint inhibitor loaded activated dendritic cells

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050158856A1 (en) * 1999-04-20 2005-07-21 Edelson Richard L. Methods for producing functional antigen presenting dendritic cells using biodegradable microparticles for delivery of antigenic materials
WO2000062818A1 (en) 1999-04-20 2000-10-26 Richard Leslie Edelson Differentiation of monocytes into functional dendritic cells
US7727523B2 (en) * 2001-08-13 2010-06-01 Yale University Method for suppressing immune system response to transplanted tissue or cells
CN102600461B (zh) * 2002-12-06 2017-07-14 西北生物治疗药物公司 给予体外部分成熟的树突细胞治疗肿瘤
US8524495B2 (en) * 2007-05-16 2013-09-03 Yale University Methods for inducing the differentiation of blood monocytes into functional dendritic cells
ES2535951T3 (es) * 2009-12-11 2015-05-19 Atyr Pharma, Inc. Histidil ARNt sintetasas para reducir la inflamación

Also Published As

Publication number Publication date
US20160298082A1 (en) 2016-10-13
EP3741843C0 (en) 2024-06-26
JP6621665B2 (ja) 2019-12-18
EP2941483A1 (en) 2015-11-11
ES2795926T3 (es) 2020-11-25
EP3741843B1 (en) 2024-06-26
KR20180128993A (ko) 2018-12-04
EP3741843A1 (en) 2020-11-25
CA2897109C (en) 2023-03-28
AU2014204344A1 (en) 2015-07-02
KR20150122638A (ko) 2015-11-02
PL3741843T3 (pl) 2025-01-07
WO2014106629A1 (en) 2014-07-10
ES2987346T3 (es) 2024-11-14
AU2014204344B2 (en) 2017-04-06
PL2941483T3 (pl) 2020-09-21
CN105008522A (zh) 2015-10-28
US20220112462A1 (en) 2022-04-14
EP2941483B1 (en) 2020-03-04
HK1210625A1 (en) 2016-04-29
CN109161528A (zh) 2019-01-08
KR20200043549A (ko) 2020-04-27
CA3187235A1 (en) 2014-07-10
GB201300049D0 (en) 2013-02-20
CA3187235C (en) 2026-06-16
CA2897109A1 (en) 2014-07-10
JP2016504912A (ja) 2016-02-18

Similar Documents

Publication Publication Date Title
PL3017520T3 (pl) Zespół ogniw słonecznych
IL245573B (en) Cell
DK2949038T3 (da) Solcellemodul
PL3075012T3 (pl) Urządzenia fotowoltaiczne na podstawie perowskitów
EP4235820C0 (en) PHOTOVOLTAIC DEVICES
EP3011599C0 (en) PHOTOVOLTAIC DEVICES
DE112014004775T8 (de) Zellenmodul-Anordnungen
DK2941484T3 (da) Fremgangsmåde til at opnå immunsuppressive dendritriske celler
DK3079658T3 (da) Kammer til indkapsling af secernerende celler
BR302014001120S1 (pt) Configuração aplicada em grelha
FR3003076B1 (fr) Supercondensateur electrochimique
DK3234476T3 (da) Solfanger
DK3071675T3 (da) Kombineret energinet
IL243514B (en) Solar collector assembly
EP2980212A4 (en) HEATABLE CELLOBIOHYDROLASE
DK3083944T3 (da) Pattedyrsmuskelafledte stamceller
EP2978028A4 (en) PHOTOVOLTAIC DEVICE
FR3007201B1 (fr) Cellule solaire multi-jonctions
EP3067936A4 (en) SOLAR CELL
EP3004640A4 (en) SOLAR POWER PLANT TOWER
FR3012417B1 (fr) Nacelle de turboreacteur
HUE045240T2 (hu) Toronyszerkezet
EP2919288A4 (en) SOLAR CELL
FI20135213L (fi) Aurinkokennomoduulin kokoonpano
TH1401007645A (th) เซลล์แสงอาทิตย์ (Solar Cells)