DK294989A - 8,9-annelerede beta-carboliner og 8,9-annelerede 3,4-dihydro-beta-carboliner - Google Patents

8,9-annelerede beta-carboliner og 8,9-annelerede 3,4-dihydro-beta-carboliner Download PDF

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Publication number
DK294989A
DK294989A DK294989A DK294989A DK294989A DK 294989 A DK294989 A DK 294989A DK 294989 A DK294989 A DK 294989A DK 294989 A DK294989 A DK 294989A DK 294989 A DK294989 A DK 294989A
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DK
Denmark
Prior art keywords
anneled
beta carbolines
carbolines
beta
dihydro
Prior art date
Application number
DK294989A
Other languages
English (en)
Other versions
DK169731B1 (da
DK294989D0 (da
Inventor
Derk Hamminga
Hans Heinz Haeck
Ineke Van Wijngaarden
Johannes Wilhelmus Cath Jansen
Original Assignee
Duphar Int Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duphar Int Res filed Critical Duphar Int Res
Publication of DK294989D0 publication Critical patent/DK294989D0/da
Publication of DK294989A publication Critical patent/DK294989A/da
Application granted granted Critical
Publication of DK169731B1 publication Critical patent/DK169731B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/16—Peri-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK294989A 1988-06-20 1989-06-15 Carbolinderivater, farmaceutiske præparater som indeholder dem, fremgangsmåde til fremstilling af disse præparater samt fremgangsmåde til fremstilling af carbolinderivaterne DK169731B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
NL8801565 1988-06-20
NL8801565 1988-06-20
NL8900136 1989-01-20
NL8900136 1989-01-20

Publications (3)

Publication Number Publication Date
DK294989D0 DK294989D0 (da) 1989-06-15
DK294989A true DK294989A (da) 1989-12-21
DK169731B1 DK169731B1 (da) 1995-01-30

Family

ID=26646394

Family Applications (1)

Application Number Title Priority Date Filing Date
DK294989A DK169731B1 (da) 1988-06-20 1989-06-15 Carbolinderivater, farmaceutiske præparater som indeholder dem, fremgangsmåde til fremstilling af disse præparater samt fremgangsmåde til fremstilling af carbolinderivaterne

Country Status (8)

Country Link
US (1) US5332746A (da)
EP (1) EP0347980A1 (da)
JP (1) JPH0245485A (da)
AU (1) AU628059B2 (da)
CA (1) CA1338190C (da)
DK (1) DK169731B1 (da)
IL (1) IL90652A (da)
NZ (1) NZ229587A (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0357122A3 (en) * 1988-08-29 1991-10-23 Duphar International Research B.V Use of beta-carbolines, their bio-isosteric benzofuran and benzothiophene analogues for the manufacture of a medicament having cytostatic properties
US5663178A (en) * 1995-02-06 1997-09-02 Eli Lilly And Company Tetrahydro-beta carbolines
MXPA01012969A (es) * 1999-06-15 2003-10-14 Bristol Myers Squibb Pharma Co Gamma-carbolinas fusionadas de heterociclo sustituido.
WO2011082266A2 (en) 2009-12-30 2011-07-07 Arqule, Inc. Substituted heterocyclic compounds
US9907786B2 (en) 2014-10-21 2018-03-06 Ions Pharmaceutical S.À R.L. Therapeutic compositions containing harmine and isovanillin components, and methods of use thereof
US10092550B2 (en) 2014-10-21 2018-10-09 Ions Pharmaceutical S.À R.L. Therapeutic compositions containing curcumin, harmine, and isovanillin components, and methods of use thereof
US10947253B2 (en) 2019-08-05 2021-03-16 Ankh Life Sciences Limited Fused polycyclic dimers
US12129265B2 (en) 2020-07-21 2024-10-29 Ankh Life Sciences Limited Therapeutic agents and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES273769A1 (es) * 1961-01-18 1962-06-01 Geigy Ag J R Procedimiento para la preparaciën de nuevos derivados de amidas de acido beta-carbolin-carboxilico
DD129791A5 (de) * 1976-04-13 1978-02-08 Synthelabo Verfahren zur herstellung von naphtyridinderivaten
GB2005267B (en) * 1977-09-30 1982-05-19 Omnium Chimique Sa Indole derivatives their preparation and pharmaceutical compositions containing them
NL189463C (nl) * 1978-12-28 1993-04-16 Omnichem Sa Indolonaftyridinederivaten, werkwijze voor het bereiden daarvan en geneesmiddel voor de behandeling van cardiocirculatore en cerebrovasculaire aandoeningen.
LU84664A1 (fr) * 1983-02-25 1984-11-08 Onmichem S A Alkyl-4-indolonaphtyridines et leur application therapeutique
EP0300541B1 (en) * 1987-07-20 1996-03-27 Duphar International Research B.V 8,9-anellated-1,2,3,4-tetrahydro-beta-carboline derivatives
DK686688A (da) * 1987-12-14 1989-06-15 Duphar Int Res 8,9-annelerede beta-carboliner, deres fremstilling og laegemidler indeholdende forbindelserne
EP0357122A3 (en) * 1988-08-29 1991-10-23 Duphar International Research B.V Use of beta-carbolines, their bio-isosteric benzofuran and benzothiophene analogues for the manufacture of a medicament having cytostatic properties

Also Published As

Publication number Publication date
JPH0245485A (ja) 1990-02-15
US5332746A (en) 1994-07-26
DK169731B1 (da) 1995-01-30
NZ229587A (en) 1991-05-28
IL90652A (en) 1993-08-18
EP0347980A1 (en) 1989-12-27
IL90652A0 (en) 1990-01-18
AU628059B2 (en) 1992-09-10
AU3650189A (en) 1989-12-21
DK294989D0 (da) 1989-06-15
CA1338190C (en) 1996-03-26

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed