DK2964258T3 - Antistoffer, der binder IL-23 - Google Patents

Antistoffer, der binder IL-23 Download PDF

Info

Publication number: DK2964258T3
Authority: DK; Denmark
Prior art keywords: antibodies; bind
Prior art date: 2013-03-08

Application number

DK14761062.0T

Other languages

English (en)

Inventor

Catherine Brautigam Beidler

Stuart Willis Bright

Daniel Scott Girard

Kristine Kay Kikly

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-03-08

Filing date

2014-03-04

Publication date

2020-09-14

2014-03-04 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2020-09-14 Application granted granted Critical

2020-09-14 Publication of DK2964258T3 publication Critical patent/DK2964258T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Mycology (AREA)
Epidemiology (AREA)
Microbiology (AREA)
Pain & Pain Management (AREA)
Neurosurgery (AREA)
Transplantation (AREA)
Hematology (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Obesity (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK14761062.0T 2013-03-08 2014-03-04 Antistoffer, der binder IL-23 DK2964258T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201361774732P	2013-03-08	2013-03-08
PCT/US2014/020064 WO2014137962A1 (en)	2013-03-08	2014-03-04	Antibodies that bind il-23

Publications (1)

Publication Number	Publication Date
DK2964258T3 true DK2964258T3 (da)	2020-09-14

Family

ID=51488096

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK14761062.0T DK2964258T3 (da)	2013-03-08	2014-03-04	Antistoffer, der binder IL-23

Country Status (41)

Country	Link
US (3)	US9023358B2 (da)
EP (3)	EP4311558A3 (da)
JP (1)	JP6096938B2 (da)
KR (2)	KR101775115B1 (da)
CN (1)	CN105307681B (da)
AP (1)	AP2015008708A0 (da)
AR (1)	AR094877A1 (da)
AU (1)	AU2014226094C1 (da)
BR (1)	BR112015019611B1 (da)
CA (1)	CA2901462C (da)
CL (1)	CL2015002388A1 (da)
CY (2)	CY1123589T1 (da)
DK (1)	DK2964258T3 (da)
EA (1)	EA031524B1 (da)
EC (1)	ECSP15038626A (da)
ES (1)	ES2822662T3 (da)
FI (1)	FIC20230030I1 (da)
FR (1)	FR23C1036I2 (da)
HR (1)	HRP20201633T1 (da)
HU (2)	HUE051357T2 (da)
IL (2)	IL240731B (da)
JO (1)	JOP20140049B1 (da)
LT (2)	LT2964258T (da)
LU (1)	LUC00318I2 (da)
MA (1)	MA38382A1 (da)
MX (1)	MX370396B (da)
MY (1)	MY171226A (da)
NL (1)	NL301247I2 (da)
NO (1)	NO2023037I1 (da)
PE (1)	PE20151529A1 (da)
PH (1)	PH12015501994B1 (da)
PL (1)	PL2964258T3 (da)
PT (1)	PT2964258T (da)
RS (1)	RS60928B1 (da)
SG (1)	SG11201507176VA (da)
SI (1)	SI2964258T1 (da)
TN (1)	TN2015000348A1 (da)
TW (1)	TWI636063B (da)
UA (1)	UA123198C2 (da)
WO (1)	WO2014137962A1 (da)
ZA (1)	ZA201505285B (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR102417A1 (es) *	2014-11-05	2017-03-01	Lilly Co Eli	Anticuerpos biespecíficos anti-tnf- / anti-il-23
JP6592600B2 (ja) *	2015-10-30	2019-10-16	イーライリリーアンドカンパニー	抗ｃｇｒｐ／抗ｉｌ−２３二重特異性抗体及びその使用
TW201902926A (zh)	2017-05-03	2019-01-16	美商美國禮來大藥廠	抗cgrp／抗il-23雙特異性抗體及其用途
TWI744617B (zh)	2018-03-30	2021-11-01	美商美國禮來大藥廠	治療潰瘍性結腸炎之方法
TWI808397B (zh)	2018-09-11	2023-07-11	美商美國禮來大藥廠	治療牛皮癬之方法
TW202515610A (zh)	2019-04-22	2025-04-16	美商美國禮來大藥廠	治療克隆氏症(crohn's disease)的方法
CN114555792A (zh)	2019-10-15	2022-05-27	伊莱利利公司	重组改造的、脂肪酶/酯酶缺陷型哺乳动物细胞系
CA3164996A1 (en)	2019-12-20	2021-06-14	Novarock Biotherapeutics, Ltd.	Anti-interleukin-23 p19 antibodies and methods of use thereof
CN112807428B (zh) *	2020-06-12	2024-08-27	江苏荃信生物医药股份有限公司	包含抗人白介素23单克隆抗体的药物组合物
WO2022041390A1 (zh) *	2020-08-28	2022-03-03	江苏荃信生物医药股份有限公司	包含高浓度抗人白介素23单克隆抗体的低粘度液体制剂及其制备方法
TWI904235B (zh) *	2020-09-10	2025-11-11	美商美國禮來大藥廠	治療性抗體調配物
US20240254217A1 (en)	2021-05-28	2024-08-01	Eli Lilly And Company	Anti -il-23p19 antibody regulation of genes involved in ulcerative colitis
CN113698480B (zh) *	2021-09-18	2022-07-01	东大生物技术(苏州)有限公司	一组il-23单克隆抗体及其医药用途
EP4409298A1 (en)	2021-09-30	2024-08-07	Eli Lilly and Company	Anti-il-23p19 antibody regulation of genes involved in bowel urgency in ulcerative colitis
WO2024077113A1 (en) *	2022-10-06	2024-04-11	Eli Lilly And Company	Methods of treating fatigue in ulcerative colitis
KR20250152080A (ko)	2023-02-22	2025-10-22	일라이 릴리 앤드 캄파니	궤양성 결장염에서의 유전자의 조절 및 그의 용도
WO2024191771A1 (en)	2023-03-10	2024-09-19	Eli Lilly And Company	Methods of treating ulcerative colitis
WO2025083549A1 (en)	2023-10-16	2025-04-24	Sun Pharma Advanced Research Company Limited	Methods and combinations of inhibitors of il-23 pathway and modulators of s1p signaling pathway for the treatment of autoimmune disorders
US20250228864A1 (en)	2023-11-29	2025-07-17	Gilead Sciences, Inc.	Therapies for the treatment of inflammatory bowel disease

Family Cites Families (18)

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Publication number	Priority date	Publication date	Assignee	Title
US6060284A (en)	1997-07-25	2000-05-09	Schering Corporation	DNA encoding interleukin-B30
US7090847B1 (en)	1999-09-09	2006-08-15	Schering Corporation	Mammalian cytokines; related reagents and methods
US7422743B2 (en)	2000-05-10	2008-09-09	Schering Corporation	Mammalian receptor protein DCRS5;methods of treatment
SI1601694T1 (sl)	2003-03-10	2010-01-29	Schering Corp	Uporabe IL-23 antagonistov; sorodni reagenti
US8003108B2 (en) *	2005-05-03	2011-08-23	Amgen Inc.	Sclerostin epitopes
PT2452694T (pt) *	2005-06-30	2019-02-21	Janssen Biotech Inc	Anticorpos anti-il-23, composições, métodos e utilizações
AU2006283194B9 (en) *	2005-08-25	2011-02-03	Eli Lilly And Company	Anti-IL-23 Antibodies
CN101248088A (zh) *	2005-08-25	2008-08-20	伊莱利利公司	抗il-23抗体
LT1931710T (lt)	2005-08-31	2017-03-27	Merck Sharp & Dohme Corp.	Rekombinantiniai anti-il-23 antikūnai
EA035459B1 (ru) *	2005-12-29	2020-06-19	Сентокор, Инк.	Антитело против il-23p19
CN103396489A (zh) *	2007-02-23	2013-11-20	默沙东公司	工程改造的抗IL-23p19抗体
PL2059534T3 (pl) *	2007-02-23	2012-09-28	Merck Sharp & Dohme	Przeciwciała Anty-IL-23p19 wytworzone metodą inżynierii genetycznej
MY149129A (en)	2007-03-20	2013-07-15	Lilly Co Eli	Anti-sclerostin antibodies
AR066476A1 (es) *	2007-05-08	2009-08-19	Genentech Inc	Anticuerpos anti-muc16 disenados con cisteina y conjugaods de anticuerpos y farmacos
WO2009082624A2 (en) *	2007-12-10	2009-07-02	Zymogenetics, Inc.	Antagonists of il-17a, il-17f, and il-23 and methods of using the same
US20120264917A1 (en) *	2009-05-27	2012-10-18	Ablynx N.V.	Biparatopic protein constructs directed against il-23
SG190006A1 (en) *	2010-11-04	2013-06-28	Boehringer Ingelheim Int	Anti-il-23 antibodies
MX2013013054A (es) *	2011-05-12	2014-02-20	Genentech Inc	Metodo de monitoreo de lc-ms/ms de reaccion multiple para detectar anticuerpos terapeuticos en muestras de animales utilizando peptidos de firma de estructura.

2014
- 2014-02-25 AR ARP140100582A patent/AR094877A1/es active IP Right Grant
- 2014-02-25 TW TW103106335A patent/TWI636063B/zh active
- 2014-02-25 JO JOP/2014/0049A patent/JOP20140049B1/ar active
- 2014-03-04 MX MX2015011959A patent/MX370396B/es active IP Right Grant
- 2014-03-04 EA EA201591368A patent/EA031524B1/ru not_active IP Right Cessation
- 2014-03-04 LT LTEP14761062.0T patent/LT2964258T/lt unknown
- 2014-03-04 UA UAA201508670A patent/UA123198C2/uk unknown
- 2014-03-04 WO PCT/US2014/020064 patent/WO2014137962A1/en not_active Ceased
- 2014-03-04 AU AU2014226094A patent/AU2014226094C1/en active Active
- 2014-03-04 CA CA2901462A patent/CA2901462C/en active Active
- 2014-03-04 KR KR1020157024032A patent/KR101775115B1/ko active Active
- 2014-03-04 JP JP2015561515A patent/JP6096938B2/ja active Active
- 2014-03-04 RS RS20201236A patent/RS60928B1/sr unknown
- 2014-03-04 ES ES14761062T patent/ES2822662T3/es active Active
- 2014-03-04 EP EP23207282.7A patent/EP4311558A3/en active Pending
- 2014-03-04 HU HUE14761062A patent/HUE051357T2/hu unknown
- 2014-03-04 MA MA38382A patent/MA38382A1/fr unknown
- 2014-03-04 SG SG11201507176VA patent/SG11201507176VA/en unknown
- 2014-03-04 BR BR112015019611-0A patent/BR112015019611B1/pt active IP Right Grant
- 2014-03-04 PT PT147610620T patent/PT2964258T/pt unknown
- 2014-03-04 EP EP14761062.0A patent/EP2964258B1/en active Active
- 2014-03-04 SI SI201431653T patent/SI2964258T1/sl unknown
- 2014-03-04 US US14/195,889 patent/US9023358B2/en active Active
- 2014-03-04 EP EP20193400.7A patent/EP3789037A1/en not_active Withdrawn
- 2014-03-04 MY MYPI2015702927A patent/MY171226A/en unknown
- 2014-03-04 KR KR1020177024414A patent/KR20170103037A/ko not_active Ceased
- 2014-03-04 PL PL14761062T patent/PL2964258T3/pl unknown
- 2014-03-04 AP AP2015008708A patent/AP2015008708A0/xx unknown
- 2014-03-04 PH PH1/2015/501994A patent/PH12015501994B1/en unknown
- 2014-03-04 PE PE2015001903A patent/PE20151529A1/es active IP Right Grant
- 2014-03-04 HR HRP20201633TT patent/HRP20201633T1/hr unknown
- 2014-03-04 DK DK14761062.0T patent/DK2964258T3/da active
- 2014-03-04 CN CN201480012747.7A patent/CN105307681B/zh active Active
2015
- 2015-05-01 US US14/702,124 patent/US9688753B2/en active Active
- 2015-07-22 ZA ZA2015/05285A patent/ZA201505285B/en unknown
- 2015-08-12 TN TN2015000348A patent/TN2015000348A1/en unknown
- 2015-08-20 IL IL240731A patent/IL240731B/en active IP Right Grant
- 2015-08-26 CL CL2015002388A patent/CL2015002388A1/es unknown
- 2015-09-08 EC ECIEPI201538626A patent/ECSP15038626A/es unknown
2017
- 2017-06-01 US US15/611,008 patent/US20170275356A1/en not_active Abandoned
2020
- 2020-01-14 IL IL272042A patent/IL272042B/en unknown
- 2020-11-16 CY CY20201101081T patent/CY1123589T1/el unknown
2023
- 2023-10-03 FI FIC20230030C patent/FIC20230030I1/fi unknown
- 2023-10-04 NO NO2023037C patent/NO2023037I1/no unknown
- 2023-10-06 NL NL301247C patent/NL301247I2/nl unknown
- 2023-10-06 CY CY2023021C patent/CY2023021I2/el unknown
- 2023-10-13 FR FR23C1036C patent/FR23C1036I2/fr active Active
- 2023-10-18 HU HUS2300036C patent/HUS2300036I1/hu unknown
- 2023-10-23 LU LU00318C patent/LUC00318I2/fr unknown
- 2023-10-23 LT LTPA2023530C patent/LTC2964258I2/lt unknown

Also Published As

Publication number	Publication date
LUC00318I2 (da)	2026-02-02
LT2964258T (lt)	2020-10-12
JOP20140049B1 (ar)	2021-08-17
MA38382A1 (fr)	2017-11-30
CN105307681A (zh)	2016-02-03
AU2014226094C1 (en)	2024-10-24
CY1123589T1 (el)	2022-03-24
EP4311558A3 (en)	2024-04-10
UA123198C2 (uk)	2021-03-03
EP2964258B1 (en)	2020-09-02
ECSP15038626A (es)	2015-11-30
IL240731A0 (en)	2015-10-29
US9688753B2 (en)	2017-06-27
JP6096938B2 (ja)	2017-03-15
TWI636063B (zh)	2018-09-21
MX370396B (es)	2019-12-11
ZA201505285B (en)	2017-11-29
CA2901462C (en)	2017-07-25
SI2964258T1 (sl)	2020-10-30
US20140255422A1 (en)	2014-09-11
CY2023021I1 (el)	2024-02-16
NZ711147A (en)	2021-03-26
EA201591368A1 (ru)	2015-12-30
AU2014226094B2 (en)	2016-06-23
AU2014226094A1 (en)	2015-08-27
CA2901462A1 (en)	2014-09-12
CY2023021I2 (el)	2024-09-20
BR112015019611A2 (pt)	2017-08-22
EP4311558A2 (en)	2024-01-31
NL301247I2 (nl)	2023-11-01
US9023358B2 (en)	2015-05-05
AP2015008708A0 (en)	2015-09-30
EP2964258A4 (en)	2016-10-12
LTC2964258I2 (da)	2025-09-10
PE20151529A1 (es)	2015-10-28
PH12015501994A1 (en)	2016-01-11
PH12015501994B1 (en)	2023-03-01
TN2015000348A1 (en)	2017-01-03
US20150232552A1 (en)	2015-08-20
TW201520225A (zh)	2015-06-01
SG11201507176VA (en)	2015-10-29
NL301247I1 (nl)	2023-10-11
HK1212252A1 (en)	2016-06-10
PL2964258T3 (pl)	2021-02-08
CL2015002388A1 (es)	2016-03-04
AR094877A1 (es)	2015-09-02
LTPA2023530I1 (da)	2023-11-10
MY171226A (en)	2019-10-03
CN105307681B (zh)	2018-06-26
EA031524B1 (ru)	2019-01-31
HUS2300036I1 (hu)	2024-07-28
IL272042B (en)	2021-07-29
IL240731B (en)	2020-01-30
NO2023037I1 (no)	2023-10-04
WO2014137962A1 (en)	2014-09-12
EP3789037A1 (en)	2021-03-10
HRP20201633T1 (hr)	2020-12-25
EP2964258A1 (en)	2016-01-13
JP2016510744A (ja)	2016-04-11
PT2964258T (pt)	2020-11-06
FIC20230030I1 (fi)	2023-10-03
FR23C1036I1 (fr)	2023-12-08
KR101775115B1 (ko)	2017-09-05
BR112015019611B1 (pt)	2023-05-02
FR23C1036I2 (fr)	2024-10-04
RS60928B1 (sr)	2020-11-30
ES2822662T3 (es)	2021-05-04
US20170275356A1 (en)	2017-09-28
HUE051357T2 (hu)	2021-03-01
MX2015011959A (es)	2016-04-07
KR20150113202A (ko)	2015-10-07
KR20170103037A (ko)	2017-09-12
IL272042A (en)	2020-02-27

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