DK2968478T3 - Sammensætninger og fremgangsmåder til behandling af carboxyhæmoglobinæmi - Google Patents
Sammensætninger og fremgangsmåder til behandling af carboxyhæmoglobinæmi Download PDFInfo
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- DK2968478T3 DK2968478T3 DK14769521.7T DK14769521T DK2968478T3 DK 2968478 T3 DK2968478 T3 DK 2968478T3 DK 14769521 T DK14769521 T DK 14769521T DK 2968478 T3 DK2968478 T3 DK 2968478T3
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- mutation
- neuroglobin
- recombinant
- leu
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- C—CHEMISTRY; METALLURGY
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Medicinal Chemistry (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (14)
1. Rekombinant globinmolekyle, der binder carbonmonoxid med høj affinitet, til anvendelse i en fremgangsmåde til behandling af carboxyhæmoglobinæmi hos et individ, hvilken fremgangsmåde omfatter: udvælgelse af et individ med carboxyhæmoglobinæmi; og indgivelse til individet af en terapeutisk virksom mængde af det rekombinante globinmolekyle, der binder carbonmonoxid med høj affinitet, hvor det rekombinante globinmolekyle, omfatter: et humant rekombinant neuroglobin med en H64Q-, H64L-, H64A- eller H64W-mutation, hvor nummereringen svarer til SEQ ID NO: 1; eller et humant rekombinant cytoglobin med en H81Q-, H81A-, H81L-eller H81W-mutation, hvor nummereringen svarer til SEQ ID NO: 4, hvorved carboxyhæmoglobinæmi hos individet behandles.
2. In vitro fremgangsmåde til fjernelse af carbonmonoxid fra hæmoglobin i blod eller væv, omfattende at bringe blodet eller vævet i kontakt med et rekombinant globinmolekyle, der binder carbonmonoxid med høj affinitet, hvor det rekombinante globinmolekyle omfatter: et humant rekombinant neuroglobin med en H64Q-, H64L-, H64A- eller H64W- mutation, hvor nummereringen svarer til SEQ ID NO: 1; eller et humant rekombinant cytoglobin med en H81Q-, H81A-, H81L-eller H81W- mutation, hvor nummereringen svarer til SEQ ID NO: 4, hvorved der fjernes carbonmonoxid fra hæmoglobin i blodet eller vævet.
3. Molekyle til anvendelse ifølge krav 1 eller fremgangsmåde ifølge krav 2, hvor det humane rekombinante neuroglobin yderligere omfatter en C46G-mu-tation, en C55S-mutation, en C120S-mutation eller en hvilken som helst kombination deraf.
4. Molekyle til anvendelse eller fremgangsmåde ifølge krav 3, hvor det humane rekombinante neuroglobin omfatter aminosyresekvensen med SEQ ID NO: 3.
5. Molekyle til anvendelse ifølge krav 1 eller fremgangsmåde ifølge krav 2, hvor det humane rekombinante cytoglobin yderligere omfatter en C38S-muta-tion eller en C83S-mutation, eller både en C38S- og en C83S-mutation.
6. Molekyle til anvendelse eller fremgangsmåde ifølge krav 5, hvor det humane rekombinante cytoglobin omfatter aminosyresekvensen med SEQ ID NO: 6.
7. Molekyle til anvendelse ifølge et hvilket som helst af kravene 1 og 3-6, hvor individet har mindst 3 %, mindst 5 %, mindst 10 %, mindst 15 % eller mindst 20 % carboxyhæmoglobin i blodet.
8. Molekyle til anvendelse ifølge et hvilket som helst af kravene 1 og 3-7, hvor det rekombinante globinmolekyle i fremgangsmåden indgives ved intravenøs infusion.
9. Molekyle til anvendelse ifølge et hvilket som helst af kravene 1 og 3-8, hvor den terapeutisk virksomme mængde af det rekombinante globinmolekyle er ca. 50 til ca. 800 gram.
10. Humant rekombinant neuroglobin omfattende en mutation ved rest 64 og yderligere omfattende en C46G-mutation, en C55S-mutation og en C120S-mutation, hvor nummereringen svarer til SEQ ID NO: 1.
11. Humant rekombinant neuroglobin ifølge krav 10, hvor mutationen ved rest 64 er en H64Q-, H64L-, H64A eller H64W-mutation.
12. Humant rekombinant neuroglobin ifølge krav 11, omfattende aminosyrese-kvensen med SEQ ID NO: 3.
13. Humant rekombinant cytoglobin omfattende en H81A- eller H81L-muta-tion, og yderligere omfattende en C38S-mutation og en C83S-mutation, hvor nummereringen svarer til SEQ ID NO: 4.
14. Sammensætning omfattende det humane rekombinante neuroglobin eller cytoglobin ifølge et hvilket som helst af kravene 10-13 og en farmaceutisk acceptabel bærer.
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| PCT/US2014/023180 WO2014150413A1 (en) | 2013-03-15 | 2014-03-11 | Compositions and methods for the treatment of carboxyhemoglobinemia |
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| WO2017201447A1 (en) * | 2016-05-19 | 2017-11-23 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Reduced oxygen carriers and their use for the treatment of carboxyhemoglobinemia |
| CN108892720B (zh) * | 2018-07-19 | 2021-01-22 | 南华大学 | 一种神经红突变体蛋白及其制备方法 |
| CN109748972B (zh) * | 2019-01-31 | 2021-12-03 | 泉州师范学院 | 一种细胞珠蛋白-人源乳铁蛋白肽融合蛋白、基因及应用 |
| EP3946431A4 (en) * | 2019-04-02 | 2023-01-18 | University of Pittsburgh - of the Commonwealth System of Higher Education | MODIFIED HEMOGLOBIN MOLECULES AND THEIR USES |
| US12228565B2 (en) * | 2021-06-16 | 2025-02-18 | Instrumentation Laboratory Company | Blood cell lysis compositions and uses thereof |
| CN116236562B (zh) * | 2022-12-30 | 2026-02-13 | 董文其 | 细胞珠蛋白在制备预防和/或治疗糖尿病的药物中的应用 |
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| CN102175682B (zh) * | 2010-03-08 | 2013-02-20 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 重组人源脑红蛋白的生物活性检测方法及其用途 |
| CN102743456B (zh) * | 2011-04-19 | 2015-10-21 | 河北以岭医药研究院有限公司 | 一种中药组合物在制备防治一氧化碳中毒迟发性脑病的药物中的应用 |
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2014
- 2014-03-11 CN CN201480027725.8A patent/CN105209060B/zh active Active
- 2014-03-11 US US14/776,363 patent/US20160039910A1/en not_active Abandoned
- 2014-03-11 DK DK14769521.7T patent/DK2968478T3/da active
- 2014-03-11 CN CN201811383281.8A patent/CN109498802B/zh active Active
- 2014-03-11 EP EP18188514.6A patent/EP3461492B1/en active Active
- 2014-03-11 CA CA2904397A patent/CA2904397C/en active Active
- 2014-03-11 AU AU2014237216A patent/AU2014237216B2/en active Active
- 2014-03-11 ES ES14769521.7T patent/ES2691086T3/es active Active
- 2014-03-11 WO PCT/US2014/023180 patent/WO2014150413A1/en not_active Ceased
- 2014-03-11 EP EP14769521.7A patent/EP2968478B1/en active Active
- 2014-03-11 PL PL14769521T patent/PL2968478T3/pl unknown
-
2017
- 2017-10-06 US US15/726,779 patent/US10421800B2/en active Active
- 2017-12-14 AU AU2017276274A patent/AU2017276274B2/en active Active
-
2019
- 2019-08-30 US US16/557,168 patent/US10851153B2/en active Active
-
2020
- 2020-11-18 US US16/951,529 patent/US11845785B2/en active Active
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2023
- 2023-11-08 US US18/504,534 patent/US12269866B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20240083979A1 (en) | 2024-03-14 |
| US10851153B2 (en) | 2020-12-01 |
| US20180118810A1 (en) | 2018-05-03 |
| WO2014150413A1 (en) | 2014-09-25 |
| EP2968478B1 (en) | 2018-08-15 |
| CA2904397A1 (en) | 2014-09-25 |
| US12269866B2 (en) | 2025-04-08 |
| CN105209060A (zh) | 2015-12-30 |
| HK1220374A1 (en) | 2017-05-05 |
| EP2968478A1 (en) | 2016-01-20 |
| AU2017276274B2 (en) | 2019-06-13 |
| AU2014237216B2 (en) | 2017-12-21 |
| US20210070841A1 (en) | 2021-03-11 |
| EP3461492A1 (en) | 2019-04-03 |
| CN105209060B (zh) | 2018-12-07 |
| EP2968478A4 (en) | 2016-09-07 |
| ES2691086T3 (es) | 2018-11-23 |
| CA2904397C (en) | 2019-12-17 |
| AU2017276274A1 (en) | 2018-01-18 |
| US11845785B2 (en) | 2023-12-19 |
| CN109498802B (zh) | 2021-11-09 |
| US20160039910A1 (en) | 2016-02-11 |
| EP3461492B1 (en) | 2025-04-30 |
| US20190389937A1 (en) | 2019-12-26 |
| CN109498802A (zh) | 2019-03-22 |
| PL2968478T3 (pl) | 2019-01-31 |
| AU2014237216A1 (en) | 2015-10-08 |
| US10421800B2 (en) | 2019-09-24 |
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