DK2970250T3 - Saltformer af (s)-quinuclidin-3-yl-(2-(2-(4-fluorphenyl)thiazol-4-yl)propan-2-yl)carbamat - Google Patents

Saltformer af (s)-quinuclidin-3-yl-(2-(2-(4-fluorphenyl)thiazol-4-yl)propan-2-yl)carbamat Download PDF

Info

Publication number: DK2970250T3
Authority: DK; Denmark
Prior art keywords: quinuclidin; thiazol; propan; fluorophenyl; carbamate
Prior art date: 2013-03-15

Application number

DK14718854.4T

Other languages

English (en)

Inventor

Craig Siegel

Jin Zhao

Original Assignee

Genzyme Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-03-15

Filing date

2014-03-14

Publication date

2021-07-12

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50543351&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2970250(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2014-03-14 Application filed by Genzyme Corp filed Critical Genzyme Corp

2021-07-12 Application granted granted Critical

2021-07-12 Publication of DK2970250T3 publication Critical patent/DK2970250T3/da

Links

YFHRCLAKZBDRHN-MRXNPFEDSA-N [(3s)-1-azabicyclo[2.2.2]octan-3-yl] n-[2-[2-(4-fluorophenyl)-1,3-thiazol-4-yl]propan-2-yl]carbamate Chemical compound O([C@H]1C2CCN(CC2)C1)C(=O)NC(C)(C)C(N=1)=CSC=1C1=CC=C(F)C=C1 YFHRCLAKZBDRHN-MRXNPFEDSA-N 0.000 title 1
150000003839 salts Chemical group 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Diabetes (AREA)
Obesity (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Epidemiology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK14718854.4T 2013-03-15 2014-03-14 Saltformer af (s)-quinuclidin-3-yl-(2-(2-(4-fluorphenyl)thiazol-4-yl)propan-2-yl)carbamat DK2970250T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201361791706P	2013-03-15	2013-03-15
PCT/US2014/027081 WO2014152215A1 (en)	2013-03-15	2014-03-14	SALT FORMS OF (S)-Quinuclidin-3-yl (2-(2-(4-fluorophenyl)thiazol-4-yl)propan-2-yl)carbamate

Publications (1)

Publication Number	Publication Date
DK2970250T3 true DK2970250T3 (da)	2021-07-12

Family

ID=50543351

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK14718854.4T DK2970250T3 (da)	2013-03-15	2014-03-14	Saltformer af (s)-quinuclidin-3-yl-(2-(2-(4-fluorphenyl)thiazol-4-yl)propan-2-yl)carbamat

Country Status (33)

Country	Link
US (1)	US9518049B2 (da)
EP (1)	EP2970250B1 (da)
JP (1)	JP6438455B2 (da)
KR (1)	KR102302064B1 (da)
CN (1)	CN105189490A (da)
AR (1)	AR095435A1 (da)
AU (1)	AU2014240028B2 (da)
BR (1)	BR112015022907B1 (da)
CA (1)	CA2906691A1 (da)
CL (1)	CL2015002701A1 (da)
DK (1)	DK2970250T3 (da)
EA (1)	EA037527B1 (da)
ES (1)	ES2872326T3 (da)
HR (1)	HRP20210692T1 (da)
HU (1)	HUE054349T2 (da)
IL (1)	IL241229B (da)
JO (1)	JO3713B1 (da)
LT (1)	LT2970250T (da)
MA (1)	MA38488A1 (da)
MX (1)	MX370178B (da)
MY (1)	MY181766A (da)
PH (1)	PH12015502021A1 (da)
PL (1)	PL2970250T3 (da)
PT (1)	PT2970250T (da)
RS (1)	RS61852B1 (da)
SA (1)	SA515361078B1 (da)
SG (1)	SG11201507054YA (da)
SI (1)	SI2970250T1 (da)
TN (1)	TN2015000427A1 (da)
TW (1)	TWI713438B (da)
UY (1)	UY35439A (da)
WO (1)	WO2014152215A1 (da)
ZA (1)	ZA201506602B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MA37975B2 (fr)	2012-09-11	2021-03-31	Genzyme Corp	Inhibiteurs de synthase de glucosylcéramide
PT3079695T (pt) *	2013-12-11	2021-05-04	Genzyme Corp	Inibidores de glicosilceramida-sintase
US10519157B2 (en) *	2018-02-09	2019-12-31	X-Cutag Therapeutics, Inc.	Deuterated compounds for treating Fabry, Gaucher, Parkinson's and related diseases and conditions, and compositions and methods thereof
CN114040762A (zh)	2019-02-04	2022-02-11	建新公司	使用葡糖神经酰胺合酶(gcs)的抑制剂治疗纤毛疾病
AU2020218496B2 (en) *	2019-02-04	2024-12-19	Genzyme Corporation	Methods for treating symptoms and disorders associated with lysosomal storage diseases
TW202142236A (zh)	2020-02-03	2021-11-16	美商健臻公司	用於治療與溶體儲積症相關的神經症狀之方法
KR20230043024A (ko)	2020-07-24	2023-03-30	젠자임 코포레이션	벤글루스타트를 포함하는 제약 조성물
EP4188381A1 (en)	2020-07-30	2023-06-07	Genzyme Corporation	Methods for reducing glycosphingolipid concentration in brain tissue and methods of treatment of neurodegenerative diseases involving the same
WO2022215083A1 (en) *	2021-04-05	2022-10-13	Msn Laboratories Private Limited, R&D Center	Solid state forms of (s)-quinuclidin-3-yl (2-(2-(4-fluorophenyl)thiazol-4-yl)propan-2-yl) carbamate or salts and process for its preparation thereof
CN120417900A (zh)	2022-12-01	2025-08-01	建新公司	文鲁司他与cyp3a4的强或中度抑制剂的组合
WO2025219951A1 (en)	2024-04-19	2025-10-23	Genzyme Corporation	Venglustat for use in methods for reducing disease related biomarker levels in patients with ganglioside storage disorders
WO2025219952A1 (en)	2024-04-19	2025-10-23	Genzyme Corporation	Venglustat for use in methods for reducing disease related biomarker levels in patients with ganglioside storage disorders
WO2025262570A1 (en)	2024-06-17	2025-12-26	Genzyme Corporation	Venglustat as an inhibitor of glucosylceramide synthase in subjects having hepatic impairment

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5236838A (en)	1988-12-23	1993-08-17	Genzyme Corporation	Enzymatically active recombinant glucocerebrosidase
US5549892A (en)	1988-12-23	1996-08-27	Genzyme Corporation	Enhanced in vivo uptake of glucocerebrosidase
US5272071A (en)	1989-12-22	1993-12-21	Applied Research Systems Ars Holding N.V.	Method for the modification of the expression characteristics of an endogenous gene of a given cell line
US5733761A (en)	1991-11-05	1998-03-31	Transkaryotic Therapies, Inc.	Protein production and protein delivery
IL135578A0 (en)	1997-10-29	2001-05-20	Genzyme Corp	Compositions and methods for treating lysosomal storage disease
GB0400812D0 (en)	2004-01-14	2004-02-18	Celltech R&D Ltd	Novel compounds
US8003617B2 (en)	2004-11-10	2011-08-23	Genzyme Corporation	Methods of treating diabetes mellitus
WO2010091104A1 (en) *	2009-02-06	2010-08-12	Exelixis, Inc.	Glucosylceramide synthase inhibitors
SI3998078T1 (sl)	2009-08-28	2026-02-27	Genzyme Corporation	Encimsko nadomestno zdravljenje z naraščajočim odmerkom za zdravljenje pomanjkanja kisle sfingomielinaze
AU2012231275A1 (en) *	2011-03-18	2013-10-17	Genzyme Corporation	Glucosylceramide synthase inhibitors

2014
- 2014-03-11 JO JOP/2014/0088A patent/JO3713B1/ar active
- 2014-03-13 AR ARP140100981A patent/AR095435A1/es unknown
- 2014-03-14 EA EA201591706A patent/EA037527B1/ru unknown
- 2014-03-14 HR HRP20210692TT patent/HRP20210692T1/hr unknown
- 2014-03-14 TW TW103109465A patent/TWI713438B/zh active
- 2014-03-14 CA CA2906691A patent/CA2906691A1/en not_active Abandoned
- 2014-03-14 PL PL14718854T patent/PL2970250T3/pl unknown
- 2014-03-14 MA MA38488A patent/MA38488A1/fr unknown
- 2014-03-14 AU AU2014240028A patent/AU2014240028B2/en active Active
- 2014-03-14 JP JP2016502330A patent/JP6438455B2/ja active Active
- 2014-03-14 MY MYPI2015702973A patent/MY181766A/en unknown
- 2014-03-14 DK DK14718854.4T patent/DK2970250T3/da active
- 2014-03-14 MX MX2015012295A patent/MX370178B/es active IP Right Grant
- 2014-03-14 US US14/776,432 patent/US9518049B2/en active Active
- 2014-03-14 KR KR1020157028855A patent/KR102302064B1/ko active Active
- 2014-03-14 BR BR112015022907-7A patent/BR112015022907B1/pt active IP Right Grant
- 2014-03-14 ES ES14718854T patent/ES2872326T3/es active Active
- 2014-03-14 CN CN201480025303.7A patent/CN105189490A/zh active Pending
- 2014-03-14 UY UY0001035439A patent/UY35439A/es not_active Application Discontinuation
- 2014-03-14 SI SI201431813T patent/SI2970250T1/sl unknown
- 2014-03-14 HU HUE14718854A patent/HUE054349T2/hu unknown
- 2014-03-14 RS RS20210607A patent/RS61852B1/sr unknown
- 2014-03-14 LT LTEP14718854.4T patent/LT2970250T/lt unknown
- 2014-03-14 SG SG11201507054YA patent/SG11201507054YA/en unknown
- 2014-03-14 PT PT147188544T patent/PT2970250T/pt unknown
- 2014-03-14 EP EP14718854.4A patent/EP2970250B1/en active Active
- 2014-03-14 WO PCT/US2014/027081 patent/WO2014152215A1/en not_active Ceased
2015
- 2015-09-06 IL IL241229A patent/IL241229B/en active IP Right Grant
- 2015-09-07 ZA ZA2015/06602A patent/ZA201506602B/en unknown
- 2015-09-09 PH PH12015502021A patent/PH12015502021A1/en unknown
- 2015-09-13 SA SA515361078A patent/SA515361078B1/ar unknown
- 2015-09-14 CL CL2015002701A patent/CL2015002701A1/es unknown
- 2015-09-15 TN TN2015000427A patent/TN2015000427A1/en unknown

Also Published As

Publication number	Publication date
SG11201507054YA (en)	2015-10-29
HUE054349T2 (hu)	2021-09-28
IL241229A0 (en)	2015-11-30
BR112015022907A8 (pt)	2019-11-26
KR20150132333A (ko)	2015-11-25
KR102302064B1 (ko)	2021-09-13
PT2970250T (pt)	2021-05-07
JO3713B1 (ar)	2021-01-31
CN105189490A (zh)	2015-12-23
EA037527B1 (ru)	2021-04-08
ES2872326T3 (es)	2021-11-02
JP2016513679A (ja)	2016-05-16
PH12015502021A1 (en)	2016-01-11
MY181766A (en)	2021-01-06
TW201502127A (zh)	2015-01-16
EP2970250A1 (en)	2016-01-20
HRP20210692T1 (hr)	2021-06-11
NZ712659A (en)	2020-11-27
BR112015022907B1 (pt)	2022-07-12
PL2970250T3 (pl)	2021-12-06
BR112015022907A2 (pt)	2017-07-18
AU2014240028B2 (en)	2018-08-02
SI2970250T1 (sl)	2021-06-30
UY35439A (es)	2014-10-31
HK1214821A1 (zh)	2016-08-05
IL241229B (en)	2019-12-31
MX2015012295A (es)	2016-05-16
CA2906691A1 (en)	2014-09-25
CL2015002701A1 (es)	2016-03-18
US20160039805A1 (en)	2016-02-11
SA515361078B1 (ar)	2018-06-14
US9518049B2 (en)	2016-12-13
MA38488A1 (fr)	2017-10-31
AR095435A1 (es)	2015-10-14
ZA201506602B (en)	2023-04-26
WO2014152215A1 (en)	2014-09-25
TWI713438B (zh)	2020-12-21
EA201591706A1 (ru)	2016-02-29
JP6438455B2 (ja)	2018-12-12
AU2014240028A1 (en)	2015-10-15
EP2970250B1 (en)	2021-04-21
TN2015000427A1 (en)	2017-01-03
MX370178B (es)	2019-12-04
RS61852B1 (sr)	2021-06-30
LT2970250T (lt)	2021-05-10

Publication	Publication Date	Title
DK2970250T3 (da)	2021-07-12	Saltformer af (s)-quinuclidin-3-yl-(2-(2-(4-fluorphenyl)thiazol-4-yl)propan-2-yl)carbamat
DK3464284T3 (da)	2021-01-11	Mikrobiocide thiazolderivater
DK3371171T3 (da)	2023-12-11	Inhibitorer af RET
DK3436444T3 (da)	2020-07-27	Heterocyklisk forbindelse
EP3392248A4 (en)	2019-05-22	2- (3-E-THANSULFONYLPYRIDIN-2-YL) -5- (trifluoromethanesulfonyl) benzoxazole-CRYSTAL
DK3160956T3 (da)	2020-08-31	Inhibitorer af lysin-specifik demethylase-1
DK3498693T3 (da)	2025-01-20	Heterocyklisk forbindelse
DK3080100T3 (da)	2023-02-06	Hæmmere af lysinspecifik demethylase-1
DK3102576T3 (da)	2019-07-22	Dihydropyrrolopyridininhibitorer af ror-gamma
DK3511319T3 (da)	2023-07-31	Hæmmere af lysinspecifik demethylase-1
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EP3337485A4 (en)	2019-01-09	CRYSTALLINE FORMS OF IBRUTINIB
DK3204352T3 (da)	2020-09-28	Hæmmere af lysin-gingipain
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