DK2970406T3 - Nye polypeptider - Google Patents
Nye polypeptider Download PDFInfo
- Publication number
- DK2970406T3 DK2970406T3 DK14710879.9T DK14710879T DK2970406T3 DK 2970406 T3 DK2970406 T3 DK 2970406T3 DK 14710879 T DK14710879 T DK 14710879T DK 2970406 T3 DK2970406 T3 DK 2970406T3
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- DK
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- fcrn
- fcrn binding
- binding polypeptide
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Classifications
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
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- C07K—PEPTIDES
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
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- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
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Claims (15)
1. FcRn-bindende polypeptid, omfattende et FcRn-bindende motiv BM, hvilket motiv består af aminosyresekvensen EX2 X3 X4 AXg X7 EIR WLPNLX16X17 Xi8 QR X21AFIX25 X26LX28 X29 hvor, uafhængigt af hinanden, X2 er udvalgt blandt A, D, E, F, Η, I, K, L, N, Q, R, S, T, V, W og Y; X3 er udvalgt blandt A, D, E, F, G, Η, I, K, L, Μ, N, Q, R, S, T, V, W og Y; X4 er udvalgt blandt A, D, E, F, G, Η, I, K, L, N, Q, R, S, T, V, W og Y; Xe er udvalgt blandt A, E, F, G, Η, I, K, Q, R, S og V; X7 er udvalgt blandt A, F, Η, K, N, Q, R, S og V; Xi6 er udvalgt blandt N og T; X17 er udvalgt blandt F, W og Y; Xi8 er udvalgt blandt A, D, E og N; X21 er udvalgt blandt A, S, V og W; X25 er udvalgt blandt D, E, G, Η, I, K, L, N, Q, R, S, T, V, W og Y; X26 er udvalgt blandt K og S; X28 er udvalgt blandt A, D, E, F, Η, I, K, L, N, Q, R, S, T, V, W og Y; og X29 er udvalgt blandt D og R.
2. FcRn-bindende polypeptid ifølge krav 1, hvor BM består af en aminosyresekvens udvalgt blandt i) EX2 X3 X4 AX6 HEIR WLPNLTX17 Xi8 QR X21AFIX25 KLX28 D hvor, uafhængigt af hinanden, X2 er udvalgt blandt A, D, E, F, Η, I, K, L, N, Q, R, S, T, V, W og Y; X3 er udvalgt blandt A, D, E, G, Η, K, L, Μ, N, Q, R, S, T, V og Y; X4 er udvalgt blandt A, D, E, F, G, I, K, L, N, Q, R, S, T, V og Y; Xe er udvalgt blandt A, G, K, R, S og V; X17 er udvalgt blandt F, W og Y; Xi8 er udvalgt blandt A, D, E og N; X21 er udvalgt blandt A, S, V og W; X25 er udvalgt blandt D, G, Η, K, L, N, R, V og W; X28 er udvalgt blandt A, D, E, Η, K, L, N, Q, R, S, T, W og Y; og ii) en aminosyresekvens, som har mindst 96 % similaritet med nævnte sekvens.
3. FcRn-bindende polypeptid ifølge et hvilket som helst af de foregående krav, hvor sekvensen i) opfylder mindst tre af de seks betingelser I-VI: I. Xe er udvalgt blandt A, G, K og S, såsom især A; II. X7 er H; III. X17 er udvalgt blandt F og Y, såsom især Fj IV. Xi8 er D; V. X2i er udvalgt blandt V og W, såsom især V; VI. X25 er udvalgt blandt H og R, såsom især H.
4. FcRn-bindende polypeptid ifølge et hvilket som helst af de foregående krav, hvor sekvensen er udvalgt fra gruppen bestående af SEQ ID NO: 1-353, såsom udvalgt fra gruppen bestående af SEQ ID NO: 1-15, SEQ ID NO: 17-140 og SEQ ID NO:353, såsom udvalgt fra gruppen bestående af SEQ ID NO: 1-2 og SEQ ID NO: 17-140, såsom udvalgt fra gruppen bestående af SEQ ID NO: 1-2, SEQ ID NO: 17-92, SEQ ID NO:94-103, SEQ ID NO: 105-125 og SEQ ID NO: 127-140 eller udvalgt fra gruppen bestående af SEQ ID NO:l-8, SEQ ID NO: 13, SEQ ID NO: 19-20, SEQ ID NO:23, SEQ ID NO:28, SEQ ID NO:41, SEQ ID NO:44, SEQ ID NO:65, SEQ ID NO:70, SEQ ID NO:73, SEQ ID NO:75-77 og SEQ ID NO:353, såsom udvalgt fra gruppen bestående af SEQ ID NO:l, SEQ ID NO:23, SEQ ID NO:28, SEQ ID NO:41, SEQ ID NO:44, SEQ ID NO:65, SEQ ID NO:73 og SEQ ID NO:75-77, såsom udvalgt fra gruppen bestående af SEQ ID NO:l, SEQ ID NO:23, SEQ ID NO:44, SEQ ID NO:65, SEQ ID NO:75 og SEQ ID NO:77, såsom udvalgt fra gruppen bestående af SEQ ID NO: 1, SEQ ID NO:23 og SEQ ID NO:75, såsom SEQ ID NO:l.
5. FcRn-bindende polypeptid ifølge et hvilket som helst af de foregående krav, som omfatter en aminosyresekvens udvalgt blandt: iii) K-[BM]-DPSQS XaXbLLXc EAKKL XdXeXfQ; hvor [.BM] er et FcRn-bindingsmotiv som defineret heri, på den betingelse, at X29 er D; Xa er udvalgt blandt A og S; Xb er udvalgt blandt N og E; Xc er udvalgt blandt A, S og C; Xd er udvalgt blandt E, N og S; Xe er udvalgt blandt D, E og S; Xf er udvalgt blandt A og S; og iv) en aminosyresekvens, som har mindst 93 % similaritet med en sekvens defineret af iii); hvor nævnte sekvens iii) eventuelt er udvalgt fra gruppen bestående af SEQ ID NO:354-706, såsom udvalgt fra gruppen bestående af SEQ ID NO:354-368, SEQ ID NO:370-493 og SEQ ID NO:706, såsom udvalgt fra gruppen bestående af SEQ ID NO:354-355 og SEQ ID NO:370-493, såsom udvalgt fra gruppen bestående af SEQ ID NO:354-355, SEQ ID NO:370-445, SEQ ID NO:447-456, SEQ ID NO:458-478 og SEQ ID NO:480-493 eller udvalgt fra gruppen bestående af SEQ ID NO:354-361, SEQ ID NO:366, SEQ ID NO:372-373, SEQ ID NO:376, SEQ ID NO:381, SEQ ID NO:394, SEQ ID NO:397, SEQ ID NO:418, SEQ ID NO:423, SEQ ID NO:426, SEQ ID NO:428-430 og SEQ ID NO:706, såsom udvalgt fra gruppen bestående af SEQ ID NO:354, SEQ ID NO:376, SEQ ID NO:381, SEQ ID NO:394, SEQ ID NO:397, SEQ ID NO:418, SEQ ID NO:426 og SEQ ID NO:428-430, såsom udvalgt fra gruppen bestående af SEQ ID NO:354, SEQ ID NO:376, SEQ ID NO:397, SEQ ID NO:418, SEQ ID NO:428 og SEQ ID NO:430, såsom udvalgt fra gruppen bestående af SEQ ID NO:354, SEQ ID NO:376 og SEQ ID NO:428, såsom SEQ ID NO:354.
6. FcRn-bindende polypeptid ifølge et hvilket som helst af de foregående krav, som omfatter en aminosyresekvens udvalgt blandt: xi) AEAKYAK-[SM]-DPSQSSELLSEAKKLNDSQAPK; hvor [BM] er et FcRn-bindingsmotiv som defineret i et hvilket som helst af kravene 1-4; og xii) en aminosyresekvens, som har mindst 94 % similaritet med sekvensen defineret i xi); hvor sekvensen xi) eventuelt er udvalgt fra gruppen bestående af SEQ ID NO: 1060-1062.
7. FcRn-bindende polypeptid ifølge et hvilket som helst af de foregående krav, som omfatter en aminosyresekvens udvalgt blandt: xiii) VDAKYAK-[BM]-DPSQSSELLSEAKKLNDSQAPK; hvor [BM] er et FcRn-bindende motiv som defineret i et hvilket som helst af kravene 1-4; og xiv) en aminosyresekvens, som har mindst 94 % similaritet med sekvensen defineret i xiii); hvor sekvensen xiii) eventuelt er udvalgt fra gruppen bestående af SEQ ID N0:707-1059, såsom udvalgt fra gruppen bestående af SEQ ID NO:707-721, SEQ ID NO:723-846 og SEQ ID NO: 1059, såsom udvalgt fra gruppen bestående af SEQ ID NO:707-708 og SEQ ID NO:723-846, såsom udvalgt fra gruppen bestående af SEQ ID N0:707-708, SEQ ID NO:723-798, SEQ ID N0:800-809, SEQ ID NO:811-831 og SEQ ID NO:833-846 eller udvalgt fra gruppen bestående af SEQ ID NO:707-714, SEQ ID NO:719, SEQ ID NO:725-726, SEQ ID NO:729, SEQ ID NO:734, SEQ ID NO:747, SEQ ID NO:750, SEQ ID NO:771, SEQ ID NO:776, SEQ ID NO:779, SEQ ID NO:781-783 og SEQ ID NO:1059, såsom udvalgt fra gruppen bestående af SEQ ID NO:707, SEQ ID NO:729, SEQ ID NO:734, SEQ ID NO:747, SEQ ID NO:750, SEQ ID NO:771, SEQ ID NO:779 og SEQ ID NO:781-783, såsom udvalgt fra gruppen bestående af SEQ ID NO:707, SEQ ID NO:729, SEQ ID NO:750, SEQ ID NO:771, SEQ ID NO:781 og SEQ ID NO:783, såsom udvalgt fra gruppen bestående af SEQ ID NO:707, SEQ ID NO:729 og SEQ ID NO:781, såsom SEQ ID NO:707.
8. FcRn-bindende polypeptid ifølge et hvilket som helst af de foregående krav, - som er stand til at binde sig til FcRn ved pH 6,0, således at KD-værdien for interaktionen er højst 1 x 10'5 M, såsom højst 1 x 10'7 M, såsom højst 1 x 10"8 M, såsom højst 1 x 10" 9 M, såsom højst 1 x ΙΟ"10 M; og/eller - hvor Ko-værdien for interaktionen mellem FcRn-bindende polypeptid og FcRn ved pH 7,4 er højere end KD-værdien for nævnte interaktion ved pH 6,0, såsom mindst 2 gange højere, såsom mindst 5 gange højere, såsom mindst 10 gange højere, såsom mindst 50 gange højere, såsom mindst 100 gange højere end KD -værdien for nævnte interaktion ved pH 6,0; og/eller - hvor Ko-værdien for interaktionen mellem FcRn-bindende polypeptid og FcRn ved pH 7,4 er mindst 1 x ΙΟ"8 M, såsom mindst 1 x ΙΟ"7 M, såsom mindst 1 x 10'6 M, såsom mindst 1 x ΙΟ 5 M; og/eller - hvor Ko-værdien for interaktionen mellem FcRn-bindende polypeptid og FcRn ved pH 7,4 er højst 1 x 10'6 M, såsom højst 1 x ΙΟ-7 M, såsom højst 1 x ΙΟ-8 M, såsom højst 1 x 10' 9 M, såsom højst 1 x ΙΟ'10 M.
9. Fusionsprotein eller konjugat omfattende - en første del bestående af et FcRn-bindende polypeptid ifølge et hvilket som helst af de foregående krav; og - en anden del bestående af et polypeptid med en ønsket biologisk aktivitet.
10. FcRn-bindende polypeptid, fusionsprotein eller konjugat ifølge et hvilket som helst af de foregående krav, som hæmmer binding af IgG til FcRn.
11. Polynukleotid kodende for et polypeptid ifølge et hvilket som helst af kravene Ι-ΙΟ.
12. Sammensætning omfattende et FcRn-bindende polypeptid, fusionsprotein eller konjugat ifølge et hvilket som helst af kravene 1-10 og mindst en farmaceutisk acceptabel exicipiens eller bærestof.
13. FcRn-bindende polypeptid, fusionsprotein eller konjugat ifølge et hvilket som helst af kravene 1-10 eller sammensætning ifølge krav 12 til anvendelse som lægemiddel.
14. FcRn-bindende polypeptid, fusionsprotein, konjugat eller sammensætning til anvendelse ifølge krav 13, hvor lægemidlet er tiltænkt behandling af en autoimmun tilstand.
15. FcRn-bindende polypeptid, fusionsprotein, konjugat eller sammensætning til anvendelse ifølge krav 13 eller 14, hvor lægemidlet er tiltænkt behandling af en tilstand udvalgt fra gruppen bestående af Erb-Goldflam-syndrom, polyradikuloneurit, autoimmun limbisk encefalit, pædiatriske autoimmune neuropsykiatriske forstyrrelser forbundet med streptokokinfektion (PANDAS), neuromyotoni, Morvans syndrom, dissemineret sklerose, pemphigus vulgaris, foliaceus, bulløs pemfigoid, erhvervet bulløs epidermolysis, pemfigoid gestationis, slimhinde-pemfigoid, lichen sclerosus, antiphospholipid-syndrom, recidiverende polychondrit, autoimmun anæmi, idiopatisk trombocyt-purpura, autoimmun basedow-syge, dilateret kardiomyopati, vaskulitis, Goodpastures syndrom, idiopatisk membran-nefropati, leddegigt og systemisk lupus erythematosus.
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| MX352889B (es) | 2011-02-25 | 2017-12-13 | Chugai Pharmaceutical Co Ltd | Anticuerpo de fc especifico para fcyriib. |
| TWI687439B (zh) | 2011-06-30 | 2020-03-11 | 中外製藥股份有限公司 | 異源二聚化多胜肽 |
| JP6322411B2 (ja) | 2011-09-30 | 2018-05-09 | 中外製薬株式会社 | 複数の生理活性を有する抗原の消失を促進する抗原結合分子 |
| KR20230143201A (ko) | 2011-11-30 | 2023-10-11 | 추가이 세이야쿠 가부시키가이샤 | 면역 복합체를 형성하는 세포내로의 운반체（캐리어）를 포함하는 의약 |
| EP3511339B1 (en) | 2012-02-20 | 2025-04-09 | IPC Research, LLC | Polypeptides binding to human complement c5 |
| SG10201709559PA (en) | 2012-08-24 | 2017-12-28 | Chugai Pharmaceutical Co Ltd | Fcγriib-specific fc region variant |
| ES2876009T3 (es) | 2012-12-27 | 2021-11-11 | Chugai Pharmaceutical Co Ltd | Polipéptido heterodimerizado |
| AU2014230018B2 (en) | 2013-03-15 | 2018-02-22 | Affibody Ab | New polypeptides |
| ZA201506407B (en) * | 2013-03-15 | 2018-11-28 | Affibody Ab | New polypeptides |
| CN105246914B (zh) | 2013-04-02 | 2021-08-27 | 中外制药株式会社 | Fc区变体 |
| PL3193930T3 (pl) | 2014-09-17 | 2019-12-31 | Affibody Ab | Nowe polipeptydy |
| KR101860280B1 (ko) | 2014-12-19 | 2018-05-21 | 추가이 세이야쿠 가부시키가이샤 | 항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법 |
| EP3245224B1 (en) * | 2015-01-12 | 2020-07-15 | Affibody AB | Il-17a-binding polypeptides |
| KR102605798B1 (ko) | 2015-02-05 | 2023-11-23 | 추가이 세이야쿠 가부시키가이샤 | 이온 농도 의존적 항원 결합 도메인을 포함하는 항체, Fc 영역 개변체, IL-8에 결합하는 항체, 및 그들의 사용 |
| CN108290931A (zh) * | 2015-10-30 | 2018-07-17 | 阿菲博迪公司 | 对pd-l1具有亲和力的新的多肽 |
| US10364280B2 (en) | 2015-10-30 | 2019-07-30 | Affibody Ab | Polypeptide |
| WO2017110981A1 (en) | 2015-12-25 | 2017-06-29 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
| EP3494991A4 (en) | 2016-08-05 | 2020-07-29 | Chugai Seiyaku Kabushiki Kaisha | COMPOSITION FOR THE PROPHYLAXIS OR TREATMENT OF IL-8 RELATED DISEASES |
| UY37651A (es) | 2017-03-31 | 2018-10-31 | Swedish Orphan Biovitrum Ab Publ | Polipéptido de unión al il-1r-i |
| EP4640703A3 (en) | 2017-11-14 | 2026-04-08 | Chugai Seiyaku Kabushiki Kaisha | Anti-c1s antibodies and methods of use |
| CA3081144A1 (en) | 2017-12-08 | 2019-06-13 | Argenx Bvba | Use of fcrn antagonists for treatment of generalized myasthenia gravis |
| US12202900B2 (en) | 2018-06-08 | 2025-01-21 | argenx BV | Compositions and methods for treating immune thrombocytopenia |
| KR102259473B1 (ko) | 2018-08-10 | 2021-06-02 | 추가이 세이야쿠 가부시키가이샤 | 항cd137 항원 결합 분자 및 그의 사용 |
| US12274759B2 (en) | 2018-08-23 | 2025-04-15 | Regents Of The University Of Minnesota | Affibody proteins specific for B7-H3 (CD276) |
| EP4696320A2 (en) | 2019-05-15 | 2026-02-18 | Chugai Seiyaku Kabushiki Kaisha | Anti-c1s antibody |
| WO2021089695A1 (en) * | 2019-11-05 | 2021-05-14 | Affibody Ab | Polypeptides |
| JP2023509195A (ja) | 2020-01-08 | 2023-03-07 | アルジェニクス ビーブイ | 天疱瘡症を治療する方法 |
| KR20240135659A (ko) * | 2022-01-24 | 2024-09-11 | 리젠츠 오브 더 유니버시티 오브 미네소타 | 항-b7-h3 화합물 및 사용 방법 |
| CN119698429A (zh) | 2022-06-15 | 2025-03-25 | 阿根思有限公司 | Fcrn结合分子及使用方法 |
| AR130995A1 (es) * | 2022-11-07 | 2025-02-05 | argenx BV | Métodos para el tratamiento de nefropatías membranosas primarias mediante el uso de antagonistas de fcrn |
| WO2025073871A1 (en) | 2023-10-03 | 2025-04-10 | Bicycletx Limited | Bicyclic peptide ligand complexes specific for tfr1 |
| CN119409765A (zh) * | 2024-10-31 | 2025-02-11 | 中山大学 | 一种FcRn亲和母体肽、衍生肽及其应用 |
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| US6602977B1 (en) * | 1999-04-19 | 2003-08-05 | Biovitrum Ab | Receptor structures |
| CA2606378A1 (en) | 2005-04-29 | 2006-11-09 | The Jackson Laboratory | Fcrn antibodies and uses thereof |
| TW200745163A (en) | 2006-02-17 | 2007-12-16 | Syntonix Pharmaceuticals Inc | Peptides that block the binding of IgG to FcRn |
| CN101421297A (zh) * | 2006-02-17 | 2009-04-29 | 森托尼克斯制药有限公司 | 阻断lgG对FcRn的结合的肽 |
| EP2190863B1 (en) | 2007-07-31 | 2015-09-02 | Affibody AB | New albumin binding compositions, methods and uses |
| TW200911289A (en) * | 2007-08-09 | 2009-03-16 | Syntonix Pharmaceuticals Inc | Immunomodulatory peptides |
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| WO2009131702A2 (en) | 2008-04-25 | 2009-10-29 | Dyax Corp. | Antibodies against fcrn and use thereof |
| WO2010054699A1 (en) | 2008-11-17 | 2010-05-20 | Affibody Ab | Conjugates of albumin binding domain |
| EP2496598B1 (en) * | 2009-11-04 | 2017-08-02 | Affibody AB | Her3 binding polypeptides |
| CN103003296A (zh) * | 2010-07-09 | 2013-03-27 | 阿菲博迪公司 | 多肽 |
| CN103379915A (zh) * | 2011-02-15 | 2013-10-30 | 米迪缪尼有限公司 | Hsa相关组合物及使用方法 |
| US9045564B2 (en) | 2011-02-15 | 2015-06-02 | Medimmune, Llc | HSA-related compositions and methods of use |
| CA2889037C (en) | 2012-10-25 | 2021-06-22 | Affibody Ab | Abd binding polypeptide |
| AU2014230018B2 (en) | 2013-03-15 | 2018-02-22 | Affibody Ab | New polypeptides |
| MX367423B (es) | 2013-08-28 | 2019-08-21 | Affibody Ab | Polipeptidos de union a c5. |
| PL3193930T3 (pl) | 2014-09-17 | 2019-12-31 | Affibody Ab | Nowe polipeptydy |
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| Publication number | Publication date |
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| WO2014140366A1 (en) | 2014-09-18 |
| CA2902657C (en) | 2022-05-10 |
| CN105209482B (zh) | 2022-04-29 |
| AU2014230018B2 (en) | 2018-02-22 |
| US20200199197A1 (en) | 2020-06-25 |
| MX366425B (es) | 2019-07-04 |
| JP2016511280A (ja) | 2016-04-14 |
| CA2902657A1 (en) | 2014-09-18 |
| US20180118807A1 (en) | 2018-05-03 |
| EP2970406B1 (en) | 2017-12-13 |
| ES2660912T3 (es) | 2018-03-26 |
| MX2015012215A (es) | 2016-05-16 |
| RU2681428C2 (ru) | 2019-03-06 |
| MY171407A (en) | 2019-10-11 |
| LT2970406T (lt) | 2018-03-12 |
| US9975943B2 (en) | 2018-05-22 |
| HK1216756A1 (en) | 2016-12-02 |
| KR102191654B1 (ko) | 2020-12-16 |
| BR112015021730A2 (pt) | 2017-08-29 |
| US20160031967A1 (en) | 2016-02-04 |
| IL240606B (en) | 2020-05-31 |
| KR20150132349A (ko) | 2015-11-25 |
| IL240606A0 (en) | 2015-09-24 |
| CN105209482A (zh) | 2015-12-30 |
| RU2015141224A (ru) | 2017-04-21 |
| AU2014230018A1 (en) | 2015-11-05 |
| JP6608288B2 (ja) | 2019-11-20 |
| EP2970406A1 (en) | 2016-01-20 |
| US10562955B2 (en) | 2020-02-18 |
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