DK297383A - Fremgangsmaade til fremstilling af piperazinderivater - Google Patents

Fremgangsmaade til fremstilling af piperazinderivater Download PDF

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Publication number
DK297383A
DK297383A DK297383A DK297383A DK297383A DK 297383 A DK297383 A DK 297383A DK 297383 A DK297383 A DK 297383A DK 297383 A DK297383 A DK 297383A DK 297383 A DK297383 A DK 297383A
Authority
DK
Denmark
Prior art keywords
preparation
piperazine derivatives
formula
procedure
halogen atoms
Prior art date
Application number
DK297383A
Other languages
Danish (da)
English (en)
Other versions
DK297383D0 (da
Inventor
Johan Gootjes
Hendricus Hyacinthus Van Kamp
Original Assignee
Gist Brocades Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades Nv filed Critical Gist Brocades Nv
Publication of DK297383D0 publication Critical patent/DK297383D0/da
Publication of DK297383A publication Critical patent/DK297383A/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Otolaryngology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK297383A 1982-06-29 1983-06-28 Fremgangsmaade til fremstilling af piperazinderivater DK297383A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8202636A NL8202636A (nl) 1982-06-29 1982-06-29 Piperazinederivaten, werkwijzen ter bereiding daarvan en farmaceutische preparaten die deze verbindingen bevatten.

Publications (2)

Publication Number Publication Date
DK297383D0 DK297383D0 (da) 1983-06-28
DK297383A true DK297383A (da) 1983-12-30

Family

ID=19839950

Family Applications (1)

Application Number Title Priority Date Filing Date
DK297383A DK297383A (da) 1982-06-29 1983-06-28 Fremgangsmaade til fremstilling af piperazinderivater

Country Status (10)

Country Link
US (1) US4476129A (fr)
EP (1) EP0099148B1 (fr)
JP (1) JPS5920275A (fr)
AT (1) ATE32512T1 (fr)
DE (1) DE3375690D1 (fr)
DK (1) DK297383A (fr)
ES (3) ES8500252A1 (fr)
GR (1) GR77523B (fr)
NL (1) NL8202636A (fr)
PT (1) PT76909B (fr)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU196194B (en) * 1986-04-28 1988-10-28 Richter Gedeon Vegyeszet Process for producing new 1-4 disubstituted piperazines and pharmaceuticals comprising the compounds
HU196195B (en) * 1986-04-28 1988-10-28 Richter Gedeon Vegyeszet Process for producing 1,4-disubstituted piperazine derivatives and pharmaceuticals comprising the compounds
FR2601366B1 (fr) * 1986-07-10 1988-11-25 Andre Buzas Derives de la benzhydryloxyethyl-piperazine, procedes d'obtention et de compositions pharmaceutiques les contenant.
US5001160A (en) * 1988-04-28 1991-03-19 Marion Laboratories, Inc. 1-aryl-1-hydroxy-1-substituted-3-(4-substituted-1-piperazinyl)-2-propanones and their use in treatment of neurogenic bladder disorders
WO1990013539A1 (fr) * 1989-04-28 1990-11-15 Meiji Seika Kaisha, Ltd. Nouveaux derives de piperazine a substitution n et medicament de traitement des troubles fonctionnels du cerveau
US5276035A (en) * 1990-07-26 1994-01-04 Novo Nordisk A/S 1,4-disubstituted piperazines
DK178490D0 (da) * 1990-07-26 1990-07-26 Novo Nordisk As 1,4-disubstituerede piperaziner
GB9523526D0 (en) * 1995-11-17 1996-01-17 Zeneca Ltd Therapeutic compounds
WO1998018769A1 (fr) 1996-10-31 1998-05-07 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Derives a liberation prolongee d'analogues hydroxyles de 1-[2[bis(aryl)methoxy]ethyl]-piperazines et -homopiperazines substituees et leur utilisation comme antagonistes non competitifs du recaptage de la dopamine
US6743797B2 (en) * 2002-02-22 2004-06-01 Chantest, Inc. Methods for treating cardiac arrhythmia
CN1181065C (zh) * 2002-05-08 2004-12-22 上海医药工业研究院 芳烷甲酰烷基哌嗪衍生物及其作为脑神经保护剂的应用
GB0220214D0 (en) * 2002-08-30 2002-10-09 Novo Pharmaceuticals De Ltd Compounds and their use
WO2004063150A2 (fr) * 2003-01-06 2004-07-29 The General Hospital Corporation Composes piperidine/piperazine alkyle therapeutiques et diagnostiques et processus
US7211407B2 (en) * 2003-07-15 2007-05-01 Chan Test, Inc. High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins
US20050054010A1 (en) * 2003-07-15 2005-03-10 Brown Arthur M. High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins
US20050208595A1 (en) * 2004-03-19 2005-09-22 Brown Arthur M High throughput assay systems and methods for identifying agents that alter expression of cellular proteins
US7381822B2 (en) * 2004-03-31 2008-06-03 The General Hospital Corporation Diagnostic and therapeutic alkyl piperidine/piperazine compounds and process
AU2008251259B2 (en) 2007-05-14 2013-02-14 Sk Biopharmaceuticals Co., Ltd. Novel carbamoyloxy arylalkanoyl arylpiperazine compound, pharmaceutical compositions comprising the compound and method for treating pain, anxiety and depression by administering the compound
US8673920B2 (en) 2009-05-06 2014-03-18 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2012058116A1 (fr) 2010-10-27 2012-05-03 Merck Sharp & Dohme Corp. Inhibiteurs du canal potassique de la médullaire externe rénale
US9056859B2 (en) 2010-10-29 2015-06-16 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
KR20140052034A (ko) 2011-08-19 2014-05-02 머크 샤프 앤드 돔 코포레이션 신장 외수질 칼륨 채널의 억제제
WO2013039802A1 (fr) 2011-09-16 2013-03-21 Merck Sharp & Dohme Corp. Inhibiteurs du canal à potassium de la medulla externe du rein
US8999991B2 (en) 2011-10-25 2015-04-07 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2013062892A1 (fr) 2011-10-25 2013-05-02 Merck Sharp & Dohme Corp. Inhibiteurs du canal potassique médullaire extérieur rénal
WO2013066717A1 (fr) 2011-10-31 2013-05-10 Merck Sharp & Dohme Corp. Inhibiteurs du canal potassique médullaire externe rénal
EP2773351B1 (fr) 2011-10-31 2017-08-23 Merck Sharp & Dohme Corp. Inhibiteurs du canal potassique médullaire externe rénal
WO2013066714A1 (fr) 2011-10-31 2013-05-10 Merck Sharp & Dohme Corp. Inhibiteurs du canal potassique médullaire externe rénal
EP2790511B1 (fr) 2011-12-16 2016-09-14 Merck Sharp & Dohme Corp. Inhibiteurs du canal à potassium de la medulla externe du rein
AR092031A1 (es) 2012-07-26 2015-03-18 Merck Sharp & Dohme Inhibidores del canal de potasio medular externo renal
WO2014059338A1 (fr) * 2012-10-11 2014-04-17 Chanrx Corporation Nouveaux composés de pipérazine, compositions pharmaceutiques contenant ceux-ci et procédés de terminaison d'épisodes aigus d'arythmie cardiaque, rétablissement du rythme sinusal normal, prévention de la récurrence d'arythmie cardiaque, et maintien d'un rythme sinusal normal chez des mammifères
WO2014059346A1 (fr) * 2012-10-11 2014-04-17 Brown Arthur M Procédés de traitement d'états impliquant la dopamine par l'administration de composés de pipérazine
WO2014059367A1 (fr) * 2012-10-11 2014-04-17 Chanrx Corporation Compositions pharmaceutiques contenant des mélanges racémiques et/ou énantiomériquement purs de composés de pipérazine chiraux et procédés d'arrêt d'épisodes aigus d'arythmie cardiaque, de rétablissement du rythme sinusal normal, de prévention de la récurrence de l'arythmie cardiaque et de maintien du rythme sinusal normal chez les mammifères par l'administration desdites compositions
WO2014085210A1 (fr) 2012-11-29 2014-06-05 Merck Sharp & Dohme Corp. Inhibiteurs du canal potassique médullaire extérieur rénal
US9573961B2 (en) 2012-12-19 2017-02-21 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US9604998B2 (en) 2013-02-18 2017-03-28 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP2968288B1 (fr) 2013-03-15 2018-07-04 Merck Sharp & Dohme Corp. Inhibiteurs du canal potassique médullaire extérieur rénal
WO2014176497A1 (fr) * 2013-04-26 2014-10-30 Chanrx Corporation Nouveaux métabolites de composés de vanoxérine, compositions pharmaceutiques contenant ceux-ci et procédés de terminaison d'épisodes aigus d'arythmie cardiaque, de rétablissement du rythme sinusal normal, de prévention de la récurrence de l'arythmie cardiaque et de maintien d'un rythme sinusal normal chez des mammifères
WO2015017305A1 (fr) 2013-07-31 2015-02-05 Merck Sharp & Dohme Corp Inhibiteurs du canal potassique médullaire externe rénal
WO2015073967A1 (fr) * 2013-11-15 2015-05-21 Brown Arthur M Nouveaux métabolites de composés de vanoxérine pour le traitement de maladies dopaminergiques
CN108329282B (zh) * 2018-01-16 2022-01-07 新乡医学院 一种苯基哌嗪类衍生物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2350100A1 (fr) * 1976-05-06 1977-12-02 Sauba Lab Derives disubstitues de la piperazine, leur procede de preparation et leurs applications therapeutiques
GB1545094A (en) * 1976-12-14 1979-05-02 Gist Brocades Nv Piperazine derivatives
FR2374318A1 (en) * 1976-12-14 1978-07-13 Gist Brocades Nv 1-Benzhydryl:oxy-alkyl-4-phenylalkyl- or cinnamyl-piperazine derivs. - with dopaminergic, anticholinergic and antiparkinson activity (BE 14.6.78)

Also Published As

Publication number Publication date
ES523689A0 (es) 1984-10-01
ES8502982A1 (es) 1985-02-01
PT76909B (en) 1986-01-24
ES8500252A1 (es) 1984-10-01
JPS5920275A (ja) 1984-02-01
ATE32512T1 (de) 1988-03-15
PT76909A (en) 1983-07-01
DE3375690D1 (en) 1988-03-24
EP0099148A1 (fr) 1984-01-25
US4476129A (en) 1984-10-09
ES8507130A1 (es) 1985-08-16
ES533068A0 (es) 1985-08-16
DK297383D0 (da) 1983-06-28
GR77523B (fr) 1984-09-24
NL8202636A (nl) 1984-01-16
ES533069A0 (es) 1985-02-01
EP0099148B1 (fr) 1988-02-17

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