DK2977057T3 - Isoleret rekombinant human N-glycosyleret lysosomal syrelipase - Google Patents

Isoleret rekombinant human N-glycosyleret lysosomal syrelipase Download PDF

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Publication number
DK2977057T3
DK2977057T3 DK14200334.2T DK14200334T DK2977057T3 DK 2977057 T3 DK2977057 T3 DK 2977057T3 DK 14200334 T DK14200334 T DK 14200334T DK 2977057 T3 DK2977057 T3 DK 2977057T3
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Prior art keywords
recombinant human
isolated recombinant
acid lipase
lysosomal acid
glycosylated lysosomal
Prior art date
Application number
DK14200334.2T
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English (en)
Inventor
Anthony Quinn
Original Assignee
Alexion Pharma Inc
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Priority claimed from PCT/US2011/033699 external-priority patent/WO2011133960A2/en
Application filed by Alexion Pharma Inc filed Critical Alexion Pharma Inc
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Publication of DK2977057T3 publication Critical patent/DK2977057T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01013—Sterol esterase (3.1.1.13)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK14200334.2T 2010-09-09 2011-09-09 Isoleret rekombinant human N-glycosyleret lysosomal syrelipase DK2977057T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US40301110P 2010-09-09 2010-09-09
US45601410P 2010-10-29 2010-10-29
US201161432372P 2011-01-13 2011-01-13
PCT/US2011/033699 WO2011133960A2 (en) 2010-04-23 2011-04-23 Lysosomal storage disease enzyme
EP11758644.6A EP2613798B2 (en) 2010-09-09 2011-09-09 Use of lysosomal acid lipase for treating lysosomal acid lipase deficiency in patients

Publications (1)

Publication Number Publication Date
DK2977057T3 true DK2977057T3 (da) 2020-02-10

Family

ID=45806910

Family Applications (2)

Application Number Title Priority Date Filing Date
DK11758644.6T DK2613798T4 (da) 2010-09-09 2011-09-09 Anvendelse af lysosomal sur lipase til behandling af patienter med mangel på lysosomal sur lipase
DK14200334.2T DK2977057T3 (da) 2010-09-09 2011-09-09 Isoleret rekombinant human N-glycosyleret lysosomal syrelipase

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK11758644.6T DK2613798T4 (da) 2010-09-09 2011-09-09 Anvendelse af lysosomal sur lipase til behandling af patienter med mangel på lysosomal sur lipase

Country Status (30)

Country Link
US (6) US8663631B2 (da)
EP (3) EP2613798B2 (da)
JP (3) JP5693728B2 (da)
KR (1) KR20150038636A (da)
CN (2) CN103200958A (da)
AR (1) AR082953A1 (da)
AU (1) AU2011314293B2 (da)
BR (2) BR122019021757B1 (da)
CA (2) CA2810999C (da)
CL (1) CL2013000664A1 (da)
CO (1) CO6710913A2 (da)
CY (1) CY1116544T1 (da)
DK (2) DK2613798T4 (da)
ES (2) ES2535605T5 (da)
HK (2) HK1220907A1 (da)
HR (1) HRP20150438T1 (da)
HU (1) HUE048688T2 (da)
IL (2) IL225095A (da)
ME (1) ME02062B (da)
MX (2) MX365007B (da)
NZ (3) NZ608292A (da)
PL (2) PL2613798T5 (da)
PT (2) PT2613798E (da)
RS (1) RS53947B1 (da)
RU (1) RU2550961C2 (da)
SG (2) SG188456A1 (da)
SI (2) SI2977057T1 (da)
SM (1) SMT201500108B (da)
TW (1) TWI482625B (da)
WO (1) WO2012050695A1 (da)

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Publication number Publication date
RU2550961C2 (ru) 2015-05-20
PT2977057T (pt) 2020-02-18
US20120064055A1 (en) 2012-03-15
PL2613798T5 (pl) 2018-06-29
SG10201507199UA (en) 2015-10-29
RS53947B1 (sr) 2015-08-31
BR112013005673A2 (pt) 2017-09-19
SG188456A1 (en) 2013-04-30
JP6156882B2 (ja) 2017-07-05
PT2613798E (pt) 2015-06-02
WO2012050695A1 (en) 2012-04-19
US12076376B2 (en) 2024-09-03
KR20150038636A (ko) 2015-04-08
MX365007B (es) 2019-05-20
AR082953A1 (es) 2013-01-23
ME02062B (me) 2015-05-20
CO6710913A2 (es) 2013-07-15
IL225095A (en) 2016-05-31
PL2977057T3 (pl) 2020-06-01
US20140348752A1 (en) 2014-11-27
DK2613798T4 (da) 2018-04-16
JP2016145257A (ja) 2016-08-12
JP2013540733A (ja) 2013-11-07
US8663631B2 (en) 2014-03-04
CL2013000664A1 (es) 2013-10-04
PL2613798T3 (pl) 2015-07-31
HUE048688T2 (hu) 2020-08-28
ES2769836T3 (es) 2020-06-29
DK2613798T3 (da) 2015-04-20
EP3650039A1 (en) 2020-05-13
US11400141B2 (en) 2022-08-02
EP2977057A1 (en) 2016-01-27
NZ608292A (en) 2014-10-31
NZ700824A (en) 2016-03-31
TW201225971A (en) 2012-07-01
HK1215532A1 (en) 2016-09-02
ES2535605T3 (es) 2015-05-13
US10166274B2 (en) 2019-01-01
CA2810999A1 (en) 2012-04-19
SI2613798T2 (en) 2018-05-31
AU2011314293A1 (en) 2013-04-04
CN103200958A (zh) 2013-07-10
JP5693728B2 (ja) 2015-04-01
RU2013110491A (ru) 2014-11-10
CN105457018A (zh) 2016-04-06
CA2810999C (en) 2023-10-03
EP2613798B2 (en) 2018-01-24
US20220362350A1 (en) 2022-11-17
US20190282671A1 (en) 2019-09-19
TWI482625B (zh) 2015-05-01
IL245283A0 (en) 2016-06-30
JP2015052014A (ja) 2015-03-19
BR112013005673B1 (pt) 2020-12-15
NZ715014A (en) 2018-10-26
CA3209456A1 (en) 2012-04-19
SI2613798T1 (sl) 2015-05-29
HK1220907A1 (zh) 2017-05-19
US20160051638A1 (en) 2016-02-25
IL245283B (en) 2019-02-28
BR122019021757B1 (pt) 2020-12-08
CA3209456C (en) 2025-05-06
AU2011314293B2 (en) 2015-06-04
ES2535605T5 (es) 2018-04-30
EP2613798B1 (en) 2015-02-11
HRP20150438T1 (hr) 2015-05-22
SMT201500108B (it) 2015-07-09
EP3650039B1 (en) 2026-04-15
US20250025538A1 (en) 2025-01-23
CY1116544T1 (el) 2018-03-07
EP2977057B1 (en) 2019-11-06
EP2613798A1 (en) 2013-07-17
MX2013002704A (es) 2013-09-13
SI2977057T1 (sl) 2020-03-31

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