DK2981541T3 - Syntese og anvendelse af isotopmærkede glycaner - Google Patents
Syntese og anvendelse af isotopmærkede glycanerInfo
- Publication number
- DK2981541T3 DK2981541T3 DK14715584.0T DK14715584T DK2981541T3 DK 2981541 T3 DK2981541 T3 DK 2981541T3 DK 14715584 T DK14715584 T DK 14715584T DK 2981541 T3 DK2981541 T3 DK 2981541T3
- Authority
- DK
- Denmark
- Prior art keywords
- isotoplable
- glycans
- synthesis
- isotoplable glycans
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0027—Methods for using particle spectrometers
- H01J49/0036—Step by step routines describing the handling of the data generated during a measurement
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/20—Labels for detection by gas chromatography, e.g. haloaryl systems
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Computational Biology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Electrochemistry (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1305986.0A GB201305986D0 (en) | 2013-04-03 | 2013-04-03 | Synthesis and use of isotopically-labelled glycans |
| PCT/EP2014/056737 WO2014161960A1 (en) | 2013-04-03 | 2014-04-03 | Synthesis and use of isotopically-labelled glycans |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2981541T3 true DK2981541T3 (da) | 2017-11-13 |
Family
ID=48445176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14715584.0T DK2981541T3 (da) | 2013-04-03 | 2014-04-03 | Syntese og anvendelse af isotopmærkede glycaner |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10001488B2 (da) |
| EP (1) | EP2981541B1 (da) |
| JP (1) | JP6602747B2 (da) |
| KR (1) | KR20150138377A (da) |
| CN (1) | CN105308061A (da) |
| AU (1) | AU2014247054B2 (da) |
| CA (1) | CA2908446C (da) |
| DK (1) | DK2981541T3 (da) |
| ES (1) | ES2644763T3 (da) |
| GB (1) | GB201305986D0 (da) |
| WO (1) | WO2014161960A1 (da) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| JP6486368B2 (ja) | 2013-09-06 | 2019-03-20 | アカデミア シニカAcademia Sinica | 改変されたグリコシル基を含む糖脂質を用いたヒトiNKT細胞の活性化 |
| CN106661099A (zh) | 2014-05-27 | 2017-05-10 | 中央研究院 | 抗her2醣抗体及其用途 |
| JP7093612B2 (ja) | 2014-05-27 | 2022-06-30 | アカデミア シニカ | Bacteroides由来のフコシダーゼおよびそれを使用する方法 |
| CA2950415A1 (en) | 2014-05-27 | 2015-12-03 | Academia Sinica | Anti-cd20 glycoantibodies and uses thereof |
| WO2015184001A1 (en) | 2014-05-28 | 2015-12-03 | Academia Sinica | Anti-tnf-alpha glycoantibodies and uses thereof |
| EP3397282A4 (en) * | 2015-12-30 | 2019-08-07 | Momenta Pharmaceuticals, Inc. | METHODS RELATING TO BIOLOGICA |
| EP3426693A4 (en) * | 2016-03-08 | 2019-11-13 | Academia Sinica | PROCESS FOR MODULAR SYNTHESIS OF N-GLYCANES AND ARRANGEMENTS THEREOF |
| CN107449650B (zh) * | 2017-06-28 | 2020-07-31 | 华中科技大学鄂州工业技术研究院 | 基于maldi-ms及稳定同位素标记n聚糖快速定量分析方法及应用 |
| CN108982569A (zh) * | 2018-07-20 | 2018-12-11 | 中国科学院昆明植物研究所 | 一种同时定量血浆内、外源性葡萄糖的二维核磁共振方法 |
| CN109187940A (zh) * | 2018-07-27 | 2019-01-11 | 南京谱利健生物技术有限公司 | 用于多糖分析的一种同位素标签试剂的制备和应用 |
| CN111208284B (zh) * | 2018-11-22 | 2021-08-24 | 北京大学 | 糖代谢标记探针、包含其的试剂盒及其应用 |
| DE102018133676A1 (de) | 2018-12-28 | 2020-07-02 | Airbus Operations Gmbh | Fügeverfahren sowie Bearbeitungskopf und Fertigungsmaschine zum Durchführen des Verfahrens |
| CN110028539B (zh) * | 2019-04-24 | 2023-01-31 | 复旦大学 | 同位素标记仿生糖或糖组、其制备方法及应用 |
| JP7127009B2 (ja) * | 2019-12-04 | 2022-08-29 | 日本電子株式会社 | 質量分析装置 |
| KR102760103B1 (ko) * | 2022-03-16 | 2025-01-24 | 국립창원대학교 산학협력단 | 정량질량분석법을 위한 엔도글리코시다제의 트랜스글리코실화와 동위원소 표지 아미노당 옥사졸린에 의한 당단백질의 동위원소 표지법 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4859581A (en) * | 1986-03-10 | 1989-08-22 | Board Of Regents, The University Of Texas System | Endoglycosidase assay |
| JPH11246586A (ja) * | 1998-03-04 | 1999-09-14 | Snow Brand Milk Prod Co Ltd | 放射標識化オリゴ糖 |
| US20070048752A1 (en) * | 2004-07-12 | 2007-03-01 | Applera Corporation | Mass tags for quantitative analyses |
| JP5139085B2 (ja) * | 2005-02-11 | 2013-02-06 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 固相のオリゴ糖タグ付け:固定化糖質の操作技術 |
| US20090216705A1 (en) * | 2005-04-13 | 2009-08-27 | National Institute Of Advanced Industrial Science And Technology | Method for predicting sugar chain structure |
| AU2007226582B2 (en) * | 2006-03-13 | 2012-07-05 | Revvity Health Sciences, Inc. | Substrates and internal standards for mass spectroscopy detection |
| US20110213137A1 (en) | 2007-04-16 | 2011-09-01 | Momenta Pharmaceuticals, Inc. | Isotopically-labeled glycans |
| KR20110084196A (ko) * | 2008-09-26 | 2011-07-21 | 유레카 쎄라퓨틱스, 인코포레이티드 | 다양한 글리코실화 패턴을 가진 세포계 및 단백질 |
| CN101907603B (zh) * | 2010-07-19 | 2012-09-05 | 复旦大学 | 一种基于18o标记的n-糖链相对定量方法 |
-
2013
- 2013-04-03 GB GBGB1305986.0A patent/GB201305986D0/en not_active Ceased
-
2014
- 2014-04-03 AU AU2014247054A patent/AU2014247054B2/en active Active
- 2014-04-03 CA CA2908446A patent/CA2908446C/en active Active
- 2014-04-03 EP EP14715584.0A patent/EP2981541B1/en active Active
- 2014-04-03 JP JP2016505831A patent/JP6602747B2/ja active Active
- 2014-04-03 WO PCT/EP2014/056737 patent/WO2014161960A1/en not_active Ceased
- 2014-04-03 US US14/781,692 patent/US10001488B2/en active Active
- 2014-04-03 KR KR1020157031606A patent/KR20150138377A/ko not_active Ceased
- 2014-04-03 DK DK14715584.0T patent/DK2981541T3/da active
- 2014-04-03 ES ES14715584.0T patent/ES2644763T3/es active Active
- 2014-04-03 CN CN201480028776.2A patent/CN105308061A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| GB201305986D0 (en) | 2013-05-15 |
| US10001488B2 (en) | 2018-06-19 |
| EP2981541A1 (en) | 2016-02-10 |
| WO2014161960A1 (en) | 2014-10-09 |
| EP2981541B1 (en) | 2017-09-13 |
| KR20150138377A (ko) | 2015-12-09 |
| ES2644763T3 (es) | 2017-11-30 |
| US20160025742A1 (en) | 2016-01-28 |
| CA2908446C (en) | 2021-03-02 |
| AU2014247054B2 (en) | 2018-05-17 |
| CN105308061A (zh) | 2016-02-03 |
| AU2014247054A1 (en) | 2015-11-12 |
| JP6602747B2 (ja) | 2019-11-06 |
| JP2016521299A (ja) | 2016-07-21 |
| CA2908446A1 (en) | 2014-10-09 |
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