DK3050883T3 - Fremgangsmåde til fremstilling af diazabicyclooctanderivater og mellemprodukter - Google Patents
Fremgangsmåde til fremstilling af diazabicyclooctanderivater og mellemprodukter Download PDFInfo
- Publication number
- DK3050883T3 DK3050883T3 DK14847854.8T DK14847854T DK3050883T3 DK 3050883 T3 DK3050883 T3 DK 3050883T3 DK 14847854 T DK14847854 T DK 14847854T DK 3050883 T3 DK3050883 T3 DK 3050883T3
- Authority
- DK
- Denmark
- Prior art keywords
- diazabicyclooctand
- intermediates
- derivatives
- procedure
- preparation
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013197110 | 2013-09-24 | ||
| PCT/JP2014/075203 WO2015046207A1 (ja) | 2013-09-24 | 2014-09-24 | ジアザビシクロオクタン誘導体の製造法とその中間体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3050883T3 true DK3050883T3 (da) | 2020-05-25 |
Family
ID=52743343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14847854.8T DK3050883T3 (da) | 2013-09-24 | 2014-09-24 | Fremgangsmåde til fremstilling af diazabicyclooctanderivater og mellemprodukter |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US10000491B2 (da) |
| EP (1) | EP3050883B1 (da) |
| JP (1) | JP6453222B2 (da) |
| KR (1) | KR102239725B1 (da) |
| CN (2) | CN105555787B (da) |
| AR (5) | AR097744A1 (da) |
| AU (1) | AU2014324302B2 (da) |
| BR (1) | BR112016006246B8 (da) |
| CA (1) | CA2924953C (da) |
| DK (1) | DK3050883T3 (da) |
| ES (1) | ES2793201T3 (da) |
| HK (1) | HK1244487A1 (da) |
| HU (1) | HUE049027T2 (da) |
| IL (1) | IL244740B (da) |
| MX (2) | MX372585B (da) |
| MY (2) | MY176278A (da) |
| NZ (1) | NZ718009A (da) |
| RU (1) | RU2719480C2 (da) |
| SG (1) | SG11201602256UA (da) |
| TW (1) | TWI644908B (da) |
| WO (1) | WO2015046207A1 (da) |
| ZA (1) | ZA201602053B (da) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE046893T2 (hu) | 2012-05-30 | 2020-04-28 | Meiji Seika Pharma Co Ltd | Új ß-laktamáz inhibitor és eljárás elõállítására |
| DK3050883T3 (da) | 2013-09-24 | 2020-05-25 | Meiji Seika Pharma Co Ltd | Fremgangsmåde til fremstilling af diazabicyclooctanderivater og mellemprodukter |
| CN105612159A (zh) * | 2013-10-08 | 2016-05-25 | 明治制果药业株式会社 | 二氮杂二环辛烷衍生物的结晶及其制备方法 |
| SG11201704576SA (en) | 2014-12-05 | 2017-07-28 | Meiji Seika Pharma Co Ltd | Method for producing crystals of diazabicyclooctane derivative and stable lyophilized preparation |
| CA2944306C (en) | 2015-10-30 | 2023-11-14 | The Toronto-Dominion Bank | Validating encrypted data from a multi-layer token |
| US11216808B2 (en) | 2015-11-04 | 2022-01-04 | The Toronto-Dominion Bank | Token-based system for excising data from databases |
| JP2020011901A (ja) * | 2016-10-20 | 2020-01-23 | 協和キリン株式会社 | ピロリジン化合物の製造方法 |
| CN106699756B (zh) * | 2016-12-30 | 2019-10-29 | 淄博鑫泉医药技术服务有限公司 | β内酰胺酶抑制剂阿维巴坦的合成方法 |
| KR20200091395A (ko) | 2017-09-27 | 2020-07-30 | 페도라 파마슈티칼스 인코포레이티드 | 디아자비시클로옥탄 유도체의 결정형 및 그의 제조 방법 |
| EP3687504B1 (en) | 2017-09-27 | 2024-11-27 | Meiji Seika Pharma Co., Ltd. | Pharmaceutical forms of diazabicyclooctane derivatives and process for producing the same |
| TW201920174A (zh) | 2017-09-27 | 2019-06-01 | 瑞士商羅氏大藥廠股份有限公司 | 二氮雜雙環辛烷衍生物之醫藥形式及其製法 |
| CN109678856B (zh) * | 2017-10-18 | 2020-09-25 | 新发药业有限公司 | 一种阿维巴坦中间体的制备方法 |
| JP7289836B2 (ja) | 2017-11-23 | 2023-06-12 | エフ． ホフマン－ラ ロシュ アーゲー | プロリンヒドロキシラーゼ、ならびにそれに伴う使用、方法および生成物 |
| US11957690B2 (en) | 2018-07-16 | 2024-04-16 | Brown University | Chromogenic beta-lactamase substrate |
| CN119707784A (zh) * | 2018-09-21 | 2025-03-28 | 株式会社Api | 氨基酸衍生物的制备方法 |
| US12195755B2 (en) | 2019-05-20 | 2025-01-14 | Brown University | Placental lipid bilayer for cell-free molecular interaction studies |
| WO2021038403A1 (en) | 2019-08-30 | 2021-03-04 | DePuy Synthes Products, Inc. | Electrical device for monitoring, prevention, and treatment of implant infections |
| WO2021087008A1 (en) | 2019-10-28 | 2021-05-06 | Brown University | Bacterial beta-lactamase responsive hydrogels |
| CN121021508B (zh) * | 2025-10-29 | 2026-02-24 | 北京耀诚惠仁科技有限公司 | β-内酰胺酶抑制剂中间体共晶或盐及其制备方法和应用 |
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| JPS5038509B1 (da) | 1970-10-21 | 1975-12-10 | ||
| JPS538509A (en) | 1976-07-13 | 1978-01-26 | Toshiba Corp | Impedance matching system for data transmission circuit |
| GB1589317A (en) | 1977-11-24 | 1981-05-13 | Lilly Co Eli | Freeze drying cephalothin sodium |
| JPS6019759B2 (ja) | 1977-11-24 | 1985-05-17 | イ−ライ・リリ−・アンド・カンパニ− | 非経口投予用１１１１５１５２１３９１９９東京都中央区京橋２丁目３番１３号 |
| JPS60255723A (ja) | 1984-05-31 | 1985-12-17 | Ono Pharmaceut Co Ltd | メシル酸ガベキサートの結晶性凍結乾燥製剤及びその製造方法 |
| JPH07117533B2 (ja) | 1985-08-28 | 1995-12-18 | 株式会社生体科学研究所 | トランスフエリンおよびその用途 |
| US20030220521A1 (en) | 1989-07-27 | 2003-11-27 | G.D. Searle & Co. | Renal-selective prodrugs for control of renal sympathetic nerve activity in the treatment of hypertension |
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| ATE177099T1 (de) * | 1993-12-29 | 1999-03-15 | Pfizer | Diazabicyclische neurokinin antagonisten |
| JP2843444B2 (ja) | 1994-05-02 | 1999-01-06 | 塩野義製薬株式会社 | ピロリジルチオカルバペネム誘導体の結晶，該結晶を含む凍結乾燥製剤，およびその製造方法 |
| US6111098A (en) | 1994-05-02 | 2000-08-29 | Shionogi & Co., Ltd. | Crystal of pyrrolidylthiocarbapenem derivative, lyophilized preparation containing said crystal, and process for producing the same |
| FR2812635B1 (fr) | 2000-08-01 | 2002-10-11 | Aventis Pharma Sa | Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens |
| FR2815420B1 (fr) | 2000-10-16 | 2003-05-16 | Cit Alcatel | Compensation de la dispersion chromatique dans un systeme de transmission a fibre optique, et fibre de compensation |
| FR2825705B1 (fr) | 2001-06-08 | 2005-05-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens |
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| JP5038509B2 (ja) | 2008-01-18 | 2012-10-03 | メルク・シャープ・エンド・ドーム・コーポレイション | β−ラクタマーゼ阻害剤 |
| FR2930553B1 (fr) | 2008-04-29 | 2010-05-21 | Novexel | Composes azabicycliques, leur preparation et leur utilisation comme medicaments, notamment inhibiteurs de beta-lactamases |
| FR2936798B1 (fr) | 2008-10-03 | 2012-09-28 | Novexel | Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens. |
| WO2010126820A2 (en) * | 2009-04-30 | 2010-11-04 | Merck Sharp & Dohme Corp. | Preparation of alkyl esters of n-protected oxo-azacycloalkylcarboxylic acids |
| FR2951171A1 (fr) | 2009-10-09 | 2011-04-15 | Novexel | Nouveau sel de sodium d'un compose azabicyclique sous forme enantiomere cristallisee et nouvelles formes polymorphes et pseudopolymorphes ainsi que leur preparation |
| JP2012122603A (ja) | 2010-11-15 | 2012-06-28 | Nifco Inc | コネクタ装置 |
| SI2657234T1 (sl) | 2010-12-22 | 2017-06-30 | Meiji Seika Pharma Co., Ltd. | Derivat optično-aktivnega diazabiciklooktana in metoda za njegovo izdelavo |
| US8772490B2 (en) | 2010-12-22 | 2014-07-08 | Meiji Seika Pharma Co., Ltd. | Optically active diazabicyclooctane derivatives and process for preparing the same |
| US8829191B2 (en) | 2011-06-17 | 2014-09-09 | Melanie Simone Ronsheim | Processes for preparing heterocyclic compounds including trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide and salts thereof |
| BR112013028813B1 (pt) | 2011-08-27 | 2020-10-20 | Wockhardt Limited | derivados de 1,6-diazabiciclo[3,2,1]octan-7-ona e composições farmacêuticas que os compreendem |
| CN103649088B (zh) | 2011-08-30 | 2016-05-11 | 沃克哈特有限公司 | 1, 6- 二氮杂双环[3, 2, 1]辛- 7- 酮衍生物及其在治疗细菌感染中的用途 |
| BR112014003476A2 (pt) | 2011-09-13 | 2017-03-01 | Wockhardt Ltd | compostos contendo nitrogênio e seu uso |
| US8796257B2 (en) | 2011-12-02 | 2014-08-05 | Naeja Pharmaceutical Inc. | Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors |
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| HUE046893T2 (hu) | 2012-05-30 | 2020-04-28 | Meiji Seika Pharma Co Ltd | Új ß-laktamáz inhibitor és eljárás elõállítására |
| DK3050883T3 (da) | 2013-09-24 | 2020-05-25 | Meiji Seika Pharma Co Ltd | Fremgangsmåde til fremstilling af diazabicyclooctanderivater og mellemprodukter |
| CN105612159A (zh) * | 2013-10-08 | 2016-05-25 | 明治制果药业株式会社 | 二氮杂二环辛烷衍生物的结晶及其制备方法 |
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2014
- 2014-09-24 DK DK14847854.8T patent/DK3050883T3/da active
- 2014-09-24 NZ NZ718009A patent/NZ718009A/en unknown
- 2014-09-24 SG SG11201602256UA patent/SG11201602256UA/en unknown
- 2014-09-24 BR BR112016006246A patent/BR112016006246B8/pt active IP Right Grant
- 2014-09-24 ES ES14847854T patent/ES2793201T3/es active Active
- 2014-09-24 JP JP2015539238A patent/JP6453222B2/ja active Active
- 2014-09-24 CA CA2924953A patent/CA2924953C/en active Active
- 2014-09-24 TW TW103132937A patent/TWI644908B/zh active
- 2014-09-24 CN CN201480052097.9A patent/CN105555787B/zh active Active
- 2014-09-24 EP EP14847854.8A patent/EP3050883B1/en active Active
- 2014-09-24 MX MX2019006550A patent/MX372585B/es unknown
- 2014-09-24 HU HUE14847854A patent/HUE049027T2/hu unknown
- 2014-09-24 MY MYPI2016700980A patent/MY176278A/en unknown
- 2014-09-24 MX MX2016003867A patent/MX367578B/es active IP Right Grant
- 2014-09-24 WO PCT/JP2014/075203 patent/WO2015046207A1/ja not_active Ceased
- 2014-09-24 RU RU2016115767A patent/RU2719480C2/ru active
- 2014-09-24 AU AU2014324302A patent/AU2014324302B2/en active Active
- 2014-09-24 MY MYPI2019004461A patent/MY193210A/en unknown
- 2014-09-24 AR ARP140103525A patent/AR097744A1/es active IP Right Grant
- 2014-09-24 KR KR1020167009769A patent/KR102239725B1/ko active Active
- 2014-09-24 CN CN201710665418.8A patent/CN107501264A/zh active Pending
- 2014-09-24 US US15/023,976 patent/US10000491B2/en active Active
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2016
- 2016-03-23 IL IL244740A patent/IL244740B/en active IP Right Grant
- 2016-03-29 ZA ZA2016/02053A patent/ZA201602053B/en unknown
- 2016-06-24 HK HK18103950.2A patent/HK1244487A1/zh unknown
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2017
- 2017-06-05 US US15/613,620 patent/US10000492B2/en active Active
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2023
- 2023-11-28 AR ARP230103207A patent/AR131188A2/es unknown
- 2023-11-28 AR ARP230103205A patent/AR131186A2/es unknown
- 2023-11-28 AR ARP230103209A patent/AR131190A2/es unknown
- 2023-11-28 AR ARP230103208A patent/AR131189A2/es unknown
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