DK2985032T3 - Glyx til anvendelse til behandling af alzheimers sygdom, parkinsons sygdom eller huntingtons sygdom - Google Patents
Glyx til anvendelse til behandling af alzheimers sygdom, parkinsons sygdom eller huntingtons sygdom Download PDFInfo
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- DK2985032T3 DK2985032T3 DK15171991.1T DK15171991T DK2985032T3 DK 2985032 T3 DK2985032 T3 DK 2985032T3 DK 15171991 T DK15171991 T DK 15171991T DK 2985032 T3 DK2985032 T3 DK 2985032T3
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- glyx
- disease
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- 150000003839 salts Chemical group 0.000 description 1
- VGKDLMBJGBXTGI-SJCJKPOMSA-N sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 description 1
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- 150000004760 silicates Chemical class 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- IZTQOLKUZKXIRV-YRVFCXMDSA-N sincalide Chemical compound C([C@@H](C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](N)CC(O)=O)C1=CC=C(OS(O)(=O)=O)C=C1 IZTQOLKUZKXIRV-YRVFCXMDSA-N 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000008109 sodium starch glycolate Substances 0.000 description 1
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- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Substances C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 1
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- 239000002562 thickening agent Substances 0.000 description 1
- 229940041597 tofranil Drugs 0.000 description 1
- 229960003991 trazodone Drugs 0.000 description 1
- YDGHCKHAXOUQOS-BTJKTKAUSA-N trimipramine maleate Chemical compound [O-]C(=O)\C=C/C([O-])=O.C1CC2=CC=CC=C2[NH+](CC(C[NH+](C)C)C)C2=CC=CC=C21 YDGHCKHAXOUQOS-BTJKTKAUSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Glass Compositions (AREA)
- Compositions Of Oxide Ceramics (AREA)
- Ceramic Products (AREA)
Claims (2)
1. GLYX-peptid til anvendelse i en fremgangsmåde til behandling afen patient, der lider af Alzheimers sygdom, Parkinsons sygdom eller Huntingtons sygdom, hvor GLYX-peptidet er GLYX-13 med strukturen ifølge formel I:
2. GLYX-peptid til anvendelse ifølge krav 1, hvor fremgangsmåden er til behandling af Alzheimers sygdom, Parkinsons sygdom eller Huntingtons sygdom hos pattedyr inkluderende mennesker.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24865009P | 2009-10-05 | 2009-10-05 | |
| EP14169137.8A EP2813236A1 (en) | 2009-10-05 | 2010-10-05 | GLYX for use in the treatment of depression or anxiety |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2985032T3 true DK2985032T3 (da) | 2019-04-15 |
Family
ID=43857351
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15171991.1T DK2985032T3 (da) | 2009-10-05 | 2010-10-05 | Glyx til anvendelse til behandling af alzheimers sygdom, parkinsons sygdom eller huntingtons sygdom |
| DK10822514.5T DK2485751T3 (da) | 2009-10-05 | 2010-10-05 | GLYX-13 til anvendelse i en fremgangsmåde til behandling af upåvirkelig depression |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10822514.5T DK2485751T3 (da) | 2009-10-05 | 2010-10-05 | GLYX-13 til anvendelse i en fremgangsmåde til behandling af upåvirkelig depression |
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| EP (4) | EP2985032B1 (da) |
| CY (1) | CY1118530T1 (da) |
| DK (2) | DK2985032T3 (da) |
| ES (2) | ES2493316T3 (da) |
| HR (1) | HRP20140784T1 (da) |
| HU (1) | HUE043807T2 (da) |
| PL (2) | PL2985032T3 (da) |
| PT (2) | PT2485751E (da) |
| RS (1) | RS53513B1 (da) |
| SI (1) | SI2485751T1 (da) |
| SM (1) | SMT201400117B (da) |
| WO (1) | WO2011044089A2 (da) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0918868B8 (pt) | 2008-09-18 | 2021-05-25 | Naurex Inc | compostos moduladores do receptor de nmda e composições compreendendo os mesmos |
| US8951968B2 (en) | 2009-10-05 | 2015-02-10 | Northwestern University | Methods of treating depression and other related diseases |
| WO2011100585A1 (en) | 2010-02-11 | 2011-08-18 | Joseph Moskal | Secondary structure stabilized nmda receptor modulators and uses thereof |
| KR101692275B1 (ko) * | 2010-02-11 | 2017-01-04 | 노오쓰웨스턴 유니버시티 | ２차 구조 안정화된 ｎｍｄａ 수용체 조절제 및 그의 용도 |
| US9737531B2 (en) | 2012-07-12 | 2017-08-22 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
| US10583138B2 (en) | 2012-07-12 | 2020-03-10 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
| CA2834286A1 (en) * | 2011-04-27 | 2012-11-01 | Northwestern University | Methods of treating alzheimer's disease, huntington's disease, autism, and other disorders |
| AU2013329000A1 (en) * | 2012-10-12 | 2015-04-30 | Northwestern University | Methods of identifying compounds for treating depression and other related diseases |
| JP2016506962A (ja) | 2013-01-29 | 2016-03-07 | ノーレックス, インコーポレイテッドNaurex, Inc. | スピロラクタム系ｎｍｄａ受容体モジュレーターおよびその使用 |
| US9758525B2 (en) | 2013-01-29 | 2017-09-12 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
| KR102410989B1 (ko) | 2013-01-29 | 2022-06-17 | 앱티닉스 인크. | 스피로-락탐 nmda 수용체 조절인자 및 그의 용도 |
| EP2951186B1 (en) | 2013-01-29 | 2018-07-25 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| PE20151416A1 (es) | 2013-01-29 | 2015-10-10 | Naurex Inc | Moduladores de receptores nmda de espiro-lactama y sus usos |
| CN111920412A (zh) * | 2013-12-13 | 2020-11-13 | 西北大学 | 治疗脑部病症或鉴定与其相关的生物标记的方法 |
| CN105327349A (zh) * | 2014-06-18 | 2016-02-17 | 上海翰森生物医药科技有限公司 | Nmda受体拮抗剂的医药用途及其药物组合物 |
| AU2015280108B2 (en) * | 2014-06-23 | 2019-11-28 | Naurex, Inc. | Methods of treating or ameliorating migraine |
| JP2017524721A (ja) * | 2014-08-14 | 2017-08-31 | ノーレックス インコーポレイテッド | Ｎｍｄａ調節剤を使用するうつ病の治療方法 |
| CN108601814A (zh) * | 2015-10-16 | 2018-09-28 | 西北大学 | 用于治疗精神分裂症、双相障碍、认知损害和重度抑郁障碍的非典型抗精神病药和nmda调节剂的药物组合 |
| WO2017189920A1 (en) * | 2016-04-28 | 2017-11-02 | The Trustees Of The University Of Pennsylvania | Method of drug design and optimisation utilizing stereochemical mimicry |
| WO2017201285A1 (en) | 2016-05-19 | 2017-11-23 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| PE20190174A1 (es) | 2016-05-19 | 2019-02-01 | Aptinyx Inc | Moduladores del receptor espiro-lactama n-metil-d-aspartato y usos de los mismos |
| IL286107B2 (en) | 2016-08-01 | 2024-09-01 | Aptinyx Inc | Spiro-lactam nmda receptor modulators and usesthereof |
| WO2018026798A1 (en) | 2016-08-01 | 2018-02-08 | Aptinyx Inc. | Spiro-lactam nmda modulators and methods of using same |
| AU2017306158B2 (en) | 2016-08-01 | 2021-10-14 | Aptinyx Inc. | Spiro-lactam and bis-spiro-lactam NMDA receptor modulators and uses thereof |
| KR102465758B1 (ko) | 2016-08-01 | 2022-11-09 | 앱티닉스 인크. | 스피로-락탐 nmda 수용체 조정제 및 그의 용도 |
| JP7036792B2 (ja) | 2016-08-01 | 2022-03-15 | アプティニックス インコーポレイテッド | スピロ－ラクタムｎｍｄａ受容体修飾因子およびその使用 |
| PE20210455A1 (es) | 2018-01-31 | 2021-03-08 | Aptinyx Inc | Moduladores del receptor nmda espiro-lactama y usos de los mismos |
| US12012413B2 (en) | 2019-11-11 | 2024-06-18 | Tenacia Biotechnology (Hong Kong) Co., Limited | Methods of treating painful diabetic peripheral neuropathy |
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| US4086196A (en) | 1975-03-28 | 1978-04-25 | Armour Pharmaceutical Company | Parathyroid hormone |
| US5763393A (en) | 1996-05-17 | 1998-06-09 | Neurotherapeutics L.P. | Neuroactive peptides |
| AU2002248553A1 (en) * | 2001-03-07 | 2002-09-24 | Cognetix, Inc | Linear y-carboxyglutamate rich conotoxins |
| WO2002072609A2 (en) * | 2001-03-12 | 2002-09-19 | Nyxis Neurotherapies, Inc | Neuroactive peptides for prevention and/or treatment of hypoxia and neuropathic pain |
| EP1660634A4 (en) * | 2003-08-08 | 2009-02-18 | Burnham Inst | P16-mediated regulation of NMDA receptors |
| US20050096311A1 (en) * | 2003-10-30 | 2005-05-05 | Cns Response | Compositions and methods for treatment of nervous system disorders |
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2010
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- 2010-10-05 EP EP15171991.1A patent/EP2985032B1/en active Active
- 2010-10-05 RS RSP20140441 patent/RS53513B1/sr unknown
- 2010-10-05 HR HRP20140784AT patent/HRP20140784T1/hr unknown
- 2010-10-05 PL PL15171991T patent/PL2985032T3/pl unknown
- 2010-10-05 EP EP14169137.8A patent/EP2813236A1/en not_active Withdrawn
- 2010-10-05 ES ES10822514.5T patent/ES2493316T3/es active Active
- 2010-10-05 PT PT108225145T patent/PT2485751E/pt unknown
- 2010-10-05 PL PL10822514T patent/PL2485751T3/pl unknown
- 2010-10-05 HU HUE15171991A patent/HUE043807T2/hu unknown
- 2010-10-05 SI SI201030702T patent/SI2485751T1/sl unknown
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2014
- 2014-08-13 CY CY20141100649T patent/CY1118530T1/el unknown
- 2014-08-19 SM SM201400117T patent/SMT201400117B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2721448T3 (es) | 2019-07-31 |
| SI2485751T1 (sl) | 2014-10-30 |
| WO2011044089A2 (en) | 2011-04-14 |
| PT2985032T (pt) | 2019-04-24 |
| EP3488856A1 (en) | 2019-05-29 |
| EP2485751A2 (en) | 2012-08-15 |
| EP2985032B1 (en) | 2019-01-02 |
| WO2011044089A3 (en) | 2012-02-16 |
| PL2485751T3 (pl) | 2014-10-31 |
| EP2485751B1 (en) | 2014-05-21 |
| ES2493316T3 (es) | 2014-09-11 |
| HUE043807T2 (hu) | 2019-09-30 |
| EP2485751A4 (en) | 2013-03-13 |
| EP2813236A1 (en) | 2014-12-17 |
| RS53513B1 (sr) | 2015-02-27 |
| PL2985032T3 (pl) | 2019-07-31 |
| DK2485751T3 (da) | 2014-08-18 |
| CY1118530T1 (el) | 2017-07-12 |
| EP2985032A1 (en) | 2016-02-17 |
| HRP20140784T1 (hr) | 2014-10-10 |
| PT2485751E (pt) | 2014-09-01 |
| SMT201400117B (it) | 2014-11-10 |
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