DK2986722T3 - Manipulerede phenylalaninammoniak-lyasepolypeptider - Google Patents

Manipulerede phenylalaninammoniak-lyasepolypeptider Download PDF

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Publication number
DK2986722T3
DK2986722T3 DK14784792.5T DK14784792T DK2986722T3 DK 2986722 T3 DK2986722 T3 DK 2986722T3 DK 14784792 T DK14784792 T DK 14784792T DK 2986722 T3 DK2986722 T3 DK 2986722T3
Authority
DK
Denmark
Prior art keywords
phenylalaninammonic
lyasepolypeptides
manipulated
phenylalaninammonic lyasepolypeptides
manipulated phenylalaninammonic
Prior art date
Application number
DK14784792.5T
Other languages
English (en)
Inventor
Gjalt W Huisman
Nicholas J Agard
Benjamin Mijts
Jonathan Vroom
Xiyun Zhang
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Application granted granted Critical
Publication of DK2986722T3 publication Critical patent/DK2986722T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y403/00—Carbon-nitrogen lyases (4.3)
    • C12Y403/01—Ammonia-lyases (4.3.1)
    • C12Y403/01005—Phenylalanine ammonia-lyase (4.3.1.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y403/00—Carbon-nitrogen lyases (4.3)
    • C12Y403/01—Ammonia-lyases (4.3.1)
    • C12Y403/01024—Phenylalanine ammonia-lyase (4.3.1.24)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
DK14784792.5T 2013-04-18 2014-04-17 Manipulerede phenylalaninammoniak-lyasepolypeptider DK2986722T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361813586P 2013-04-18 2013-04-18
US201361897932P 2013-10-31 2013-10-31
PCT/US2014/034500 WO2014172541A2 (en) 2013-04-18 2014-04-17 Engineered phenylalanine ammonia lyase polypeptides

Publications (1)

Publication Number Publication Date
DK2986722T3 true DK2986722T3 (da) 2019-05-13

Family

ID=51729192

Family Applications (2)

Application Number Title Priority Date Filing Date
DK14784792.5T DK2986722T3 (da) 2013-04-18 2014-04-17 Manipulerede phenylalaninammoniak-lyasepolypeptider
DK19163814.7T DK3521423T3 (da) 2013-04-18 2014-04-17 Manipulerede phenylalaninammoniaklyase-polypeptider

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK19163814.7T DK3521423T3 (da) 2013-04-18 2014-04-17 Manipulerede phenylalaninammoniaklyase-polypeptider

Country Status (27)

Country Link
US (17) US9611468B2 (da)
EP (3) EP3521423B1 (da)
JP (5) JP6637410B2 (da)
KR (1) KR102218930B1 (da)
CN (2) CN105324483B (da)
AU (2) AU2014253900C1 (da)
CA (1) CA2909719C (da)
CY (1) CY1121891T1 (da)
DK (2) DK2986722T3 (da)
EA (1) EA034034B1 (da)
ES (2) ES2890955T3 (da)
HR (1) HRP20190928T1 (da)
HU (2) HUE043549T2 (da)
IL (1) IL242067B (da)
LT (1) LT2986722T (da)
MX (1) MX366196B (da)
MY (1) MY193198A (da)
NZ (1) NZ713396A (da)
PE (1) PE20151775A1 (da)
PH (1) PH12015502412B1 (da)
PL (1) PL2986722T3 (da)
PT (1) PT2986722T (da)
RS (1) RS58802B1 (da)
SG (1) SG11201508598YA (da)
SI (1) SI2986722T1 (da)
SM (1) SMT201900315T1 (da)
WO (1) WO2014172541A2 (da)

Families Citing this family (23)

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SMT201900315T1 (it) 2013-04-18 2019-07-11 Codexis Inc Polipeptidi di fenilalanina ammoniaca liasi ingegnerizzati
CA2943432A1 (en) 2014-04-16 2015-10-22 Codexis, Inc. Engineered tyrosine ammonia lyase
EP3294760B1 (en) 2015-05-13 2021-03-24 Synlogic Operating Company, Inc. Bacteria engineered to reduce hyperphenylalaninemia
CN106636048A (zh) * 2016-12-14 2017-05-10 江南大学 一株酶活提高的苯丙氨酸脱氨酶突变体
CN106755160B (zh) * 2017-01-17 2019-08-02 湖州颐辉生物科技有限公司 一种组氨酸解氨酶及其用途
SG11201906880VA (en) * 2017-02-13 2019-08-27 Codexis Inc Engineered phenylalanine ammonia lyase polypeptides
EP3630795B1 (en) * 2017-05-27 2023-07-26 Enzymaster (Ningbo) Bio-Engineering Co., Ltd. Engineered aldolase polypeptides and uses thereof
AU2018290278B2 (en) 2017-06-21 2022-12-15 Synlogic Operating Company, Inc. Bacteria for the treatment of disorders
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JP2021531749A (ja) * 2018-07-12 2021-11-25 コデクシス， インコーポレイテッド 操作されたフェニルアラニンアンモニアリアーゼポリペプチド
CN113316635A (zh) * 2018-10-29 2021-08-27 科德克希思公司 工程化dna聚合酶变体
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JP2023518184A (ja) 2020-03-20 2023-04-28 シンロジック オペレーティング カンパニー インコーポレイテッド 高フェニルアラニン血症を軽減するように遺伝子改変された微生物
CN116847860A (zh) * 2020-12-31 2023-10-03 同生运营公司 经工程化以减轻高苯丙氨酸血症的微生物
AU2022279241A1 (en) * 2021-05-21 2023-11-30 Syntis Bio, Inc. Engineered methionine gamma lyase variants
CN114015636B (zh) * 2021-12-08 2023-09-29 天地壹号饮料股份有限公司 重组醋酸菌及其制备方法和应用
CN114457151B (zh) * 2022-01-27 2024-06-11 宁夏医科大学总医院 一种用于检测苯丙氨酸羟化酶基因突变的检测试剂盒及其检测方法
CN117417925A (zh) * 2022-07-18 2024-01-19 浙江泽科塔生物医药有限公司 Pal变体、包含该pal变体的药物组合物以及用于制备该pal变体的方法
CN115518691B (zh) * 2022-10-14 2023-11-21 天津大学 一种具有类漆酶活性的人工酶及制备方法和应用
CN115873837A (zh) * 2022-11-18 2023-03-31 安徽盈科生物科技有限公司 高表达的新型的苯丙氨酸解氨酶
CN116478975B (zh) * 2023-06-16 2023-09-01 苏州优信合生技术有限公司 高活性苯丙氨酸解氨酶突变体及其表达菌株
TW202519654A (zh) * 2023-09-19 2025-05-16 日商積水化學工業股份有限公司 解氨酶及其用途

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Also Published As

Publication number Publication date
BR112015026160A2 (pt) 2017-10-10
CN105324483A (zh) 2016-02-10
US20210222146A1 (en) 2021-07-22
PL2986722T3 (pl) 2019-10-31
AU2014253900B2 (en) 2019-09-19
JP6637410B2 (ja) 2020-01-29
JP2020185016A (ja) 2020-11-19
JP2016516428A (ja) 2016-06-09
US10640759B2 (en) 2020-05-05
HUE055899T2 (hu) 2022-01-28
KR102218930B1 (ko) 2021-02-23
US11136571B2 (en) 2021-10-05
PH12015502412A1 (en) 2016-02-22
EP2986722A4 (en) 2017-02-22
US20190055536A1 (en) 2019-02-21
EA034034B1 (ru) 2019-12-20
US9611468B2 (en) 2017-04-04
JP2018166524A (ja) 2018-11-01
US20170191050A1 (en) 2017-07-06
US11401515B2 (en) 2022-08-02
US20140314843A1 (en) 2014-10-23
US20190055535A1 (en) 2019-02-21
EP3971288A1 (en) 2022-03-23
LT2986722T (lt) 2019-09-10
US11130947B2 (en) 2021-09-28
JP7129715B2 (ja) 2022-09-02
US20200032233A1 (en) 2020-01-30
MX366196B (es) 2019-07-01
US10494623B2 (en) 2019-12-03
SG11201508598YA (en) 2015-11-27
ES2890955T3 (es) 2022-01-25
US20200040325A1 (en) 2020-02-06
JP2022183356A (ja) 2022-12-08
HUE043549T2 (hu) 2019-08-28
CN109486803A (zh) 2019-03-19
US10975367B2 (en) 2021-04-13
US20200032235A1 (en) 2020-01-30
JP2020185017A (ja) 2020-11-19
PE20151775A1 (es) 2015-12-02
DK3521423T3 (da) 2021-09-06
US10941391B2 (en) 2021-03-09
WO2014172541A3 (en) 2015-02-19
US20200399627A1 (en) 2020-12-24
EP2986722B1 (en) 2019-04-03
CA2909719C (en) 2022-09-27
CA2909719A1 (en) 2014-10-23
US20200032234A1 (en) 2020-01-30
US10358639B2 (en) 2019-07-23
RS58802B1 (sr) 2019-07-31
CN109486803B (zh) 2022-10-25
US10717974B2 (en) 2020-07-21
US10487319B2 (en) 2019-11-26
WO2014172541A2 (en) 2014-10-23
US20190241882A1 (en) 2019-08-08
US20200032236A1 (en) 2020-01-30
US10160963B2 (en) 2018-12-25
AU2014253900C1 (en) 2020-04-02
US20200199566A1 (en) 2020-06-25
HRP20190928T1 (hr) 2019-07-26
US20190040377A1 (en) 2019-02-07
MY193198A (en) 2022-09-26
EP2986722A2 (en) 2016-02-24
US11913045B2 (en) 2024-02-27
CY1121891T1 (el) 2020-10-14
US10144924B2 (en) 2018-12-04
EP3521423A1 (en) 2019-08-07
US20180016568A1 (en) 2018-01-18
AU2019272057B2 (en) 2021-05-27
US10294468B2 (en) 2019-05-21
US20180037880A1 (en) 2018-02-08
NZ713396A (en) 2020-06-26
EP3521423B1 (en) 2021-07-21
IL242067B (en) 2018-03-29
KR20150143816A (ko) 2015-12-23
PT2986722T (pt) 2019-06-21
PH12015502412B1 (en) 2016-02-22
AU2014253900A1 (en) 2015-11-12
US20200231959A1 (en) 2020-07-23
MX2015014662A (es) 2016-03-03
ES2729048T3 (es) 2019-10-30
US10870843B2 (en) 2020-12-22
SMT201900315T1 (it) 2019-07-11
AU2019272057A1 (en) 2019-12-19
EA201591995A1 (ru) 2016-04-29
CN105324483B (zh) 2018-11-30
SI2986722T1 (sl) 2019-07-31

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