PL2986722T3 - Skonstruowane polipeptydy amoniakoliazy fenyloalaniny - Google Patents

Skonstruowane polipeptydy amoniakoliazy fenyloalaniny

Info

Publication number: PL2986722T3
Authority: PL; Poland
Prior art keywords: ammonia lyase; phenylalanine ammonia; engineered phenylalanine; lyase polypeptides; polypeptides
Prior art date: 2013-04-18

Application number

PL14784792T

Other languages

English (en)

Inventor

Gjalt W Huisman

Nicholas J Agard

Benjamin Mijts

Jonathan Vroom

Xiyun Zhang

Original Assignee

Codexis Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-04-18

Filing date

2014-04-17

Publication date

2019-10-31

2014-04-17 Application filed by Codexis Inc filed Critical Codexis Inc

2019-10-31 Publication of PL2986722T3 publication Critical patent/PL2986722T3/pl

Links

108700023158 Phenylalanine ammonia-lyases Proteins 0.000 title 1
229920001184 polypeptide Polymers 0.000 title 1
102000004196 processed proteins & peptides Human genes 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y403/00—Carbon-nitrogen lyases (4.3)
- C12Y403/01—Ammonia-lyases (4.3.1)
- C12Y403/01005—Phenylalanine ammonia-lyase (4.3.1.5)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y403/00—Carbon-nitrogen lyases (4.3)
- C12Y403/01—Ammonia-lyases (4.3.1)
- C12Y403/01024—Phenylalanine ammonia-lyase (4.3.1.24)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Neurosurgery (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Neurology (AREA)
Enzymes And Modification Thereof (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)

PL14784792T 2013-04-18 2014-04-17 Skonstruowane polipeptydy amoniakoliazy fenyloalaniny PL2986722T3 (pl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US201361813586P	2013-04-18	2013-04-18
US201361897932P	2013-10-31	2013-10-31
PCT/US2014/034500 WO2014172541A2 (en)	2013-04-18	2014-04-17	Engineered phenylalanine ammonia lyase polypeptides
EP14784792.5A EP2986722B1 (en)	2013-04-18	2014-04-17	Engineered phenylalanine ammonia lyase polypeptides

Publications (1)

Publication Number	Publication Date
PL2986722T3 true PL2986722T3 (pl)	2019-10-31

Family

ID=51729192

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL14784792T PL2986722T3 (pl)	2013-04-18	2014-04-17	Skonstruowane polipeptydy amoniakoliazy fenyloalaniny

Country Status (27)

Country	Link
US (17)	US9611468B2 (pl)
EP (3)	EP2986722B1 (pl)
JP (5)	JP6637410B2 (pl)
KR (1)	KR102218930B1 (pl)
CN (2)	CN109486803B (pl)
AU (2)	AU2014253900C1 (pl)
CA (1)	CA2909719C (pl)
CY (1)	CY1121891T1 (pl)
DK (2)	DK3521423T3 (pl)
EA (1)	EA034034B1 (pl)
ES (2)	ES2729048T3 (pl)
HR (1)	HRP20190928T1 (pl)
HU (2)	HUE043549T2 (pl)
IL (1)	IL242067B (pl)
LT (1)	LT2986722T (pl)
MX (1)	MX366196B (pl)
MY (1)	MY193198A (pl)
NZ (1)	NZ713396A (pl)
PE (1)	PE20151775A1 (pl)
PH (1)	PH12015502412B1 (pl)
PL (1)	PL2986722T3 (pl)
PT (1)	PT2986722T (pl)
RS (1)	RS58802B1 (pl)
SG (1)	SG11201508598YA (pl)
SI (1)	SI2986722T1 (pl)
SM (1)	SMT201900315T1 (pl)
WO (1)	WO2014172541A2 (pl)

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PL2986722T3 (pl)	2013-04-18	2019-10-31	Codexis Inc	Skonstruowane polipeptydy amoniakoliazy fenyloalaniny
EP3145536B1 (en) *	2014-04-16	2021-10-27	Codexis, Inc.	Engineered tyrosine ammonia lyase
EP3882259B1 (en)	2015-05-13	2026-01-28	Synlogic Operating Company, Inc.	Bacteria engineered to reduce hyperphenylalaninemia
CN106636048A (zh) *	2016-12-14	2017-05-10	江南大学	一株酶活提高的苯丙氨酸脱氨酶突变体
CN106755160B (zh) *	2017-01-17	2019-08-02	湖州颐辉生物科技有限公司	一种组氨酸解氨酶及其用途
AU2018217495B2 (en) *	2017-02-13	2021-03-04	Codexis, Inc.	Engineered phenylalanine ammonia lyase polypeptides
CN110914288B (zh) *	2017-05-27	2023-05-05	宁波酶赛生物工程有限公司	工程化醛缩酶多肽及其应用
EP3642221A1 (en)	2017-06-21	2020-04-29	Synlogic Operating Company, Inc.	Bacteria for the treatment of disorders
EP3807409A4 (en) *	2018-06-12	2022-08-03	Codexis, Inc.	Engineered tyrosine ammonia lyase
EP3820833A4 (en) *	2018-07-12	2022-08-03	Codexis, Inc.	MODIFIED AMMONIA-LYASE PHENYLALANINE POLYPEPTIDES
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AU2019397401A1 (en) *	2018-12-14	2021-06-17	Codexis, Inc.	Engineered tyrosine ammonia lyase
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WO2021188819A1 (en) *	2020-03-20	2021-09-23	Synlogic Operating Company, Inc.	Microorganisms engineered to reduce hyperphenylalaninemia
WO2022146718A1 (en) *	2020-12-31	2022-07-07	Synlogic Operating Company, Inc.	Microorganisms engineered to reduce hyperphenylalaninemia
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CN114015636B (zh) *	2021-12-08	2023-09-29	天地壹号饮料股份有限公司	重组醋酸菌及其制备方法和应用
CN114457151B (zh) *	2022-01-27	2024-06-11	宁夏医科大学总医院	一种用于检测苯丙氨酸羟化酶基因突变的检测试剂盒及其检测方法
CN117417925A (zh) *	2022-07-18	2024-01-19	浙江泽科塔生物医药有限公司	Pal变体、包含该pal变体的药物组合物以及用于制备该pal变体的方法
CN115518691B (zh) *	2022-10-14	2023-11-21	天津大学	一种具有类漆酶活性的人工酶及制备方法和应用
CN115873837A (zh) *	2022-11-18	2023-03-31	安徽盈科生物科技有限公司	高表达的新型的苯丙氨酸解氨酶
CN116478975B (zh) *	2023-06-16	2023-09-01	苏州优信合生技术有限公司	高活性苯丙氨酸解氨酶突变体及其表达菌株
JPWO2025063255A1 (pl) *	2023-09-19	2025-03-27

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2014
- 2014-04-17 PL PL14784792T patent/PL2986722T3/pl unknown
- 2014-04-17 SI SI201431165T patent/SI2986722T1/sl unknown
- 2014-04-17 SG SG11201508598YA patent/SG11201508598YA/en unknown
- 2014-04-17 NZ NZ713396A patent/NZ713396A/en not_active IP Right Cessation
- 2014-04-17 CN CN201811343013.3A patent/CN109486803B/zh not_active Expired - Fee Related
- 2014-04-17 KR KR1020157032841A patent/KR102218930B1/ko not_active Expired - Fee Related
- 2014-04-17 AU AU2014253900A patent/AU2014253900C1/en not_active Ceased
- 2014-04-17 MY MYPI2015002575A patent/MY193198A/en unknown
- 2014-04-17 SM SM20190315T patent/SMT201900315T1/it unknown
- 2014-04-17 EP EP14784792.5A patent/EP2986722B1/en active Active
- 2014-04-17 HU HUE14784792A patent/HUE043549T2/hu unknown
- 2014-04-17 CA CA2909719A patent/CA2909719C/en active Active
- 2014-04-17 JP JP2016509098A patent/JP6637410B2/ja not_active Expired - Fee Related
- 2014-04-17 LT LTEP14784792.5T patent/LT2986722T/lt unknown
- 2014-04-17 EA EA201591995A patent/EA034034B1/ru not_active IP Right Cessation
- 2014-04-17 ES ES14784792T patent/ES2729048T3/es active Active
- 2014-04-17 CN CN201480035201.3A patent/CN105324483B/zh not_active Expired - Fee Related
- 2014-04-17 RS RS20190709A patent/RS58802B1/sr unknown
- 2014-04-17 US US14/255,539 patent/US9611468B2/en not_active Expired - Fee Related
- 2014-04-17 DK DK19163814.7T patent/DK3521423T3/da active
- 2014-04-17 HR HRP20190928TT patent/HRP20190928T1/hr unknown
- 2014-04-17 DK DK14784792.5T patent/DK2986722T3/da active
- 2014-04-17 WO PCT/US2014/034500 patent/WO2014172541A2/en not_active Ceased
- 2014-04-17 EP EP19163814.7A patent/EP3521423B1/en active Active
- 2014-04-17 PT PT14784792T patent/PT2986722T/pt unknown
- 2014-04-17 HU HUE19163814A patent/HUE055899T2/hu unknown
- 2014-04-17 MX MX2015014662A patent/MX366196B/es active IP Right Grant
- 2014-04-17 ES ES19163814T patent/ES2890955T3/es active Active
- 2014-04-17 PE PE2015002177A patent/PE20151775A1/es unknown
- 2014-04-17 EP EP21186620.7A patent/EP3971288A1/en not_active Withdrawn
2015
- 2015-10-14 IL IL242067A patent/IL242067B/en active IP Right Grant
- 2015-10-19 PH PH12015502412A patent/PH12015502412B1/en unknown
2017
- 2017-02-13 US US15/431,491 patent/US10160963B2/en active Active
- 2017-09-29 US US15/720,060 patent/US10487319B2/en active Active
- 2017-09-29 US US15/720,198 patent/US10144924B2/en active Active
2018
- 2018-08-08 JP JP2018149210A patent/JP2018166524A/ja not_active Withdrawn
- 2018-10-22 US US16/166,359 patent/US10358639B2/en active Active
- 2018-10-31 US US16/176,896 patent/US10294468B2/en active Active
- 2018-10-31 US US16/176,986 patent/US10494623B2/en active Active
2019
- 2019-04-19 US US16/389,203 patent/US10717974B2/en not_active Expired - Fee Related
- 2019-06-26 CY CY20191100659T patent/CY1121891T1/el unknown
- 2019-10-14 US US16/601,278 patent/US11130947B2/en not_active Expired - Fee Related
- 2019-10-14 US US16/601,173 patent/US10640759B2/en active Active
- 2019-10-14 US US16/601,228 patent/US11136571B2/en not_active Expired - Fee Related
- 2019-10-15 US US16/601,993 patent/US10870843B2/en not_active Expired - Fee Related
- 2019-10-15 US US16/653,061 patent/US10941391B2/en not_active Expired - Fee Related
- 2019-11-29 AU AU2019272057A patent/AU2019272057B2/en not_active Ceased
2020
- 2020-03-09 US US16/813,207 patent/US10975367B2/en not_active Expired - Fee Related
- 2020-03-26 US US16/831,698 patent/US11401515B2/en active Active
- 2020-08-19 JP JP2020138453A patent/JP7129715B2/ja active Active
- 2020-08-19 JP JP2020138454A patent/JP2020185017A/ja not_active Withdrawn
- 2020-09-02 US US17/009,925 patent/US11913045B2/en active Active
2021
- 2021-04-01 US US17/220,684 patent/US20210222146A1/en not_active Abandoned
2022
- 2022-10-21 JP JP2022169038A patent/JP2022183356A/ja active Pending

Also Published As

Publication number	Publication date
PH12015502412A1 (en)	2016-02-22
US20190055536A1 (en)	2019-02-21
US10870843B2 (en)	2020-12-22
US10144924B2 (en)	2018-12-04
EP3521423A1 (en)	2019-08-07
JP7129715B2 (ja)	2022-09-02
EP2986722A2 (en)	2016-02-24
MX2015014662A (es)	2016-03-03
US20200032235A1 (en)	2020-01-30
AU2019272057B2 (en)	2021-05-27
US20190055535A1 (en)	2019-02-21
JP6637410B2 (ja)	2020-01-29
HUE043549T2 (hu)	2019-08-28
EP2986722A4 (en)	2017-02-22
US20200040325A1 (en)	2020-02-06
US10487319B2 (en)	2019-11-26
PE20151775A1 (es)	2015-12-02
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Publication	Publication Date	Title
IL242067B (en)	2018-03-29	Transgenic phenylalanine ammonia lyase polypeptides
IL242005B (en)	2019-05-30	A peptide compound
IL268226A (en)	2019-09-26	Phenylalanine ammonia lyase engineered polypeptides
ZA201600729B (en)	2019-12-18	Peptides
ZA201504986B (en)	2019-04-24	Peptide
PL3061771T3 (pl)	2020-10-19	Nowy peptyd o czterech połączonych epitopach dla ctl
ZA201504987B (en)	2017-11-29	Peptide
GB201315130D0 (en)	2013-10-09	Peptides
TWM475710U (en)	2014-04-01	Clip
GB201304080D0 (en)	2013-04-17	Clip
AU353153S (en)	2014-01-02	Limestone block
AU353156S (en)	2014-01-02	Limestone block
AU353154S (en)	2014-01-02	Limestone block
AU353151S (en)	2014-01-02	Limestone block
AU353152S (en)	2014-01-02	Limestone block
AU353155S (en)	2014-01-02	Limestone block
GB201316660D0 (en)	2013-11-06	Peptides
GB201305465D0 (en)	2013-05-08	Novel peptides
GB201322749D0 (en)	2014-02-05	Cyclic peptide
GB201300381D0 (en)	2013-02-20	Peptides
GB201313647D0 (en)	2013-09-11	ClipOn - LED clip