DK2992020T3 - Cs1-specifik kimær antigenreceptor-manipulerede immuneffektorceller - Google Patents

Cs1-specifik kimær antigenreceptor-manipulerede immuneffektorceller Download PDF

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Publication number
DK2992020T3
DK2992020T3 DK14791494.9T DK14791494T DK2992020T3 DK 2992020 T3 DK2992020 T3 DK 2992020T3 DK 14791494 T DK14791494 T DK 14791494T DK 2992020 T3 DK2992020 T3 DK 2992020T3
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Prior art keywords
antigen receptor
specific chemical
immune effect
effect cells
manipulated immune
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DK14791494.9T
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English (en)
Inventor
Jianhua Yu
Craig Hofmeister
Jianhong Chu
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Ohio State Innovation Foundation
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
DK14791494.9T 2013-05-03 2014-05-02 Cs1-specifik kimær antigenreceptor-manipulerede immuneffektorceller DK2992020T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361819141P 2013-05-03 2013-05-03
US201361876492P 2013-09-11 2013-09-11
PCT/US2014/036684 WO2014179759A1 (en) 2013-05-03 2014-05-02 Cs1-specific chimeric antigen receptor engineered immune effector cells

Publications (1)

Publication Number Publication Date
DK2992020T3 true DK2992020T3 (da) 2020-02-10

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DK14791494.9T DK2992020T3 (da) 2013-05-03 2014-05-02 Cs1-specifik kimær antigenreceptor-manipulerede immuneffektorceller

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US (3) US10358494B2 (da)
EP (2) EP3663320A1 (da)
JP (3) JP6856188B2 (da)
KR (1) KR102098985B1 (da)
CN (2) CN115028735A (da)
AU (2) AU2014259675B2 (da)
BR (1) BR112015027567B1 (da)
DK (1) DK2992020T3 (da)
ES (1) ES2777940T3 (da)
HU (1) HUE048312T2 (da)
IL (1) IL242315B (da)
MX (1) MX370173B (da)
PL (1) PL2992020T3 (da)
PT (1) PT2992020T (da)
WO (1) WO2014179759A1 (da)

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Publication number Publication date
EP2992020A1 (en) 2016-03-09
JP6856188B2 (ja) 2021-04-07
EP3663320A1 (en) 2020-06-10
HK1218925A1 (en) 2017-03-17
US20160075784A1 (en) 2016-03-17
JP2019146579A (ja) 2019-09-05
KR102098985B1 (ko) 2020-04-09
AU2019203823A1 (en) 2019-06-20
WO2014179759A1 (en) 2014-11-06
PL2992020T3 (pl) 2020-06-01
JP7221338B2 (ja) 2023-02-13
US10227409B2 (en) 2019-03-12
JP2016524598A (ja) 2016-08-18
IL242315B (en) 2020-07-30
CN105377897A (zh) 2016-03-02
KR20160003071A (ko) 2016-01-08
AU2014259675B2 (en) 2019-05-02
EP2992020A4 (en) 2016-12-28
JP2021177771A (ja) 2021-11-18
US10358494B2 (en) 2019-07-23
BR112015027567B1 (pt) 2024-02-20
PT2992020T (pt) 2020-02-28
US11845794B2 (en) 2023-12-19
EP2992020B1 (en) 2020-01-15
ES2777940T3 (es) 2020-08-06
MX370173B (es) 2019-12-04
CA2910666A1 (en) 2014-11-06
AU2019203823B2 (en) 2021-05-13
BR112015027567A2 (pt) 2017-12-05
CN115028735A (zh) 2022-09-09
AU2014259675A1 (en) 2015-11-12
HUE048312T2 (hu) 2020-07-28
US20170320941A1 (en) 2017-11-09
MX2015015182A (es) 2016-05-05
US20200002418A1 (en) 2020-01-02

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