DK302486A - 11-substituerede 5,11-dihydro-6h-pyrido(2,3-b)(1,4)benzodiazepin-6-oner - Google Patents

11-substituerede 5,11-dihydro-6h-pyrido(2,3-b)(1,4)benzodiazepin-6-oner Download PDF

Info

Publication number: DK302486A
Authority: DK; Denmark
Prior art keywords: compounds; group; alkyl; groups; oner
Prior art date: 1985-06-27

Application number

DK302486A

Other languages

English (en)

Other versions

DK302486D0 (da

DK161200C (da

DK161200B (da

Inventor

Wolfgang Eberlein

Guenter Trummlitz

Wolfhard Engel

Gerhard Mihm

Rudolf Hammer

Norbert Mayer

Antonio Giachetti

Adriaan De Jonge

Helmut Ballhause

Original Assignee

Thomae Gmbh Dr K

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-06-27

Filing date

1986-06-26

Publication date

1986-12-28

1985-06-27 Priority claimed from DE19853523002 external-priority patent/DE3523002A1/de

1986-04-03 Priority claimed from DE19863611097 external-priority patent/DE3611097A1/de

1986-06-26 Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K

1986-06-26 Publication of DK302486D0 publication Critical patent/DK302486D0/da

1986-12-28 Publication of DK302486A publication Critical patent/DK302486A/da

1991-06-10 Publication of DK161200B publication Critical patent/DK161200B/da

1991-12-30 Application granted granted Critical

1991-12-30 Publication of DK161200C publication Critical patent/DK161200C/da

Links

125000000217 alkyl group Chemical group 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 4
208000006218 bradycardia Diseases 0.000 abstract 2
125000003884 phenylalkyl group Chemical group 0.000 abstract 2
206010049765 Bradyarrhythmia Diseases 0.000 abstract 1
230000002785 anti-thrombosis Effects 0.000 abstract 1
230000036471 bradycardia Effects 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000002349 favourable effect Effects 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000001515 vagal effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Macromonomer-Based Addition Polymer (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Liquid Crystal Substances (AREA)
Photoreceptors In Electrophotography (AREA)
Secondary Cells (AREA)

DK302486A 1985-06-27 1986-06-26 11-substituerede 5,11-dihydro-6h-pyridooe2,3-baaoe1,4aa-benzodiazepin-6-oner, fremgangsmaade til fremstilling heraf, laegemiddel indeholdende en saadan forbindelse samt anvendelse af en saadan forbindelse tilfremstilling af laegemidler DK161200C (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
DE19853523002 DE3523002A1 (de)	1985-06-27	1985-06-27	Neue in 11-stellung substituierte 5,11-dihydro-6h-pyrido(2,3-b) (1,4)benzodiazepin-6-one, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3523002		1985-06-27
DE19863611097 DE3611097A1 (de)	1986-04-03	1986-04-03	Neues, in 11-stellung substituiertes 5,11-dihydro-6h-pyrido(2,3-b)(1,4)benzodiazepin-6-on, verfahren zu seiner herstellung und diese verbindung enthaltende arzneimittel
DE3611097		1986-04-03

Publications (4)

Publication Number	Publication Date
DK302486D0 DK302486D0 (da)	1986-06-26
DK302486A true DK302486A (da)	1986-12-28
DK161200B DK161200B (da)	1991-06-10
DK161200C DK161200C (da)	1991-12-30

Family

ID=25833506

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK302486A DK161200C (da)	1985-06-27	1986-06-26	11-substituerede 5,11-dihydro-6h-pyridooe2,3-baaoe1,4aa-benzodiazepin-6-oner, fremgangsmaade til fremstilling heraf, laegemiddel indeholdende en saadan forbindelse samt anvendelse af en saadan forbindelse tilfremstilling af laegemidler

Country Status (17)

Country	Link
US (1)	US4724236A (da)
EP (1)	EP0213293B1 (da)
KR (1)	KR870000334A (da)
AT (1)	ATE71097T1 (da)
AU (1)	AU582249B2 (da)
CA (1)	CA1269374A (da)
DE (1)	DE3683217D1 (da)
DK (1)	DK161200C (da)
ES (1)	ES2000170A6 (da)
FI (1)	FI83317C (da)
GR (1)	GR861637B (da)
HU (1)	HU194228B (da)
IL (1)	IL79233A0 (da)
NO (1)	NO163099C (da)
NZ (1)	NZ216670A (da)
PH (1)	PH21976A (da)
PT (1)	PT82848B (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3643666A1 (de) *	1986-12-20	1988-06-30	Thomae Gmbh Dr K	Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3802334A1 (de) *	1988-01-27	1989-08-10	Thomae Gmbh Dr K	Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3816709A1 (de) *	1988-05-17	1989-11-30	Thomae Gmbh Dr K	Verwendung von diazepinonen zur therapie von stoerungen der mikrozirkulation
DE3818299A1 (de) *	1988-05-30	1989-12-07	Thomae Gmbh Dr K	Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3820347A1 (de) *	1988-06-15	1989-12-21	Thomae Gmbh Dr K	Verwendung von in 11-stellung substituierten 5,11-dihydro-6h-pyrido(2,3-b) (1,4)benzodiazepin-6-onen zur behandlung von bradycardien und bradyarrhythmien in der human- und veterinaermedizin
DE3820346A1 (de) *	1988-06-15	1989-12-21	Thomae Gmbh Dr K	Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5420123A (en) *	1992-12-21	1995-05-30	Bristol-Myers Squibb Company	Dibenzodiazepine endothelin antagonists
EP1781300A1 (en)	2004-07-16	2007-05-09	ProteoSys AG	Muscarinic antagonists with parp and sir modulatng activity as agents for inflammatory diseases
EP2387405A2 (en)	2009-01-13	2011-11-23	ProteoSys AG	Pirenzepine as an agent in cancer treatment

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1130973B (it) *	1980-03-17	1986-06-18	Microsules Argentina Sa De S C	Processo per la preparazione di derivati di 5,11-di-idro-6h-pirido(2,3-b) (1,4)-benzodiazepin-6-one,derivati finali ed intermedi di sintesi in tal modo ottenuti
DE3204401A1 (de) *	1982-02-09	1983-08-11	Dr. Karl Thomae Gmbh, 7950 Biberach	Pyridobenzodiazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3204403A1 (de) *	1982-02-09	1983-08-11	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue pyridobenzodiazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
IT1212742B (it) *	1983-05-17	1989-11-30	Dompe Farmaceutici Spa	Derivati dibenzo [1,4]diazepinonici pirido [1,4] benzodiazepinonici,pirido [1,5] benzodiazepinonici e loro attivita' farmacologica
IT1212743B (it) *	1983-05-17	1989-11-30	Dompe Farmaceutici Spa	Sali quaternari di derivati di benzo[ 1,4 ]diazepinonici,pirido [1,4]benzodiazepinonici,prido [1,5]benzodiazepinonici e loro atti vita' farmacologica
DE3409237A1 (de) *	1984-03-14	1985-09-19	Dr. Karl Thomae Gmbh, 7950 Biberach	Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

1986
- 1986-06-13 AT AT86108098T patent/ATE71097T1/de not_active IP Right Cessation
- 1986-06-13 EP EP86108098A patent/EP0213293B1/de not_active Expired - Lifetime
- 1986-06-13 DE DE8686108098T patent/DE3683217D1/de not_active Expired - Lifetime
- 1986-06-24 GR GR861637A patent/GR861637B/el unknown
- 1986-06-25 IL IL79233A patent/IL79233A0/xx not_active IP Right Cessation
- 1986-06-25 FI FI862694A patent/FI83317C/fi not_active IP Right Cessation
- 1986-06-26 HU HU862674A patent/HU194228B/hu not_active IP Right Cessation
- 1986-06-26 NZ NZ216670A patent/NZ216670A/xx unknown
- 1986-06-26 PT PT82848A patent/PT82848B/pt not_active IP Right Cessation
- 1986-06-26 AU AU59287/86A patent/AU582249B2/en not_active Ceased
- 1986-06-26 CA CA000512576A patent/CA1269374A/en not_active Expired - Lifetime
- 1986-06-26 DK DK302486A patent/DK161200C/da not_active IP Right Cessation
- 1986-06-26 NO NO862584A patent/NO163099C/no unknown
- 1986-06-26 KR KR1019860005126A patent/KR870000334A/ko not_active Ceased
- 1986-06-26 ES ES8600005A patent/ES2000170A6/es not_active Expired
- 1986-06-27 PH PH33960A patent/PH21976A/en unknown
- 1986-12-19 US US06/944,146 patent/US4724236A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PT82848A (de)	1986-07-01
DK302486D0 (da)	1986-06-26
US4724236A (en)	1988-02-09
DK161200C (da)	1991-12-30
DE3683217D1 (de)	1992-02-13
AU582249B2 (en)	1989-03-16
ATE71097T1 (de)	1992-01-15
KR870000334A (ko)	1987-02-17
HU194228B (en)	1988-01-28
FI862694A0 (fi)	1986-06-25
EP0213293A3 (en)	1988-06-08
PH21976A (en)	1988-05-02
EP0213293A2 (de)	1987-03-11
ES2000170A6 (es)	1988-01-01
FI83317C (fi)	1991-06-25
PT82848B (pt)	1988-12-15
NO163099C (no)	1990-04-04
FI83317B (fi)	1991-03-15
FI862694L (fi)	1986-12-28
CA1269374A (en)	1990-05-22
NO862584D0 (no)	1986-06-26
AU5928786A (en)	1987-01-08
NO862584L (no)	1986-12-29
NO163099B (no)	1989-12-27
EP0213293B1 (de)	1992-01-02
DK161200B (da)	1991-06-10
GR861637B (en)	1986-10-30
NZ216670A (en)	1989-05-29
HUT42090A (en)	1987-06-29
IL79233A0 (en)	1986-09-30

Legal Events

Date	Code	Title	Description
1994-02-28	PBP	Patent lapsed

Publication	Publication Date	Title
AU582249B2 (en)	1989-03-16	Diazepinones
GR3002051T3 (en)	1992-12-30	3-oxadiazolyl and 3-carboxylic-acid beta-carboline derivatives, their preparation and their use as medicaments
GR860900B (en)	1986-08-04	Amino-propanol derivatives method for their preparation their use and medicaments containing them
DE3474144D1 (en)	1988-10-27	Chromone- and thiochromone-substituted 1,4-dihydropyridines, processes for their preparation and their use in pharmaceutical preparations
SG47947A1 (en)	1998-04-17	Biologically active amines
ZA842166B (en)	1984-10-31	Chromone-and thiochromone-substituted 1,4-dihydro-pyridinelactones,several processes for their preparation and their use in medicaments
GR3000831T3 (en)	1991-11-15	Piperazine compounds, process for preparing them, pharmaceutical composition and use
FR2540870B1 (da)	1985-05-17
ES8604960A1 (es)	1986-03-01	Procedimiento para preparar derivados de 1,6-naftiridina
HUT46214A (en)	1988-10-28	Process for producing medical preparation suitable for treatment of peptic ulcer
EP0223647A3 (en)	1987-09-30	Alkyl carboxamides of pyridyl alkyl amines, their preparation and their use as medicaments
GR3001468T3 (en)	1992-10-08	5-aminoalkyl-beta-carboline derivatives, their preparation and their use as medicaments
JPS57175194A (en)	1982-10-28	10b-carboxy-aminoboran and physiologically available salts of same, manufacture and use as neutron catching treatment medicine
DE3265847D1 (en)	1985-10-03	Diglycidyl pteridine compounds, method for their preparation and their use in drugs with a cytostatic activity