DK3027624T3 - Thieno[3,2-d]pyrimidinderivater til behandling af virusinfektioner - Google Patents
Thieno[3,2-d]pyrimidinderivater til behandling af virusinfektioner Download PDFInfo
- Publication number
- DK3027624T3 DK3027624T3 DK14744834.4T DK14744834T DK3027624T3 DK 3027624 T3 DK3027624 T3 DK 3027624T3 DK 14744834 T DK14744834 T DK 14744834T DK 3027624 T3 DK3027624 T3 DK 3027624T3
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- Prior art keywords
- compound
- pharmaceutically acceptable
- formula
- polymorph
- solvate
- Prior art date
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- 241000700605 Viruses Species 0.000 title 1
- 208000015181 infectious disease Diseases 0.000 title 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Claims (6)
1. Forbindelse med formel (I)
eller et farmaceutisk acceptabelt salt, en eller flere tautomerer, en stereoisomer form, et solvat eller en polymorf deraf, hvor Ri er valgt blandt hydrogen, halogen, -CH3 eller -CF3, R2 er valgt blandt hydrogen, halogen, Ci-6alkyl eller C3-6cycloalkyl, R3 er Ci-8alkyl, der eventuelt er substitueret med en eller flere substituenter, der er valgt uafhængigt blandt aryl, aryloxy, halogen, hydroxyl, alkylamino, dialkylamino, Ci-6alkenyl, Ci-6alkoxy, carboxylsyre, carboxylester, carboxylamid, nitril, sulfonamid, sulfamid, acylsulfonamid, eller R3 er en alkylaryl, der eventuelt er substitueret med en eller flere substituenter, der er valgt uafhængigt blandt aryl, aryloxy, halogen, hydroxyl, alkylamino, dialkylamino, Ci-6alkyl, Ci-6alkenyl, Ci-6alkoxy, carboxylsyre, carboxylester, carboxylamid, nitril, sulfonamid, sulfamid eller acylsulfonamid.
2. Forbindelse ifølge krav 1, hvor Ri og R2 begge er hydrogen, og hvor R3 er Ci-salkyl substitueret med hydroxyl.
3. Forbindelse ifølge krav 2, der har strukturen
4. Farmaceutisk sammensætning, der omfatter en forbindelse med formel (I) eller et farmaceutisk acceptabelt salt, en eller flere tautomerer, stereoisomere former, et solvat eller en polymorf deraf ifølge krav 1 sammen med et eller flere
farmaceutisk acceptable excipienser, fortyndingsmidler eller bærematerialer.
5. Forbindelse med formel (I) eller et farmaceutisk acceptabelt salt, en eller flere tautomerer, stereoisomere former, et solvat eller en polymorf deraf ifølge krav 1 eller farmaceutisk sammensætning ifølge krav 4 til anvendelse som et medikament.
6. Forbindelse med formel (I) eller et farmaceutisk acceptabelt salt, en eller flere tautomerer, stereoisomere former, et solvat eller en polymorf deraf ifølge krav 1 eller farmaceutisk sammensætning ifølge krav 4 til anvendelse til behandling af en forstyrrelse, hvor modulering af TLR7 og/eller TLR8 er inddraget, fortrinsvis TLR8.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13178534 | 2013-07-30 | ||
| PCT/EP2014/066219 WO2015014815A1 (en) | 2013-07-30 | 2014-07-29 | THIENO[3,2-d]PYRIMIDINES DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3027624T3 true DK3027624T3 (da) | 2019-01-07 |
Family
ID=48874951
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14744834.4T DK3027624T3 (da) | 2013-07-30 | 2014-07-29 | Thieno[3,2-d]pyrimidinderivater til behandling af virusinfektioner |
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