DK302886A - 4-amino-2-(imidazolidin-2-on-l-yl)-pyrimidin-5-carboxylsyre-(n-(3-trifluormethyl-phenyl)-amider) til profylakse og terapi af thromboser samt deres anvendelse til fremstilling af antithrombotisk virksomme laegemidler - Google Patents

4-amino-2-(imidazolidin-2-on-l-yl)-pyrimidin-5-carboxylsyre-(n-(3-trifluormethyl-phenyl)-amider) til profylakse og terapi af thromboser samt deres anvendelse til fremstilling af antithrombotisk virksomme laegemidler Download PDF

Info

Publication number: DK302886A
Authority: DK; Denmark
Prior art keywords: thromboses; therapy; imidazolidin; amino; prophylaxy
Prior art date: 1985-06-27

Application number

DK302886A

Other languages

English (en)

Other versions

DK302886D0 (da

DK167098B1 (da

Inventor

Ernold Granzer

Klaus-Dieter Kampe

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-06-27

Filing date

1986-06-26

Publication date

1986-12-28

1986-06-26 Application filed by Hoechst Ag filed Critical Hoechst Ag

1986-06-26 Publication of DK302886D0 publication Critical patent/DK302886D0/da

1986-12-28 Publication of DK302886A publication Critical patent/DK302886A/da

1993-08-30 Application granted granted Critical

1993-08-30 Publication of DK167098B1 publication Critical patent/DK167098B1/da

Links

208000007536 Thrombosis Diseases 0.000 title abstract 3
238000002560 therapeutic procedure Methods 0.000 title abstract 3
-1 3-TRIFLUOROMETHYL-PHENYL Chemical class 0.000 title 1
NPFJOSKCSJJZPP-UHFFFAOYSA-N 4-amino-2-(2-oxoimidazolidin-1-yl)pyrimidine-5-carboxylic acid Chemical compound C1=C(C(O)=O)C(N)=NC(N2C(NCC2)=O)=N1 NPFJOSKCSJJZPP-UHFFFAOYSA-N 0.000 title 1
150000001408 amides Chemical class 0.000 title 1
229940126601 medicinal product Drugs 0.000 title 1
238000011321 prophylaxis Methods 0.000 abstract 2
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DK302886A 1985-06-27 1986-06-26 Anvendelse af 4-amino-2-(imidazolidin-2-on-1-yl)-pyrimidin-5-carboxylsyre-(n-(3-trifluormethyl-phenyl)-amider) til fremstilling af et laegemiddel til profylakse og terapi af thromboser DK167098B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3522940		1985-06-27
DE19853522940 DE3522940A1 (de)	1985-06-27	1985-06-27	4-amino-2-(imidazolidin-2-on-1-yl)-pyrimidin-5-carbonsaeure-(n-(3-trifluormethyl-phenyl)-amide) zur antithrombotischen prophylaxe und behandlung sowie ihre verwendung zur herstellung von antithrombotisch wirksamen arzneimitteln

Publications (3)

Publication Number	Publication Date
DK302886D0 DK302886D0 (da)	1986-06-26
DK302886A true DK302886A (da)	1986-12-28
DK167098B1 DK167098B1 (da)	1993-08-30

Family

ID=6274303

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK302886A DK167098B1 (da)	1985-06-27	1986-06-26	Anvendelse af 4-amino-2-(imidazolidin-2-on-1-yl)-pyrimidin-5-carboxylsyre-(n-(3-trifluormethyl-phenyl)-amider) til fremstilling af et laegemiddel til profylakse og terapi af thromboser

Country Status (12)

Country	Link
US (1)	US4705792A (da)
EP (1)	EP0206297B1 (da)
JP (1)	JPH0680011B2 (da)
AT (1)	ATE44875T1 (da)
AU (1)	AU595810B2 (da)
CA (1)	CA1267603A (da)
DE (2)	DE3522940A1 (da)
DK (1)	DK167098B1 (da)
GR (1)	GR861646B (da)
IL (1)	IL79253A (da)
PT (1)	PT82847B (da)
ZA (1)	ZA864773B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE59307402D1 (de) *	1992-02-22	1997-10-30	Hoechst Ag	Lösliche Salze von 4-Amino-2-(4,4-dimethyl-imidazolidin-2-on-1-yl)-pyrimidin-5 -carbonsäure- N-methyl-N-(3-trifluormethyl-phenyl)- amid, Verfahren zu ihrer Herstellung, ihre Verwendung als Arzneimittel und Ausgangsprodukte
ATE147384T1 (de) *	1992-02-22	1997-01-15	Hoechst Ag	4-amino-2-ureido-pyrimidin-5-carbonsäureamide, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
DE19625089A1 (de) *	1996-06-24	1998-01-02	Hoechst Ag	4-Amino-2-ureido-pyrimidin-5-carbonsäureamide, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE19625088A1 (de) *	1996-06-24	1998-01-02	Hoechst Ag	4-Amino-2-ureido-pyrimidin-5-carbonsäureamide, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
US7176310B1 (en)	2002-04-09	2007-02-13	Ucb Sa	Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents
CN112574124B (zh) *	2020-12-07	2022-04-26	浙江乐普药业股份有限公司	一种替格瑞洛衍生物及其制备方法和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2853220A1 (de) *	1978-12-09	1980-07-03	Hoechst Ag	Neue amino-pyrimidin-carbanilide, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung

1985
- 1985-06-27 DE DE19853522940 patent/DE3522940A1/de not_active Withdrawn
1986
- 1986-06-21 EP EP86108486A patent/EP0206297B1/de not_active Expired
- 1986-06-21 AT AT86108486T patent/ATE44875T1/de active
- 1986-06-21 DE DE8686108486T patent/DE3664564D1/de not_active Expired
- 1986-06-25 US US06/878,854 patent/US4705792A/en not_active Expired - Fee Related
- 1986-06-25 GR GR861646A patent/GR861646B/el unknown
- 1986-06-26 DK DK302886A patent/DK167098B1/da not_active IP Right Cessation
- 1986-06-26 IL IL79253A patent/IL79253A/xx not_active IP Right Cessation
- 1986-06-26 PT PT82847A patent/PT82847B/pt not_active IP Right Cessation
- 1986-06-26 ZA ZA864773A patent/ZA864773B/xx unknown
- 1986-06-26 CA CA000512595A patent/CA1267603A/en not_active Expired - Fee Related
- 1986-06-26 JP JP61148338A patent/JPH0680011B2/ja not_active Expired - Lifetime
- 1986-06-27 AU AU59326/86A patent/AU595810B2/en not_active Ceased

Also Published As

Publication number	Publication date
DE3664564D1 (en)	1989-08-31
DE3522940A1 (de)	1987-01-08
US4705792A (en)	1987-11-10
ATE44875T1 (de)	1989-08-15
AU5932686A (en)	1987-01-08
PT82847A (de)	1986-07-01
DK302886D0 (da)	1986-06-26
IL79253A0 (en)	1986-09-30
PT82847B (pt)	1988-12-15
EP0206297A1 (de)	1986-12-30
GR861646B (en)	1986-10-30
DK167098B1 (da)	1993-08-30
IL79253A (en)	1990-12-23
AU595810B2 (en)	1990-04-12
JPS624230A (ja)	1987-01-10
EP0206297B1 (de)	1989-07-26
CA1267603A (en)	1990-04-10
JPH0680011B2 (ja)	1994-10-12
ZA864773B (en)	1987-02-25

Similar Documents

Publication	Publication Date	Title
DK0593639T3 (da)	1995-07-03	Pyrrolidin- og thiazolidinderivater, fremstilling af disse forbindelser og lægemidler indeholdende disse
ZA874812B (en)	1988-10-26	Drug
DK0502788T3 (da)	1994-09-12	Trisubstituerede triaziner og pyrimidiner, fremgangsmåde til fremstilling heraf og farmaceutiske midler, som indeholder dem
DK581889A (da)	1990-05-22	Antiatherosclerotiske diarylforbindelser
DK324185A (da)	1986-01-19	2-substituerede 1,3-propylidendiphosphonatderivater, deres fremstilling og farmaceutiske praeparater med indhold deraf
DK302886D0 (da)	1986-06-26	4-amino-2-(imidazolidin-2-on-l-yl)-pyrimidin-5-carboxylsyre-(n-(3-trifluormethyl-phenyl)-amider) til profylakse og terapi af thromboser samt deres anvendelse til fremstilling af antithrombotisk virksomme laegemidler
DK149383D0 (da)	1983-03-30	Salicylsyrederivater, fremgangsmader til fremstilling deraf, farmaceutiske praeparater pa basis af disse forbindelser og deres anvendelse
DK408083D0 (da)	1983-09-08	Isoquinilinderivater, deres fremstilling og anvendelse
NO881308L (no)	1988-10-10	Dihydropyridinamider, fremgangsmaate til deres fremstilling og deres anvendelse i legemidler.
DK0634396T3 (da)	1999-07-05	Aminosyrederivater og deres anvendelse som enkeltfalinaseinhibitorer
DK114286A (da)	1986-09-14	Pyridylmethylnaphthylderivater eller fysiologisk acceptable syreadditionssalte deraf, deres fremstilling og anvendelse som laegemidler
DK222588D0 (da)	1988-04-22	5-quinoxalyl-imidazolidin-2,4-dioner, deres fremstilling og anvendelse som laegemidler
DK284588A (da)	1988-11-27	Beta-lactam-forbindelser, deres fremstilling og anvendelse som laegemidler.
DK114186A (da)	1986-09-14	Imidazolylforbindelser eller fysiologisk acceptable syreadditionssalte deraf, deres fremstilling og anvendelse som laegemidler
DK10187D0 (da)	1987-01-09	Methioninsubstituerede 1,4-dihydropuyridiner, deres fremstilling og anvendelse som laegemidler
DK0418990T3 (da)	1994-03-14	13-brom- og 13,14-dibrom-ergoliner, deres fremstilling og anvendelse i lægemidler
FI890173L (fi)	1989-01-13	Isoxazoler med nootropisk verkan.
DK48489A (da)	1989-08-04	Heteroanellerede phenylglycin-beta-lactam-antibiotika og farmaceutisk acceptable salte deraf, deres fremstilling og anvendelse
ZA828127B (en)	1983-10-26	Pyridazinone-imines and their physiologically tolerated acid addition salts, their preparation, and therapeutic agents containing these compounds
DK514786D0 (da)	1986-10-28	5-heterocyclyl-2,4-dialkyl-3h-1,2,4-triazol-3-thioner og tautomere og farmaceutisk acceptable salte deraf, deres fremstilling og anvendelsesom antidepressive midler
DK163506C (da)	1992-07-27	N-bicycloheptyl- og n-bicycloheptenyl-imidazoler, deres fremstilling og farmaceutiske praeparater indeholdende disse
DK554688D0 (da)	1988-10-04	Farmaceutisk aktive derivater af (r)-5-pentyl-amino-5-oxopentansyre og farmaceutisk acceptable salte deraf, deres fremstilling og anvendelse

Legal Events

Date	Code	Title	Description
1993-08-30	B1	Patent granted (law 1993)
1999-05-03	PBP	Patent lapsed