DK0593639T3 - Pyrrolidin- og thiazolidinderivater, fremstilling af disse forbindelser og lægemidler indeholdende disse - Google Patents

Pyrrolidin- og thiazolidinderivater, fremstilling af disse forbindelser og lægemidler indeholdende disse

Info

Publication number
DK0593639T3
DK0593639T3 DK92915456.5T DK92915456T DK0593639T3 DK 0593639 T3 DK0593639 T3 DK 0593639T3 DK 92915456 T DK92915456 T DK 92915456T DK 0593639 T3 DK0593639 T3 DK 0593639T3
Authority
DK
Denmark
Prior art keywords
compounds
preparation
pyrrolidine
drugs containing
thiazolidine derivatives
Prior art date
Application number
DK92915456.5T
Other languages
English (en)
Inventor
Marc Capet
Gerard Roussel
Claude Guyon
Claude Cotrel
Michel Joannic
Franco Manfre
Marie-Christine Dubroeucq
Michel Cheve
Gilles Dutruc-Rosset
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Application granted granted Critical
Publication of DK0593639T3 publication Critical patent/DK0593639T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK92915456.5T 1991-07-10 1992-07-03 Pyrrolidin- og thiazolidinderivater, fremstilling af disse forbindelser og lægemidler indeholdende disse DK0593639T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9108675A FR2678938B1 (fr) 1991-07-10 1991-07-10 Derives de pyrrolidine, leur preparation et les medicaments les contenant.

Publications (1)

Publication Number Publication Date
DK0593639T3 true DK0593639T3 (da) 1995-07-03

Family

ID=9414933

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92915456.5T DK0593639T3 (da) 1991-07-10 1992-07-03 Pyrrolidin- og thiazolidinderivater, fremstilling af disse forbindelser og lægemidler indeholdende disse

Country Status (23)

Country Link
US (1) US5610144A (da)
EP (2) EP0593639B1 (da)
JP (1) JP3034043B2 (da)
KR (1) KR100234927B1 (da)
AT (1) ATE120732T1 (da)
AU (1) AU662345B2 (da)
BR (1) BR1100717A (da)
CA (1) CA2102697C (da)
CZ (1) CZ283602B6 (da)
DE (1) DE69201956T2 (da)
DK (1) DK0593639T3 (da)
ES (1) ES2071510T3 (da)
FI (1) FI105190B (da)
FR (1) FR2678938B1 (da)
HU (1) HU223470B1 (da)
IE (1) IE66331B1 (da)
NO (1) NO180166C (da)
NZ (1) NZ243514A (da)
PL (5) PL171112B1 (da)
RU (1) RU2118316C1 (da)
SK (1) SK1694A3 (da)
WO (1) WO1993001167A1 (da)
ZA (1) ZA925128B (da)

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FR2695641B1 (fr) * 1992-09-11 1994-11-25 Rhone Poulenc Rorer Sa (Amino-3 phényl)-1 éthanesulfonate d'hydroquinine optiquement actif, sa préparation et son utilisation.
FR2700167B1 (fr) * 1993-01-07 1995-02-03 Rhone Poulenc Rorer Sa Dérivés de pyrrolidine et thiazolidine, leur préparation et les médicaments les contenant.
FR2700165B1 (fr) * 1993-01-07 1995-02-17 Rhone Poulenc Rorer Sa Dérivés de pyrrolidine, leur préparation et les médicaments les contenant.
FR2700166B1 (fr) * 1993-01-07 1995-02-17 Rhone Poulenc Rorer Sa Dérivés de pyrrolidine, leur préparation et les médicaments les contenant.
FR2700168B1 (fr) * 1993-01-07 1995-02-03 Rhone Poulenc Rorer Sa Dérivés de thiazolidine, leur préparation et les médicaments les contenant.
US5744485A (en) * 1994-03-25 1998-04-28 Vertex Pharmaceuticals Incorporated Carbamates and ureas as modifiers of multi-drug resistance
FR2721314B1 (fr) * 1994-06-20 1996-07-19 Rhone Poulenc Rorer Sa Dérivés de pyrrolidine, leur préparation et les médicaments les contenant.
FR2721608B1 (fr) * 1994-06-22 1996-07-19 Rhone Poulenc Rorer Sa Dérivés de thiazolidine, leur préparation et les médicaments les contenant.
FR2734724B1 (fr) * 1995-06-01 1997-07-04 Rhone Poulenc Rorer Sa Application de derives de pyrrolidine a la preparation de medicaments destines au traitement de l'alcoolisme
MY114711A (en) * 1995-06-06 2002-12-31 Pfizer Substituted n-(indole-2-carbonyl)-b-alanmamides and derivatives as antidiabetic agents
FI974437A7 (fi) 1995-06-06 1997-12-05 Pfizer Substituoituja N-(indoli-2-karbonyyli)amideja ja johdannaisia glykogee nifosforylaasi-inhibiittoreina
FR2744361B1 (fr) * 1996-02-07 1998-02-27 Rhone Poulenc Rorer Sa Application de derives de pyrrolidine a la preparation de medicaments destines au traitement de l'abus de drogues ou de substances donnant lieu a des pharmacomanies ou a un usage excessif
TW442449B (en) 1996-07-04 2001-06-23 Hoechst Ag Process for preparing 1,2-dichloroethane by direct chlorination
DE19816880A1 (de) * 1998-04-17 1999-10-21 Boehringer Ingelheim Pharma Neue Diphenyl-substituierte 5-Ring-Heterocyclen, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel
YU26700A (sh) * 1999-05-24 2002-06-19 Pfizer Products Inc. Postupak za cis-1-(2-(4-(6-metoksi-2-fenil-1,2,3,4- tetrahidronaftalen-1-il)fenoksi)etil)pirolidin
WO2001098268A2 (en) 2000-06-21 2001-12-27 Bristol-Myers Squibb Pharma Company Piperidine amides as modulators of chemokine receptor activity
US6277877B1 (en) * 2000-08-15 2001-08-21 Pfizer, Inc. Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors
DE60128731T2 (de) 2000-10-30 2008-02-07 Janssen Pharmaceutica N.V. Tripeptidylpeptidase-hemmer
US7105556B2 (en) 2001-05-30 2006-09-12 Bristol-Myers Squibb Company Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method
US7262207B2 (en) 2002-09-19 2007-08-28 Abbott Laboratories Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
CA2768674A1 (en) * 2002-09-19 2004-04-01 Abbott Laboratories Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-iv (dpp-iv)
US7238724B2 (en) 2002-09-19 2007-07-03 Abbott Laboratories Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
US6846836B2 (en) * 2003-04-18 2005-01-25 Bristol-Myers Squibb Company N-substituted phenylurea inhibitors of mitochondrial F1F0 ATP hydrolase
US7230002B2 (en) 2004-02-03 2007-06-12 Glenmark Pharmaceuticals Ltd. Dipeptidyl peptidase IV inhibitors; processes for their preparation and compositions thereof
BRPI0507612A (pt) * 2004-02-11 2007-07-03 Univ Ohio State Res Found análogos exibindo inibição de proliferação de célula e métodos para fabricação e uso destes
WO2007086584A1 (ja) * 2006-01-30 2007-08-02 Meiji Seika Kaisha, Ltd. 新規ＦａｂＫおよびＦａｂＩ／Ｋ阻害剤
EP2057145B1 (en) * 2006-07-20 2012-08-22 Abbott Laboratories Synthesis of (2s,5r)-5-ethynyl-1-{n-(4-methyl-1-(4-carboxy-pyridin-2-yl)piperidin-4-yl)glycyl}pyrrolidine-2-carbonitrile
US8247438B2 (en) 2008-02-27 2012-08-21 Neuropill, Inc. Methods for treating schizophrenia
CN101407502B (zh) * 2008-11-21 2010-12-22 南京大学 一类n-(叔丁氧基羰基)噻唑烷酸类化合物及其制法和用途
DE102009004204A1 (de) * 2009-01-09 2010-07-15 Christian-Albrechts-Universität Zu Kiel Verfahren zur verbesserten Bioaktivierung von Arzneistoffen
CN102812003B (zh) * 2009-12-18 2015-01-21 欧洲筛选有限公司 吡咯烷羧酸衍生物、药物组合物以及在代谢紊乱中作为g-蛋白偶联受体43(gpr43)激动剂使用的方法
US9249181B2 (en) 2010-09-13 2016-02-02 Amylin Pharmaceuticals, Llc C-terminal amidation of polypeptides
CN105916500A (zh) 2013-11-27 2016-08-31 欧洲筛选有限公司 用于治疗炎性疾病的化合物、药物组合物和方法
AU2016209056B2 (en) 2015-01-24 2021-01-28 Academia Sinica Cancer markers and methods of use thereof
MX2022015718A (es) 2020-06-10 2023-01-24 Epics Therapeutics Sintesis del acido (2s,5r)-5-(2-clorofenilo)-1-(2'-metoxi-[1,1'-bi fenilo]-4-carbonilo)pirrolidina-2-carboxilico.

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US4499102A (en) * 1979-12-13 1985-02-12 Santen Pharmaceutical Co., Ltd. Thiazolidine and pyrrolidine compounds and pharmaceutical compositions containing them
DE3272505D1 (en) * 1981-03-09 1986-09-18 Merck & Co Inc Substituted thiazolidine carboxylic acid analogs and derivatives as antihypertensives
DE3332633A1 (de) * 1983-09-09 1985-04-04 Luitpold-Werk Chemisch-pharmazeutische Fabrik GmbH & Co, 8000 München Substituierte carbonsaeurederivate, verfahren zu ihrer herstellung, und arzneimittel
AU629376B2 (en) * 1989-08-04 1992-10-01 Mitsubishi Chemical Corporation 1-phenylalkyl-3-phenylurea derivatives
US5258405A (en) * 1990-03-12 1993-11-02 Yamanouchi Pharmaceutical Co., Ltd. Urea derivatives and salts thereof in method for inhibiting the ACAT enzyme

Also Published As

Publication number Publication date
AU662345B2 (en) 1995-08-31
NO934300D0 (no) 1993-11-26
CZ4994A3 (en) 1994-04-13
FR2678938A1 (fr) 1993-01-15
EP0593639B1 (fr) 1995-04-05
EP0593639A1 (fr) 1994-04-27
PL171095B1 (pl) 1997-03-28
PL171094B1 (pl) 1997-03-28
DE69201956T2 (de) 1995-11-30
PL171333B1 (pl) 1997-04-30
RU2118316C1 (ru) 1998-08-27
WO1993001167A1 (fr) 1993-01-21
JP3034043B2 (ja) 2000-04-17
PL171112B1 (pl) 1997-03-28
JPH06509331A (ja) 1994-10-20
HU223470B1 (hu) 2004-07-28
HU9400061D0 (en) 1994-05-30
FI105190B (fi) 2000-06-30
ZA925128B (en) 1993-04-28
ES2071510T3 (es) 1995-06-16
US5610144A (en) 1997-03-11
AU2327592A (en) 1993-02-11
ATE120732T1 (de) 1995-04-15
NO180166C (no) 1997-02-26
FR2678938B1 (fr) 1993-10-08
NO180166B (no) 1996-11-18
CZ283602B6 (cs) 1998-05-13
HUT70403A (en) 1995-10-30
CA2102697A1 (fr) 1993-01-11
FI940072A0 (fi) 1994-01-07
SK1694A3 (en) 1994-12-07
IE66331B1 (en) 1995-12-27
KR100234927B1 (ko) 2000-02-01
IE922244A1 (en) 1993-01-13
EP0527069A1 (fr) 1993-02-10
BR1100717A (pt) 2000-03-14
NZ243514A (en) 1995-03-28
PL171054B1 (pl) 1997-02-28
CA2102697C (fr) 2003-09-30
FI940072L (fi) 1994-01-07
NO934300L (no) 1993-11-26
DE69201956D1 (de) 1995-05-11

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