DK3045183T3 - Pegyleret apelin og anvendelser deraf - Google Patents
Pegyleret apelin og anvendelser deraf Download PDFInfo
- Publication number
- DK3045183T3 DK3045183T3 DK16155181.7T DK16155181T DK3045183T3 DK 3045183 T3 DK3045183 T3 DK 3045183T3 DK 16155181 T DK16155181 T DK 16155181T DK 3045183 T3 DK3045183 T3 DK 3045183T3
- Authority
- DK
- Denmark
- Prior art keywords
- apelin
- peg
- molecule
- pegylated
- disease
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- 239000006187 pill Substances 0.000 description 1
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- 229920005862 polyol Polymers 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Marine Sciences & Fisheries (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (11)
1. Pegyleret apelin 36-molekyle, der omfatter et eller flere polyethylenglycol (PEG)-molekyler, der er operabelt koblet til en leucin i N-terminalen af apelin 36.
2. Molekyle ifølge krav 1, hvor det pegylerede apelin 36 er i stand til at fremvise en forlænget cirkulationstid eller en forlænget inotrop virkning i forhold til ikke-pegyleret apelin 36.
3. Molekyle ifølge krav 1, hvor det pegylerede apelin 36 er et monopegyleret eller et dipegyleret apelin 36.
4. Molekyle ifølge krav 1, hvor det ene eller de flere PEG-molekyler er kovalent bundet til aminosyreresten enten direkte eller via en linker.
5. Molekyle ifølge krav 1, hvor hvert PEG-molekyle har en molekylvægt i intervallet fra ca. 5.000 til ca. 50.000 dalton.
6. Molekyle ifølge krav 1, hvor det pegylerede apelin 36 omfatter monomert apelin 36.
7. Molekyle ifølge krav 1, hvor det pegylerede apelin 36 omfatter et oligomert apelin 36, hvor en eller flere monomerer er operabelt koblet til hinanden.
8. Molekyle ifølge krav 1, hvor apelin 36 omfatter aminosyresekvensen ifølge aminosyreresterne 42-77 af SEQ ID NO: 1.
9. Molekyle ifølge krav 8, hvor aminosyresekvensen kodes af en nukleinsyresekvens, som er 123-234 bp af SEQ ID NO: 2.
10. Pegyleret apelin 36-molekyle ifølge et hvilket som helst af kravene 1-8 til anvendelse som et medikament.
11. Terapeutisk effektiv mængde af det pegylerede apelin 36-molekyle ifølge et hvilket som helst af kravene 1-8 til anvendelse til behandling af en sygdom eller forstyrrelse, der er forbundet med apelin, hvor sygdommen eller forstyrrelsen er en kardiovaskulær sygdom, en iskæmireperfusionsskade, myokardieinfarkt, akut dekompenseret hjerteinsufficiens, kronisk hjerteinsufficiens, kardiomyopati, endokrin forstyrrelse, metabolisk forstyrrelse eller pulmonal hypertension hos et menneske.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161451623P | 2011-03-11 | 2011-03-11 | |
| EP12757055.4A EP2683360B1 (en) | 2011-03-11 | 2012-03-08 | Pegylated apelin and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3045183T3 true DK3045183T3 (da) | 2018-10-22 |
Family
ID=46831054
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16155181.7T DK3045183T3 (da) | 2011-03-11 | 2012-03-08 | Pegyleret apelin og anvendelser deraf |
| DK12757055.4T DK2683360T3 (da) | 2011-03-11 | 2012-03-08 | Pegyleret apelin og anvendelser deraf |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12757055.4T DK2683360T3 (da) | 2011-03-11 | 2012-03-08 | Pegyleret apelin og anvendelser deraf |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20140142049A1 (da) |
| EP (2) | EP2683360B1 (da) |
| AU (2) | AU2012229336B2 (da) |
| CA (1) | CA2829693C (da) |
| CY (1) | CY1117654T1 (da) |
| DK (2) | DK3045183T3 (da) |
| ES (2) | ES2690147T3 (da) |
| HR (2) | HRP20160547T1 (da) |
| HU (1) | HUE027579T2 (da) |
| LT (1) | LT3045183T (da) |
| PL (2) | PL3045183T3 (da) |
| PT (1) | PT3045183T (da) |
| SI (2) | SI3045183T1 (da) |
| WO (1) | WO2012125408A1 (da) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3045183T1 (sl) | 2011-03-11 | 2018-11-30 | Genzyme Corporation | Pegiliran Apelin in njegove uporabe |
| US20160067347A1 (en) * | 2012-12-20 | 2016-03-10 | Amgen Inc. | Apj receptor agonists and uses thereof |
| US9353163B2 (en) | 2013-03-14 | 2016-05-31 | Regeneron Pharmaceuticals, Inc. | Apelin fusion proteins and uses thereof |
| HK1218252A1 (zh) | 2013-07-25 | 2017-02-10 | Novartis Ag | 合成apelin多肽之生物结合物 |
| KR20160031551A (ko) | 2013-07-25 | 2016-03-22 | 노파르티스 아게 | 심부전의 치료를 위한 시클릭 폴리펩티드 |
| CN105612174A (zh) * | 2013-07-25 | 2016-05-25 | 诺华股份有限公司 | 用于治疗心力衰竭的二硫化物环状多肽 |
| WO2015013165A1 (en) * | 2013-07-25 | 2015-01-29 | Novartis Ag | Cyclic apelin derivatives for the treatment of heart failure |
| WO2015077491A1 (en) | 2013-11-20 | 2015-05-28 | Regeneron Pharmaceuticals, Inc. | Aplnr modulators and uses thereof |
| DK3122764T3 (da) | 2014-03-25 | 2019-04-15 | Lanthiopep Bv | Cykliske apelin-analoger |
| WO2015191781A2 (en) * | 2014-06-10 | 2015-12-17 | Amgen Inc. | Apelin polypeptides |
| MA41580A (fr) | 2015-01-23 | 2017-11-29 | Novartis Ag | Conjugués d'acides gras de l'apeline synthétique présentant une demi-vie améliorée |
| CN110072531A (zh) | 2016-10-19 | 2019-07-30 | 阿维夫公司 | 用于治疗心血管相关疾病的爱帕琳的新型聚乙二醇化的脂质体制剂 |
| EP4168054A1 (en) * | 2020-06-18 | 2023-04-26 | Universite d'Aix Marseille | Conjugated and labelled apelin, preparation and uses thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6420339B1 (en) * | 1998-10-14 | 2002-07-16 | Amgen Inc. | Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility |
| US20020102208A1 (en) | 1999-03-01 | 2002-08-01 | Paul Chinn | Radiolabeling kit and binding assay |
| EP1613348B1 (en) * | 2003-03-12 | 2010-06-23 | The Arizona Board of Regents on Behalf of the University of Arizona | Methods for modulating angiogenesis with apelin compositions |
| US7947280B2 (en) * | 2003-05-22 | 2011-05-24 | The Board Of Trustees Of The Leland Stanford Junior University | Apelin and uses thereof |
| WO2007022123A2 (en) * | 2005-08-11 | 2007-02-22 | Amylin Pharmaceuticals, Inc. | Hybrid polypeptides with selectable properties |
| WO2008051383A2 (en) * | 2006-10-19 | 2008-05-02 | Amgen Inc. | Use of alcohol co-solvents to improve pegylation reaction yields |
| SI3045183T1 (sl) | 2011-03-11 | 2018-11-30 | Genzyme Corporation | Pegiliran Apelin in njegove uporabe |
-
2012
- 2012-03-08 SI SI201231407T patent/SI3045183T1/sl unknown
- 2012-03-08 PL PL16155181T patent/PL3045183T3/pl unknown
- 2012-03-08 WO PCT/US2012/028298 patent/WO2012125408A1/en not_active Ceased
- 2012-03-08 SI SI201230560A patent/SI2683360T1/sl unknown
- 2012-03-08 HR HRP20160547TT patent/HRP20160547T1/hr unknown
- 2012-03-08 CA CA2829693A patent/CA2829693C/en not_active Expired - Fee Related
- 2012-03-08 EP EP12757055.4A patent/EP2683360B1/en active Active
- 2012-03-08 EP EP16155181.7A patent/EP3045183B1/en active Active
- 2012-03-08 ES ES16155181.7T patent/ES2690147T3/es active Active
- 2012-03-08 PL PL12757055.4T patent/PL2683360T3/pl unknown
- 2012-03-08 US US14/004,377 patent/US20140142049A1/en active Pending
- 2012-03-08 DK DK16155181.7T patent/DK3045183T3/da active
- 2012-03-08 AU AU2012229336A patent/AU2012229336B2/en not_active Ceased
- 2012-03-08 PT PT16155181T patent/PT3045183T/pt unknown
- 2012-03-08 DK DK12757055.4T patent/DK2683360T3/da active
- 2012-03-08 HU HUE12757055A patent/HUE027579T2/en unknown
- 2012-03-08 LT LTEP16155181.7T patent/LT3045183T/lt unknown
- 2012-03-08 ES ES12757055.4T patent/ES2573337T3/es active Active
-
2016
- 2016-05-24 CY CY20161100447T patent/CY1117654T1/el unknown
-
2017
- 2017-05-02 AU AU2017202919A patent/AU2017202919B2/en not_active Ceased
-
2018
- 2018-10-03 HR HRP20181589TT patent/HRP20181589T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SI2683360T1 (sl) | 2016-06-30 |
| AU2017202919A1 (en) | 2017-05-25 |
| AU2012229336A1 (en) | 2013-10-10 |
| HRP20160547T1 (hr) | 2016-06-17 |
| WO2012125408A1 (en) | 2012-09-20 |
| CA2829693A1 (en) | 2012-09-20 |
| DK2683360T3 (da) | 2016-05-30 |
| HRP20181589T1 (hr) | 2018-12-28 |
| PL3045183T3 (pl) | 2018-12-31 |
| CA2829693C (en) | 2020-04-21 |
| EP2683360B1 (en) | 2016-02-24 |
| AU2012229336B2 (en) | 2017-02-02 |
| PT3045183T (pt) | 2018-11-02 |
| PL2683360T3 (pl) | 2016-09-30 |
| SI3045183T1 (sl) | 2018-11-30 |
| AU2017202919B2 (en) | 2019-03-14 |
| EP2683360A4 (en) | 2014-09-03 |
| EP3045183A1 (en) | 2016-07-20 |
| EP2683360A1 (en) | 2014-01-15 |
| CY1117654T1 (el) | 2018-03-07 |
| LT3045183T (lt) | 2018-10-25 |
| US20140142049A1 (en) | 2014-05-22 |
| WO2012125408A8 (en) | 2018-01-25 |
| HUE027579T2 (en) | 2016-10-28 |
| ES2690147T3 (es) | 2018-11-19 |
| EP3045183B1 (en) | 2018-07-04 |
| ES2573337T3 (es) | 2016-06-07 |
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