DK30488D0 - Steroidderivater, fremgangsmaade til fremstilling heraf samt farmacetisk middel indeholdende disse - Google Patents

Steroidderivater, fremgangsmaade til fremstilling heraf samt farmacetisk middel indeholdende disse

Info

Publication number
DK30488D0
DK30488D0 DK030488A DK30488A DK30488D0 DK 30488 D0 DK30488 D0 DK 30488D0 DK 030488 A DK030488 A DK 030488A DK 30488 A DK30488 A DK 30488A DK 30488 D0 DK30488 D0 DK 30488D0
Authority
DK
Denmark
Prior art keywords
carbon atoms
group
hydrocarbon
oxo
saturated
Prior art date
Application number
DK030488A
Other languages
English (en)
Other versions
DK163307B (da
DK163307C (da
DK30488A (da
Inventor
Hubert Jan Jozef Loozen
Original Assignee
Akzo Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nv filed Critical Akzo Nv
Publication of DK30488D0 publication Critical patent/DK30488D0/da
Publication of DK30488A publication Critical patent/DK30488A/da
Publication of DK163307B publication Critical patent/DK163307B/da
Application granted granted Critical
Publication of DK163307C publication Critical patent/DK163307C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001—Lactones
    • C07J21/003—Lactones at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK030488A 1987-01-23 1988-01-22 11-phenyl-14betah-steroidderivater, fremgangsmaade til fremstilling heraf samt farmaceutisk middel indeholdende disse DK163307C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL8700157 1987-01-23
NL8700157 1987-01-23

Publications (4)

Publication Number Publication Date
DK30488D0 true DK30488D0 (da) 1988-01-22
DK30488A DK30488A (da) 1988-07-24
DK163307B DK163307B (da) 1992-02-17
DK163307C DK163307C (da) 1992-07-06

Family

ID=19849457

Family Applications (1)

Application Number Title Priority Date Filing Date
DK030488A DK163307C (da) 1987-01-23 1988-01-22 11-phenyl-14betah-steroidderivater, fremgangsmaade til fremstilling heraf samt farmaceutisk middel indeholdende disse

Country Status (16)

Country Link
EP (1) EP0277676B1 (da)
JP (1) JP2664390B2 (da)
KR (1) KR960013448B1 (da)
CN (1) CN1030081C (da)
AT (1) ATE73137T1 (da)
AU (1) AU603637B2 (da)
CA (1) CA1339570C (da)
DE (1) DE3868647D1 (da)
DK (1) DK163307C (da)
ES (1) ES2031991T3 (da)
FI (1) FI89054C (da)
GR (1) GR3004783T3 (da)
IE (1) IE60780B1 (da)
NZ (1) NZ223262A (da)
PT (1) PT86602B (da)
ZA (1) ZA88317B (da)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2785023B2 (ja) * 1987-12-30 1998-08-13 ルセル―ユクラフ １７α位置を置換された１７β―ＯＨ―１９―ノルステロイドの新誘導体、その製造方法、その薬剤としての使用及びそれを含有する製薬組成物
US4954490A (en) * 1988-06-23 1990-09-04 Research Triangle Institute 11 β-substituted progesterone analogs
DE3832303A1 (de) * 1988-09-20 1990-04-12 Schering Ag 11ss-phenyl-14ssh-steroide
US5364847A (en) * 1989-03-10 1994-11-15 Endorecherche Inhibitors of sex steroid biosynthesis and methods for their production and use
US5372996A (en) * 1989-03-10 1994-12-13 Endorecherche, Inc. Method of treatment of androgen-related diseases
WO1991000732A1 (en) * 1989-07-07 1991-01-24 Endorecherche Inc. Androgen derivatives for use in the inhibition of sex steroid activity
HUT60139A (en) * 1989-07-07 1992-08-28 Endorecherche Inc Process for producing pharmaceutical composition suitable for treating prostate cancer connected with androgen
DE59010853D1 (de) * 1989-08-04 1998-12-03 Schering Ag 11 Beta-Aryl-gona-4,9-dien-3-one
FR2650748B1 (fr) * 1989-08-08 1991-11-08 Roussel Uclaf Nouveaux esters d'acides organiques avec des alcools derives de 19-nor steroides et leurs sels, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicaments et les compositions les renfermant
DE4018167A1 (de) * 1990-06-01 1991-12-05 Schering Ag Verfahren zur herstellung von 10(beta)-h-steroiden
US5407928A (en) * 1990-08-15 1995-04-18 Schering Aktiengesellschaft 11β-aryl-gona-4,9-dien-3-ones
ZA929315B (en) * 1991-12-20 1993-05-24 Akzo Nv 17-spirofuran-3'-ylidene steroids.
JPH07506575A (ja) * 1992-05-21 1995-07-20 アンドルシェルシュ・インコーポレイテッド テストステロン５α−レダクターゼ活性の阻害剤
AU680818B2 (en) * 1992-05-21 1997-08-14 Endorecherche Inc. Improved antiandrogens
AU693077B2 (en) * 1993-06-15 1998-06-25 Pherin Pharmaceuticals, Inc. Estrene steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods
DE4415590A1 (de) * 1994-04-28 1995-11-02 Schering Ag Verfahren zur stereoselektiven Einführung einer Alkinylseitenkette an 11ß-Aryl-substituierten 13alpha-Alkylgonan-17-onen
ZA9510926B (en) 1994-12-23 1996-07-03 Schering Ag Compounds with progesterone-antagonistic and antiestrogenic action to be used together for female contraception
IL118974A (en) * 1995-08-17 2001-09-13 Akzo Nobel Nv History 11 - (Transformed Phenyl) - Astra - 4, 9 - Diane, their preparation and pharmaceutical preparations containing them
US6020328A (en) * 1998-03-06 2000-02-01 Research Triangle Institute 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US5962444A (en) * 1998-05-29 1999-10-05 Research Triangle Institute 17β-nitro-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US6262042B1 (en) 1998-05-29 2001-07-17 Research Triangle Institute 17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
EP1163259B1 (en) * 1999-03-08 2002-11-20 Akzo Nobel N.V. 14.beta.,17-alpha-hydroxymethylandrostane derivatives as androgens
AU778017B2 (en) * 1999-12-02 2004-11-11 N.V. Organon 14,15-beta-methylene substituted androgens
BR0016092A (pt) * 1999-12-02 2002-07-30 Akzo Nobel Nv Composto, uso de um composto kit para contracepção hormonal em um macho, e, método de tratamento
TW200531977A (en) 2004-03-25 2005-10-01 Akzo Nobel Nv Progesterone receptor modulators
WO2011157443A1 (en) 2010-06-17 2011-12-22 N.V. Organon (11b,17a)-11-(4-(2-11c-acetyl)phenyl)-17,23-epoxy-19,24-dinorchola-4,9,20-trien-3-one
HUE029252T2 (en) 2011-06-01 2017-02-28 Estetra Sprl Process for the preparation of intermediates of estetrol
SG195121A1 (en) 2011-06-01 2013-12-30 Estetra S A Process for the production of estetrol intermediates
EP2383279A1 (en) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Process for the preparation of estetrol
CN113559075A (zh) 2014-11-17 2021-10-29 康泰科思特生物制药公司 奥那司酮延长释放组合物和方法
EP3389632A4 (en) 2015-12-15 2019-11-06 Context Biopharma Inc. AMORPHIC ONAPRISTON COMPOSITIONS AND METHOD FOR THE PRODUCTION THEREOF
WO2018102369A1 (en) 2016-11-30 2018-06-07 Arno Therapeutics, Inc. Methods for onapristone synthesis dehydration and deprotection
CN110437294A (zh) * 2019-07-21 2019-11-12 浙江神洲药业有限公司 一种制备群勃龙醋酸酯的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
ES8502612A1 (es) * 1983-06-15 1985-02-01 Schering Ag Procedimiento para la preparacion de 13a-alquilgonanos

Also Published As

Publication number Publication date
FI880257A7 (fi) 1988-07-24
JP2664390B2 (ja) 1997-10-15
FI89054B (fi) 1993-04-30
CA1339570C (en) 1997-12-09
JPS63216895A (ja) 1988-09-09
CN1030081C (zh) 1995-10-18
KR880009036A (ko) 1988-09-13
EP0277676A1 (en) 1988-08-10
ZA88317B (en) 1988-07-27
FI89054C (fi) 1993-08-10
CN88100979A (zh) 1988-08-17
AU1066988A (en) 1988-07-28
DE3868647D1 (de) 1992-04-09
NZ223262A (en) 1989-08-29
AU603637B2 (en) 1990-11-22
ATE73137T1 (de) 1992-03-15
DK163307B (da) 1992-02-17
DK163307C (da) 1992-07-06
ES2031991T3 (es) 1993-01-01
KR960013448B1 (ko) 1996-10-05
GR3004783T3 (da) 1993-04-28
EP0277676B1 (en) 1992-03-04
PT86602A (pt) 1988-02-01
DK30488A (da) 1988-07-24
FI880257A0 (fi) 1988-01-21
IE60780B1 (en) 1994-08-10
PT86602B (pt) 1991-12-31
IE880103L (en) 1988-07-23

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