DK3049059T3 - Intranasal dhe formulering til behandlingen af hovedpine - Google Patents
Intranasal dhe formulering til behandlingen af hovedpine Download PDFInfo
- Publication number
- DK3049059T3 DK3049059T3 DK14830861.2T DK14830861T DK3049059T3 DK 3049059 T3 DK3049059 T3 DK 3049059T3 DK 14830861 T DK14830861 T DK 14830861T DK 3049059 T3 DK3049059 T3 DK 3049059T3
- Authority
- DK
- Denmark
- Prior art keywords
- headache
- treatment
- dhe formulation
- intranasal
- intranasal dhe
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Otolaryngology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361881947P | 2013-09-24 | 2013-09-24 | |
| PCT/IB2014/002706 WO2015044782A2 (en) | 2013-09-24 | 2014-09-24 | Intranasal dhe for the treatment of headache |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3049059T3 true DK3049059T3 (da) | 2022-01-31 |
Family
ID=52424045
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14830861.2T DK3049059T3 (da) | 2013-09-24 | 2014-09-24 | Intranasal dhe formulering til behandlingen af hovedpine |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US20160228433A1 (da) |
| EP (2) | EP4008307A1 (da) |
| JP (2) | JP2016531850A (da) |
| DK (1) | DK3049059T3 (da) |
| ES (1) | ES2904570T3 (da) |
| WO (1) | WO2015044782A2 (da) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8757146B2 (en) | 2008-02-07 | 2014-06-24 | University Of Washington Through Its Center For Commercialization | Circumferential aerosol device |
| JP6339371B2 (ja) | 2011-03-03 | 2018-06-06 | インペル ニューロファーマ インコーポレイテッド | 経鼻薬物送達デバイス |
| CN103619485B (zh) | 2011-05-09 | 2017-08-08 | 英倍尔药业股份有限公司 | 用于鼻腔药物递送的喷嘴 |
| EP2991713B1 (en) | 2013-04-28 | 2019-06-19 | Impel Neuropharma Inc. | Medical unit dose container |
| DK3049059T3 (da) | 2013-09-24 | 2022-01-31 | Satsuma Pharmaceuticals Inc | Intranasal dhe formulering til behandlingen af hovedpine |
| MX2018002895A (es) | 2015-09-10 | 2018-07-06 | Impel Neuropharma Inc | Dispositivo de administracion nasal en linea. |
| EP3493789A2 (en) | 2016-08-05 | 2019-06-12 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal pharmaceutical powder compositions |
| BR112019027508A2 (pt) * | 2017-07-02 | 2020-07-07 | Dr. Reddys Laboratories Limited | formas de dosagem nasal de di-hidroergotamina |
| WO2019104205A1 (en) | 2017-11-21 | 2019-05-31 | Impel Neuropharma, Inc. | Intranasal device with dip tube |
| EP3713626A4 (en) | 2017-11-21 | 2021-08-18 | Impel Neuropharma Inc. | INTRA-NASAL DEVICE WITH INPUT INTERFACE |
| BR112020013750A8 (pt) | 2018-01-05 | 2022-10-18 | Impel Neuropharma Inc | Dispensação intranasal de olanzapina por dispositivo olfativo de precisão |
| JP7317020B2 (ja) * | 2018-01-05 | 2023-07-28 | インペル ファーマシューティカルズ インコーポレイテッド | 精密嗅覚デバイスによるジヒドロエルゴタミンの鼻腔内送達 |
| US11517548B2 (en) | 2018-07-19 | 2022-12-06 | Impel Pharmaceuticals Inc. | Respiratory tract delivery of levodopa and DOPA decarboxylase inhibitor for treatment of Parkinson's Disease |
| GB2581431A (en) * | 2018-12-11 | 2020-08-19 | Satsuma Pharmaceuticals Inc | Compositions, devices, and methods for treating or preventing headaches |
| CN120284965A (zh) * | 2018-12-11 | 2025-07-11 | 小蜜橘制药公司 | 用于治疗或预防头痛的组合物、装置和方法 |
| WO2020142206A1 (en) | 2019-01-03 | 2020-07-09 | Impel Neuropharma, Inc. | Nasal drug delivery device |
| CN114025816A (zh) | 2019-05-17 | 2022-02-08 | 英倍尔药业股份有限公司 | 一次性鼻腔给送装置 |
| AU2024282997A1 (en) * | 2023-05-31 | 2026-01-22 | Shin Nippon Biomedical Laboratories, Ltd. | Compositions for enhanced mucosal penetration |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2750090A1 (de) | 1976-11-19 | 1978-06-01 | Sandoz Ag | Neue verabreichungsformen fuer organische verbindungen |
| US5169849A (en) * | 1982-02-01 | 1992-12-08 | Sandoz Ltd. | Nasal pharmaceutical compositions |
| JPS59163313A (ja) * | 1983-03-09 | 1984-09-14 | Teijin Ltd | 経鼻投与用ペプチドホルモン類組成物 |
| ATE290864T1 (de) * | 1993-03-26 | 2005-04-15 | Franciscus Wilhelmus He Merkus | Pharmazeutische zusammensetzungen zur intranasalen verabreichung von dihydroergotamin |
| JP3197221B2 (ja) * | 1996-02-27 | 2001-08-13 | 帝人株式会社 | 吸収性が改善された粉末状経鼻投与組成物 |
| SE9803770D0 (sv) | 1998-11-05 | 1998-11-05 | Astra Ab | Dry powder pharmaceutical formulation |
| JP4691298B2 (ja) * | 1999-10-12 | 2011-06-01 | 科研製薬株式会社 | 粉末吸入用製剤及びその製造方法 |
| JP2004531333A (ja) * | 2001-06-20 | 2004-10-14 | ネクター セラピューティクス | 粉末エアロゾル化装置及び方法 |
| KR20030027108A (ko) * | 2001-07-05 | 2003-04-03 | 트렌스레셔널 리서치 가부시키가이샤 | 인슐린의 경비 투여용 조성물 |
| US20030044458A1 (en) | 2001-08-06 | 2003-03-06 | Curtis Wright | Oral dosage form comprising a therapeutic agent and an adverse-effect agent |
| FR2834212B1 (fr) * | 2001-12-27 | 2004-07-09 | Besins Int Belgique | Utilisation d'une poudre a liberation immediate dans des compositions pharmaceutiques et nutraceutiques |
| JP4212019B2 (ja) * | 2002-01-09 | 2009-01-21 | Translational Research 株式会社 | 薬物の経鼻投与用組成物 |
| GB0228826D0 (en) * | 2002-12-11 | 2003-01-15 | Okpala Joseph | Hair technology in creating particles with improved delivery capabilities |
| US7638138B2 (en) * | 2003-02-21 | 2009-12-29 | Translational Research, Ltd. | Compositions for nasal administration of pharmaceuticals |
| GB0304636D0 (en) * | 2003-02-28 | 2003-04-02 | Britannia Pharmaceuticals Ltd | Pharmaceutical composition for nasal delivery |
| JP2007505136A (ja) | 2003-09-10 | 2007-03-08 | マツプ・フアーマシユーテイカルズ・インコーポレーテツド | ジヒドロエルゴタミンを肺吸入により体循環に送達するためのエアゾール製剤 |
| WO2006016530A1 (ja) * | 2004-08-10 | 2006-02-16 | Translational Research, Ltd. | 速効性でかつ高い吸収性を可能とする経鼻投与用組成物 |
| CA2617909C (en) * | 2005-08-05 | 2014-02-04 | 3M Innovative Properties Company | Compositions exhibiting improved flowability |
| US8106100B2 (en) * | 2005-12-06 | 2012-01-31 | Asahi Kasei Chemicals Corporation | Process for producing tablet by high-speed direct compression |
| US8337817B2 (en) * | 2006-12-26 | 2012-12-25 | Shin Nippon Biomedical Laboratories, Ltd. | Preparation for transnasal application |
| WO2008097664A1 (en) | 2007-02-11 | 2008-08-14 | Map Pharmaceuticals, Inc. | Method of therapeutic administration of dhe to enable rapid relief of migraine while minimizing side effect profile |
| JP2009076785A (ja) * | 2007-09-21 | 2009-04-09 | Panasonic Corp | 半導体装置の製造方法 |
| US20110082150A1 (en) | 2008-02-11 | 2011-04-07 | Robert Owen Cook | Headache pre-emption by dihydroergotamine treatment during headache Precursor events |
| WO2010131486A1 (en) * | 2009-05-15 | 2010-11-18 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal pharmaceutical compositions with improved pharmacokinetics |
| WO2010151804A1 (en) | 2009-06-26 | 2010-12-29 | Map Pharmaceuticals, Inc. | Administration of dihydroergotamine mesylate particles using a metered dose inhaler |
| WO2011013003A2 (en) | 2009-07-31 | 2011-02-03 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal granisetron and nasal applicator |
| IN2012DN04858A (da) | 2009-12-23 | 2015-09-25 | Map Pharmaceuticals Inc | |
| CN103126996A (zh) * | 2010-04-15 | 2013-06-05 | 株式会社新日本科学 | 用于鼻内递送的方法和组合物 |
| WO2011163600A2 (en) * | 2010-06-25 | 2011-12-29 | Apt Pharmaceuticals, Inc. | Tacrolimus compositions for aerosol administration |
| CA2825541C (en) | 2011-01-31 | 2020-06-02 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal delivery devices |
| JP6339371B2 (ja) | 2011-03-03 | 2018-06-06 | インペル ニューロファーマ インコーポレイテッド | 経鼻薬物送達デバイス |
| WO2013090278A2 (en) * | 2011-12-11 | 2013-06-20 | Recro Pharma, Inc. | Intranasal dexmedetomidine compositions and methods of use thereof |
| AU2013361337A1 (en) | 2012-12-21 | 2015-07-09 | Map Pharmaceuticals, Inc. | 8'-Hydroxy-Dihydroergotamine compounds and compositions |
| US20140179705A1 (en) | 2012-12-21 | 2014-06-26 | Map Pharmaceuticals, Inc. | 8'-hydroxy-dihydroergotamine compounds and compositions |
| DK3049059T3 (da) | 2013-09-24 | 2022-01-31 | Satsuma Pharmaceuticals Inc | Intranasal dhe formulering til behandlingen af hovedpine |
| US9561177B2 (en) | 2014-03-14 | 2017-02-07 | Adapt Pharma Limited | Nasal drug products and methods of their use |
| EP3493789A2 (en) | 2016-08-05 | 2019-06-12 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal pharmaceutical powder compositions |
| JP7523879B2 (ja) | 2016-10-31 | 2024-07-29 | エスエス製薬株式会社 | 医薬組成物 |
| BR112019027508A2 (pt) | 2017-07-02 | 2020-07-07 | Dr. Reddys Laboratories Limited | formas de dosagem nasal de di-hidroergotamina |
| US11744967B2 (en) | 2017-09-26 | 2023-09-05 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal delivery devices |
| JP7317020B2 (ja) | 2018-01-05 | 2023-07-28 | インペル ファーマシューティカルズ インコーポレイテッド | 精密嗅覚デバイスによるジヒドロエルゴタミンの鼻腔内送達 |
| CN120284965A (zh) | 2018-12-11 | 2025-07-11 | 小蜜橘制药公司 | 用于治疗或预防头痛的组合物、装置和方法 |
-
2014
- 2014-09-24 DK DK14830861.2T patent/DK3049059T3/da active
- 2014-09-24 EP EP21205407.6A patent/EP4008307A1/en active Pending
- 2014-09-24 ES ES14830861T patent/ES2904570T3/es active Active
- 2014-09-24 WO PCT/IB2014/002706 patent/WO2015044782A2/en not_active Ceased
- 2014-09-24 JP JP2016516520A patent/JP2016531850A/ja active Pending
- 2014-09-24 US US15/023,206 patent/US20160228433A1/en not_active Abandoned
- 2014-09-24 EP EP14830861.2A patent/EP3049059B1/en active Active
-
2019
- 2019-05-16 US US16/414,350 patent/US20190275036A1/en not_active Abandoned
- 2019-09-06 JP JP2019162995A patent/JP6902583B2/ja active Active
-
2020
- 2020-02-14 US US16/791,431 patent/US20200179379A1/en not_active Abandoned
-
2022
- 2022-06-07 US US17/834,583 patent/US12594273B2/en active Active
-
2023
- 2023-10-02 US US18/479,335 patent/US20240108619A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015044782A3 (en) | 2015-06-11 |
| JP6902583B2 (ja) | 2021-07-14 |
| EP4008307A1 (en) | 2022-06-08 |
| US20200179379A1 (en) | 2020-06-11 |
| US20230000860A1 (en) | 2023-01-05 |
| JP2020007342A (ja) | 2020-01-16 |
| EP3049059A2 (en) | 2016-08-03 |
| US12594273B2 (en) | 2026-04-07 |
| EP3049059B1 (en) | 2021-11-03 |
| JP2016531850A (ja) | 2016-10-13 |
| WO2015044782A2 (en) | 2015-04-02 |
| ES2904570T3 (es) | 2022-04-05 |
| US20240108619A1 (en) | 2024-04-04 |
| US20160228433A1 (en) | 2016-08-11 |
| US20190275036A1 (en) | 2019-09-12 |
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