DK3055005T3 - Lægemiddelafgivelsesindretning - Google Patents

Lægemiddelafgivelsesindretning Download PDF

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DK3055005T3
DK3055005T3 DK14781554.2T DK14781554T DK3055005T3 DK 3055005 T3 DK3055005 T3 DK 3055005T3 DK 14781554 T DK14781554 T DK 14781554T DK 3055005 T3 DK3055005 T3 DK 3055005T3
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locking
energy
release mechanism
release
delivery device
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DK14781554.2T
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Stephan Olson
Gunnar Elmén
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Carebay Europe Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
    • A61M11/007—Syringe-type or piston-type sprayers or atomisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
    • A61M11/08—Pocket atomisers of the injector type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0003—Details of inhalators; Constructional features thereof with means for dispensing more than one drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2066—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
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    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M5/31515—Connection of piston with piston rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/3157—Means providing feedback signals when administration is completed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
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    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
    • A61M2005/2451—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing preventing delivery before mixing is completed, e.g. by locking mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A61M5/326—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
    • A61M2005/3267—Biased sleeves where the needle is uncovered by insertion of the needle into a patient's body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/582—Means for facilitating use, e.g. by people with impaired vision by tactile feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8275—Mechanical
    • A61M2205/8281—Mechanical spring operated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod

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  • Health & Medical Sciences (AREA)
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  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mechanical Engineering (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Claims (13)

1. Lægemiddelafgivelsesindretning (2) omfattende: et hus (4), en beholdergriber (22) til en lægemiddelbeholder (11) anbragt i huset (4), et første energiakkumulerende organ (14) til energisætning af en afgivelse af et lægemiddel fra lægemiddelbeholderen (11), og et løsbart første låsearrangement (18) til låsning af det første energiakkumulerende organ (14) i en første energilagrende position, et andet energiakkumulerende organ (16) til energisætning af en blanding af et lægemiddel i lægemiddelbeholderen (11), og et løsbart andet låsearrangement (20) til låsning af det andet energiakkumulerende organ (16) i en anden energilagrende position, hvor det andet låsearrangement (20) i en første stilling forhindrer frigivelse af det første låsearrangement (18), og hvor det andet låsearrangement (20) i en anden stilling tillader det første låsearrangement (18) at blive frigivet; kendetegnet ved, at det første låsearrangement (18) omfatter: en første frigivelsesmekanisme (52) i form af en første manuelt betjent knop, hvilken knop kan flyttes mellem en første låseposition, hvor det første energiakkumulerende organ (14) låses i den første energilagrende position, og en første frigivelsesposition, hvor det første energiakkumulerende organ (14) frigøres fra den første energilagrende position, og at det andet låsearrangement (20) omfatter: en anden frigivelsesmekanisme (64) i form af en anden manuelt betjent knop, hvilken knop kan flyttes mellem en anden låseposition, hvor det andet energiakkumulerende organ (16) låses i den anden energilagrende position, og en anden frigivelsesposition, hvor det andet energiakkumulerende organ (16) frigøres fra den anden energilagrende position, og hvor, i den første stilling, den anden frigivelsesmekanisme (64) i den anden låseposition forhindrer den første frigivelsesmekanisme (52) i at blive flyttet til den første frigivelsesposition, og i den anden stilling tillader den anden frigivelsesmekanisme (64) i den anden frigivelsesposition, at den første frigivelsesmekanisme (52) bliver flyttet til den første frigivelsesposition.
2. Lægemiddelafgivelsesindretning (2) ifølge krav 1, hvor den anden frigivelsesmekanisme (64) et anbragt i blokerende kontakt med den første frigivelsesmekanisme (52), når den anden frigivelsesmekanisme (64) er i den anden låseposition, og den første frigivelsesmekanisme (52) er i den første låseposition, og hvor den anden frigivelsesmekanisme (64) flyttes ud af den blokerende kontakt med den første frigivelsesmekanisme (52), når den anden frigivelsesmekanisme (64) flyttes til den anden frigivelsesposition.
3. Lægemiddelafgivelsesindretning (2) ifølge krav 1 eller 2, hvor den første frigivelsesmekanisme (52) er forbundet til huset (4), således at i den første låseposition er det første låsearrangement (18) sikret til huset (4) til fastholdelse af det første energiakkumulerende organ (14) i den første energilagrende position, og hvor den anden frigivelsesmekanisme (64) er forbundet til huset (4), således at i den anden låseposition er det andet låsearrangement (20) fastholdt til huset (4) til fastholdelse af det andet energiakkumulerende organ (16) i den anden energilagrende position.
4. Lægemiddelafgivelsesindretning (2) ifølge ethvert af kravene 1 - 3, hvor den første frigivelsesmekanisme (52) kan flyttes manuelt mellem den første låseposition og den første frigivelsesposition, og hvor den anden frigivelsesmekanisme (64) kan flyttes manuelt mellem den anden låseposition og den anden frigivelsesposition.
5. Lægemiddelafgivelsesindretning (2) ifølge krav 2 eller 3, hvor huset (4) har en længdeakse (6), der strækker sig mellem og langs med en proksimal endedel (8) og en distal endedel (10) af huset (4), hvor beholdergriberen (22) er anbragt i huset (4) ved den proksimale endedel (8), hvilken lægemiddelafgivelsesindretning (2) omfatter en dykker (24), hvor dykkeren (24) kan bevæges aksialt og er indrettet til forskydning langs længdeaksen (6) ind i beholdergriberen (22), hvor det første energiakkumulerende organ (14) er indrettet til forskydning af dykkeren (24) langs længdeaksen (6) mod den proksimale endedel (8) til energisætningen af en afgivelse af et lægemiddel ved frigivelse fra den første energilagrende position, hvor beholdergriberen (22) er indrettet til at rumme en lægemiddelbeholder (11), der er beregnet til tilslutning af et lægemiddelafgivelsesorgan (75) ved en første endedel (26) af lægemiddelbeholderen (11) og omfatter et første stempel (28), der er anbragt tæt og glidbart indvendigt i en modsat endedel af lægemiddelbeholderen (11) og et andet stempel (30) anbragt glidbart inden i et mellemafsnit af lægemiddelbeholderen (11), og hvor dykkeren (24) omfatter en ydre dykkerstang (32) og en indre dykkerstang (34) anbragt i det mindste delvis inden i den udvendige dykkerstang (32), og hvor det andet energiakkumulerende organ (16) er indrettet til aktivering af den indre dykkerstang (34) til energisætningen af en blanding af et lægemiddel, når organet frigives fra den anden energilagrende position.
6. Lægemiddelafgivelsesindretning (2) ifølge ethvert af kravene 1 - 3, hvor det andet energiakkumulerende organ (16) er anbragt inden i den ydre dykkerstang (32) og omfatter en trykfjeder (42), der strækker sig langs længdeaksen (6), hvilken trykfjeder (42) i den anden energilagrende position udsættes for en aksial kompression, hvor det andet låsearrangement (20) omfatter en trykstang (44), der strækker sig langs længdeaksen (6), og hvor, når det andet låsearrangement (20) er i den anden låseposition, trykstangen (44) står i indgreb med trykfjederen (42) og med huset (4) ved den distale endedel (10) til frembringelse af den aksiale kompression.
7. Lægemiddelafgivelsesindretning (2) ifølge krav 5 eller 6, hvor den indre dykkerstang (34) er indrettet til at gå i indgreb med den ydre dykkerstang (32), når den indre dykkerstang (34) anbringes i en endeposition mod den proksimale endedel (8).
8. Lægemiddelafgivelsesindretning (2) ifølge krav 6, hvor den indre dykkerstang (34) omfatter mindst ét elastisk fremspring (76), der er indrettet til at gå i indgreb med en forsænkning (78) i den ydre dykkerstang (32), når den indre dykkerstang (34) anbringes i endepositionen mod den proksimale endedel (8).
9. Lægemiddelafgivelsesindretning (2) ifølge krav 8, hvor den ydre dykkerstang (32) er udstyret med en række forhøjninger og/eller fordybninger (80), og hvor det elastiske fremspring (76) er beregnet til at løbe langs med og i kontakt med rækkerne af forhøjninger og/eller fordybninger (80), når den indre dykkerstang (34) bevæges mod endepositionen mod den proksimale endedel (8) til frembringelse af en hørbar og/eller mærkbar tilbagemelding til en bruger af lægemiddelafgivelsesindretningen (2).
10. Lægemiddelafgivelsesindretning (2) ifølge krav 1 og ethvert af kravene 5 - 9, omfattende et fastholdt organ (82) anbragt indvendigt i huset (4), og det fastholdte organ (82) er udstyret med en gevindforsynet indre overflade (84), hvor den ydre dykkerstang (32) har en gevindforsynet ydre overflade (86), og den gevindforsynede indre overflade (84) af det fastholdte organ (82) er i indgreb med den gevindforsynede ydre overflade (86) af den ydre dykkerstang (32), hvor det første energiakkumulerende organ (14) omfatter en torsionsfjeder (36) til omsætning af lagret energi i en rotationsbevægelse til forskydningen af dykkeren (24) langs længdeaksen (6) mod den proksimale endedel (8), hvor en første ende (38) af torsionsfjederen (36) er forbundet til huset (4), og en anden ende (40) af torsionsfjederen (36) er forbundet til den ydre dykkerstang (32), og hvor det første låsearrangement (18) omfatter et første låseorgan (54), der er forbundet med den anden ende (40) af torsionsfjederen (36), og den første frigivelsesmekanisme (52) er i indgreb med det første låseorgan (54) i den første låseposition.
11. Lægemiddelafgivelsesindretning (2) ifølge krav 2, hvor den ydre dykkerstang (32) står i indgreb med den anden ende (40) af torsionsfjederen (36) via et drivorgan (46), den ydre dykkerstang (32) er glidbart forbundet med drivorganet (46) til glidende bevægelse af den ydre dykkerstang (32) langs drivorganet (46) og længdeaksen (6), og hvor det første låseorgan (54) er forbundet med drivorganet (46) til at kunne rotere sammen med den anden ende (40) af torsionsfjederen (36).
12. Lægemiddelafgivelsesindretning (2) ifølge krav 10 eller 11, hvor det første låseorgan (54) er udstyret med en forsænkning (60), og den første frigivelsesmekanisme (52) er udstyret med et fremspring (86), hvor fremspringet (86) går i indgreb med forsænkningen (60), når det første låseorgan (54) er i den første låseposition.
13. Lægemiddelafgivelsesindretning (2) ifølge krav 12, hvor fremspringet (86) og forsænkningen (60) ved rotation af det første låseorgan (54) frembringer en hørbar og/eller mærkbar tilbagemelding til en bruger af lægemiddelafgivelsesindretningen (2).
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